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Conserved domains on  [gi|24581061|ref|NP_608664|]
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secretory 24CD, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COG5028 super family cl34873
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
395-1190 2.68e-168

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5028:

Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 520.50  E-value: 2.68e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  395 QPGRPGFNQPPMPGAGNMYQQAPQ-ARRLDPDQMPNPI-QVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPR 472
Cdd:COG5028   72 NNPAPSVMSPAFQSQQKFSSPYGGsMADGTAPKPTNPLvPVDLFEDQPPPISDLFLPPPPIVPPLTTNFVGSEQSNCSPK 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  473 FLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEmgPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKV 552
Cdd:COG5028  152 YVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRS 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  553 TSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPevPAFIFIIDVSYNTVKSGLVHLLCSQIKNILK 632
Cdd:COG5028  230 KNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPP--PVYVFLIDVSFEAIKNGLVKAAIRAILENLD 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  633 HLPVDQGqdksKVRVGFITYNSTVHFYNIKSSLaQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVI-DALMEEIPRMFAD 711
Cdd:COG5028  308 QIPNFDP----RTKIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGLFVLPLKSCKQIiETLLDRVPRIFQD 382
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  712 TKETETILYPAIQAGLEALKASnaAGKLLVFNSTLPiAEAPGKLKNRDDrkllgtdKEKTVLTPQTTAYNTLGQECVQQG 791
Cdd:COG5028  383 NKSPKNALGPALKAAKSLIGGT--GGKIIVFLSTLP-NMGIGKLQLRED-------KESSLLSCKDSFYKEFAIECSKVG 452
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  792 CSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQAD--VDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGH 869
Cdd:COG5028  453 ISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGN 532
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  870 FFMSNTTDVELASIDATKSISIEIKHDDKLApEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMML 949
Cdd:COG5028  533 FFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIAC 611
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  950 FFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSdMTLDDRS 1029
Cdd:COG5028  612 ILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSGS-TPSDIRI 690
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061 1030 YVIQFILSMDLNQSVSYLYPRFIPIHNVVPE-------ETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFV 1102
Cdd:COG5028  691 SALNRLTSLPLKQLMRNIYPTLYALHDMPIEaglpdegLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLL 770
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061 1103 QSVFGVQGLQQIALERFNIVPE-TPLAKRIHGILEQImkeRSRYMRITW----LRQN--DKLESVFRHFLVEDRgTDGSA 1175
Cdd:COG5028  771 QDLFGVDSLSDIPSGKFTLPPTgNEFNERVRNIIGEL---RSVNDDSTLplvlVRGGgdPSLRLWFFSTLVEDK-TLNIP 846
                        810
                 ....*....|....*
gi 24581061 1176 SYVDFLCHMHKEIKD 1190
Cdd:COG5028  847 SYLDYLQILHEKIKS 861
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
119-321 3.53e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   119 QFNSNAAPPPTNNNNAAFGAP----------PPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPK-AA 187
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPaaaapaaaapAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGpGG 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   188 TPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPssrPGQPQLPPGATPPTYTQPGLPPQQQQ 267
Cdd:PRK12323  447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP---PWEELPPEFASPAPAQPDAAPAGWVA 523
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24581061   268 GIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQG--GYSGGFPG 321
Cdd:PRK12323  524 ESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASasGLPDMFDG 579
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
395-1190 2.68e-168

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 520.50  E-value: 2.68e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  395 QPGRPGFNQPPMPGAGNMYQQAPQ-ARRLDPDQMPNPI-QVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPR 472
Cdd:COG5028   72 NNPAPSVMSPAFQSQQKFSSPYGGsMADGTAPKPTNPLvPVDLFEDQPPPISDLFLPPPPIVPPLTTNFVGSEQSNCSPK 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  473 FLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEmgPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKV 552
Cdd:COG5028  152 YVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRS 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  553 TSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPevPAFIFIIDVSYNTVKSGLVHLLCSQIKNILK 632
Cdd:COG5028  230 KNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPP--PVYVFLIDVSFEAIKNGLVKAAIRAILENLD 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  633 HLPVDQGqdksKVRVGFITYNSTVHFYNIKSSLaQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVI-DALMEEIPRMFAD 711
Cdd:COG5028  308 QIPNFDP----RTKIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGLFVLPLKSCKQIiETLLDRVPRIFQD 382
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  712 TKETETILYPAIQAGLEALKASnaAGKLLVFNSTLPiAEAPGKLKNRDDrkllgtdKEKTVLTPQTTAYNTLGQECVQQG 791
Cdd:COG5028  383 NKSPKNALGPALKAAKSLIGGT--GGKIIVFLSTLP-NMGIGKLQLRED-------KESSLLSCKDSFYKEFAIECSKVG 452
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  792 CSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQAD--VDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGH 869
Cdd:COG5028  453 ISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGN 532
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  870 FFMSNTTDVELASIDATKSISIEIKHDDKLApEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMML 949
Cdd:COG5028  533 FFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIAC 611
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  950 FFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSdMTLDDRS 1029
Cdd:COG5028  612 ILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSGS-TPSDIRI 690
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061 1030 YVIQFILSMDLNQSVSYLYPRFIPIHNVVPE-------ETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFV 1102
Cdd:COG5028  691 SALNRLTSLPLKQLMRNIYPTLYALHDMPIEaglpdegLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLL 770
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061 1103 QSVFGVQGLQQIALERFNIVPE-TPLAKRIHGILEQImkeRSRYMRITW----LRQN--DKLESVFRHFLVEDRgTDGSA 1175
Cdd:COG5028  771 QDLFGVDSLSDIPSGKFTLPPTgNEFNERVRNIIGEL---RSVNDDSTLplvlVRGGgdPSLRLWFFSTLVEDK-TLNIP 846
                        810
                 ....*....|....*
gi 24581061 1176 SYVDFLCHMHKEIKD 1190
Cdd:COG5028  847 SYLDYLQILHEKIKS 861
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
599-847 1.30e-120

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 372.38  E-value: 1.30e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  599 PEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQgqdkSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQE 678
Cdd:cd01479    1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  679 MFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKasNAAGKLLVFNSTLPIAEApGKLKNR 758
Cdd:cd01479   77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  759 DDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYT--YFQADVDGKRLI 836
Cdd:cd01479  154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPsfNFSAPNDVEKLV 233
                        250
                 ....*....|.
gi 24581061  837 QDIIKNVSRPI 847
Cdd:cd01479  234 NELARYLTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
599-843 2.96e-109

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 341.92  E-value: 2.96e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    599 PEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDqgqdkSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQE 678
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGD-----PRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    679 MFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNR 758
Cdd:pfam04811   76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    759 DDRKLLGTDKEKTVLTPQTT-AYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQ 837
Cdd:pfam04811  156 LDESHHGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235

                   ....*.
gi 24581061    838 DIIKNV 843
Cdd:pfam04811  236 DLQRYF 241
PTZ00395 PTZ00395
Sec24-related protein; Provisional
586-1186 7.85e-51

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 197.22  E-value: 7.85e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   586 FLATKDYCRNNTPPevpAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQgqdkskVRVGFITYNSTVHFYNIKSSL 665
Cdd:PTZ00395  940 FLAKYPQVKNMLPP---YFVFVVECSYNAIYNNITYTILEGIRYAVQNVKCPQ------TKIAIITFNSSIYFYHCKGGK 1010
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   666 AQP-------------QMMVVGDVQEMFMPL-LDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALK 731
Cdd:PTZ00395 1011 GVSgeegdggggsgnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLK 1090
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   732 ASNAAGKLLVFNSTLPIAeAPGKLKNrddrklLGTDKEKTVL-TPQTTAYNTLGQECVQQGCSVDLFVF--NNAYIDLAT 808
Cdd:PTZ00395 1091 ERNGLGSICMFYTTTPNC-GIGAIKE------LKKDLQENFLeVKQKIFYDSLLLDLYAFNISVDIFIIssNNVRVCVPS 1163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   809 IGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNV-SRPIAFDAVMRVRTSAGIRPTEFyghfFMSNTTDVELASIDATK 887
Cdd:PTZ00395 1164 LQYVAQNTGGKILFVENFLWQKDYKEIYMNIMDTLtSEDIAYCCELKLRYSHHMSVKKL----FCCNNNFNSIISVDTIK 1239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   888 SIsiEIKHDDKLA----------PEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACF 957
Cdd:PTZ00395 1240 IP--KIRHDQTFAfllnysdiseSKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCT 1317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   958 KLM--EHSPKQVKDNLihrsAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISggSDMTLDDRSYVIQFI 1035
Cdd:PTZ00395 1318 NILhnDNYSKIIIDNL----AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYSLIKL 1391
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  1036 LSMDLNQSVSYLYPRFIPIH--------NVVPEETDL--PTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSV 1105
Cdd:PTZ00395 1392 LSMPIISSLLYVYPVMYVIHikgktneiDSMDVDDDLfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEI 1471
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  1106 FGVQGLQQIALErFNIVpETPLAKRIHGILEQIMK--ERSRYMRITWLRQNDKLESVFRHFLVEDRGtDGSASYVDFLCH 1183
Cdd:PTZ00395 1472 VGDIPTEKNAHE-LNLT-DTPNAQKVQRIIKNLSRihHFNKYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCF 1548

                  ...
gi 24581061  1184 MHK 1186
Cdd:PTZ00395 1549 IHK 1551
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
119-321 3.53e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   119 QFNSNAAPPPTNNNNAAFGAP----------PPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPK-AA 187
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPaaaapaaaapAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGpGG 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   188 TPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPssrPGQPQLPPGATPPTYTQPGLPPQQQQ 267
Cdd:PRK12323  447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP---PWEELPPEFASPAPAQPDAAPAGWVA 523
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24581061   268 GIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQG--GYSGGFPG 321
Cdd:PRK12323  524 ESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASasGLPDMFDG 579
 
Name Accession Description Interval E-value
COG5028 COG5028
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ...
395-1190 2.68e-168

Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];


Pssm-ID: 227361 [Multi-domain]  Cd Length: 861  Bit Score: 520.50  E-value: 2.68e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  395 QPGRPGFNQPPMPGAGNMYQQAPQ-ARRLDPDQMPNPI-QVMIENQRLSGGPFVTNQPGLLPPLVTTKFVVHDQGNSSPR 472
Cdd:COG5028   72 NNPAPSVMSPAFQSQQKFSSPYGGsMADGTAPKPTNPLvPVDLFEDQPPPISDLFLPPPPIVPPLTTNFVGSEQSNCSPK 151
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  473 FLRSSLYCIPNTGDLLKTTALPLTLNISPLAKVGEGEMEPPIVNFGEmgPIRCNRCKAYMSPNMQFVDAGRRFQCLMCKV 552
Cdd:COG5028  152 YVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNICRS 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  553 TSEVHQNYYQHLDHTGQRVDKHERPELLLGTYEFLATKDYCRNNTPPevPAFIFIIDVSYNTVKSGLVHLLCSQIKNILK 632
Cdd:COG5028  230 KNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEYSLRQPPP--PVYVFLIDVSFEAIKNGLVKAAIRAILENLD 307
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  633 HLPVDQGqdksKVRVGFITYNSTVHFYNIKSSLaQPQMMVVGDVQEMFMPLLDGFLCHPEESAAVI-DALMEEIPRMFAD 711
Cdd:COG5028  308 QIPNFDP----RTKIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGLFVLPLKSCKQIiETLLDRVPRIFQD 382
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  712 TKETETILYPAIQAGLEALKASnaAGKLLVFNSTLPiAEAPGKLKNRDDrkllgtdKEKTVLTPQTTAYNTLGQECVQQG 791
Cdd:COG5028  383 NKSPKNALGPALKAAKSLIGGT--GGKIIVFLSTLP-NMGIGKLQLRED-------KESSLLSCKDSFYKEFAIECSKVG 452
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  792 CSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQAD--VDGKRLIQDIIKNVSRPIAFDAVMRVRTSAGIRPTEFYGH 869
Cdd:COG5028  453 ISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLRVSSFYGN 532
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  870 FFMSNTTDVELASIDATKSISIEIKHDDKLApEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMML 949
Cdd:COG5028  533 FFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASADQLAIAC 611
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  950 FFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSdMTLDDRS 1029
Cdd:COG5028  612 ILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSGS-TPSDIRI 690
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061 1030 YVIQFILSMDLNQSVSYLYPRFIPIHNVVPE-------ETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFV 1102
Cdd:COG5028  691 SALNRLTSLPLKQLMRNIYPTLYALHDMPIEaglpdegLLVLPSPINATSSLLESGGLYLIDTGQKIFLWFGKDAVPSLL 770
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061 1103 QSVFGVQGLQQIALERFNIVPE-TPLAKRIHGILEQImkeRSRYMRITW----LRQN--DKLESVFRHFLVEDRgTDGSA 1175
Cdd:COG5028  771 QDLFGVDSLSDIPSGKFTLPPTgNEFNERVRNIIGEL---RSVNDDSTLplvlVRGGgdPSLRLWFFSTLVEDK-TLNIP 846
                        810
                 ....*....|....*
gi 24581061 1176 SYVDFLCHMHKEIKD 1190
Cdd:COG5028  847 SYLDYLQILHEKIKS 861
Sec24-like cd01479
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ...
599-847 1.30e-120

Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.


Pssm-ID: 238756 [Multi-domain]  Cd Length: 244  Bit Score: 372.38  E-value: 1.30e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  599 PEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQgqdkSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQE 678
Cdd:cd01479    1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGDD----PRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  679 MFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKasNAAGKLLVFNSTLPIAEApGKLKNR 758
Cdd:cd01479   77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  759 DDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYT--YFQADVDGKRLI 836
Cdd:cd01479  154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPsfNFSAPNDVEKLV 233
                        250
                 ....*....|.
gi 24581061  837 QDIIKNVSRPI 847
Cdd:cd01479  234 NELARYLTRKI 244
Sec23_trunk pfam04811
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
599-843 2.96e-109

Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.


Pssm-ID: 398467 [Multi-domain]  Cd Length: 241  Bit Score: 341.92  E-value: 2.96e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    599 PEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDqgqdkSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQE 678
Cdd:pfam04811    1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGD-----PRARVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    679 MFMPLLDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEAPGKLKNR 758
Cdd:pfam04811   76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    759 DDRKLLGTDKEKTVLTPQTT-AYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLIQ 837
Cdd:pfam04811  156 LDESHHGTDKEKAKLVKKADkFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235

                   ....*.
gi 24581061    838 DIIKNV 843
Cdd:pfam04811  236 DLQRYF 241
trunk_domain cd01468
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ...
599-838 1.08e-97

trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.


Pssm-ID: 238745 [Multi-domain]  Cd Length: 239  Bit Score: 310.72  E-value: 1.08e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  599 PEVPAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDqgqdkSKVRVGFITYNSTVHFYNIKSSLAQPQMMVVGDVQE 678
Cdd:cd01468    1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGD-----PRARVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  679 MFMPLLDGFLCHPEESAAVIDALMEEIPRMFAD--TKETETILYPAIQAGLEALKASNAAGKLLVFNSTLPIAEaPGKLK 756
Cdd:cd01468   76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  757 NRDDRKLLGTDKEKTVLTPQTTAYNTLGQECVQQGCSVDLFVFNNAYIDLATIGQVSRLTGGEVFKYTYFQADVDGKRLI 836
Cdd:cd01468  155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234

                 ..
gi 24581061  837 QD 838
Cdd:cd01468  235 QD 236
PTZ00395 PTZ00395
Sec24-related protein; Provisional
586-1186 7.85e-51

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 197.22  E-value: 7.85e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   586 FLATKDYCRNNTPPevpAFIFIIDVSYNTVKSGLVHLLCSQIKNILKHLPVDQgqdkskVRVGFITYNSTVHFYNIKSSL 665
Cdd:PTZ00395  940 FLAKYPQVKNMLPP---YFVFVVECSYNAIYNNITYTILEGIRYAVQNVKCPQ------TKIAIITFNSSIYFYHCKGGK 1010
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   666 AQP-------------QMMVVGDVQEMFMPL-LDGFLCHPEESAAVIDALMEEIPRMFADTKETETILYPAIQAGLEALK 731
Cdd:PTZ00395 1011 GVSgeegdggggsgnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLK 1090
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   732 ASNAAGKLLVFNSTLPIAeAPGKLKNrddrklLGTDKEKTVL-TPQTTAYNTLGQECVQQGCSVDLFVF--NNAYIDLAT 808
Cdd:PTZ00395 1091 ERNGLGSICMFYTTTPNC-GIGAIKE------LKKDLQENFLeVKQKIFYDSLLLDLYAFNISVDIFIIssNNVRVCVPS 1163
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   809 IGQVSRLTGGEVFKYTYFQADVDGKRLIQDIIKNV-SRPIAFDAVMRVRTSAGIRPTEFyghfFMSNTTDVELASIDATK 887
Cdd:PTZ00395 1164 LQYVAQNTGGKILFVENFLWQKDYKEIYMNIMDTLtSEDIAYCCELKLRYSHHMSVKKL----FCCNNNFNSIISVDTIK 1239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   888 SIsiEIKHDDKLA----------PEENVYLQVALLYTSCSGQRRLRILNLALRVTTTIADVFKCCDLDAMMLFFAKQACF 957
Cdd:PTZ00395 1240 IP--KIRHDQTFAfllnysdiseSKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCT 1317
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   958 KLM--EHSPKQVKDNLihrsAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISggSDMTLDDRSYVIQFI 1035
Cdd:PTZ00395 1318 NILhnDNYSKIIIDNL----AAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYSLIKL 1391
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  1036 LSMDLNQSVSYLYPRFIPIH--------NVVPEETDL--PTPVRCTHEKTQEDGAYILENGVHLFVWLGQALSPDFVQSV 1105
Cdd:PTZ00395 1392 LSMPIISSLLYVYPVMYVIHikgktneiDSMDVDDDLfiPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEI 1471
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  1106 FGVQGLQQIALErFNIVpETPLAKRIHGILEQIMK--ERSRYMRITWLRQNDKLESVFRHFLVEDRGtDGSASYVDFLCH 1183
Cdd:PTZ00395 1472 VGDIPTEKNAHE-LNLT-DTPNAQKVQRIIKNLSRihHFNKYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCF 1548

                  ...
gi 24581061  1184 MHK 1186
Cdd:PTZ00395 1549 IHK 1551
Sec23_helical pfam04815
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ...
943-1044 1.14e-35

Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.


Pssm-ID: 461441 [Multi-domain]  Cd Length: 103  Bit Score: 130.70  E-value: 1.14e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    943 DLDAMMLFFAKQACFKLMEHSPKQVKDNLIHRSAQILACYRKHCTSPTSAGQLILPECLKLLPLYASCLLKNDAISGGSD 1022
Cdd:pfam04815    1 DQEAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNS 80
                           90       100
                   ....*....|....*....|..
gi 24581061   1023 MTLDDRSYVIQFILSMDLNQSV 1044
Cdd:pfam04815   81 SPSDERAYARHLLLSLPVEELL 102
Sec23_BS pfam08033
Sec23/Sec24 beta-sandwich domain;
848-932 1.41e-31

Sec23/Sec24 beta-sandwich domain;


Pssm-ID: 429794 [Multi-domain]  Cd Length: 86  Bit Score: 118.41  E-value: 1.41e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061    848 AFDAVMRVRTSAGIRPTEFYGHFFMSNTTD-VELASIDATKSISIEIKHDDKLAPEENVYLQVALLYTSCSGQRRLRILN 926
Cdd:pfam08033    1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80

                   ....*.
gi 24581061    927 LALRVT 932
Cdd:pfam08033   81 VALPVT 86
Gelsolin pfam00626
Gelsolin repeat;
1061-1135 1.80e-12

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 63.87  E-value: 1.80e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24581061   1061 ETDLPTPVRCTHEKTQEDGAYILENGVHLFVWLGQalSPDFVQSVFGVQGLQQIALERFNIVPE---TPLAKRIHGIL 1135
Cdd:pfam00626    1 KFVLPPPVPLSQESLNSGDCYLLDNGFTIFLWVGK--GSSLLEKLFAALLAAQLDDDERFPLPEvirVPQGKEPARFL 76
SEC23 COG5047
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
496-1097 3.44e-12

Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];


Pssm-ID: 227380 [Multi-domain]  Cd Length: 755  Bit Score: 71.07  E-value: 3.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  496 TLNISPLAKVGEGEMEPPIVNFGEMGPIRCNR-CKAYMSPNMQfVDAGRRF-QCLMCkvtsevhqNYYQHLDHTGQRVDK 573
Cdd:COG5047   27 TRTVIPIACLYTPLHEDDALTVNYYEPVKCTApCKAVLNPYCH-IDERNQSwICPFC--------NQRNTLPPQYRDISN 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  574 HERPELLLGTYeflATKDYCRNNTPPEVPAFIFIIDVSYNTVKsglVHLLCSQIKNILKHLPVDqgqdkskVRVGFITYN 653
Cdd:COG5047   98 ANLPLELLPQS---STIEYTLSKPVILPPVFFFVVDACCDEEE---LTALKDSLIVSLSLLPPE-------ALVGLITYG 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  654 STVHFYNIkSSLAQPQMMVVGDVQEMFMPLLDGFLCHPEES------AAVIDALMEEIPRMFADTKETETILYPAIQ--- 724
Cdd:COG5047  165 TSIQVHEL-NAENHRRSYVFSGNKEYTKENLQELLALSKPTksggfeSKISGIGQFASSRFLLPTQQCEFKLLNILEqlq 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  725 ---------------AGLeALKAS---------NAAGKLLVFNSTlPIAEAPGKLKNRDDRK------LLGTDKEKTVlT 774
Cdd:COG5047  244 pdpwpvpagkrplrcTGS-ALNIAsslleqcfpNAGCHIVLFAGG-PCTVGPGTVVSTELKEpmrshhDIESDSAQHS-K 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  775 PQTTAYNTLGQECVQQGCSVDLFVfnnAYIDLATIGQVSRL---TGGEVFKYTYFQADvdgkRLIQDIIKNVSR------ 845
Cdd:COG5047  321 KATKFYKGLAERVANQGHALDIFA---GCLDQIGIMEMEPLttsTGGALVLSDSFTTS----IFKQSFQRIFNRdsegyl 393
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  846 PIAFDAVMRVRTSAGIRPTEFYGH---------------FFMSNTTDVELASIDATKSISI------EIKHDDKLAPEEn 904
Cdd:COG5047  394 KMGFNANMEVKTSKNLKIKGLIGHavsvkkkannisdseIGIGATNSWKMASLSPKSNYALyfeialGAASGSAQRPAE- 472
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  905 VYLQVALLYTSCSGQRRLRILNLALRVTTTIADV-FKCCDLDAMMLFFAKQACFKLMEHSPKQV----KDNLIhRSAQIL 979
Cdd:COG5047  473 AYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIAAFKAETEDIIDVfrwiDRNLI-RLCQKF 551
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061  980 ACYRKhcTSPTSAGqliLPECLKLLPLYASCLLKNDAISGGSDmTLDDRSYVIQFILSMDLNQSVSYLYPRFIPIH---N 1056
Cdd:COG5047  552 ADYRK--DDPSSFR---LDPNFTLYPQFMYHLRRSPFLSVFNN-SPDETAFYRHMLNNADVNDSLIMIQPTLQSYSfekG 625
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|.
gi 24581061 1057 VVPEETDLPTpvrcthekTQEDGAYILENGVHLFVWLGQAL 1097
Cdd:COG5047  626 GVPVLLDSVS--------VKPDVILLLDTFFHILIFHGSYI 658
zf-Sec23_Sec24 pfam04810
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ...
522-559 3.11e-11

Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.


Pssm-ID: 461437 [Multi-domain]  Cd Length: 38  Bit Score: 59.00  E-value: 3.11e-11
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 24581061    522 PIRCNRCKAYMSPNMQFVDAGRRFQCLMCKVTSEVHQN 559
Cdd:pfam04810    1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
119-321 3.53e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   119 QFNSNAAPPPTNNNNAAFGAP----------PPTQAGSYVNGALPPSSTPQSVASGINQMSLNSATLAGLPHMPPPK-AA 187
Cdd:PRK12323  367 QSGGGAGPATAAAAPVAQPAPaaaapaaaapAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGpGG 446
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   188 TPGAAPGQPPIPAAGSTSQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPssrPGQPQLPPGATPPTYTQPGLPPQQQQ 267
Cdd:PRK12323  447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP---PWEELPPEFASPAPAQPDAAPAGWVA 523
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24581061   268 GIPPLQQPGIPQQQPGFPPQQPGLPPLSQPGLPPQPGAPYGAPQQG--GYSGGFPG 321
Cdd:PRK12323  524 ESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASasGLPDMFDG 579
PHA03247 PHA03247
large tegument protein UL36; Provisional
124-320 2.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   124 AAPPPTNNNNAAFGAPPPTQAGSYVNGALPPS----STPQSVASGINQMSLNSATLAGLphMPPPKAATPgAAPGQPPIP 199
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLTRPAVASLSESRESLPSpwdpADPPAAVLAPAAALPPAASPAGP--LPPPTSAQP-TAPPPPPGP 2845
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   200 AAGSTSQPPLPGQPPLpgqppFSGQIPTSQPAPSPYG---VPSSRPGQPQLPPgatPPTYTQPGLPPQQQQGIPPLQQPG 276
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGD-----VRRRPPSRSPAAKPAAparPPVRRLARPAVSR---STESFALPPDQPERPPQPQAPPPP 2917
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 24581061   277 IPQQQPGFPPQQPGLPPlsQPGLPPQPGAPYGAPQ-QGGYSGGFP 320
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPP--PPPRPQPPLAPTTDPAgAGEPSGAVP 2960
PHA03247 PHA03247
large tegument protein UL36; Provisional
125-424 2.61e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   125 APPPTNnnnAAFGAPPPTQAGSYVNGALPPSSTPQSVASGiNQMSLNSATLAGLPHMPPPKAATPGAAPGQPPIPAAGST 204
Cdd:PHA03247 2711 APHALV---SATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   205 SQPPLPGQPPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPPTytqpglppqqqqgipplqqpgipqqqpgf 284
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT----------------------------- 2837
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   285 ppqqpglpplsQPGLPPQPGAPYGAPQQGGYSGG-----FPGQAPGGFPGAPPPLPGQQAAAPPqfgAPQPGYPGQQPGY 359
Cdd:PHA03247 2838 -----------APPPPPGPPPPSLPLGGSVAPGGdvrrrPPSRSPAAKPAAPARPPVRRLARPA---VSRSTESFALPPD 2903
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24581061   360 PPQPGQQPMPGYPPQPGQQLGGPGYPPQPGAgFPGQPgrpgfNQPPMPGAGNMYQQAPQARRLDP 424
Cdd:PHA03247 2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPPP-PPPRP-----QPPLAPTTDPAGAGEPSGAVPQP 2962
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
133-254 4.70e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 41.12  E-value: 4.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581061   133 NAAFGAPPPTQAGSYVNGALPPSSTPQSVAsginqmslnsatlAGLPHMPPPKAATPGAAPGQPPIPAAGSTSQPPLPGQ 212
Cdd:PRK07764  386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAA-------------APAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGG 452
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 24581061   213 PPLPGQPPFSGQIPTSQPAPSPYGVPSSRPGQPQLPPGATPP 254
Cdd:PRK07764  453 APSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAP 494
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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