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Conserved domains on  [gi|24581471|ref|NP_608789|]
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scavenger receptor class C, type IV [Drosophila melanogaster]

Protein Classification

MAM and Somatomedin_B domain-containing protein( domain architecture ID 13332466)

protein containing domains PHA02927, MAM, and Somatomedin_B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 132-301 3.79e-49

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


:

Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 163.69  E-value: 3.79e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   132 CDFESEDMCGWTAELSFLGTWKRVSTvadfHSEKTGPQKDHTfQNQSIGHYVRMETESDAFG-TYHFLSPLYPkeLSLSG 210
Cdd:pfam00629   1 CDFEDGNLCGWTQDSSDDFDWERVSG----PSVKTGPSSDHT-QGTGSGHFMYVDTSSGAPGqTARLLSPLLP--PSRSP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   211 ACFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFktnhpykfdqFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQY 290
Cdd:pfam00629  74 QCLRFWYHMSGSGVGTLRVYVRENGGTLDTLL----------WSISGDQGPSWKEARVTLSSSTQPFQVVFEGIRGGGSR 143

                         170
                  ....*....|.
gi 24581471   291 GDIAIDDVKLM 301
Cdd:pfam00629 144 GGIALDDISLS 154
Somatomedin_B pfam01033
Somatomedin B domain;
336-377 6.78e-08

Somatomedin B domain;


:

Pssm-ID: 460034  Cd Length: 40  Bit Score: 48.45  E-value: 6.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24581471   336 CSGRCGQDFVRGRyineGCRCQESCLVNGNCCLNYVKECHKD 377
Cdd:pfam01033   3 CKGRCGESFDRGR----LCQCDDDCVKYGDCCPDYESLCLGE 40
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 19-115 6.58e-05

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   19 RCLESVHLEHGSTEIvNGSIIFHCDQGYFLQGSKVFTCDRG-----IPRGKKPFCAKSGCQEYEQIQNG-------FVLN 86
Cdd:PHA02927  90 RDIDNGQLDIGGVDF-GSSITYSCNSGYQLIGESKSYCELGstgsmVWNPEAPICESVKCQSPPSISNGrhngyedFYTD 168

                         90       100
                 ....*....|....*....|....*....
gi 24581471   87 APMkAKIICSDGHGLVGNRIAYCDGEKWS 115
Cdd:PHA02927 169 GSV-VTYSCNSGYSLIGNSGVLCSGGEWS 196
 
Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 132-301 3.79e-49

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 163.69  E-value: 3.79e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   132 CDFESEDMCGWTAELSFLGTWKRVSTvadfHSEKTGPQKDHTfQNQSIGHYVRMETESDAFG-TYHFLSPLYPkeLSLSG 210
Cdd:pfam00629   1 CDFEDGNLCGWTQDSSDDFDWERVSG----PSVKTGPSSDHT-QGTGSGHFMYVDTSSGAPGqTARLLSPLLP--PSRSP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   211 ACFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFktnhpykfdqFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQY 290
Cdd:pfam00629  74 QCLRFWYHMSGSGVGTLRVYVRENGGTLDTLL----------WSISGDQGPSWKEARVTLSSSTQPFQVVFEGIRGGGSR 143

                         170
                  ....*....|.
gi 24581471   291 GDIAIDDVKLM 301
Cdd:pfam00629 144 GGIALDDISLS 154
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 129-302 7.65e-37

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 131.70  E-value: 7.65e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471    129 DVSCDFESEDMCGWTAELSFLGTWKRVSTVADfhseKTGPQKDHTFQNqsiGHYVRMETESDAFG-TYHFLSP-LYPKel 206
Cdd:smart00137   3 PGNCDFEEGSTCGWHQDSNDDGHWERVSSATG----IPGPNRDHTTGN---GHFMFFETSSGAEGqTARLLSPpLYEN-- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471    207 sLSGACFQFHYFMFGSGVGSLLVSIKpvsvtigdifKTNHPYKFDQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDA 286
Cdd:smart00137  74 -RSTHCLTFWYYMYGSGSGTLNVYVR----------ENNGSQDTLLWSRSGTQGGQWLQAEVALSSWPQPFQVVFEGTRG 142

                          170
                   ....*....|....*.
gi 24581471    287 RSQYGDIAIDDVKLMA 302
Cdd:smart00137 143 KGHSGYIALDDILLSN 158
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 132-301 1.67e-34

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 125.18  E-value: 1.67e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471 132 CDFEsEDMCGWTAELSFLGTWKRVStvadfHSEKTGPQKDHTFQNQSIGHYVRMETESDAFG-TYHFLSPLYPkeLSLSG 210
Cdd:cd06263   1 CDFE-DGLCGWTQDSTDDFDWTRVS-----GSTPSPGTPPDHTHGTGSGHYLYVESSSGREGqKARLLSPLLP--PPRSS 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471 211 ACFQFHYFMFGSGVGSLLVSIKPvsvtigdifkTNHPYKFDQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQY 290
Cdd:cd06263  73 HCLSFWYHMYGSGVGTLNVYVRE----------EGGGLGTLLWSASGGQGNQWQEAEVTLSASSKPFQVVFEGVRGSGSR 142

                       170
                ....*....|.
gi 24581471 291 GDIAIDDVKLM 301
Cdd:cd06263 143 GDIALDDISLS 153
Somatomedin_B pfam01033
Somatomedin B domain;
336-377 6.78e-08

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 48.45  E-value: 6.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24581471   336 CSGRCGQDFVRGRyineGCRCQESCLVNGNCCLNYVKECHKD 377
Cdd:pfam01033   3 CKGRCGESFDRGR----LCQCDDDCVKYGDCCPDYESLCLGE 40
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 19-115 6.58e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   19 RCLESVHLEHGSTEIvNGSIIFHCDQGYFLQGSKVFTCDRG-----IPRGKKPFCAKSGCQEYEQIQNG-------FVLN 86
Cdd:PHA02927  90 RDIDNGQLDIGGVDF-GSSITYSCNSGYQLIGESKSYCELGstgsmVWNPEAPICESVKCQSPPSISNGrhngyedFYTD 168

                         90       100
                 ....*....|....*....|....*....
gi 24581471   87 APMkAKIICSDGHGLVGNRIAYCDGEKWS 115
Cdd:PHA02927 169 GSV-VTYSCNSGYSLIGNSGVLCSGGEWS 196
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 332-376 4.93e-04

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 37.35  E-value: 4.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 24581471    332 QMTDCSGRCGQDFVRGRyineGCRCQESCLVNGNCCLNYVKECHK 376
Cdd:smart00201   1 AIGSCKGRCGESFNEGN----ACRCDALCLSYGDCCTDYESVCKK 41
 
Name Accession Description Interval E-value
MAM pfam00629
MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain ...
 132-301 3.79e-49

MAM domain, meprin/A5/mu; An extracellular domain found in many receptors. The MAM domain along with the associated Ig domain in type IIB receptor protein tyrosine phosphatases forms a structural unit (termed MIg) with a seamless interdomain interface. It plays a major role in homodimerization of the phosphatase ectoprotein and in cell adhesion. MAM is a beta-sandwich consisting of two five-stranded antiparallel beta-sheets rotated away from each other by approx 25 degrees, and plays a similar role in meprin metalloproteinases.


Pssm-ID: 459878 [Multi-domain]  Cd Length: 159  Bit Score: 163.69  E-value: 3.79e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   132 CDFESEDMCGWTAELSFLGTWKRVSTvadfHSEKTGPQKDHTfQNQSIGHYVRMETESDAFG-TYHFLSPLYPkeLSLSG 210
Cdd:pfam00629   1 CDFEDGNLCGWTQDSSDDFDWERVSG----PSVKTGPSSDHT-QGTGSGHFMYVDTSSGAPGqTARLLSPLLP--PSRSP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   211 ACFQFHYFMFGSGVGSLLVSIKPVSVTIGDIFktnhpykfdqFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQY 290
Cdd:pfam00629  74 QCLRFWYHMSGSGVGTLRVYVRENGGTLDTLL----------WSISGDQGPSWKEARVTLSSSTQPFQVVFEGIRGGGSR 143

                         170
                  ....*....|.
gi 24581471   291 GDIAIDDVKLM 301
Cdd:pfam00629 144 GGIALDDISLS 154
MAM smart00137
Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an ...
 129-302 7.65e-37

Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others); Likely to have an adhesive function. Mutations in the meprin MAM domain affect noncovalent associations within meprin oligomers. In receptor tyrosine phosphatase mu-like molecules the MAM domain is important for homophilic cell-cell interactions.


Pssm-ID: 214533 [Multi-domain]  Cd Length: 161  Bit Score: 131.70  E-value: 7.65e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471    129 DVSCDFESEDMCGWTAELSFLGTWKRVSTVADfhseKTGPQKDHTFQNqsiGHYVRMETESDAFG-TYHFLSP-LYPKel 206
Cdd:smart00137   3 PGNCDFEEGSTCGWHQDSNDDGHWERVSSATG----IPGPNRDHTTGN---GHFMFFETSSGAEGqTARLLSPpLYEN-- 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471    207 sLSGACFQFHYFMFGSGVGSLLVSIKpvsvtigdifKTNHPYKFDQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDA 286
Cdd:smart00137  74 -RSTHCLTFWYYMYGSGSGTLNVYVR----------ENNGSQDTLLWSRSGTQGGQWLQAEVALSSWPQPFQVVFEGTRG 142

                          170
                   ....*....|....*.
gi 24581471    287 RSQYGDIAIDDVKLMA 302
Cdd:smart00137 143 KGHSGYIALDDILLSN 158
MAM cd06263
Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular ...
 132-301 1.67e-34

Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members include: type IIB receptor protein tyrosine phosphatases (such as RPTPmu), meprins (plasma membrane metalloproteases), neuropilins (receptors of secreted semaphorins), and zonadhesins (sperm-specific membrane proteins which bind to the extracellular matrix of the egg). In meprin A and neuropilin-1 and -2, MAM is involved in homo-oligomerization. In RPTPmu, it has been associated with both homophilic adhesive (trans) interactions and lateral (cis) receptor oligomerization. In a GPI-anchored protein that is expressed in cells in the embryonic chicken spinal chord, MDGA1, the MAM domain has been linked to heterophilic interactions with axon-rich region.


Pssm-ID: 99706  Cd Length: 157  Bit Score: 125.18  E-value: 1.67e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471 132 CDFEsEDMCGWTAELSFLGTWKRVStvadfHSEKTGPQKDHTFQNQSIGHYVRMETESDAFG-TYHFLSPLYPkeLSLSG 210
Cdd:cd06263   1 CDFE-DGLCGWTQDSTDDFDWTRVS-----GSTPSPGTPPDHTHGTGSGHYLYVESSSGREGqKARLLSPLLP--PPRSS 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471 211 ACFQFHYFMFGSGVGSLLVSIKPvsvtigdifkTNHPYKFDQFVMTGSQGARWLEHTIDINKMDEDFQVIFTATDARSQY 290
Cdd:cd06263  73 HCLSFWYHMYGSGVGTLNVYVRE----------EGGGLGTLLWSASGGQGNQWQEAEVTLSASSKPFQVVFEGVRGSGSR 142

                       170
                ....*....|.
gi 24581471 291 GDIAIDDVKLM 301
Cdd:cd06263 143 GDIALDDISLS 153
Somatomedin_B pfam01033
Somatomedin B domain;
336-377 6.78e-08

Somatomedin B domain;


Pssm-ID: 460034  Cd Length: 40  Bit Score: 48.45  E-value: 6.78e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24581471   336 CSGRCGQDFVRGRyineGCRCQESCLVNGNCCLNYVKECHKD 377
Cdd:pfam01033   3 CKGRCGESFDRGR----LCQCDDDCVKYGDCCPDYESLCLGE 40
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 19-115 6.58e-05

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 44.26  E-value: 6.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24581471   19 RCLESVHLEHGSTEIvNGSIIFHCDQGYFLQGSKVFTCDRG-----IPRGKKPFCAKSGCQEYEQIQNG-------FVLN 86
Cdd:PHA02927  90 RDIDNGQLDIGGVDF-GSSITYSCNSGYQLIGESKSYCELGstgsmVWNPEAPICESVKCQSPPSISNGrhngyedFYTD 168

                         90       100
                 ....*....|....*....|....*....
gi 24581471   87 APMkAKIICSDGHGLVGNRIAYCDGEKWS 115
Cdd:PHA02927 169 GSV-VTYSCNSGYSLIGNSGVLCSGGEWS 196
SO smart00201
Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from ...
 332-376 4.93e-04

Somatomedin B -like domains; Somatomedin-B is a peptide, proteolytically excised from vitronectin, that is a growth hormone-dependent serum factor with protease-inhibiting activity.


Pssm-ID: 197571  Cd Length: 43  Bit Score: 37.35  E-value: 4.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 24581471    332 QMTDCSGRCGQDFVRGRyineGCRCQESCLVNGNCCLNYVKECHK 376
Cdd:smart00201   1 AIGSCKGRCGESFNEGN----ACRCDALCLSYGDCCTDYESVCKK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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