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Conserved domains on  [gi|28574026|ref|NP_608823|]
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uncharacterized protein Dmel_CG15429, isoform A [Drosophila melanogaster]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 10445738)

cytochrome b5-like heme/steroid binding domain-containing protein such as cytochrome b5, a membrane-bound hemoprotein that functions as an electron carrier for several membrane-bound oxygenases and Arabidopsis thaliana steroid-binding proteins

CATH:  3.10.120.10
Gene Ontology:  GO:0097159|GO:0016020
PubMed:  12537557|7893819

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 13-63 3.19e-08

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 49.16  E-value: 3.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28574026    13 KDEVVSHNKKDDCWVIIHRNIYDLTPMLKDrfdnWNRTLDYLVAHAGKDLT 63
Cdd:pfam00173   2 LEELSKHNGDGDCWVAINGKVYDVTKFLKE----HPGGEDVILSAAGKDAT 48
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 13-63 3.19e-08

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 49.16  E-value: 3.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28574026    13 KDEVVSHNKKDDCWVIIHRNIYDLTPMLKDrfdnWNRTLDYLVAHAGKDLT 63
Cdd:pfam00173   2 LEELSKHNGDGDCWVAINGKVYDVTKFLKE----HPGGEDVILSAAGKDAT 48
PLN02252 PLN02252
nitrate reductase [NADPH]
 9-42 1.03e-06

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 48.52  E-value: 1.03e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 28574026    9 RYYLKDEVVSHNKKDDCWVIIHRNIYDLTPMLKD 42
Cdd:PLN02252 518 KQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKD 551
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 14-68 1.26e-05

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 42.33  E-value: 1.26e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28574026  14 DEVVSHNKKDDCWVIIHRNIYDLTPMLKD----RFdnwnrtldYLVAHAGKDLTHFFHE 68
Cdd:COG5274  21 AEVATHNTLSDCWMAIDGNVYDLTEYIPKhpggEA--------VILRWCGKDATEAFNT 71
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 13-63 3.19e-08

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 49.16  E-value: 3.19e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 28574026    13 KDEVVSHNKKDDCWVIIHRNIYDLTPMLKDrfdnWNRTLDYLVAHAGKDLT 63
Cdd:pfam00173   2 LEELSKHNGDGDCWVAINGKVYDVTKFLKE----HPGGEDVILSAAGKDAT 48
PLN02252 PLN02252
nitrate reductase [NADPH]
 9-42 1.03e-06

nitrate reductase [NADPH]


Pssm-ID: 215141 [Multi-domain]  Cd Length: 888  Bit Score: 48.52  E-value: 1.03e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 28574026    9 RYYLKDEVVSHNKKDDCWVIIHRNIYDLTPMLKD 42
Cdd:PLN02252 518 KQYTMSEVRKHNSEDSCWIVVHGHVYDCTRFLKD 551
CYB5 COG5274
Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport ...
 14-68 1.26e-05

Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism];


Pssm-ID: 444085 [Multi-domain]  Cd Length: 93  Bit Score: 42.33  E-value: 1.26e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28574026  14 DEVVSHNKKDDCWVIIHRNIYDLTPMLKD----RFdnwnrtldYLVAHAGKDLTHFFHE 68
Cdd:COG5274  21 AEVATHNTLSDCWMAIDGNVYDLTEYIPKhpggEA--------VILRWCGKDATEAFNT 71
PLN03198 PLN03198
delta6-acyl-lipid desaturase; Provisional
 7-37 2.42e-03

delta6-acyl-lipid desaturase; Provisional


Pssm-ID: 178739 [Multi-domain]  Cd Length: 526  Bit Score: 38.52  E-value: 2.42e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 28574026    7 KMRYYLKDEVVSHNKKDDCWVIIHRNIYDLT 37
Cdd:PLN03198 102 KSKSHLLSEVAAHNKPNDCWIVIKNKVYDVS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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