|
Name |
Accession |
Description |
Interval |
E-value |
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
276-795 |
3.99e-134 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 415.39 E-value: 3.99e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 276 IVEQPKLLssGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAhLIVVPSSTLDNWEA 355
Cdd:COG0553 231 LESLPAGL--KATLRPYQLEGAAWLLFLRRLGLGGLLADDMGLGKTIQALALLLELKERGLARPV-LIVAPTSLVGNWQR 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 356 EISRWCPELVVEKYHGSqdeRRRMRGRfakDGFTGFDVLLTTYHIVGStpeERKMFRVCKLDYVIFDEAHMLKNMTTQRY 435
Cdd:COG0553 308 ELAKFAPGLRVLVLDGT---RERAKGA---NPFEDADLVITSYGLLRR---DIELLAAVDWDLVILDEAQHIKNPATKRA 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 436 ANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAKKgksdgdqdeVSQFQETQIQRAKRIMKPF 515
Cdd:COG0553 379 KAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLG-SLKAFRERFARP---------IEKGDEEALERLRRLLRPF 448
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 516 VLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELVDYYSNNKGEvcSSSERAGIAI---MMEMRRIANHPLLmrhyft 592
Cdd:COG0553 449 LLRRTKEDVLKDLPEKTEETLYVELTPEQRALYEAVLEYLRRELEG--AEGIRRRGLIlaaLTRLRQICSHPAL------ 520
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 593 danlrgfskrlanassfkktneqyifeelaVMSDFQVYQMmnkhefydvkipdnlicDSGKFLYLDTLLPKLKAEGHRVL 672
Cdd:COG0553 521 ------------------------------LLEEGAELSG-----------------RSAKLEALLELLEELLAEGEKVL 553
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 673 LFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSIFVFLLSTKAGGVGINLTAADTcVIH-DIDFNP 751
Cdd:COG0553 554 VFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADH-VIHyDLWWNP 632
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 24583161 752 YNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKL 795
Cdd:COG0553 633 AVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRAL 676
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
271-815 |
5.93e-118 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 382.61 E-value: 5.93e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 271 SNGAGIVEQPKLLSSglQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTL 350
Cdd:PLN03142 154 SGGTRLLVQPSCIKG--KMRDYQLAGLNWLIRLYENGINGILADEMGLGKTLQTISLLGYLHEYRGITGPHMVVAPKSTL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 351 DNWEAEISRWCPELVVEKYHGSQDERRRMRGRFAKDGftGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNM 430
Cdd:PLN03142 232 GNWMNEIRRFCPVLRAVKFHGNPEERAHQREELLVAG--KFDVCVTSFEMA---IKEKTALKRFSWRYIIIDEAHRIKNE 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 431 TTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAKKGKsdGDQDEVsqfqetqIQRAKR 510
Cdd:PLN03142 307 NSLLSKTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFS-SAETFDEWFQISGE--NDQQEV-------VQQLHK 376
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 511 IMKPFVLRRLKKDVLKNLPKKLSLVEKVPMSSQQKIYYHELV--DYYSNNKGevcssSERAGIA-IMMEMRRIANHPLLM 587
Cdd:PLN03142 377 VLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLqkDLDVVNAG-----GERKRLLnIAMQLRKCCNHPYLF 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 588 RH------YFTDanlrgfskrlanassfkktneqyifeelavmsdfqvyqmmnkhefydvkipDNLICDSGKFLYLDTLL 661
Cdd:PLN03142 452 QGaepgppYTTG---------------------------------------------------EHLVENSGKMVLLDKLL 480
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 662 PKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLLSTKAGGVGINLTAAD 740
Cdd:PLN03142 481 PKLKERDSRVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSeKFVFLLSTRAGGLGINLATAD 560
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24583161 741 TCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLekDITSNEKGEVHEQRCVVK 815
Cdd:PLN03142 561 IVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEYTIEEKVIERAYKKLAL--DALVIQQGRLAEQKTVNK 633
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
289-473 |
8.40e-114 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 344.37 E-value: 8.40e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGlSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd17998 1 LKDYQLIGLNWLNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIG-IPGPHLVVVPSSTLDNWLREFKRWCPSLKVEP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRGrFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRIL 448
Cdd:cd17998 80 YYGSQEERKHLRY-DILKGLEDFDVIVTTYNLATSNPDDRSFFKRLKLNYVVYDEGHMLKNMTSERYRHLMTINANFRLL 158
|
170 180
....*....|....*....|....*
gi 24583161 449 LTGTPLQNNLLELISLLCFVMPKFF 473
Cdd:cd17998 159 LTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
289-519 |
2.94e-74 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 241.87 E-value: 2.94e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd18003 1 LREYQHIGLDWLATLYEKNLNGILADEMGLGKTIQTIALLAHLACEKGNWGPHLIVVPTSVMLNWEMEFKRWCPGFKILT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRGRFAKDgfTGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRIL 448
Cdd:cd18003 81 YYGSAKERKLKRQGWMKP--NSFHVCITSYQLV---VQDHQVFKRKKWKYLILDEAHNIKNFKSQRWQTLLNFNTQRRLL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24583161 449 LTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAK--KGKSDGDQDEvsqfQETQIQRAKRIMKPFVLRR 519
Cdd:cd18003 156 LTGTPLQNSLMELWSLMHFLMPHIFQ-SHQEFKEWFSNplTAMSEGSQEE----NEELVRRLHKVLRPFLLRR 223
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
289-473 |
3.34e-73 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 237.46 E-value: 3.34e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd17919 1 LRPYQLEGLNFLLELYENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGPVLVVCPLSVLENWEREFEKWTPDLRVVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRmrgRFAKDGFTGFDVLLTTYHIVGStpeERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRIL 448
Cdd:cd17919 81 YHGSQRERAQ---IRAKEKLDKFDVVLTTYETLRR---DKASLRKFRWDLVVVDEAHRLKNPKSQLSKALKALRAKRRLL 154
|
170 180
....*....|....*....|....*
gi 24583161 449 LTGTPLQNNLLELISLLCFVMPKFF 473
Cdd:cd17919 155 LTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
292-584 |
3.95e-72 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 238.35 E-value: 3.95e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 292 YQIIGLNWLTVMHKQEM-NGILADEMGLGKTIQVIAFLAYLKENG-LSQAAHLIVVPSSTLDNWEAEISRWC--PELVVE 367
Cdd:pfam00176 1 YQIEGVNWMLSLENNLGrGGILADEMGLGKTLQTISLLLYLKHVDkNWGGPTLIVVPLSLLHNWMNEFERWVspPALRVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 368 KYHGsqDERRRMRGRFAKDGFTGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRI 447
Cdd:pfam00176 81 VLHG--NKRPQERWKNDPNFLADFDVVITTYETL---RKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSLKTRNRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 448 LLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAKKGKSDGDQDEVSQFQEtqiqrakrIMKPFVLRRLKKDVLKN 527
Cdd:pfam00176 156 ILTGTPLQNNLEELWALLNFLRPGPFG-SLSTFRNWFDRPIERGGGKKGVSRLHK--------LLKPFLLRRTKKDVEKS 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 528 LPKKLSLVEKVPMSSQQKIYYHELV---DYYSNNKGEVCSSSERAGIAIMMEMRRIANHP 584
Cdd:pfam00176 227 LPPKVEYILFCRLSKLQRKLYQTFLlkkDLNAIKTGEGGREIKASLLNILMRLRKICNHP 286
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
288-521 |
2.49e-69 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 228.36 E-value: 2.49e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 288 QLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVE 367
Cdd:cd17997 3 TMRDYQIRGLNWLISLFENGINGILADEMGLGKTLQTISLLGYLKHYKNINGPHLIIVPKSTLDNWMREFKRWCPSLRVV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 368 KYHGSQDERRRMRGRFAKDGftGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRI 447
Cdd:cd17997 83 VLIGDKEERADIIRDVLLPG--KFDVCITSYEMV---IKEKTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNRL 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24583161 448 LLTGTPLQNNLLELISLLCFVMPKFFAKSiEDIKSLFaKKGKSDGDQDEVsqfqetqIQRAKRIMKPFVLRRLK 521
Cdd:cd17997 158 LLTGTPLQNNLHELWALLNFLLPDVFTSS-EDFDEWF-NVNNCDDDNQEV-------VQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
286-521 |
7.94e-67 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 222.26 E-value: 7.94e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 286 GLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLsQAAHLIVVPSSTLDNWEAEISRWCPELV 365
Cdd:cd18009 1 GGVMRPYQLEGMEWLRMLWENGINGILADEMGLGKTIQTIALLAHLRERGV-WGPFLVIAPLSTLPNWVNEFARFTPSVP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 366 VEKYHGSQDERRRMRG--RFAKDGFTGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINA 443
Cdd:cd18009 80 VLLYHGTKEERERLRKkiMKREGTLQDFPVVVTSYEIA---MRDRKALQHYAWKYLIVDEGHRLKNLNCRLIQELKTFNS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 444 RMRILLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAKKGKSDGDQDEVSQFQETQ---IQRAKRIMKPFVLRRL 520
Cdd:cd18009 157 DNRLLLTGTPLQNNLSELWSLLNFLLPDVFD-DLSSFESWFDFSSLSDNAADISNLSEEREqniVHMLHAILKPFLLRRL 235
|
.
gi 24583161 521 K 521
Cdd:cd18009 236 K 236
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
286-521 |
1.29e-63 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 213.38 E-value: 1.29e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 286 GLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELV 365
Cdd:cd17996 1 GGTLKEYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQTISLITYLMEKKKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 366 VEKYHGSQDERRRMrgrFAKDGFTGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLIT-INAR 444
Cdd:cd17996 81 KIVYKGTPDVRKKL---QSQIRAGKFNVLLTTYEYI---IKDKPLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTyYHAR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 445 MRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDGDQDEVSQFQETQ---IQRAKRIMKPFVLRRLK 521
Cdd:cd17996 155 YRLLLTGTPLQNNLPELWALLNFLLPKIF-KSCKTFEQWFNTPFANTGEQVKIELNEEETlliIRRLHKVLRPFLLRRLK 233
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
288-521 |
5.20e-63 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 211.27 E-value: 5.20e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 288 QLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAhLIVVPSSTLDNWEAEISRWCPELVVE 367
Cdd:cd18012 4 TLRPYQKEGFNWLSFLRHYGLGGILADDMGLGKTLQTLALLLSRKEEGRKGPS-LVVAPTSLIYNWEEEAAKFAPELKVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 368 KYHGSQDERRRMRgrfakdGFTGFDVLLTTYHIVGSTPEERKMFRvckLDYVIFDEAHMLKNMTTQRYANLITINARMRI 447
Cdd:cd18012 83 VIHGTKRKREKLR------ALEDYDLVITSYGLLRRDIELLKEVK---FHYLVLDEAQNIKNPQTKTAKAVKALKADHRL 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24583161 448 LLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAKKGKSDGDQDEVSQFqetqiqraKRIMKPFVLRRLK 521
Cdd:cd18012 154 ALTGTPIENHLGELWSIFDFLNPGLLG-SYKRFKKRFAKPIEKDGDEEALEEL--------KKLISPFILRRLK 218
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
651-776 |
6.65e-61 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 202.32 E-value: 6.65e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 651 SGKFLYLDTLLPKLKAEGHRVLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSIFVFLLSTKAG 730
Cdd:cd18793 10 SGKLEALLELLEELREPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 24583161 731 GVGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLI 776
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
289-519 |
1.33e-58 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 199.65 E-value: 1.33e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd18002 1 LKEYQLKGLNWLANLYEQGINGILADEMGLGKTVQSIAVLAHLAEEHNIWGPFLVIAPASTLHNWQQEISRFVPQFKVLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRGRFAKDGFT----GFDVLLTTYHIVGStpeERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINAR 444
Cdd:cd18002 81 YWGNPKDRKVLRKFWDRKNLYtrdaPFHVVITSYQLVVQ---DEKYFQRVKWQYMVLDEAQAIKSSSSSRWKTLLSFHCR 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24583161 445 MRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDGDQdeVSQFQETQIQRAKRIMKPFVLRR 519
Cdd:cd18002 158 NRLLLTGTPIQNSMAELWALLHFIMPTLF-DSHDEFNEWFSKDIESHAEN--KTGLNEHQLKRLHMILKPFMLRR 229
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
289-519 |
1.84e-53 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 185.14 E-value: 1.84e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVeK 368
Cdd:cd17995 1 LRDYQLEGVNWLLFNWYNRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFLVIAPLSTIPNWQREFETWTDMNVV-V 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRGR--FAKD-------GFTGFDVLLTTYHIVGStpeERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLI 439
Cdd:cd17995 80 YHGSGESRQIIQQYemYFKDaqgrkkkGVYKFDVLITTYEMVIA---DAEELRKIPWRVVVVDEAHRLKNRNSKLLQGLK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 440 TINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEdikslFakkgksdgdQDEVSQFQ-ETQIQRAKRIMKPFVLR 518
Cdd:cd17995 157 KLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEE-----F---------LEEFGDLKtAEQVEKLQALLKPYMLR 222
|
.
gi 24583161 519 R 519
Cdd:cd17995 223 R 223
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
288-519 |
4.85e-52 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 181.01 E-value: 4.85e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 288 QLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVE 367
Cdd:cd17993 1 ELRDYQLTGLNWLAHSWCKGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPFLVVVPLSTMPAWQREFAKWAPDMNVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 368 KYHGSQDERRRMRG-RFAKDGFT--GFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINAR 444
Cdd:cd17993 81 VYLGDIKSRDTIREyEFYFSQTKklKFNVLLTTYEII---LKDKAFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTN 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24583161 445 MRILLTGTPLQNNLLELISLLCFVMP-KFfaKSIEDIkslfakkgksdgdQDEVSQFQETQIQRAKRIMKPFVLRR 519
Cdd:cd17993 158 NRLLITGTPLQNSLKELWALLHFLMPgKF--DIWEEF-------------EEEHDEEQEKGIADLHKELEPFILRR 218
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
289-519 |
2.76e-50 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 176.79 E-value: 2.76e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAhLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd18001 1 LYPHQREGVAWLWSLHDGGKGGILADDMGLGKTVQICAFLSGMFDSGLIKSV-LVVMPTSLIPHWVKEFAKWTPGLRVKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHG-SQDERRRMRGRFAKdgftGFDVLLTTYHIVGSTPEERKMFRV--CKLDYVIFDEAHMLKNMTTQRYANLITINARM 445
Cdd:cd18001 80 FHGtSKKERERNLERIQR----GGGVLLTTYGMVLSNTEQLSADDHdeFKWDYVILDEGHKIKNSKTKSAKSLREIPAKN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 446 RILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLFAK-------KGKSDGDQDEVSQFQETQIQrakrIMKPFVLR 518
Cdd:cd18001 156 RIILTGTPIQNNLKELWALFDFACNGSLLGTRKTFKMEFENpitrgrdKDATQGEKALGSEVAENLRQ----IIKPYFLR 231
|
.
gi 24583161 519 R 519
Cdd:cd18001 232 R 232
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
289-519 |
2.07e-46 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 165.30 E-value: 2.07e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAEQHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSVIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRgRFAKDgFTGFDVLLTTYHIVGSTPEERKMFrvcKLDYVIFDEAHMLKNMTTQRYANLITINARMRIL 448
Cdd:cd18006 81 YMGDKEKRLDLQ-QDIKS-TNRFHVLLTTYEICLKDASFLKSF---PWASLVVDEAHRLKNQNSLLHKTLSEFSVDFRLL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24583161 449 LTGTPLQNNLLELISLLCFVMPKFFAK-SIEDIKSLFAKKGKSDGDQDEVsqfqetqiqraKRIMKPFVLRR 519
Cdd:cd18006 156 LTGTPIQNSLQELYALLSFIEPNVFPKdKLDDFIKAYSETDDESETVEEL-----------HLLLQPFLLRR 216
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
288-531 |
1.52e-45 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 163.68 E-value: 1.52e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 288 QLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVE 367
Cdd:cd18064 15 KLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKSTLHNWMAEFKRWVPTLRAV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 368 KYHGSQDErrrmRGRFAKDGFT--GFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARM 445
Cdd:cd18064 95 CLIGDKDQ----RAAFVRDVLLpgEWDVCVTSYEML---IKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVREFKTTN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 446 RILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFaKKGKSDGDQDEVsqfqetqiQRAKRIMKPFVLRRLKKDVL 525
Cdd:cd18064 168 RLLLTGTPLQNNLHELWALLNFLLPDVF-NSAEDFDSWF-DTNNCLGDQKLV--------ERLHMVLRPFLLRRIKADVE 237
|
....*.
gi 24583161 526 KNLPKK 531
Cdd:cd18064 238 KSLPPK 243
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
278-519 |
6.70e-45 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 161.71 E-value: 6.70e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 278 EQPKLL-SSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAE 356
Cdd:cd18054 9 KQPSYIgGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 357 ISRWCPELVVEKYHGSQDERRRMRGR---FAKDGFTGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQ 433
Cdd:cd18054 89 FEIWAPEINVVVYIGDLMSRNTIREYewiHSQTKRLKFNALITTYEIL---LKDKTVLGSINWAFLGVDEAHRLKNDDSL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 434 RYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAkKGKSDGdqdevsqfqetqIQRAKRIMK 513
Cdd:cd18054 166 LYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKF-EFWEDFEEDHG-KGRENG------------YQSLHKVLE 231
|
....*.
gi 24583161 514 PFVLRR 519
Cdd:cd18054 232 PFLLRR 237
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
278-521 |
7.68e-44 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 158.64 E-value: 7.68e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 278 EQPKLLSSGlQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEI 357
Cdd:cd18065 6 ESPSYVKGG-TLRDYQVRGLNWMISLYENGVNGILADEMGLGKTLQTIALLGYLKHYRNIPGPHMVLVPKSTLHNWMNEF 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 358 SRWCPELVVEKYHGSQDerrrMRGRFAKDGFT--GFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRY 435
Cdd:cd18065 85 KRWVPSLRAVCLIGDKD----ARAAFIRDVMMpgEWDVCVTSYEMV---IKEKSVFKKFNWRYLVIDEAHRIKNEKSKLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 436 ANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKgKSDGDQDEVsqfqetqiQRAKRIMKPF 515
Cdd:cd18065 158 EIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVF-NSADDFDSWFDTK-NCLGDQKLV--------ERLHAVLKPF 227
|
....*.
gi 24583161 516 VLRRLK 521
Cdd:cd18065 228 LLRRIK 233
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
289-519 |
2.94e-43 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 156.74 E-value: 2.94e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLA---YLKENGLSQAA--HLIVVPSSTLDNWEAEISRWCPE 363
Cdd:cd17999 1 LRPYQQEGINWLAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhHKRANSFNSENlpSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 364 --LVVEKYHGSQDERRRMRGRFAKDgftgfDVLLTTYHIVgstpeeRK---MFRVCKLDYVIFDEAHMLKNMTTQRYANL 438
Cdd:cd17999 81 afLKPLAYVGPPQERRRLREQGEKH-----NVIVASYDVL------RNdieVLTKIEWNYCVLDEGHIIKNSKTKLSKAV 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 439 ITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFAKKGKSDGDQDEVSQFQETQIQRAKRIMK---PF 515
Cdd:cd17999 150 KQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLG-TEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKqvlPF 228
|
....
gi 24583161 516 VLRR 519
Cdd:cd17999 229 LLRR 232
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
278-521 |
7.09e-42 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 153.66 E-value: 7.09e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 278 EQPKLLSSGlQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEI 357
Cdd:cd18062 14 KQSSLLVNG-VLKQYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRINGPFLIIVPLSTLSNWVYEF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 358 SRWCPELVVEKYHGSQDERRrmrgRFAKDGFTG-FDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRYA 436
Cdd:cd18062 93 DKWAPSVVKVSYKGSPAARR----AFVPQLRSGkFNVLLTTYEYI---IKDKQILAKIRWKYMIVDEGHRMKNHHCKLTQ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 437 NLIT-INARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDGDQDEVSQfQET--QIQRAKRIMK 513
Cdd:cd18062 166 VLNThYVAPRRLLLTGTPLQNKLPELWALLNFLLPTIF-KSCSTFEQWFNAPFAMTGEKVDLNE-EETilIIRRLHKVLR 243
|
....*...
gi 24583161 514 PFVLRRLK 521
Cdd:cd18062 244 PFLLRRLK 251
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
276-521 |
8.67e-42 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 153.29 E-value: 8.67e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 276 IVEQPKLLSSGlQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEA 355
Cdd:cd18063 12 VEKQSSLLING-TLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTY 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 356 EISRWCPELVVEKYHGSQDERRRMRGRFAKDgftGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTTQRY 435
Cdd:cd18063 91 EFDKWAPSVVKISYKGTPAMRRSLVPQLRSG---KFNVLLTTYEYI---IKDKHILAKIRWKYMIVDEGHRMKNHHCKLT 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 436 ANLIT-INARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDGDQDEVSQfQET--QIQRAKRIM 512
Cdd:cd18063 165 QVLNThYVAPRRILLTGTPLQNKLPELWALLNFLLPTIF-KSCSTFEQWFNAPFAMTGERVDLNE-EETilIIRRLHKVL 242
|
....*....
gi 24583161 513 KPFVLRRLK 521
Cdd:cd18063 243 RPFLLRRLK 251
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
289-472 |
9.34e-42 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 150.94 E-value: 9.34e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVV-- 366
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRVGGILGDEMGLGKTIQIIAFLAALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFRVvv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 367 ----------EKYHGSQDERRRMRGRFAKDGftgfDVLLTTYhiVGSTPEERKMFRVCkLDYVIFDEAHMLKNMTTQrya 436
Cdd:cd18000 81 lhssgsgtgsEEKLGSIERKSQLIRKVVGDG----GILITTY--EGFRKHKDLLLNHN-WQYVILDEGHKIRNPDAE--- 150
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 24583161 437 nlITINARM-----RILLTGTPLQNNLLELISLLCFVMPKF 472
Cdd:cd18000 151 --ITLACKQlrtphRLILSGTPIQNNLKELWSLFDFVFPPY 189
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
289-519 |
4.95e-40 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 147.91 E-value: 4.95e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLA-----------------YLKENGLSQAAH---LIVVPSS 348
Cdd:cd18005 1 LRDYQREGVEFMYDLYKNGRGGILGDDMGLGKTVQVIAFLAavlgktgtrrdrennrpRFKKKPPASSAKkpvLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 349 TLDNWEAEISRWcPELVVEKYHGSQDERRRMrGRfAKDGftGFDVLLTTYhivgstpeerKMFRVCK-------LDYVIF 421
Cdd:cd18005 81 VLYNWKDELDTW-GHFEVGVYHGSRKDDELE-GR-LKAG--RLEVVVTTY----------DTLRRCIdslnsinWSAVIA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 422 DEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIKSLFA---KKGKS-DGDQDEV 497
Cdd:cd18005 146 DEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALG-SRSQFKKHFSepiKRGQRhTATAREL 224
|
250 260
....*....|....*....|..
gi 24583161 498 sQFQETQIQRAKRIMKPFVLRR 519
Cdd:cd18005 225 -RLGRKRKQELAVKLSKFFLRR 245
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
289-519 |
9.07e-39 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 142.58 E-value: 9.07e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQderrrmrgrfakdgftgfdVLLTTYHIVGStpeERKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINARMRIL 448
Cdd:cd17994 81 YVGDH-------------------VLLTSYELISI---DQAILGSIDWAVLVVDEAHRLKNNQSKFFRILNSYKIGYKLL 138
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24583161 449 LTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDgdqdevsqfqetQIQRAKRIMKPFVLRR 519
Cdd:cd17994 139 LTGTPLQNNLEELFHLLNFLTPERF-NNLQGFLEEFADISKED------------QIKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
289-519 |
1.34e-38 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 143.27 E-value: 1.34e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLsQAAHLIVVPSSTLDNWEAEISRWCpELVVEK 368
Cdd:cd18060 1 LREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSIAFLQEVYNVGI-HGPFLVIAPLSTITNWEREFNTWT-EMNTIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRG--RFAKD-------GFTGFDVLLTTYHIVGS-TPEERKMFRVCkldyVIFDEAHMLKNMTTQRYANL 438
Cdd:cd18060 79 YHGSLASRQMIQQyeMYCKDsrgrlipGAYKFDALITTFEMILSdCPELREIEWRC----VIIDEAHRLKNRNCKLLDSL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 439 ITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLfakkgksdGDQDevsqfQETQIQRAKRIMKPFVLR 518
Cdd:cd18060 155 KHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF--------GDLK-----TEEQVQKLQAILKPMMLR 221
|
.
gi 24583161 519 R 519
Cdd:cd18060 222 R 222
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
311-486 |
2.43e-38 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 142.82 E-value: 2.43e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 311 ILADEMGLGKTIQVIAFL-AYLKeNGLSQAAHLIVVPSSTLDNWEAEISRWCPE-----LVVEKYHGSQDERRRMR--GR 382
Cdd:cd18007 30 ILAHTMGLGKTLQVITFLhTYLA-AAPRRSRPLVLCPASTLYNWEDEFKKWLPPdlrplLVLVSLSASKRADARLRkiNK 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 383 FAKDG---FTGFDVLLTTYHIVGSTPEERKMFRVCKL----DYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQ 455
Cdd:cd18007 109 WHKEGgvlLIGYELFRNLASNATTDPRLKQEFIAALLdpgpDLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQ 188
|
170 180 190
....*....|....*....|....*....|.
gi 24583161 456 NNLLELISLLCFVMPKFFaKSIEDIKSLFAK 486
Cdd:cd18007 189 NNLKEYWTMVDFARPKYL-GTLKEFKKKFVK 218
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
289-519 |
7.57e-37 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 138.96 E-value: 7.57e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLtvMHKqemNGILADEMGLGKTIQVIAFLA---------YLKENGLSQAAH--------LIVVPSSTLD 351
Cdd:cd18008 1 LLPYQKQGLAWM--LPR---GGILADEMGLGKTIQALALILatrpqdpkiPEELEENSSDPKklylskttLIVVPLSLLS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 352 NWEAEISR--WCPELVVEKYHGSQderrrmRGRFAKDgFTGFDVLLTTYHIVGS--TPEERKMFRVCKLDY--------- 418
Cdd:cd18008 76 QWKDEIEKhtKPGSLKVYVYHGSK------RIKSIEE-LSDYDIVITTYGTLASefPKNKKGGGRDSKEKEasplhrirw 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 419 --VIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSI---EDIKSLFAKKGKSDgd 493
Cdd:cd18008 149 yrVILDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPwfnSDISKPFSKNDRKA-- 226
|
250 260
....*....|....*....|....*.
gi 24583161 494 qdevsqfqetqIQRAKRIMKPFVLRR 519
Cdd:cd18008 227 -----------LERLQALLKPILLRR 241
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
278-519 |
4.26e-36 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 136.72 E-value: 4.26e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 278 EQPKLL--SSGLQLADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEA 355
Cdd:cd18053 8 KQPSYIggHEGLELRDYQLNGLNWLAHSWCKGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPFLLVVPLSTLTSWQR 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 356 EISRWCPELVVEKYHGSQDERRRMRGR---FAKDGFTGFDVLLTTYHIVgstPEERKMFRVCKLDYVIFDEAHMLKNMTT 432
Cdd:cd18053 88 EIQTWAPQMNAVVYLGDINSRNMIRTHewmHPQTKRLKFNILLTTYEIL---LKDKSFLGGLNWAFIGVDEAHRLKNDDS 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 433 QRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAkSIEDIkslfakkgksdgdQDEVSQFQETQIQRAKRIM 512
Cdd:cd18053 165 LLYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFS-SWEDF-------------EEEHGKGREYGYASLHKEL 230
|
....*..
gi 24583161 513 KPFVLRR 519
Cdd:cd18053 231 EPFLLRR 237
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
293-519 |
5.18e-36 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 136.26 E-value: 5.18e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 293 QIIGLNWL----TVMHKQEMNG-ILADEMGLGKTIQVIAFL-AYLKEN-GLSQAAH--LIVVPSSTLDNWEAEISRWCPE 363
Cdd:cd18004 5 QREGVQFLydclTGRRGYGGGGaILADEMGLGKTLQAIALVwTLLKQGpYGKPTAKkaLIVCPSSLVGNWKAEFDKWLGL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 364 LVVEKYHGSQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEerKMFRVCKLDYVIFDEAHMLKNMTTQRYANLITINA 443
Cdd:cd18004 85 RRIKVVTADGNAKDVKASLDFFSSASTYPVLIISYETLRRHAE--KLSKKISIDLLICDEGHRLKNSESKTTKALNSLPC 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 444 RMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFA----KKGKSDGDQDEVSQFQETQiQRAKRIMKPFVLRR 519
Cdd:cd18004 163 RRRLLLTGTPIQNDLDEFFALVDFVNPGIL-GSLASFRKVFEepilRSRDPDASEEDKELGAERS-QELSELTSRFILRR 240
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
289-519 |
1.54e-35 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 134.40 E-value: 1.54e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLsQAAHLIVVPSSTLDNWEAEISRWCpELVVEK 368
Cdd:cd18058 1 LREYQLEGMNWLLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLMGI-RGPFLIIAPLSTITNWEREFRTWT-EMNAIV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERR-----RMRGRFAK----DGFTGFDVLLTTYH-IVGSTPEERKMFRVCkldyVIFDEAHMLKNMTTQRYANL 438
Cdd:cd18058 79 YHGSQISRQmiqqyEMYYRDEQgnplSGIFKFQVVITTFEmILADCPELKKINWSC----VIIDEAHRLKNRNCKLLEGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 439 ITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLfakkgksdGDQDevsqfQETQIQRAKRIMKPFVLR 518
Cdd:cd18058 155 KLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF--------GDLK-----TEEQVKKLQSILKPMMLR 221
|
.
gi 24583161 519 R 519
Cdd:cd18058 222 R 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
289-519 |
1.76e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 131.31 E-value: 1.76e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLsQAAHLIVVPSSTLDNWEAEISRWCpELVVEK 368
Cdd:cd18059 1 LREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFLYEIYLKGI-HGPFLVIAPLSTIPNWEREFRTWT-ELNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMR----------GRFAKDGFTgFDVLLTTYH-IVGSTPEERKMFRVCkldyVIFDEAHMLKNMTTQRYAN 437
Cdd:cd18059 79 YHGSQASRRTIQlyemyfkdpqGRVIKGSYK-FHAIITTFEmILTDCPELRNIPWRC----VVIDEAHRLKNRNCKLLEG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 438 LITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKSIEDIKSLfakkgksdGDQDevsqfQETQIQRAKRIMKPFVL 517
Cdd:cd18059 154 LKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF--------GDLK-----TEEQVQKLQAILKPMML 220
|
..
gi 24583161 518 RR 519
Cdd:cd18059 221 RR 222
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
289-519 |
2.09e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 131.34 E-value: 2.09e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTIVFLYSLYKEGHSKGPYLVSAPLSTIINWEREFEMWAPDFYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRG-----------------RFAKDGFTGFDVLLTTYHIVGStpeERKMFRVCKLDYVIFDEAHMLKNMT 431
Cdd:cd18057 81 YTGDKESRSVIREnefsfednairsgkkvfRMKKEAQIKFHVLLTSYELITI---DQAILGSIEWACLVVDEAHRLKNNQ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 432 TQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDgdqdevsqfqetQIQRAKRI 511
Cdd:cd18057 158 SKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERF-NNLEGFLEEFADISKED------------QIKKLHDL 224
|
....*...
gi 24583161 512 MKPFVLRR 519
Cdd:cd18057 225 LGPHMLRR 232
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
289-519 |
3.55e-34 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 130.96 E-value: 3.55e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEK 368
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVVT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMR-----------------GRFAKDGFTGFDVLLTTYHIVgstpeERKMFRVCKLDY--VIFDEAHMLKN 429
Cdd:cd18056 81 YVGDKDSRAIIRenefsfednairggkkaSRMKKEASVKFHVLLTSYELI-----TIDMAILGSIDWacLIVDEAHRLKN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 430 MTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDgdqdevsqfqetQIQRAK 509
Cdd:cd18056 156 NQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERF-HNLEGFLEEFADIAKED------------QIKKLH 222
|
250
....*....|
gi 24583161 510 RIMKPFVLRR 519
Cdd:cd18056 223 DMLGPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
292-519 |
1.06e-33 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 129.36 E-value: 1.06e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 292 YQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHG 371
Cdd:cd18055 4 YQLEGLNWLRFSWAQGTDTILADEMGLGKTIQTIVFLYSLYKEGHTKGPFLVSAPLSTIINWEREFQMWAPDFYVVTYTG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 372 SQDERRRMRG-----------------RFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLdyvIFDEAHMLKNMTTQR 434
Cdd:cd18055 84 DKDSRAIIREnefsfddnavkggkkafKMKREAQVKFHVLLTSYELVTIDQAALGSIRWACL---VVDEAHRLKNNQSKF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 435 YANLITINARMRILLTGTPLQNNLLELISLLCFVMPKFFaKSIEDIKSLFAKKGKSDgdqdevsqfqetQIQRAKRIMKP 514
Cdd:cd18055 161 FRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERF-NNLEGFLEEFADISKED------------QIKKLHDLLGP 227
|
....*
gi 24583161 515 FVLRR 519
Cdd:cd18055 228 HMLRR 232
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
289-519 |
4.07e-32 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 124.73 E-value: 4.07e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLsQAAHLIVVPSSTLDNWEAEISRWCpELVVEK 368
Cdd:cd18061 1 LREYQLEGLNWLLFNWYNRRNCILADEMGLGKTIQSITFLYEILLTGI-RGPFLIIAPLSTIANWEREFRTWT-DLNVVV 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDER----------RRMRGRFAKDGFTgFDVLLTTYH-IVGSTPEERKMFRVCkldyVIFDEAHMLKNMTTQRYAN 437
Cdd:cd18061 79 YHGSLISRqmiqqyemyfRDSQGRIIRGAYR-FQAIITTFEmILGGCPELNAIDWRC----VIIDEAHRLKNKNCKLLEG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 438 LITINARMRILLTGTPLQNNLLELISLLCFVMPKFFAKsiediKSLFAKKGksdGDQDevsqfQETQIQRAKRIMKPFVL 517
Cdd:cd18061 154 LKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPS-----ESTFMQEF---GDLK-----TEEQVQKLQAILKPMML 220
|
..
gi 24583161 518 RR 519
Cdd:cd18061 221 RR 222
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
311-478 |
4.67e-32 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 124.24 E-value: 4.67e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 311 ILADEMGLGKTIQVIAFLAYLKENG-LsqaahLIVVPSSTLDNWEAEISRWCPELVVEKYH---GSQDERRRMRGRfakd 386
Cdd:cd18010 20 LIADEMGLGKTVQAIAIAAYYREEWpL-----LIVCPSSLRLTWADEIERWLPSLPPDDIQvivKSKDGLRDGDAK---- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 387 gftgfdVLLTTYHIVgSTPEERKM---FRVckldyVIFDEAHMLKNMTTQRYANLITI--NARMRILLTGTPLQNNLLEL 461
Cdd:cd18010 91 ------VVIVSYDLL-RRLEKQLLarkFKV-----VICDESHYLKNSKAKRTKAALPLlkRAKRVILLSGTPALSRPIEL 158
|
170
....*....|....*..
gi 24583161 462 ISLLCFVMPKFFAKSIE 478
Cdd:cd18010 159 FTQLDALDPKLFGRFHD 175
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
311-478 |
9.73e-27 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 109.13 E-value: 9.73e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 311 ILADEMGLGKTIQVIAFL-AYLKENGLSQAahLIVVPSSTLDNWEAEISRWCPELVVE--------KYHGSQDERRRMRG 381
Cdd:cd18069 32 ILAHSMGLGKTLQVISFLdVLLRHTGAKTV--LAIVPVNTLQNWLSEFNKWLPPPEALpnvrprpfKVFILNDEHKTTAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 382 R------FAKDGftgfDVLLTTYhivgstpeerKMFRVCK-LDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPL 454
Cdd:cd18069 110 RakviedWVKDG----GVLLMGY----------EMFRLRPgPDVVICDEGHRIKNCHASTSQALKNIRSRRRIVLTGYPL 175
|
170 180
....*....|....*....|....
gi 24583161 455 QNNLLELISLLCFVMPKFFAKSIE 478
Cdd:cd18069 176 QNNLIEYWCMVDFVRPDFLGTRQE 199
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
284-474 |
4.64e-26 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 106.42 E-value: 4.64e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 284 SSGLQLADYQIIGLNWltvMHKQEMNGILADEMGLGKTIQ-VIAFLAYLKENGLSQAahLIVVPSSTL-DNWEAEISRWC 361
Cdd:smart00487 4 FGFEPLRPYQKEAIEA---LLSGLRDVILAAPTGSGKTLAaLLPALEALKRGKGGRV--LVLVPTRELaEQWAEELKKLG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 362 PEL---VVEKYHGsqDERRRMRGRFAKDgftGFDVLLTTYHIVGSTPEERKMFRVcKLDYVIFDEAHMLKNMTtqRYANL 438
Cdd:smart00487 79 PSLglkVVGLYGG--DSKREQLRKLESG---KTDILVTTPGRLLDLLENDKLSLS-NVDLVILDEAHRLLDGG--FGDQL 150
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 24583161 439 ITINARM-----RILLTGTP---LQNNLLELISLLCFVMPKFFA 474
Cdd:smart00487 151 EKLLKLLpknvqLLLLSATPpeeIENLLELFLNDPVFIDVGFTP 194
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
311-519 |
2.49e-24 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 102.55 E-value: 2.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 311 ILADEMGLGKTIQVIAFLAYLKENG------LSQAahLIVVPSSTLDNWEAEISRW----CPELVVEKYHGSQDERRRMR 380
Cdd:cd18067 28 IMADEMGLGKTLQCITLMWTLLRQSpqckpeIDKA--IVVSPSSLVKNWANELGKWlggrLQPLAIDGGSKKEIDRKLVQ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 381 GRFAKDGFTGFDVLLTTYHIVGSTPEERKMfrvCKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLE 460
Cdd:cd18067 106 WASQQGRRVSTPVLIISYETFRLHVEVLQK---GEVGLVICDEGHRLKNSDNQTYQALDSLNTQRRVLLSGTPIQNDLSE 182
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24583161 461 LISLLCFVMPKFFAKSIEdikslFAK-------KGK-SDGDQDEVsQFQETQIQRAKRIMKPFVLRR 519
Cdd:cd18067 183 YFSLVNFVNPGILGTAAE-----FKKnfelpilKGRdADASEKER-QLGEEKLQELISIVNRCIIRR 243
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
310-519 |
2.89e-24 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 102.55 E-value: 2.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 310 GILADEMGLGKTIQVIAFLAYLKEnglsqaahLIVVPSSTLDNWEAEISRWCPE--LVVEKYHGSQderrrmRGRFAKDg 387
Cdd:cd18071 51 GILADDMGLGKTLTTISLILANFT--------LIVCPLSVLSNWETQFEEHVKPgqLKVYTYHGGE------RNRDPKL- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 388 FTGFDVLLTTYHIVGSTPEERKMFRVCKLDY--VIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLL 465
Cdd:cd18071 116 LSKYDIVLTTYNTLASDFGAKGDSPLHTINWlrVVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQNSPKDLGSLL 195
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 24583161 466 CFVMPKFFaksieDIKSLFakkgkSDGDQDEVSQFQETQIQRAKRIMKPFVLRR 519
Cdd:cd18071 196 SFLHLKPF-----SNPEYW-----RRLIQRPLTMGDPTGLKRLQVLMKQITLRR 239
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
652-765 |
4.66e-23 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 94.58 E-value: 4.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 652 GKFLYLDTLLPKlkAEGHRVLLFSQFTMMLDIvEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDsiFVFLLSTKAGG 731
Cdd:pfam00271 1 EKLEALLELLKK--ERGGKVLIFSQTKKTLEA-ELLLEKEGIKVARLHGDLSQEEREEILEDFRKGK--IDVLVATDVAE 75
|
90 100 110
....*....|....*....|....*....|....
gi 24583161 732 VGINLTAADTCVIHDIDFNPYNDKQAEDRCHRMG 765
Cdd:pfam00271 76 RGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
299-470 |
8.21e-23 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 97.99 E-value: 8.21e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 299 WLTVM---HKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAA-----HLIVVPSSTLDNWEAEISRWCPELVVEKYH 370
Cdd:cd18066 13 YECVMgmrVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKpvikrALIVTPGSLVKNWKKEFQKWLGSERIKVFT 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 371 GSQDERRRmrgRFAKDGFtgFDVLLTTYHIVGSTPEERKMFrvcKLDYVIFDEAHMLKNMTTQRYANLITINARMRILLT 450
Cdd:cd18066 93 VDQDHKVE---EFIASPL--YSVLIISYEMLLRSLDQISKL---NFDLVICDEGHRLKNTSIKTTTALTSLSCERRIILT 164
|
170 180
....*....|....*....|
gi 24583161 451 GTPLQNNLLELISLLCFVMP 470
Cdd:cd18066 165 GTPIQNDLQEFFALIDFVNP 184
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
289-468 |
3.57e-22 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 96.40 E-value: 3.57e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLNWLTVMHKQEMNG-ILADEMGLGKTIQVIAFLAYLKEN--------------GLSQAAH--------LIVV 345
Cdd:cd18072 1 LLLHQKQALAWLLWRERQKPRGgILADDMGLGKTLTMIALILAQKNTqnrkeeekekalteWESKKDStlvpsagtLVVC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 346 PSSTLDNWEAEISRWCPE--LVVEKYHGSQDERRrmrGRFAKDgftgFDVLLTTYHIV-------GSTPEERKMFRVcKL 416
Cdd:cd18072 81 PASLVHQWKNEVESRVASnkLRVCLYHGPNRERI---GEVLRD----YDIVITTYSLVakeiptyKEESRSSPLFRI-AW 152
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 24583161 417 DYVIFDEAHMLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFV 468
Cdd:cd18072 153 ARIILDEAHNIKNPKVQASIAVCKLRAHARWALTGTPIQNNLLDMYSLLKFL 204
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
310-470 |
9.36e-22 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 95.34 E-value: 9.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 310 GILADEMGLGKTIQVIAFLAYL----KENGLSQAahLIVVPSSTLDNWEAEISRWCPEL----VVEKYHGSQ----DERR 377
Cdd:cd18068 31 CILAHCMGLGKTLQVVTFLHTVllceKLENFSRV--LVVCPLNTVLNWLNEFEKWQEGLkdeeKIEVNELATykrpQERS 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 378 RMRGRFAKDG---FTGFDV--LLTTYHIVGSTPEERKMFRVCKL----DYVIFDEAHMLKNMTTQRYANLITINARMRIL 448
Cdd:cd18068 109 YKLQRWQEEGgvmIIGYDMyrILAQERNVKSREKLKEIFNKALVdpgpDFVVCDEGHILKNEASAVSKAMNSIRTKRRIV 188
|
170 180
....*....|....*....|..
gi 24583161 449 LTGTPLQNNLLELISLLCFVMP 470
Cdd:cd18068 189 LTGTPLQNNLIEYHCMVNFVKP 210
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
289-474 |
3.30e-21 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 92.74 E-value: 3.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGLnwLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAhLIVVPSSTLDNWEAEISR--WCPELVV 366
Cdd:cd18011 1 PLPHQIDAV--LRALRKPPVRLLLADEVGLGKTIEAGLIIKELLLRGDAKRV-LILCPASLVEQWQDELQDkfGLPFLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 367 ekyhgsQDERRRMRGRFAKDGFTGFDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHMLKN----MTTQRY--ANLIT 440
Cdd:cd18011 78 ------DRETAAQLRRLIGNPFEEFPIVIVSLDLLKRSEERRGLLLSEEWDLVVVDEAHKLRNsgggKETKRYklGRLLA 151
|
170 180 190
....*....|....*....|....*....|....
gi 24583161 441 INARMRILLTGTPLQNNLLELISLLCFVMPKFFA 474
Cdd:cd18011 152 KRARHVLLLTATPHNGKEEDFRALLSLLDPGRFA 185
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
682-765 |
8.59e-19 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 81.49 E-value: 8.59e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 682 DIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDSifVFLLSTKAGGVGINLTAADTCVIHDIDFNPYNDKQAEDRC 761
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKI--KVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRA 78
|
....
gi 24583161 762 HRMG 765
Cdd:smart00490 79 GRAG 82
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
292-470 |
7.90e-15 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 75.07 E-value: 7.90e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 292 YQIIGLNWLTVMhkqemNGILADEMGLGKTIQVIAFL------------AYLKENGLSQAAH-------------LIVVP 346
Cdd:cd18070 4 YQRRAVNWMLVP-----GGILADEMGLGKTVEVLALIllhprpdndldaADDDSDEMVCCPDclvaetpvsskatLIVCP 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 347 SSTLDNWEAEISRWCPE-LVVEKYHGsqDERRRMRGRFAKDGFTGFDVLLTTY-------HIVGSTPEERKMFRVCKLD- 417
Cdd:cd18070 79 SAILAQWLDEINRHVPSsLKVLTYQG--VKKDGALASPAPEILAEYDIVVTTYdvlrtelHYAEANRSNRRRRRQKRYEa 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24583161 418 -----------YVIFDEAHMLKnMTTQRYANLIT-INARMRILLTGTPLQNNLLELISLLCFVMP 470
Cdd:cd18070 157 ppsplvlvewwRVCLDEAQMVE-SSTSKAAEMARrLPRVNRWCVSGTPIQRGLDDLFGLLSFLGV 220
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
284-453 |
2.31e-10 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 63.89 E-value: 2.31e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 284 SSGLQLADYQIIGLN-WLTVMHKQEMNGILADEMGLGKTIqVIAFLAylKENGLSQAAhLIVVPSSTL-DNWEAEISRWc 361
Cdd:COG1061 76 GTSFELRPYQQEALEaLLAALERGGGRGLVVAPTGTGKTV-LALALA--AELLRGKRV-LVLVPRRELlEQWAEELRRF- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 362 peLVVEKYHGSQDERrrmrgrfakdgftGFDVLLTTYHIVGSTPEERKMFRVCklDYVIFDEAHmlkNMTTQRYANLIT- 440
Cdd:COG1061 151 --LGDPLAGGGKKDS-------------DAPITVATYQSLARRAHLDELGDRF--GLVIIDEAH---HAGAPSYRRILEa 210
|
170
....*....|...
gi 24583161 441 INARMRILLTGTP 453
Cdd:COG1061 211 FPAAYRLGLTATP 223
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
307-452 |
6.33e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 55.49 E-value: 6.33e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 307 EMNGILADEMGLGKTIqvIAFLAyLKENGLSQAAH-LIVVPSSTLDN-WEAEISRW-CPELVVEKYHGSQD--ERRRMRG 381
Cdd:cd00046 1 GENVLITAPTGSGKTL--AALLA-ALLLLLKKGKKvLVLVPTKALALqTAERLRELfGPGIRVAVLVGGSSaeEREKNKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24583161 382 RFAkdgftgfDVLLTTYHIVGSTPEERKMFRVCKLDYVIFDEAHML------KNMTTQRYANLITINARmRILLTGT 452
Cdd:cd00046 78 GDA-------DIIIATPDMLLNLLLREDRLFLKDLKLIIVDEAHALlidsrgALILDLAVRKAGLKNAQ-VILLSAT 146
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
291-461 |
7.97e-09 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 56.59 E-value: 7.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 291 DYQIIGLNWLTvmhKQEMNGILADeMGLGKTIQVIAFLAYLKEngLSQAAHLIVVPSSTL--DNWEAEISRWcpELVVEK 368
Cdd:cd18013 3 PYQKVAINFII---EHPYCGLFLD-MGLGKTVTTLTALSDLQL--DDFTRRVLVIAPLRVarSTWPDEVEKW--NHLRNL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 369 YHGSQDERRRMRGRFAKdgfTGFDVLLTTYH----IVGSTPEErkmfrvCKLDYVIFDEAHMLKNMTTQRYANLITINAR 444
Cdd:cd18013 75 TVSVAVGTERQRSKAAN---TPADLYVINREnlkwLVNKSGDP------WPFDMVVIDELSSFKSPRSKRFKALRKVRPV 145
|
170
....*....|....*....
gi 24583161 445 MR--ILLTGTPLQNNLLEL 461
Cdd:cd18013 146 IKrlIGLTGTPSPNGLMDL 164
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
289-453 |
2.09e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 53.85 E-value: 2.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 289 LADYQIIGL-NWLTvmHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLsqaahLIVVPSSTLDN-WEAEISRWcpelvv 366
Cdd:cd17926 1 LRPYQEEALeAWLA--HKNNRRGILVLPTGSGKTLTALALIAYLKELRT-----LIVVPTDALLDqWKERFEDF------ 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 367 ekyhGSQDERRRMRGRfAKDGFTGFDVLLTTYHIVGSTPEE-RKMFRVCklDYVIFDEAHmlkNMTTQRYANLITINARM 445
Cdd:cd17926 68 ----LGDSSIGLIGGG-KKKDFDDANVVVATYQSLSNLAEEeKDLFDQF--GLLIVDEAH---HLPAKTFSEILKELNAK 137
|
....*....
gi 24583161 446 RIL-LTGTP 453
Cdd:cd17926 138 YRLgLTATP 146
|
|
| DpdE |
NF041062 |
protein DpdE; |
282-465 |
2.48e-08 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 58.06 E-value: 2.48e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 282 LLSSGLQLADYQIIGLnwLTVMHKQEMNGILADEMGLGKTIQ---VIafLAYLKENglSQAAHLIVVPSSTLDNWEAEis 358
Cdd:NF041062 147 LLSSAVELEPHQVAVV--RRVLQDPVQRYLLADEVGLGKTIEaglVI--RQHLLDN--PDARVLVLVPDALVRQWRRE-- 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 359 rwcpelvvekyhgsqderrrMRGRFakdgFTGfDVLLTTYHIVG-STPEERKMFRVcKLDYVIFDEAHMLKNMTT----- 432
Cdd:NF041062 219 --------------------LRDKF----FLD-DFPGARVRVLShEEPERWEPLLD-APDLLVVDEAHQLARLAWsgdpp 272
|
170 180 190
....*....|....*....|....*....|....*..
gi 24583161 433 --QRYANLITI--NARMRILLTGTPLQNNLLELISLL 465
Cdd:NF041062 273 erARYRELAALahAAPRLLLLSATPVLGNEETFLALL 309
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
287-453 |
2.73e-08 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 53.83 E-value: 2.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 287 LQLADYQIIGL-NWLTVMHKQEMNGILADEMGLGKTIQVIAFLAYLKENGLSQAAhLIVVPSSTLDN-WEAEISRW--CP 362
Cdd:pfam04851 2 LELRPYQIEAIeNLLESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIKKV-LFLVPRKDLLEqALEEFKKFlpNY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 363 ELVVEKYHGsqDERRRMRGrfakdgftGFDVLLTTYH-IVGSTPEERKMFRVCKLDYVIFDEAHMLknmTTQRYANLIT- 440
Cdd:pfam04851 81 VEIGEIISG--DKKDESVD--------DNKIVVTTIQsLYKALELASLELLPDFFDVIIIDEAHRS---GASSYRNILEy 147
|
170
....*....|...
gi 24583161 441 INARMRILLTGTP 453
Cdd:pfam04851 148 FKPAFLLGLTATP 160
|
|
| ComEA |
COG1555 |
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair]; ... |
192-233 |
5.68e-04 |
|
DNA uptake protein ComE or related DNA-binding protein [Replication, recombination and repair];
Pssm-ID: 441164 [Multi-domain] Cd Length: 72 Bit Score: 39.08 E-value: 5.68e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 24583161 192 NEASLIELQSVKTLSEKKALAIIDVR----PFSDWSDLRQ-------KLESIR 233
Cdd:COG1555 16 NTATAEELQTLPGIGPKLAQRIVEYRekngPFKSVEDLLEvkgigpkTLEKLK 68
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
317-453 |
6.36e-04 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 41.46 E-value: 6.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 317 GLGKTIqvIAFLAYL----KENGLSQAahLIVVPSSTL-----DNWEaEISRWCPELVVEKYHGsqDERRRMRGRFAkdg 387
Cdd:pfam00270 24 GSGKTL--AFLLPALealdKLDNGPQA--LVLAPTRELaeqiyEELK-KLGKGLGLKVASLLGG--DSRKEQLEKLK--- 93
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24583161 388 ftGFDVLLTTYHIVGSTPEERKMFRvcKLDYVIFDEAHMLKNMTtqRYANLITINARMR-----ILLTGTP 453
Cdd:pfam00270 94 --GPDILVGTPGRLLDLLQERKLLK--NLKLLVLDEAHRLLDMG--FGPDLEEILRRLPkkrqiLLLSATL 158
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
350-425 |
8.47e-04 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 42.90 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 350 LDNWEAEISRWCPELVVEKYHG--SQDERRRMRgrfaKDGftgfDVLLTT-----YHIVGSTPEERKMFRvcKLDYVIFD 422
Cdd:COG1205 118 LRRLRELAEALGLGVRVATYDGdtPPEERRWIR----EHP----DIVLTNpdmlhYGLLPHHTRWARFFR--NLRYVVID 187
|
...
gi 24583161 423 EAH 425
Cdd:COG1205 188 EAH 190
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
317-452 |
5.07e-03 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 38.82 E-value: 5.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 317 GLGKTIQVIAFLAYLKENGLsqaahlIVVPSST-LDNWEAEISRWCpelvvekyhgsqDERRRMRGRFAKDGFTGFD--- 392
Cdd:cd18029 36 GAGKTLVGITAACTIKKSTL------VLCTSAVsVEQWRRQFLDWT------------TIDDEQIGRFTSDKKEIFPeag 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24583161 393 VLLTTYHIVGST----PEERKMFRVCKL---DYVIFDEAHMLKNMTTQRYANLitINARMRILLTGT 452
Cdd:cd18029 98 VTVSTYSMLANTrkrsPESEKFMEFITErewGLIILDEVHVVPAPMFRRVLTL--QKAHCKLGLTAT 162
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
309-455 |
5.25e-03 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 38.72 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 309 NGILADEMGLGKTIQviAFLAYL---KENGLSQAAHLIVVPSSTLDN-WEAEISRWC----PELVVEKYHG--SQDERRR 378
Cdd:cd17922 3 NVLIAAPTGSGKTEA--AFLPALsslADEPEKGVQVLYISPLKALINdQERRLEEPLdeidLEIPVAVRHGdtSQSEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583161 379 MRGRFAkdgftgfDVLLTT---YHIVGSTPEERKMFRVCKldYVIFDEAHMLknMTTQRYANLITINARMRiLLTGTPLQ 455
Cdd:cd17922 81 QLKNPP-------GILITTpesLELLLVNKKLRELFAGLR--YVVVDEIHAL--LGSKRGVQLELLLERLR-KLTGRPLR 148
|
|
| |
