|
Name |
Accession |
Description |
Interval |
E-value |
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
33-1261 |
0e+00 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 1084.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 33 CVWYGVCNTNDFSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENSENKFCCDKNQVELLNKNVELAGNILDRCPSCMEN 112
Cdd:TIGR00917 1 CAMYDICGARSDGKVLNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVRCPACLRN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 113 LVRHICQFTCSPKQAEFMHVVATQKNKKGDEyISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGaYSASRCNPT 192
Cdd:TIGR00917 81 FLNLFCELTCSPDQSLFINVTSTTKVKTNST-VDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGG-GAKNFKEWF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 193 KWFNFMGDATNPYVPFQITYIqHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCPQGPPEPPRPEPFKIVGL 272
Cdd:TIGR00917 159 NWIGQKAGVNLPGAPYGIAFL-PTPCPVSSGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKKHSCSIKLGV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 273 DAYFVIMAAVFLVGVLVFLMGSFLFT-----QGSSMDDNFQVDG--NDVSDEMPYSENDSYFEKLGAhTETFLETFFTKW 345
Cdd:TIGR00917 238 KCVDFILAILYIVLVSVFLGGGLLHPvrgkkKTSQMGTLSEADGeiNSVNQQKDQNTPQRNWGQLST-VQGHLARFFGKY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 346 GTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKLWASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVhnt 425
Cdd:TIGR00917 317 GIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIATVQTSSHE--- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 426 sngpyTFGPVFDREFLTKVLDLQEGIKEINAN----GTQLKDICYAPLSDdgseidvSQCVVQSIWGYFGDDRERLDDHD 501
Cdd:TIGR00917 394 -----KAPEILTDDNLKLLFDIQKKVSQLFANyegeLITLDSPCFKPNHP-------YNCFIYSTCKKLQNMYSKLKPEN 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 502 EDNGFNVTYLDALYDCISNPYLCLAPYGGPVDPAIALGGFlppgdqltGSTKFELANAIILTFLVKNHHNKTD-LENALT 580
Cdd:TIGR00917 462 YDDYGGVDYVKYCFEHFTSPESCLSAFGGPVDPTTVLGGF--------SGNNFSEASAFVVTFPVNNFVNKTNkTEKAVA 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 581 WEKKFVEFMTNYtKNNMSQYmDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGI 660
Cdd:TIGR00917 534 WEKAFIQLAKDE-LLPMVQA-TISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGDSPRLKSLYVTSKVLLGL 611
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 661 GGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNE---------TLEQQVGRILG 731
Cdd:TIGR00917 612 SGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQvgvdneqelTLERRLSRALM 691
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 732 KVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKGKKPD-- 809
Cdd:TIGR00917 692 EVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTEDKRVDCFPCIKTSKSSis 771
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 810 ----SITSNEGLLYKFFSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLN 885
Cdd:TIGR00917 772 aekgSGQRKAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLPQDSYLQIYFASLTPLLE 851
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 886 IGPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIylasrhSNQTYIARPASSWIDDYFDWAAAASSCCKYRKDSG 965
Cdd:TIGR00917 852 VGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNVF------NNLSYIAKPASSWLDDYLVWLSPQASCCCRKFTNG 925
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 966 DFCPHQDTSCLRC-NITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKAGHAAYGGAVRYSNSHERlnIEASYFMAYHTIL 1044
Cdd:TIGR00917 926 TFCNGPDPQCFRCaDLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVDLQGYATI--IQASSFRTYHTPL 1003
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1045 KSSADYFLALESARKISANITQmlqgrlmsngvpmasALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFV 1124
Cdd:TIGR00917 1004 NTQVDFINAMRAAQEFAAKVSR---------------SSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLF 1068
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1125 LMGFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMG 1204
Cdd:TIGR00917 1069 LLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMG 1148
|
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*..
gi 24583258 1205 SSIFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIG 1261
Cdd:TIGR00917 1149 SSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLGFLHGLVFLPVLLSVLG 1205
|
|
| NPC1_N |
pfam16414 |
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ... |
31-256 |
2.27e-99 |
|
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.
Pssm-ID: 465110 Cd Length: 239 Bit Score: 316.47 E-value: 2.27e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 31 QDCVWYGVCNTND-FSHSQNCPYNGTAKEMATDGLELLKKRCGFLLENsENKFCCDKNQVELLNKNVELAGNILDRCPSC 109
Cdd:pfam16414 1 GRCAWYGECGKKSlFGKDLPCPYNGPAKPLDDEVRDLLAELCPLLFAD-ETPVCCDADQLNTLRSNLKLAEGLLSRCPAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 110 MENLVRHICQFTCSPKQAEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYsasrC 189
Cdd:pfam16414 80 KKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKEYVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICGGA----C 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24583258 190 NPTKWFNFMGDATNPYVPFQITYIQhEPKSNSNNFTPLNVTTVPCNQAVSSKlPACSCSDCDLSCPQ 256
Cdd:pfam16414 156 NYTRWLKFMGDKKNGGSPFQINFPD-PPEEDPSGMVPLNPNTKDCNESYDAS-YACSCVDCPLSCPP 220
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
538-1258 |
3.41e-68 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 246.50 E-value: 3.41e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 538 LGGFLPP---GDQLTGSTKFELANAIILTFLVKNHHNKTDlENALTWEKKFVEFMTNYTKnnmSQYMDIAFTSERSIEDE 614
Cdd:pfam02460 132 TPIYLGPhfgGVDFEPPGNISYAKAIVLWYFLKFDEEEVE-EDSKEWEDELSQLLHNKYA---SEHIQFTIFHDQILNDE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 615 LNRESQSDVLTILVSYLIMFMYIAISLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATlIIVEVIPF 694
Cdd:pfam02460 208 LVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFN-SIVCVTPF 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 695 LVLAVGVDNIFILVQTHQRDQRKpnETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDF 774
Cdd:pfam02460 287 LVLAIGVDDMFLMVAAWQRTTAT--LSVKKRMGEALSEAGVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDF 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 775 LLQITCFVSLFTLDTKRREENRMdiCCFIKGKKPDSITSNEG-----------LLYKFFSSVYVPFLMKKIVRASVMVIF 843
Cdd:pfam02460 365 IYQITFFAAIMAICAKPEAEGRH--CLFVWATSSPQRIDSEGsepdkshnieqLKSRFFLDIYCPFLLNPSVRVCMLVLF 442
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 844 FAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENL-NIGPPVYFVLK--GDLayTNSSdqnlvcagqycNDDSV 920
Cdd:pfam02460 443 VVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFwPEGLQIQVAVNnpPNL--TIPE-----------SRDRM 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 921 LTqiyLASRHSNQTYIARPASS--WIDDYFDWaaaasscckyrkdsgdfcphqdtsclRCNITKNSLLRPEEKEFVKYLP 998
Cdd:pfam02460 510 NE---MVDEFENTPYSLGPNSTlfWLREYENF--------------------------LSTLNMEEEEDEEKEWSYGNLP 560
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 999 FFLKdnpddtcakaghaaYGGavrysNSHERLNIeasYFMAYHTILKSsadyFLALESARKIS--ANITQMLQG-RLMSN 1075
Cdd:pfam02460 561 SFLK--------------APG-----NSHWAGDL---VWDDNTTMVTK----FRFTLAGKGLStwNDRTRALQEwRSIAD 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1076 GVPMASALTvevfpYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGfdvHSALVVVITITMIVVNLG--GLMYY 1153
Cdd:pfam02460 615 QYPEFNVTV-----FDEDAPFADQYLTILPSTIQNIVITLICMFIVCFLFIP---NPPCVFVITLAIASIDIGvfGFLSL 686
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1154 WNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSSIFSGITLTkFAGILVLAFAKSQIFQVF 1233
Cdd:pfam02460 687 WGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLST-ILGVLVLLFVPSYMVVVF 765
|
730 740
....*....|....*....|....*
gi 24583258 1234 YFRMYLgIVVIGAAHGLIFLPVLLS 1258
Cdd:pfam02460 766 FKTVFL-VVAIGLLHGLFILPIILS 789
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
651-805 |
1.42e-65 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 218.22 E-value: 1.42e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 651 FIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILVQTHQRDQRKPNEtlEQQVGRIL 730
Cdd:pfam12349 1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDV--SERIAEAL 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24583258 731 GKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDICCFIKG 805
Cdd:pfam12349 79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIRV 153
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
581-1263 |
5.72e-59 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 222.45 E-value: 5.72e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 581 WEKKFVEFMTNYTKNNMSQYMdIAFTSErSIEDELNRESQSDVLTILVSYLIMFMYIAISLghvkeFKRVFIDSKITLGI 660
Cdd:TIGR00918 359 WQRNFSEEVQQSLPKNSSQKI-LVFSST-TLDDILKKFSDVSAIRIVSGYLLMLAYACLTM-----LRWDCAKSQGSVGL 431
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 661 GGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNIFILvqTHQRDQRKPNETLEQQVGRILGKVGPSMLLT 740
Cdd:TIGR00918 432 AGVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLL--AHAFSETGQNIPFEERTGECLKRTGASVVLT 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 741 SLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRMDI-CCFIKG-------------- 805
Cdd:TIGR00918 510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIfCCFFSPcsarviqiepqaya 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 806 -------------------------------------------------KKPDSITSNEGLLYKFFSSV----------- 825
Cdd:TIGR00918 590 dgsappvysshmqstvqlrteydpgtqhyyttneprshlsvqpsdplscQSPDIAGSTRDLLSQFEDSKaaclslpcarw 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 826 ---------YVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDS----FV---LHYFQSLNenlnigpp 889
Cdd:TIGR00918 670 tlatfaekhYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTnehdFLdaqFRYFSFYN-------- 741
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 890 VYFVLKGDLAYTNSSDqnlvcagqycnddsvltQIY-LASRHSNQTYIARPA------------SSW---IDDYFD--WA 951
Cdd:TIGR00918 742 MYAVTQGNFDYPTQQQ-----------------LLYdLHQSFSSVKYVLKEDngqlprmwlhyfRDWlqgLQKAFDedWR 804
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 952 AAASSCCKYRKDSGDFC---------PHQDTSCLRCNITKNSLLRPE----EKEFVKYLPFFLKDNPddtcakAGHAAYG 1018
Cdd:TIGR00918 805 DGRITKENYRNGSDDAVlaykllvqtGHRDKPVDKEQLTTQRLVNADgiinPNAFYIYLSAWVSNDP------VAYAASQ 878
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1019 GAVR----------YSNSHERLNIEASYFMAYHTI------LKSSADYFLALESARKISANITQMlqgrlmsnGVPmasa 1082
Cdd:TIGR00918 879 ANIYphppewlhdkNDYDPENLRIPAAEPLEYAQFpfylngLRETSQFVEAIEHVRAICNNYEGF--------GLP---- 946
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1083 ltveVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMgFDVHSALVVVITITMIVVNLGGLMYYWNISLNAVS 1162
Cdd:TIGR00918 947 ----SYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIP 1021
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1163 LVNLVMAVGISVEFCSHLVHSFATSKSVSQIdRAADSLSKMGSSIFSGiTLTKFAGILVLAFAKSQiFQVFYFRMYLGIV 1242
Cdd:TIGR00918 1022 VVILIASVGIGVEFTVHIALGFLTAIGDRNR-RAVLALEHMFAPVLDG-ALSTLLGVLMLAGSEFD-FIVRYFFAVLAVL 1098
|
810 820
....*....|....*....|..
gi 24583258 1243 -VIGAAHGLIFLPVLLSYIGAP 1263
Cdd:TIGR00918 1099 tCLGVLNGLVLLPVLLSMFGPE 1120
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
339-1257 |
1.54e-38 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 155.40 E-value: 1.54e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 339 ETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKlWASPNSKSRLEREFFDTKFSPfyrLEQIIIkavnl 418
Cdd:COG1033 1 ERLMERLARFILRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFES-LLPEDDPSVQAYDEFEEEFGG---DDTVVV----- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 419 pqIVHNTSNgpytfgpVFDREFLTKVLDLQEGIKEI-NANGTQ-LKDICYAPLSDDGSEIDvsqcvvQSIWGYFGDDRER 496
Cdd:COG1033 72 --AVEGKDD-------IFTPETLEALRELTEELEEIpGVDSVTsLTNVRATEGTEDGLTVE------PLIPDELPASPEE 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 497 LDDHDEDNGFNVTYLDALYdcisnpylclapyggpvdpaialggflppgdqltgSTKFELAnAIILTFlvknhhnKTDLE 576
Cdd:COG1033 137 LAELREKVLSSPLYVGRLV-----------------------------------SPDGKAT-LIVVTL-------DPDPL 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 577 NALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTIL-VSYLIMFMYIAISLGHVKEfkrVFIdsk 655
Cdd:COG1033 174 SSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRGDIAEAIQSDLAIFFpLALLLILLLLFLFFRSLRG---VLL--- 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 656 itlgigGVIIVLASVVSSVGVFGYIGLPATLIIVeVIPFLVLAVGVDN-IFILVqtHQRDQRKPNETLEQQVGRILGKVG 734
Cdd:COG1033 248 ------PLLVVLLAVIWTLGLMGLLGIPLSPLTI-LVPPLLLAIGIDYgIHLLN--RYREERRKGLDKREALREALRKLG 318
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 735 PSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLdTKRREEnrmdiccfiKGKKPDSITSN 814
Cdd:COG1033 319 PPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSL-LPRPKP---------KTRRLKKPPEL 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 815 EGLLYKFFSsvyvpFLMKKivRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNIGPPVYFVL 894
Cdd:COG1033 389 GRLLAKLAR-----FVLRR--PKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVV 461
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 895 KGDlaytnssdqnlvcAGQYCNDDSVLTQIYLASRH-SNQTYIARPASswIDDYFDWAAAAsscckYRKDSGDFcphqdt 973
Cdd:COG1033 462 DTG-------------EPDGLKDPEVLKEIDRLQDYlESLPEVGKVLS--LADLVKELNQA-----LNEGDPKY------ 515
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 974 sclrcnitkNSLlrPEEKEFVKYLPFFLKDNPDDTcakaghaayggAVRYSNS-HERLNIeaSYFMAYHtilkSSADYFL 1052
Cdd:COG1033 516 ---------YAL--PESRELLAQLLLLLSSPPGDD-----------LSRFVDEdYSAARV--TVRLKDL----DSEEIKA 567
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1053 ALESARKISANItqmlqgrlmsngvpmASALTVEVFPYSVFYVFYEqyltMWSDTLQSMGISVLSIFVVTFVLMGFDVHS 1132
Cdd:COG1033 568 LVEEVRAFLAEN---------------FPPDGVEVTLTGSAVLFAA----INESVIESQIRSLLLALLLIFLLLLLAFRS 628
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1133 ---ALVVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSF--ATSKSVSQIDRAADSLSKMGSSI 1207
Cdd:COG1033 629 lrlGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYreERRKGGDLEEAIRRALRTTGKAI 708
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|..
gi 24583258 1208 -FSGITLtkFAGILVLAFAKSQIFQvfYFRMYLGIVVIGAAHG-LIFLPVLL 1257
Cdd:COG1033 709 lFTSLTL--AAGFGVLLFSSFPPLA--DFGLLLALGLLVALLAaLLLLPALL 756
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
1103-1272 |
6.67e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 76.44 E-value: 6.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1103 MWSDTLQSMGISVLSIFVVTFVLMGfDVHSALVVVITITM-IVVNLGgLMYYWNISLNAVS--LVNLVMAVGISveFCSH 1179
Cdd:COG1033 216 IQSDLAIFFPLALLLILLLLFLFFR-SLRGVLLPLLVVLLaVIWTLG-LMGLLGIPLSPLTilVPPLLLAIGID--YGIH 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1180 LVHSF--ATSKSVSQIDRAADSLSKMGSSIFSGiTLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHgLIFLPVLL 1257
Cdd:COG1033 292 LLNRYreERRKGLDKREALREALRKLGPPVLLT-SLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTS-LTLLPALL 369
|
170
....*....|....*
gi 24583258 1258 SYIGAPVSNARLRYH 1272
Cdd:COG1033 370 SLLPRPKPKTRRLKK 384
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
325-776 |
2.51e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 68.35 E-value: 2.51e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 325 SYFEKL-----GAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKlWASPNSKSRLEREFFD 399
Cdd:COG1033 370 SLLPRPkpktrRLKKPPELGRLLAKLARFVLRRPKVILVVALVLAVVSLYGISRLKVEYDFED-YLPEDSPIRQDLDFIE 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 400 TKFSPFYRLEqIIIKAVNLpqivhntsngpytfGPVFDREFLTKVLDLQEGIKEINangtqlkdicyaplsddgseiDVS 479
Cdd:COG1033 449 ENFGGSDPLE-VVVDTGEP--------------DGLKDPEVLKEIDRLQDYLESLP---------------------EVG 492
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 480 QcvVQSI--------WGYFGDDRE--RLDDHDEdngfnvtYLDALYDCISNPylclapyggpvdPAIALGGFLPPGDQLT 549
Cdd:COG1033 493 K--VLSLadlvkelnQALNEGDPKyyALPESRE-------LLAQLLLLLSSP------------PGDDLSRFVDEDYSAA 551
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 550 gstkfelanaiILTFLVKNHhnktDLENALTWEKKFVEFMTNYTKNNMsqyMDIAFTSERSIEDELNRESQSD-VLTILV 628
Cdd:COG1033 552 -----------RVTVRLKDL----DSEEIKALVEEVRAFLAENFPPDG---VEVTLTGSAVLFAAINESVIESqIRSLLL 613
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 629 SYLIMFMYIAISLGHVKefkrvfidskitLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPfLVLAVGVDN-IFIL 707
Cdd:COG1033 614 ALLLIFLLLLLAFRSLR------------LGLISLIPNLLPILLTFGLMGLLGIPLNIATAVVAS-IALGIGVDYtIHFL 680
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24583258 708 vqTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAG----VALIIDFLL 776
Cdd:COG1033 681 --SRYREERRKGGDLEEAIRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLAlgllVALLAALLL 751
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
662-1263 |
8.05e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.40 E-value: 8.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 662 GVIIVLASVVSSVGVFGYIGLPATLIIVEVIPfLVLAVGVDNIfilVQTHQR--DQRKPNETLEQQVGRILGKVGPSMLL 739
Cdd:TIGR00921 223 PLVIILFGVAWVLGIMGWLGIPLYATTLLAVP-MLIGVGIDYG---IQTLNRyeEERDIGRAKGEAIVTAVRRTGRAVLI 298
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 740 TSLSESFCFFLGGLSDMPAVRAFALYAGVALIIDFLLQITCFVSLFTLDTKRREENRmdiccfikgKKPDSITSNEGLLY 819
Cdd:TIGR00921 299 ALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSIDIGREKVK---------KEIIAIGGKSSEIE 369
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 820 KFFSSVyvpflMKKIVRASV--MVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNI-GPPVYFVLKG 896
Cdd:TIGR00921 370 EELSKV-----LSITVRHPVpaLVAALIITGLGLYGAAGIKPEVNIEKFIPQDLPSLQARKVIESHMGGsHDFATILVKA 444
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 897 DLAytnssdqnlvcagqycNDDSVLTQIYLASRHSNqtyiarpASSWIDDYFDwaaaASSCCKYRKDSGDFCPhQDTSCL 976
Cdd:TIGR00921 445 DDV----------------RDPELVRFMDELSRDIK-------ATGVAARVFG----APSIIDLVKEVEGLPA-PERSAL 496
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 977 rcnitkNSLLRPEEKEFVKylpfflkdnpddtcakaghaayGGAVRYSNSHERLNIeasyfmayhTILKSSADYFLAles 1056
Cdd:TIGR00921 497 ------EPIPEDEEGGYIS----------------------GGQIKVAVIQVQLKQ---------GEPKVQGRKILR--- 536
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1057 arkisanitqMLQGRLMSNGVpmasalTVEVFPYSVfyVFYEQYLTMWSDtlQSMgISVLSIFVVTFVLMGF--DVHSAL 1134
Cdd:TIGR00921 537 ----------DVQHEHPPPGV------KVGVTGLPV--AFAEMHELVNEG--MRR-MTIAGAILVLMILLAVfrNPIKAV 595
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1135 VVVITITMIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHS-FATSKSVSQIDRAADSLSKMGSSIFSGiTL 1213
Cdd:TIGR00921 596 FPLIAIGSGILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERyFEERKEHGPKEAITHTMERTGPGILFS-GL 674
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 24583258 1214 TKFAGILVLAFAKSQIFQVFYFrmylgIVVIGaahglIFLPVLLSYIGAP 1263
Cdd:TIGR00921 675 TTAGGFLSLLLSHFPIMRNFGL-----VQGIG-----VLSSLTAALVVFP 714
|
|
| CusA |
COG3696 |
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism]; |
1118-1224 |
5.28e-05 |
|
Cu/Ag efflux pump CusA [Inorganic ion transport and metabolism];
Pssm-ID: 442911 [Multi-domain] Cd Length: 1031 Bit Score: 47.72 E-value: 5.28e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1118 IFVVTFVLMGF--DVHSALVVVITI------TMIVvnlgglMYYWNISLNAVSLVNLVMAVG-------ISVEFC-SHLV 1181
Cdd:COG3696 345 ALLVILVLFLFlgNLRAALIVALAIplsllfAFIV------MRLFGISANLMSLGGLAIDFGiivdgavVMVENIlRRLE 418
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 24583258 1182 HSFATSKSVSQIDRAADSLSKMGSSIFSGITltkfagILVLAF 1224
Cdd:COG3696 419 ENRAAGTPRERLEVVLEAAREVRRPIFFATL------IIILVF 455
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
614-787 |
8.78e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.75 E-value: 8.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 614 ELNRESQSDVLTI-LVSYLIMFMYIAIslghvkefkrVFIDskITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVI 692
Cdd:TIGR00921 560 EMHELVNEGMRRMtIAGAILVLMILLA----------VFRN--PIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTI 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 693 PfLVLAVGVD-NIFILVQ-THQRDQRKPNETLEQQVGRilgkVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVAL 770
Cdd:TIGR00921 628 S-IILGLGMDySIHLAERyFEERKEHGPKEAITHTMER----TGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGV 702
|
170
....*....|....*..
gi 24583258 771 IIDFLLQITCFVSLFTL 787
Cdd:TIGR00921 703 LSSLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
1097-1260 |
8.86e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 46.75 E-value: 8.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1097 YEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITITMIVVNLGgLMYYWNISLNAVSLVNLVMAVGISVEF 1176
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLG-IMGWLGIPLYATTLLAVPMLIGVGIDY 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1177 CSHLVHSFATS----KSVSQIdrAADSLSKMGSSIFsGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVViGAAHGLIF 1252
Cdd:TIGR00921 264 GIQTLNRYEEErdigRAKGEA--IVTAVRRTGRAVL-IALLTTSAGFAALALSEFPMVSEFGLGLVAGLIT-AYLLTLLV 339
|
....*...
gi 24583258 1253 LPVLLSYI 1260
Cdd:TIGR00921 340 LPALLQSI 347
|
|
| ACR_tran |
pfam00873 |
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are ... |
1105-1232 |
1.74e-04 |
|
AcrB/AcrD/AcrF family; Members of this family are integral membrane proteins. Some are involved in drug resistance. AcrB cooperates with a membrane fusion protein, AcrA, and an outer membrane channel TolC. The structure shows the AcrB forms a homotrimer.
Pssm-ID: 395701 [Multi-domain] Cd Length: 1021 Bit Score: 46.13 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1105 SDTLQSMGISVLSIFVVTFVLMGfDVHSALVVVITITmiVVNLGGL--MYYWNISLNAVSLVNLVMAVGISV-------E 1175
Cdd:pfam00873 331 EEVVKTLLEAIVLVILVMFLFLQ-NWRATLIPAIAIP--LSLLGTFavMKAFGFSINTLTLGGLVLAIGLVVddaivvvE 407
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24583258 1176 FCS------HLVHSFATSKSVSQIDRAADSLSKMGSSIF------SGIT---LTKFAGILVLAFAKSQIFQV 1232
Cdd:pfam00873 408 NIErvleenGLKPLEAAYKSMGEIGGALVAIALVLSAVFlpilflGGLTgriFRQFAITIVLAILLSVLVAL 479
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
660-779 |
4.60e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 43.82 E-value: 4.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 660 IGGVIIVLASVVSSVGVFGY---IGLPATLIIVEVIpfLVLAVGVD-NIFILvqTHQRDQRKPNETLEQQVGRILGKVGP 735
Cdd:pfam03176 173 LLTVGLSLGAAQGLVAILAHilgIGLSTFALNLLVV--LLIAVGTDyALFLV--SRYREELRAGEDREEAVIRAVRGTGK 248
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 24583258 736 SMLLTSLSesFCFFLGGL--SDMPAVRAFALYAGVALIIDFLLQIT 779
Cdd:pfam03176 249 VVTAAGLT--VAIAMLALsfARLPVFAQVGPTIAIGVLVDVLAALT 292
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
1096-1268 |
7.55e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.07 E-value: 7.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1096 FYEQYLTmwsDTLQSMGISVLSIFVVtFVLMGFDVHSALVVVI--TITMIVVnLGgLMYYWNISLNAVSLVNLVMAVGIS 1173
Cdd:COG4258 633 LFGRYRN---DALWLLLLALLLILLL-LLLRLRSLRRALRVLLppLLAVLLT-LA-ILGLLGIPLNLFHLIALLLVLGIG 706
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1174 VEFCshLvhsFATsksvSQIDRAADSLSKMGSSIFSgiTLTKFAGILVLAFAKSQIFQVFyfrmylGIVV-IGaahglIF 1252
Cdd:COG4258 707 IDYA--L---FFT----EGLLDKGELARTLLSILLA--ALTTLLGFGLLAFSSTPALRSF------GLTVlLG-----IL 764
|
170
....*....|....*.
gi 24583258 1253 LPVLLSYIGAPVSNAR 1268
Cdd:COG4258 765 LALLLAPLLAPRRRPR 780
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
1105-1268 |
1.95e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 42.78 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1105 SDTLQSMGISVLSIFVVTFVLMGfDVHSALVVVITI------TMIVvnlgglMYYWNISLNAVSLVNLVMAVGISV---- 1174
Cdd:COG0841 331 EEVVKTLLEAILLVVLVVFLFLR-SWRATLIPAVAIpvsligTFAV------MYLLGFSLNILTLFALVLAIGIVVddai 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 1175 ---EFCSHLVHsfatsKSVSQIDRAADSLSKMGSSIFSgITLTkfagiLVLAFAK----SQIFQVFYFrmYLGIVVIGA- 1246
Cdd:COG0841 404 vvvENIERHME-----EGLSPLEAAIKGAREVAGAVIA-STLT-----LVAVFLPlafmGGITGQLFR--QFALTVAIAl 470
|
170 180
....*....|....*....|....*...
gi 24583258 1247 ------AhgLIFLPVLLSYIGAPVSNAR 1268
Cdd:COG0841 471 lislfvA--LTLTPALCARLLKPHPKGK 496
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
626-777 |
4.45e-03 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 41.38 E-value: 4.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24583258 626 ILVSYLIMFMYIAISLGHVKEFKRVfidskitlgiggVIIVLASVVSSVGVFGYIGLPATLIIVeVIPFLVLAVGVD-NI 704
Cdd:COG4258 645 LLLALLLILLLLLLRLRSLRRALRV------------LLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyAL 711
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24583258 705 FIlvqthQRDQRKPNETLEQQVGRILgkvgpSMLLTSLSesfcFFLGGLSDMPAVRAF----ALYAGVALIIDFLLQ 777
Cdd:COG4258 712 FF-----TEGLLDKGELARTLLSILL-----AALTTLLG----FGLLAFSSTPALRSFgltvLLGILLALLLAPLLA 774
|
|
| |
