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Conserved domains on  [gi|24584272|ref|NP_609697|]
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uncharacterized protein Dmel_CG18095, isoform A [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-338 4.90e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 4.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  22 LQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNlss 101
Cdd:COG4886  31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 102 lrswSSEPLGALTNLDLSHNMLSKLSvKSFEQYPQLQQLDLRYNRISQIeNDSFDGLSHLKHLYLNGNQLAHIDGSFFrG 181
Cdd:COG4886 108 ----ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG-N 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 182 LHRLSSLSLQHNRIEFIEmDSFESNTHLRSLRLDQNLLSSLQfLSQRGLARLVHLNLSSNLLQKLEpfVFSKNFELQDLD 261
Cdd:COG4886 181 LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELD 256

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24584272 262 LSYNNITKLNKEAlsGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNK 338
Cdd:COG4886 257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-338 4.90e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 4.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  22 LQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNlss 101
Cdd:COG4886  31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 102 lrswSSEPLGALTNLDLSHNMLSKLSvKSFEQYPQLQQLDLRYNRISQIeNDSFDGLSHLKHLYLNGNQLAHIDGSFFrG 181
Cdd:COG4886 108 ----ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG-N 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 182 LHRLSSLSLQHNRIEFIEmDSFESNTHLRSLRLDQNLLSSLQfLSQRGLARLVHLNLSSNLLQKLEpfVFSKNFELQDLD 261
Cdd:COG4886 181 LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELD 256

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24584272 262 LSYNNITKLNKEAlsGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNK 338
Cdd:COG4886 257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-342 2.11e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 2.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 110 LGALTNLDLSHNMLSKLSVksFEQYPQLQQLDLRYNRISQIENdsFDGLSHLKHLYLNGNQLAHIDGsfFRGLHRLSSLS 189
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 190 LQHNRIEFIEmdSFESNTHLRSLRLD-QNLLSSLQFL----SQRGLARlvhlnlssnllqklepfvfsknfELQDLDLSY 264
Cdd:cd21340  75 LGGNRISVVE--GLENLTNLEELHIEnQRLPPGEKLTfdprSLAALSN-----------------------SLRVLNISG 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 265 NNITKLnkEALSGLDSLERLNISHNYVDKIYD--ESLDSLIALLQLDISFNLLTTLPdNLFhfntqlEEIILANNKIEEI 342
Cdd:cd21340 130 NNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP-KYR------DKIILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
113-171 1.79e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.79e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24584272   113 LTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQL 171
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-388 1.61e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   89 LQYLSLSHNNLSSLRSWSSEPLgaLTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNG 168
Cdd:PLN00113 120 LRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  169 NQLA---------------------HIDGSFFRGLHRLSSLS---LQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQF 224
Cdd:PLN00113 198 NQLVgqiprelgqmkslkwiylgynNLSGEIPYEIGGLTSLNhldLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIP 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  225 LSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIA 304
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNN 357

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  305 LLQLDISFNLLT-TLPDNLFHfNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISdaaflDRLSPSVNRFTL-- 381
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLCS-SGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFS-----GELPSEFTKLPLvy 431


                 ....*..
gi 24584272  382 YVDLSSN 388
Cdd:PLN00113 432 FLDISNN 438
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-338 4.90e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 4.90e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  22 LQLSKCNNTEVTLIRKTELLTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNlss 101
Cdd:COG4886  31 LLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE--- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 102 lrswSSEPLGALTNLDLSHNMLSKLSvKSFEQYPQLQQLDLRYNRISQIeNDSFDGLSHLKHLYLNGNQLAHIDGSFFrG 181
Cdd:COG4886 108 ----ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELG-N 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 182 LHRLSSLSLQHNRIEFIEmDSFESNTHLRSLRLDQNLLSSLQfLSQRGLARLVHLNLSSNLLQKLEpfVFSKNFELQDLD 261
Cdd:COG4886 181 LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELD 256

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24584272 262 LSYNNITKLNKEAlsGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNK 338
Cdd:COG4886 257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLK 331
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
83-384 1.34e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 97.31  E-value: 1.34e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  83 LNGLTKLQYLSLSHNNLSSLrSWSSEPLGALTNLDLSHNMLSKLSvKSFEQYPQLQQLDLRYNRISQIeNDSFDGLSHLK 162
Cdd:COG4886 109 LSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLK 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 163 HLYLNGNQLAHIDGSFFrGLHRLSSLSLQHNRIEFIEmDSFESNTHLRSLRLDQNLLSSLQFLSQrgLARLVHLNLSSNL 242
Cdd:COG4886 186 ELDLSNNQITDLPEPLG-NLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPELGN--LTNLEELDLSNNQ 261

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 243 LQKLEPFVFSKNfeLQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIydESLDSLIALLQLDISFNLLTTLPDNL 322
Cdd:COG4886 262 LTDLPPLANLTN--LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL--ELLILLLLLTTLLLLLLLLKGLLVTL 337

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24584272 323 FHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVD 384
Cdd:COG4886 338 TTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
22-337 2.26e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 2.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  22 LQLSKCNNTEVTLIRKTELLTSLTLSNctlphveNGFFVRFDHLLHLELQHSGLSDLDDfSLNGLTKLQYLSLSHNNLSS 101
Cdd:COG4886  79 LLLLSLLLLGLTDLGDLTNLTELDLSG-------NEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTD 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 102 LrswsSEPLGALTNL---DLSHNMLSKLSvKSFEQYPQLQQLDLRYNRISQIEnDSFDGLSHLKHLYLNGNQLAHIDGSf 178
Cdd:COG4886 151 L----PEPLGNLTNLkslDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP- 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 179 FRGLHRLSSLSLQHNRIEfiEMDSFESNTHLRSLRLDQNLLSSLQFLSQrgLARLVHLNLSSNLLQKLEPFVFSKNFELQ 258
Cdd:COG4886 224 LANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKLKELELLLGLN 299

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24584272 259 DLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANN 337
Cdd:COG4886 300 SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 110-342 2.11e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 84.07  E-value: 2.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 110 LGALTNLDLSHNMLSKLSVksFEQYPQLQQLDLRYNRISQIENdsFDGLSHLKHLYLNGNQLAHIDGsfFRGLHRLSSLS 189
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 190 LQHNRIEFIEmdSFESNTHLRSLRLD-QNLLSSLQFL----SQRGLARlvhlnlssnllqklepfvfsknfELQDLDLSY 264
Cdd:cd21340  75 LGGNRISVVE--GLENLTNLEELHIEnQRLPPGEKLTfdprSLAALSN-----------------------SLRVLNISG 129

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 265 NNITKLnkEALSGLDSLERLNISHNYVDKIYD--ESLDSLIALLQLDISFNLLTTLPdNLFhfntqlEEIILANNKIEEI 342
Cdd:cd21340 130 NNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP-KYR------DKIILASKSLEVL 200
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
75-459 2.79e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 2.79e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  75 LSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDS 154
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 155 FDGLSHLKHLYLNGNQlahidgsFFRGLHRLSSLSLQHNRIEFIEmDSFESNTHLRSLRLDQNLLSSLQfLSQRGLARLV 234
Cdd:COG4886  92 LGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 235 HLNLSSNLLQKLePFVFSKNFELQDLDLSYNNITKLnKEALSGLDSLERLNISHNYVDKIyDESLDSLIALLQLDISFNL 314
Cdd:COG4886 163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 315 LTTLPDnlFHFNTQLEEIILANNKIEEISSQmmFNQNHLRYIKLSGNAISDAAFLDRLSPSVNRFTLYVDLSSNRLKSLN 394
Cdd:COG4886 240 LTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24584272 395 LSSLLHFRYINLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIEGGTNR 459
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLL 380
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
41-323 1.82e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.60  E-value: 1.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  41 LTSLTLSNCTLPHVENGFFvRFDHLLHLELQHSGLSDLDDfSLNGLTKLQYLSLSHNNLSSLrswsSEPLGALTNL---D 117
Cdd:COG4886 138 LKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL----PEPLGNLTNLeelD 211

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 118 LSHNMLSKLSvKSFEQYPQLQQLDLRYNRISQIEndSFDGLSHLKHLYLNGNQLAHIDGSFfrGLHRLSSLSLQHNRIEF 197
Cdd:COG4886 212 LSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTD 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 198 IEMDSFESNTHLRSlrLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSG 277
Cdd:COG4886 287 LKLKELELLLGLNS--LLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 24584272 278 LDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLF 323
Cdd:COG4886 365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 65-272 8.82e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 79.44  E-value: 8.82e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  65 LLHLELQHSGLSDLDDFSLngLTKLQYLSLSHNNLSSLrswssEPLGALTNLdlshnmlsklsvksfeqypqlQQLDLRY 144
Cdd:cd21340   4 ITHLYLNDKNITKIDNLSL--CKNLKVLYLYDNKITKI-----ENLEFLTNL---------------------THLYLQN 55

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 145 NRISQIENdsFDGLSHLKHLYLNGNQLAHIDGsfFRGLHRLSSLSLQHNRI---EFIEMDSFESNTHLRSLR-LD--QNL 218
Cdd:cd21340  56 NQIEKIEN--LENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLppgEKLTFDPRSLAALSNSLRvLNisGNN 131

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24584272 219 LSSLQFLSqrGLARLVHLNLSSNLLQKLEPF--VFSKNFELQDLDLSYNNITKLNK 272
Cdd:cd21340 132 IDSLEPLA--PLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCKKPK 185
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 182-364 2.76e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 2.76e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 182 LHRLSSLSLQHNRIEfiEMDSFESNTHLRSLRLDQNLLSSLQFLSQrgLARLVHLNLSSNLLQKLEPFVFSKNfeLQDLD 261
Cdd:cd21340   1 LKRITHLYLNDKNIT--KIDNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIENLENLVN--LKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 262 LSYNNITKLnkEALSGLDSLERLNISHNYVDKiyDESL----DSLIALLQ----LDISFNLLTTLpDNLFHFnTQLEEII 333
Cdd:cd21340  75 LGGNRISVV--EGLENLTNLEELHIENQRLPP--GEKLtfdpRSLAALSNslrvLNISGNNIDSL-EPLAPL-RNLEQLD 148

                       170       180       190
                ....*....|....*....|....*....|...
gi 24584272 334 LANNKIEEIS--SQMMFNQNHLRYIKLSGNAIS 364
Cdd:cd21340 149 ASNNQISDLEelLDLLSSWPSLRELDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
86-495 4.60e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 4.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  86 LTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLY 165
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 166 LNGNQLahiDGSFFRGLHRLSSLSLQHNriefiemDSFESNTHLRSLRLDQNLLSSL-QFLSQrgLARLVHLNLSSNLLQ 244
Cdd:COG4886  82 LSLLLL---GLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLpEELAN--LTNLKELDLSNNQLT 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 245 KLePFVFSKNFELQDLDLSYNNITKLnKEALSGLDSLERLNISHNYVDKIyDESLDSLIALLQLDISFNLLTTLPDNLFH 324
Cdd:COG4886 150 DL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLAN 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 325 FnTQLEEIILANNKIEEISSqmMFNQNHLRYIKLSGNAISDAAFLDRLSPSVnrftlYVDLSSNRLKSLNLSSLLHFRYI 404
Cdd:COG4886 227 L-TNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTNLK-----TLDLSNNQLTDLKLKELELLLGL 298

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 405 NLADNNWSCNWLVANLVQKLPNSVNFARPWTVINNLSENTTNVEGIDCIEGGTNRSIILLDVSGVPQPKSDNCDCVVAYD 484
Cdd:COG4886 299 NSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEAT 378

                       410
                ....*....|.
gi 24584272 485 ETNPSPPPLTW 495
Cdd:COG4886 379 LLTLALLLLTL 389
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 115-384 3.20e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 64.68  E-value: 3.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 115 NLDLSHNMLSKLSVKS-FEQYPQLQQLDLRYNRISQIE-NDSFDGLSH---LKHLYLNGNQLAHID------GSFFRGLH 183
Cdd:cd00116   2 QLSLKGELLKTERATElLPKLLCLQVLRLEGNTLGEEAaKALASALRPqpsLKELCLSLNETGRIPrglqslLQGLTKGC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 184 RLSSLSLQHNRIEFIEMDSFES---NTHLRSLRLDQNLLSSLQF-LSQRGL----ARLVHLNLSSNLL--QKLEPF--VF 251
Cdd:cd00116  82 GLQELDLSDNALGPDGCGVLESllrSSSLQELKLNNNGLGDRGLrLLAKGLkdlpPALEKLVLGRNRLegASCEALakAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 252 SKNFELQDLDLSYNNIT----KLNKEALSGLDSLERLNISHNYV----DKIYDESLDSLIALLQLDISFNLLT-----TL 318
Cdd:cd00116 162 RANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTdagaaAL 241

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24584272 319 PDNLFHFNTQLEEIILANNKIEEISSQM----MFNQNHLRYIKLSGNAISDA----AFLDRLSPSVNRFTLYVD 384
Cdd:cd00116 242 ASALLSPNISLLTLSLSCNDITDDGAKDlaevLAEKESLLELDLRGNKFGEEgaqlLAESLLEPGNELESLWVK 315
LRR_8 pfam13855
Leucine rich repeat;
113-171 1.79e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.76  E-value: 1.79e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24584272   113 LTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQL 171
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
135-195 1.87e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 1.87e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584272   135 PQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRI 195
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
232-289 9.51e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.51e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24584272   232 RLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHN 289
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-388 1.61e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   89 LQYLSLSHNNLSSLRSWSSEPLgaLTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNG 168
Cdd:PLN00113 120 LRYLNLSNNNFTGSIPRGSIPN--LETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  169 NQLA---------------------HIDGSFFRGLHRLSSLS---LQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQF 224
Cdd:PLN00113 198 NQLVgqiprelgqmkslkwiylgynNLSGEIPYEIGGLTSLNhldLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIP 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  225 LSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIA 304
Cdd:PLN00113 278 PSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNN 357

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  305 LLQLDISFNLLT-TLPDNLFHfNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISdaaflDRLSPSVNRFTL-- 381
Cdd:PLN00113 358 LTVLDLSTNNLTgEIPEGLCS-SGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFS-----GELPSEFTKLPLvy 431


                 ....*..
gi 24584272  382 YVDLSSN 388
Cdd:PLN00113 432 FLDISNN 438
LRR_8 pfam13855
Leucine rich repeat;
159-219 3.85e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584272   159 SHLKHLYLNGNQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLL 219
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
37-347 4.78e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 4.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   37 KTEL-LTSLTLSncTLPHVENgffvrfDHLLHLELQHSGLSDLDDfSLNGltKLQYLSLSHNNLSSLRSWSSEplgALTN 115
Cdd:PRK15370 180 KTELrLKILGLT--TIPACIP------EQITTLILDNNELKSLPE-NLQG--NIKTLYANSNQLTSIPATLPD---TIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  116 LDLSHNMLSKLSvksfEQYPQ-LQQLDLRYNRISQIENDSFDGLSHLKhLYLNGNQL--AHIDGSffrglhrLSSLSLQH 192
Cdd:PRK15370 246 MELSINRITELP----ERLPSaLQSLDLFHNKISCLPENLPEELRYLS-VYDNSIRTlpAHLPSG-------ITHLNVQS 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  193 NRIEFIEmDSFESNthLRSLRLDQNLLSSLQflsqrglarlvhlnlssnllQKLEPfvfsknfELQDLDLSYNNITKLnK 272
Cdd:PRK15370 314 NSLTALP-ETLPPG--LKTLEAGENALTSLP--------------------ASLPP-------ELQVLDVSKNQITVL-P 362

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24584272  273 EALSglDSLERLNISHNYVDKIyDESLDSliALLQLDISFNLLTTLPDNLFHFNT---QLEEIILANNKIEEISSQMM 347
Cdd:PRK15370 363 ETLP--PTITTLDVSRNALTNL-PENLPA--ALQIMQASRNNLVRLPESLPHFRGegpQPTRIIVEYNPFSERTIQNM 435
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 12-389 1.97e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 1.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   12 IFSFSPRLSCLQLSKCNNTEVTLIRKTELLTSLTLSNCTLP---HVENGFFVRfdhLLHLELQHSGLSDLDDFSLNGLTK 88
Cdd:PLN00113 113 IFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgeiPNDIGSFSS---LKVLDLGGNVLVGKIPNSLTNLTS 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   89 LQYLSLSHNNLSSlrsWSSEPLGALTNLD---LSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLY 165
Cdd:PLN00113 190 LEFLTLASNQLVG---QIPRELGQMKSLKwiyLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLF 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  166 LNGNQLA-HIDGSFFrGLHRLSSLSLQHNRIE------FIEMDSFESnTHLRSLRLDQNLLSSLQflsqrGLARLVHLNL 238
Cdd:PLN00113 267 LYQNKLSgPIPPSIF-SLQKLISLDLSDNSLSgeipelVIQLQNLEI-LHLFSNNFTGKIPVALT-----SLPRLQVLQL 339

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  239 SSNLLQKLEPFVFSKNFELQDLDLSYNNIT-----------KLNK-------------EALSGLDSLERLNISHNYVDKI 294
Cdd:PLN00113 340 WSNKFSGEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgNLFKlilfsnslegeipKSLGACRSLRRVRLQDNSFSGE 419

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  295 YDESLDSLIALLQLDISFNLLT-------------------------TLPDnlFHFNTQLEEIILANNKIEEISSQMMFN 349
Cdd:PLN00113 420 LPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGS 497

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 24584272  350 QNHLRYIKLSGNAISdAAFLDRLSPSVNRFTLyvDLSSNR 389
Cdd:PLN00113 498 LSELMQLKLSENKLS-GEIPDELSSCKKLVSL--DLSHNQ 534
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 65-322 2.32e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 2.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   65 LLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSK------LSVKSFE------ 132
Cdd:PLN00113 238 LNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGeipelvIQLQNLEilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  133 ------------QYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAhidGSFFRGL---HRLSSLSLQHNRIEF 197
Cdd:PLN00113 318 nnftgkipvaltSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLT---GEIPEGLcssGNLFKLILFSNSLEG 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  198 IEMDSFESNTHLRSLRLDQNLLS-----------------------------------SLQFLS------------QRGL 230
Cdd:PLN00113 395 EIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgrinsrkwdmpSLQMLSlarnkffgglpdSFGS 474

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  231 ARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDI 310
Cdd:PLN00113 475 KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDL 554

                        330
                 ....*....|...
gi 24584272  311 SFNLLT-TLPDNL 322
Cdd:PLN00113 555 SQNQLSgEIPKNL 567
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-315 2.68e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.78  E-value: 2.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   89 LQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNG 168
Cdd:PLN00113 358 LTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISN 437

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  169 NQLAHIDGSFFRGLHRLSSLSLQHNRIEFIEMDSFESNtHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEP 248
Cdd:PLN00113 438 NNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSK-RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIP 516

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24584272  249 FVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLL 315
Cdd:PLN00113 517 DELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
256-315 1.22e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   256 ELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLL 315
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
64-123 2.16e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272    64 HLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNML 123
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
184-243 6.79e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 6.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   184 RLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLL 243
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 58-316 7.22e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 7.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   58 FFVRFdHLLH---LELQHSGLSDLDDfslngltKLQYLSlSHNNLSSLRSWSS---EPLGALTNLDLS-HNMLSKLSVKS 130
Cdd:PLN00113  19 LFLNF-SMLHaeeLELLLSFKSSIND-------PLKYLS-NWNSSADVCLWQGitcNNSSRVVSIDLSgKNISGKISSAI 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  131 FeQYPQLQQLDLRYNRIS-QIENDSFDGLSHLKHLYLNGNQLAhidGSFFRG-LHRLSSLSLQHNRIE---FIEMDSFES 205
Cdd:PLN00113  90 F-RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFT---GSIPRGsIPNLETLDLSNNMLSgeiPNDIGSFSS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  206 nthLRSLRLDQNLL-----------SSLQFLS----------QRGLARLVHLN---LSSNLLQKLEPFVFSKNFELQDLD 261
Cdd:PLN00113 166 ---LKVLDLGGNVLvgkipnsltnlTSLEFLTlasnqlvgqiPRELGQMKSLKwiyLGYNNLSGEIPYEIGGLTSLNHLD 242

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24584272  262 LSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLT 316
Cdd:PLN00113 243 LVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLS 297
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 89-291 8.13e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 8.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  89 LQYLSLSHNNL-SSLRSWSSEPLG-----ALTNLDLSHNMLSKLSVKSFE---QYPQLQQLDLRYNRIS-QIENDSFDGL 158
Cdd:cd00116  53 LKELCLSLNETgRIPRGLQSLLQGltkgcGLQELDLSDNALGPDGCGVLEsllRSSSLQELKLNNNGLGdRGLRLLAKGL 132

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 159 SHLKH----LYLNGNQLAHID----GSFFRGLHRLSSLSLQHNRI--EFIEM--DSFESNTHLRSLRLDQNLLSSL--QF 224
Cdd:cd00116 133 KDLPPalekLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEgaSA 212

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24584272 225 LSQ--RGLARLVHLNLSSNLL-----QKLEPFVFSKNFELQDLDLSYNNITKLN----KEALSGLDSLERLNISHNYV 291
Cdd:cd00116 213 LAEtlASLKSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSLSCNDITDDGakdlAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
87-147 1.43e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584272    87 TKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRI 147
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 230-369 3.74e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 3.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 230 LARLVHLNLSSNLLQKLEPFVFSKNfeLQDLDLSYNNITKLnkEALSGLDSLERLNISHNYVDKIydESLDSLIALLQLD 309
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKN--LKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLY 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24584272 310 ISFNLLTTLP--DNLfhfnTQLEEIILANNKIEEiSSQMMFN-------QNHLRYIKLSGNAISDAAFL 369
Cdd:cd21340  75 LGGNRISVVEglENL----TNLEELHIENQRLPP-GEKLTFDprslaalSNSLRVLNISGNNIDSLEPL 138
LRR_8 pfam13855
Leucine rich repeat;
207-267 7.22e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 7.22e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24584272   207 THLRSLRLDQNLLSSLQFLSQRGLARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNI 267
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
41-99 1.04e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24584272    41 LTSLTLSNCTLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNL 99
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
280-339 1.04e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.04e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   280 SLERLNISHNYVDKIYDESLDSLIALLQLDISFNLLTTLPDNLFHFNTQLEEIILANNKI 339
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 59-148 1.48e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   59 FVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQ 138
Cdd:PLN00113 471 SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLS 550

                         90
                 ....*....|
gi 24584272  139 QLDLRYNRIS 148
Cdd:PLN00113 551 QLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
308-363 1.76e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 1.76e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24584272   308 LDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAI 363
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
211-381 5.40e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.76  E-value: 5.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  211 SLRLDQNLLSSLqflSQRGLARLVHLNLSSNLLQKLePFVFSKNfeLQDLDLSYNNITKLNKEALSGLDSLErlnISHNY 290
Cdd:PRK15370 203 TLILDNNELKSL---PENLQGNIKTLYANSNQLTSI-PATLPDT--IQEMELSINRITELPERLPSALQSLD---LFHNK 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  291 VDKIYDESLDSliaLLQLDISFNLLTTLPDnlfHFNTQLEEIILANNKIEEISSQMMFNqnhLRYIKLSGNAI-----SD 365
Cdd:PRK15370 274 ISCLPENLPEE---LRYLSVYDNSIRTLPA---HLPSGITHLNVQSNSLTALPETLPPG---LKTLEAGENALtslpaSL 344

                        170
                 ....*....|....*.
gi 24584272  366 AAFLDRLSPSVNRFTL 381
Cdd:PRK15370 345 PPELQVLDVSKNQITV 360
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 244-368 6.45e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 39.84  E-value: 6.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   244 QKLEPFVFsKNFELQDLDLSyNNITKLNKEALSGLDSLERLNISHNyVDKIYDESLDSlIALLQLDISfNLLTTLPDNLF 323
Cdd:pfam13306   1 TSIGSYAF-YNCSLTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYN-CSLTSITIP-SSLTSIGEYAF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 24584272   324 HFNTQLEEIILaNNKIEEISSqMMFNQNHLRYIKLSGN--AISDAAF 368
Cdd:pfam13306  76 SNCSNLKSITL-PSNLTSIGS-YAFSNCSLKSITIPSSvtTIGSYAF 120
LRR_9 pfam14580
Leucine-rich repeat;
125-241 6.78e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.90  E-value: 6.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   125 KLSVKSFEQYPQL------QQLDLRYNRISQIEN-----DSFDGLShlkhlyLNGNQLAHIDGsfFRGLHRLSSLSLQHN 193
Cdd:pfam14580   3 KLTAELIEQSAQYtnpvreRELDLRGYKIPIIENlgatlDQFDTID------FSDNEIRKLDG--FPLLRRLKTLLLNNN 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 24584272   194 RIEFIEMDSFESNTHLRSLRLDQNLLSSL-QFLSQRGLARLVHLNLSSN 241
Cdd:pfam14580  75 RICRIGEGLGEALPNLTELILTNNNLQELgDLDPLASLKKLTFLSLLRN 123
PLN03150 PLN03150
hypothetical protein; Provisional
 230-291 1.44e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 1.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24584272  230 LARLVHLNLSSNLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYV 291
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
PLN03150 PLN03150
hypothetical protein; Provisional
 68-148 2.23e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.95  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272   68 LELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGALTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRI 147
Cdd:PLN03150 423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502


                 .
gi 24584272  148 S 148
Cdd:PLN03150 503 S 503
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 112-307 2.67e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.16  E-value: 2.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 112 ALTNLDLSHNMLSKLSVKSFEQY----PQLQQLDLRYNrisQIENDSFDGL-------SHLKHLYLNGNQLAHID----G 176
Cdd:COG5238 209 TVTTLWLKRNPIGDEGAEILAEAlkgnKSLTTLDLSNN---QIGDEGVIALaealknnTTVETLYLSGNQIGAEGaialA 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272 177 SFFRGLHRLSSLSLQHNRIEF---IEM-DSFESNTHLRSLRLDQN---------LLSSLQFLSQrglarLVHLNLSSN-- 241
Cdd:COG5238 286 KALQGNTTLTSLDLSVNRIGDegaIALaEGLQGNKTLHTLNLAYNgigaqgaiaLAKALQENTT-----LHSLDLSDNqi 360

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24584272 242 -------LLQKLEpfvfsKNFELQDLDLSYNNITKLNKEALSGL---DSLERLNISHNyvdKIYDESLDSLIALLQ 307
Cdd:COG5238 361 gdegaiaLAKYLE-----GNTTLRELNLGKNNIGKQGAEALIDAlqtNRLHTLILDGN---LIGAEAQQRLEQLLE 428
PLN03150 PLN03150
hypothetical protein; Provisional
 113-172 2.80e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.80e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24584272  113 LTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLA 172
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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