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Conserved domains on  [gi|20129529|ref|NP_609721|]
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uncharacterized protein Dmel_CG4701 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 96-261 2.20e-102

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 299.73  E-value: 2.20e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILRRM 255
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                ....*.
gi 20129529 256 PAQFHI 261
Cdd:cd19520 161 PKRFHI 166
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 21-368 1.37e-57

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 199.75  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    21 FSALTYYTAKWMINALDPNNKIRGKAKYVAEEQLRKLnssaigaakKFRARDFNEHEMMIASHL---VTPEDIDISWSDI 97
Cdd:TIGR01243 385 LAALAKEAAMAALRRFIREGKINFEAEEIPAEVLKEL---------KVTMKDFMEALKMVEPSAireVLVEVPNVRWSDI 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    98 AGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKL 177
Cdd:TIGR01243 456 GGLEEVKQELREAVEWPLKHPEIFEKMGI-RPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKA 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   178 ATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEA-TAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR--R 254
Cdd:TIGR01243 535 IREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPALLRpgR 612

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   255 MPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMReklntgeEIGKDKI 334
Cdd:TIGR01243 613 FDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIG-------SPAKEKL 685

                         330       340       350
                  ....*....|....*....|....*....|....
gi 20129529   335 EwdfEVKDQALQEwehLEIQMEDLLKSLSVMKAS 368
Cdd:TIGR01243 686 E---VGEEEFLKD---LKVEMRHFLEALKKVKPS 713
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 96-261 2.20e-102

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 299.73  E-value: 2.20e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILRRM 255
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                ....*.
gi 20129529 256 PAQFHI 261
Cdd:cd19520 161 PKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 85-316 7.01e-73

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 230.28  E-value: 7.01e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  85 VTPEDIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVG 164
Cdd:COG1222  68 VPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGI-EPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 165 VLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRG-SNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNR 243
Cdd:COG1222 147 ELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTdDGTSGEVQRTVNQLLAELDGFESRGD--VLIIAATNR 224

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529 244 PQDLDKAILRrmPAQF----HIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMR 316
Cdd:COG1222 225 PDLLDPALLR--PGRFdrviEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIR 299
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 21-368 1.37e-57

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 199.75  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    21 FSALTYYTAKWMINALDPNNKIRGKAKYVAEEQLRKLnssaigaakKFRARDFNEHEMMIASHL---VTPEDIDISWSDI 97
Cdd:TIGR01243 385 LAALAKEAAMAALRRFIREGKINFEAEEIPAEVLKEL---------KVTMKDFMEALKMVEPSAireVLVEVPNVRWSDI 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    98 AGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKL 177
Cdd:TIGR01243 456 GGLEEVKQELREAVEWPLKHPEIFEKMGI-RPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKA 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   178 ATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEA-TAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR--R 254
Cdd:TIGR01243 535 IREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPALLRpgR 612

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   255 MPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMReklntgeEIGKDKI 334
Cdd:TIGR01243 613 FDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIG-------SPAKEKL 685

                         330       340       350
                  ....*....|....*....|....*....|....
gi 20129529   335 EwdfEVKDQALQEwehLEIQMEDLLKSLSVMKAS 368
Cdd:TIGR01243 686 E---VGEEEFLKD---LKVEMRHFLEALKKVKPS 713
cell_div_CdvC NF041006
cell division protein CdvC;
74-371 1.83e-53

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 181.09  E-value: 1.83e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   74 NEHEMMIASHLVTPEDIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSklWraPKGVLLHGPPGCGKTLIAKAIAKD 153
Cdd:NF041006  82 PDVEKESDEELVVKEKPKVTFSDIVGLEDVKEALKEAIVYPSKRPDLFPLG--W--PRGILLYGPPGCGKTMLAAAVANE 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  154 AGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKL-----QPCIIFIDEIESFLrmrGSNDHE--ATAMIKTQFMLQWDG 226
Cdd:NF041006 158 IDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKskeegKPAIIFIDEIDALL---GVYSSEvgGEVRVRNQFLKEMDG 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  227 LM-SNTNICVLVLGATNRPQDLDKAILRRMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRE 305
Cdd:NF041006 235 LQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLENDVDLDELAEMTEGYTASDIRD 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20129529  306 LCRHASMYRMRQFMREKLNtgeeigkdkiewdfevkdqalqewEHLEIQMEDLLKSLSVMKASKHQ 371
Cdd:NF041006 315 IVQAAHMRVVKEMFEKGLG------------------------EPRPITMEDFKEVLKIRKPSVNQ 356
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 91-316 3.54e-53

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 180.80  E-value: 3.54e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   91 DISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLdVGV-LTDK 169
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRV-VGSeLVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  170 WYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMR----GSNDHEA--TAMiktQFMLQWDGLMSNTNicVLVLGATNR 243
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVqrTLM---QLLAEMDGFDPRGN--VKIIAATNR 279

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529  244 PQDLDKAILRrmPAQF----HIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMR 316
Cdd:PRK03992 280 IDILDPAILR--PGRFdriiEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAIR 354
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 91-368 1.65e-52

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 185.88  E-value: 1.65e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    91 DISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKW 170
Cdd:TIGR01243 174 KVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGI-EPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKY 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   171 YGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKA 250
Cdd:TIGR01243 253 YGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGLKGRGR--VIVIGATNRPDALDPA 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   251 iLRRmPAQFH----IGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMREklntg 326
Cdd:TIGR01243 331 -LRR-PGRFDreivIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIRE----- 403

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 20129529   327 eeigkDKIewDFEVKDQALQEWEHLEIQMEDLLKSLSVMKAS 368
Cdd:TIGR01243 404 -----GKI--NFEAEEIPAEVLKELKVTMKDFMEALKMVEPS 438
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 133-265 1.84e-45

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 152.75  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEA 212
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 20129529   213 TAMIKTQFMLQWDGlMSNTNICVLVLGATNRPQDLDKAILRRMpaQFHIGVPR 265
Cdd:pfam00004  81 SRRVVNQLLTELDG-FTSSNSKVIVIAATNRPDKLDPALLGRF--DRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 130-265 3.56e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 75.10  E-value: 3.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    130 PKGVLLHGPPGCGKTLIAKAIAK-----DAGMRFINLD------------VGVLTDKWYGESQKLATAVFTLAKKLQPCI 192
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARelgppGGGVIYIDGEdileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529    193 IFIDEIESFLrmrgsnDHEATAMIKTQFMLQWDGLMSNTNIcVLVLGATNRPQDLDKAILRRMpAQFHIGVPR 265
Cdd:smart00382  82 LILDEITSLL------DAEQEALLLLLEELRLLLLLKSEKN-LTVILTTNDEKDLGPALLRRR-FDRRIVLLL 146
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 285-321 6.45e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.39  E-value: 6.45e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 20129529   285 SVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMRE 321
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
 
Name Accession Description Interval E-value
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 96-261 2.20e-102

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 299.73  E-value: 2.20e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19520   1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILRRM 255
Cdd:cd19520  81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNCRVIVMGATNRPQDLDEAILRRM 160


                ....*.
gi 20129529 256 PAQFHI 261
Cdd:cd19520 161 PKRFHI 166
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 85-316 7.01e-73

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 230.28  E-value: 7.01e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  85 VTPEDIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVG 164
Cdd:COG1222  68 VPAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGI-EPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGS 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 165 VLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRG-SNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNR 243
Cdd:COG1222 147 ELVSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTdDGTSGEVQRTVNQLLAELDGFESRGD--VLIIAATNR 224

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529 244 PQDLDKAILRrmPAQF----HIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMR 316
Cdd:COG1222 225 PDLLDPALLR--PGRFdrviEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVTEAGMFAIR 299
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 97-261 9.16e-69

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 213.75  E-value: 9.16e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  97 IAGLDGTIQELRETVVLPVRHRKLFSRSKLWraPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQK 176
Cdd:cd19509   1 IAGLDDAKEALKEAVILPSLRPDLFPGLRGP--PRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 177 LATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILRRMP 256
Cdd:cd19509  79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNKPEDRVLVLGATNRPWELDEAFLRRFE 158


                ....*
gi 20129529 257 AQFHI 261
Cdd:cd19509 159 KRIYI 163
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 94-325 3.46e-65

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 212.46  E-value: 3.46e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  94 WSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGE 173
Cdd:COG0464 156 LDDLGGLEEVKEELRELVALPLKRPELREEYGL-PPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGE 234

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 174 SQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFmLQW-DGLMSNtnicVLVLGATNRPQDLDKAIL 252
Cdd:COG0464 235 TEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTL-LTEmEELRSD----VVVIAATNRPDLLDPALL 309

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529 253 RRMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQfMREKLNT 325
Cdd:COG0464 310 RRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDVDLEELAEATEGLSGADIRNVVRRAALQALRL-GREPVTT 381
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 21-368 1.37e-57

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 199.75  E-value: 1.37e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    21 FSALTYYTAKWMINALDPNNKIRGKAKYVAEEQLRKLnssaigaakKFRARDFNEHEMMIASHL---VTPEDIDISWSDI 97
Cdd:TIGR01243 385 LAALAKEAAMAALRRFIREGKINFEAEEIPAEVLKEL---------KVTMKDFMEALKMVEPSAireVLVEVPNVRWSDI 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    98 AGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKL 177
Cdd:TIGR01243 456 GGLEEVKQELREAVEWPLKHPEIFEKMGI-RPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVGESEKA 534

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   178 ATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEA-TAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR--R 254
Cdd:TIGR01243 535 IREIFRKARQAAPAIIFFDEIDAIAPARGARFDTSvTDRIVNQLLTEMDGIQELSN--VVVIAATNRPDILDPALLRpgR 612

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   255 MPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMReklntgeEIGKDKI 334
Cdd:TIGR01243 613 FDRLILVPPPDEEARKEIFKIHTRSMPLAEDVDLEELAEMTEGYTGADIEAVCREAAMAALRESIG-------SPAKEKL 685

                         330       340       350
                  ....*....|....*....|....*....|....
gi 20129529   335 EwdfEVKDQALQEwehLEIQMEDLLKSLSVMKAS 368
Cdd:TIGR01243 686 E---VGEEEFLKD---LKVEMRHFLEALKKVKPS 713
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 96-261 3.39e-55

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 178.89  E-value: 3.39e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSrsKLWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19524   1 DIAGQDLAKQALQEMVILPSLRPELFT--GLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILRRM 255
Cdd:cd19524  79 KLVRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSNGDDRVLVMGATNRPQELDDAVLRRF 158


                ....*.
gi 20129529 256 PAQFHI 261
Cdd:cd19524 159 TKRVYV 164
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 91-261 1.85e-54

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 177.87  E-value: 1.85e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  91 DISWSDIAGLDGTIQELRETVVLPVRHRKLFSrsKLWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKW 170
Cdd:cd19525  18 PINWADIAGLEFAKKTIKEIVVWPMLRPDIFT--GLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKW 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 171 YGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKA 250
Cdd:cd19525  96 VGEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEA 175

                       170
                ....*....|.
gi 20129529 251 ILRRMPAQFHI 261
Cdd:cd19525 176 ARRRLVKRLYI 186
cell_div_CdvC NF041006
cell division protein CdvC;
74-371 1.83e-53

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 181.09  E-value: 1.83e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   74 NEHEMMIASHLVTPEDIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSklWraPKGVLLHGPPGCGKTLIAKAIAKD 153
Cdd:NF041006  82 PDVEKESDEELVVKEKPKVTFSDIVGLEDVKEALKEAIVYPSKRPDLFPLG--W--PRGILLYGPPGCGKTMLAAAVANE 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  154 AGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKL-----QPCIIFIDEIESFLrmrGSNDHE--ATAMIKTQFMLQWDG 226
Cdd:NF041006 158 IDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKskeegKPAIIFIDEIDALL---GVYSSEvgGEVRVRNQFLKEMDG 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  227 LM-SNTNICVLVLGATNRPQDLDKAILRRMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRE 305
Cdd:NF041006 235 LQdKSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLENDVDLDELAEMTEGYTASDIRD 314

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20129529  306 LCRHASMYRMRQFMREKLNtgeeigkdkiewdfevkdqalqewEHLEIQMEDLLKSLSVMKASKHQ 371
Cdd:NF041006 315 IVQAAHMRVVKEMFEKGLG------------------------EPRPITMEDFKEVLKIRKPSVNQ 356
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 91-316 3.54e-53

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 180.80  E-value: 3.54e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   91 DISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLdVGV-LTDK 169
Cdd:PRK03992 127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGI-EPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRV-VGSeLVQK 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  170 WYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMR----GSNDHEA--TAMiktQFMLQWDGLMSNTNicVLVLGATNR 243
Cdd:PRK03992 205 FIGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVqrTLM---QLLAEMDGFDPRGN--VKIIAATNR 279

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529  244 PQDLDKAILRrmPAQF----HIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMR 316
Cdd:PRK03992 280 IDILDPAILR--PGRFdriiEVPLPDEEGRLEILKIHTRKMNLADDVDLEELAELTEGASGADLKAICTEAGMFAIR 354
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 91-368 1.65e-52

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 185.88  E-value: 1.65e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    91 DISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKW 170
Cdd:TIGR01243 174 KVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGI-EPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKY 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   171 YGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKA 250
Cdd:TIGR01243 253 YGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMDGLKGRGR--VIVIGATNRPDALDPA 330

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   251 iLRRmPAQFH----IGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMREklntg 326
Cdd:TIGR01243 331 -LRR-PGRFDreivIRVPDKRARKEILKVHTRNMPLAEDVDLDKLAEVTHGFVGADLAALAKEAAMAALRRFIRE----- 403

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 20129529   327 eeigkDKIewDFEVKDQALQEWEHLEIQMEDLLKSLSVMKAS 368
Cdd:TIGR01243 404 -----GKI--NFEAEEIPAEVLKELKVTMKDFMEALKMVEPS 438
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 91-261 1.20e-48

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 162.34  E-value: 1.20e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  91 DISWSDIAGLDGTIQELRETVVLPVRHRKLFS-RSKLWRapkGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDK 169
Cdd:cd19521   3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTgNRKPWS---GILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSK 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 170 WYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLmSNTNICVLVLGATNRPQDLDK 249
Cdd:cd19521  80 WMGESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGV-GNDSQGVLVLGATNIPWQLDS 158

                       170
                ....*....|..
gi 20129529 250 AILRRMPAQFHI 261
Cdd:cd19521 159 AIRRRFEKRIYI 170
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 96-259 3.53e-46

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 155.53  E-value: 3.53e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19503   1 DIGGLDEQIASLKELIELPLKYPELFRALGL-KPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGlMSNTNiCVLVLGATNRPQDLDKAiLRRm 255
Cdd:cd19503  80 KNLREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDG-MSSRG-KVVVIAATNRPDAIDPA-LRR- 155


                ....
gi 20129529 256 PAQF 259
Cdd:cd19503 156 PGRF 159
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 53-317 1.19e-45

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 163.61  E-value: 1.19e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    53 QLRKLNSSAIGAAKKfRARDFNEhemmiashlvtpEDIDISWSDIAGLDGTIQELRETVVL---PVRHRKLFSRSklwra 129
Cdd:TIGR01241  26 QMQGGGGRAFSFGKS-KAKLLNE------------EKPKVTFKDVAGIDEAKEELMEIVDFlknPSKFTKLGAKI----- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   130 PKGVLLHGPPGCGKTLIAKAIAKDA--------GMRFINLDVGVltdkwyGESQklATAVFTLAKKLQPCIIFIDEIESF 201
Cdd:TIGR01241  88 PKGVLLVGPPGTGKTLLAKAVAGEAgvpffsisGSDFVEMFVGV------GASR--VRDLFEQAKKNAPCIIFIDEIDAV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   202 LRMRG-----SNDH-EATAmikTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILRrmPAQF--HIGVPR-DCQ-RRE 271
Cdd:TIGR01241 160 GRQRGaglggGNDErEQTL---NQLLVEMDGFGTNTG--VIVIAATNRPDVLDPALLR--PGRFdrQVVVDLpDIKgREE 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 20129529   272 ILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQ 317
Cdd:TIGR01241 233 ILKVHAKNKKLAPDVDLKAVARRTPGFSGADLANLLNEAALLAARK 278
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 133-265 1.84e-45

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 152.75  E-value: 1.84e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEA 212
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 20129529   213 TAMIKTQFMLQWDGlMSNTNICVLVLGATNRPQDLDKAILRRMpaQFHIGVPR 265
Cdd:pfam00004  81 SRRVVNQLLTELDG-FTSSNSKVIVIAATNRPDKLDPALLGRF--DRIIEFPL 130
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 105-253 1.07e-44

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 151.67  E-value: 1.07e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 105 QELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTL 184
Cdd:cd19511   3 RELKEAVEWPLKHPDAFKRLGI-RPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 185 AKKLQPCIIFIDEIESFLRMRG-SNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR 253
Cdd:cd19511  82 ARQAAPCIIFFDEIDSLAPRRGqSDSSGVTDRVVSQLLTELDGIESLKG--VVVIAATNRPDMIDPALLR 149
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 103-261 6.84e-44

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 149.36  E-value: 6.84e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 103 TIQELRETVVLPVRHRKLFSRSKlwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVF 182
Cdd:cd19481   1 LKASLREAVEAPRRGSRLRRYGL--GLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 183 TLAKKLQPCIIFIDEIESFLRMRGSN-DHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILRRMPAQFHI 261
Cdd:cd19481  79 ERARRLAPCILFIDEIDAIGRKRDSSgESGELRRVLNQLLTELDGVNSRSK--VLVIAATNRPDLLDPALLRPGRFDEVI 156
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 82-273 7.27e-44

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 159.10  E-value: 7.27e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    82 SHLVTPEDIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMR---- 157
Cdd:TIGR03689 169 EDLVLEEVPDVTYADIGGLGSQIEQIRDAVELPFLHPELYREYGL-KPPKGVLLYGPPGCGKTLIAKAVANSLAARigae 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   158 ------FINLDVGVLTDKWYGESQKLATAVFTLAKKL----QPCIIFIDEIESFLRMRG---SNDHEATamIKTQFMLQW 224
Cdd:TIGR03689 248 gggksyFLNIKGPELLNKYVGETERQIRLIFQRAREKasegRPVIVFFDEMDSLFRTRGsgvSSDVETT--VVPQLLAEI 325

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 20129529   225 DGLMSNTNicVLVLGATNRPQDLDKAILR--RMPAQFHIGVPRDCQRREIL 273
Cdd:TIGR03689 326 DGVESLDN--VIVIGASNREDMIDPAILRpgRLDVKIRIERPDAEAAADIF 374
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 96-261 3.33e-41

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 142.82  E-value: 3.33e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFsrsKLWRAP-KGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGES 174
Cdd:cd19522   1 DIADLEEAKKLLEEAVVLPMWMPEFF---KGIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGES 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 175 QKLATAVFTLAKKLQPCIIFIDEIESFLRMRG-SNDHEATAMIKTQFMLQWDGL-----MSNTNICVLVLGATNRPQDLD 248
Cdd:cd19522  78 EKLVRLLFEMARFYAPTTIFIDEIDSICSRRGtSEEHEASRRVKSELLVQMDGVggaseNDDPSKMVMVLAATNFPWDID 157

                       170
                ....*....|...
gi 20129529 249 KAILRRMPAQFHI 261
Cdd:cd19522 158 EALRRRLEKRIYI 170
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
84-307 7.54e-41

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 151.73  E-value: 7.54e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  84 LVTPEDIDISWSDIAGLDGTIQELRETV-VL--PVRHRKLFSRsklwrAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFIN 160
Cdd:COG0465 131 LYDEDKPKVTFDDVAGVDEAKEELQEIVdFLkdPEKFTRLGAK-----IPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFS 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 161 LD--------VGVltdkwyGesqklATAV---FTLAKKLQPCIIFIDEIESFLRMRGS-----ND-HEAT------AMik 217
Cdd:COG0465 206 ISgsdfvemfVGV------G-----ASRVrdlFEQAKKNAPCIIFIDEIDAVGRQRGAglgggHDeREQTlnqllvEM-- 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 218 tqfmlqwDGLMSNTNicVLVLGATNRPQDLDKAILRrmPAQF--HIGVPR-DCQ-RREILQLILQTEQLSPSVNLKELAR 293
Cdd:COG0465 273 -------DGFEGNEG--VIVIAATNRPDVLDPALLR--PGRFdrQVVVDLpDVKgREAILKVHARKKPLAPDVDLEVIAR 341

                       250
                ....*....|....
gi 20129529 294 LTIGFSGSDLRELC 307
Cdd:COG0465 342 RTPGFSGADLANLV 355
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
82-347 2.82e-40

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 150.96  E-value: 2.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   82 SHLVTPEDIDISWSDIAGLDGTIQELRETVVL---PVRHRKLFSRsklwrAPKGVLLHGPPGCGKTLIAKAIAKDAGMRF 158
Cdd:PRK10733 139 ARMLTEDQIKTTFADVAGCDEAKEEVAELVEYlrePSRFQKLGGK-----IPKGVLMVGPPGTGKTLLAKAIAGEAKVPF 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  159 INLDVGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGS---NDHEATAMIKTQFMLQWDGLMSNTNIcv 235
Cdd:PRK10733 214 FTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAglgGGHDEREQTLNQMLVEMDGFEGNEGI-- 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  236 LVLGATNRPQDLDKAILR--RMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMY 313
Cdd:PRK10733 292 IVIAATNRPDVLDPALLRpgRFDRQVVVGLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAALF 371

                        250       260       270
                 ....*....|....*....|....*....|....
gi 20129529  314 RMRQFMREKLNTGEEIGKDKIEWDFEVKDQALQE 347
Cdd:PRK10733 372 AARGNKRVVSMVEFEKAKDKIMMGAERRSMVMTE 405
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
94-357 2.85e-40

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 142.72  E-value: 2.85e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  94 WSDIAGLDGTIQELREtVVLPVRHRKLFSRSKLWrAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGE 173
Cdd:COG1223   1 LDDVVGQEEAKKKLKL-IIKELRRRENLRKFGLW-PPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 174 SQKLATAVFTLAKKLqPCIIFIDEIESFLRMRG-SNDHEATAMIKTQFMLQWDGLMSNtnicVLVLGATNRPQDLDKAIL 252
Cdd:COG1223  79 TARNLRKLFDFARRA-PCVIFFDEFDAIAKDRGdQNDVGEVKRVVNALLQELDGLPSG----SVVIAATNHPELLDSALW 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 253 RRMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHAsmyrMRQFMREklntgeeiGKD 332
Cdd:COG1223 154 RRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAKKLEGLSGADIEKVLKTA----LKKAILE--------DRE 221

                       250       260
                ....*....|....*....|....*
gi 20129529 333 KIEWdfEVKDQALQEWEHLEIQMED 357
Cdd:COG1223 222 KVTK--EDLEEALKQRKERKKEPKK 244
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 93-259 4.60e-40

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 139.78  E-value: 4.60e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  93 SWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYG 172
Cdd:cd19502   1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGI-EPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 173 ESQKLATAVFTLAKKLQPCIIFIDEIESFLRMR------GSNDHEATAMiktQFMLQWDGLMSNTNIcvLVLGATNRPQD 246
Cdd:cd19502  80 EGARLVRELFEMAREKAPSIIFIDEIDAIGAKRfdsgtgGDREVQRTML---ELLNQLDGFDPRGNI--KVIMATNRPDI 154

                       170
                ....*....|...
gi 20129529 247 LDKAILRrmPAQF 259
Cdd:cd19502 155 LDPALLR--PGRF 165
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 105-253 7.74e-39

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 136.47  E-value: 7.74e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 105 QELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTL 184
Cdd:cd19529   3 QELKEAVEWPLLKPEVFKRLGI-RPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 185 AKKLQPCIIFIDEIESFLRMRGSN-DHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR 253
Cdd:cd19529  82 ARQVAPCVIFFDEIDSIAPRRGTTgDSGVTERVVNQLLTELDGLEEMNG--VVVIAATNRPDIIDPALLR 149
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 92-259 2.69e-38

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 135.44  E-value: 2.69e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  92 ISWSDIAGLDGTIQELRETV-VL--PVRHRKLFSRSklwraPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTD 168
Cdd:cd19501   1 VTFKDVAGCEEAKEELKEVVeFLknPEKFTKLGAKI-----PKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 169 KWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRG-----SNDH-EATAmikTQFMLQWDGLMSNTNicVLVLGATN 242
Cdd:cd19501  76 MFVGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGaglggGHDErEQTL---NQLLVEMDGFESNTG--VIVIAATN 150

                       170
                ....*....|....*..
gi 20129529 243 RPQDLDKAILRrmPAQF 259
Cdd:cd19501 151 RPDVLDPALLR--PGRF 165
ftsH CHL00176
cell division protein; Validated
 89-339 2.88e-38

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 145.19  E-value: 2.88e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   89 DIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKlwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLD------ 162
Cdd:CHL00176 177 DTGITFRDIAGIEEAKEEFEEVVSFLKKPERFTAVGA--KIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISgsefve 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  163 --VGVltdkwyGESQklATAVFTLAKKLQPCIIFIDEIESFLRMRGS-----ND-HEATAMiktQFMLQWDGLMSNTNic 234
Cdd:CHL00176 255 mfVGV------GAAR--VRDLFKKAKENSPCIVFIDEIDAVGRQRGAgigggNDeREQTLN---QLLTEMDGFKGNKG-- 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  235 VLVLGATNRPQDLDKAILR--RMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASM 312
Cdd:CHL00176 322 VIVIAATNRVDILDAALLRpgRFDRQITVSLPDREGRLDILKVHARNKKLSPDVSLELIARRTPGFSGADLANLLNEAAI 401

                        250       260
                 ....*....|....*....|....*..
gi 20129529  313 YRMRqfmREKlntgEEIGKDKIEWDFE 339
Cdd:CHL00176 402 LTAR---RKK----ATITMKEIDTAID 421
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 96-259 3.88e-38

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 134.87  E-value: 3.88e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19519   1 DIGGCRKQLAQIREMVELPLRHPELFKAIGI-KPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAiLRRm 255
Cdd:cd19519  80 SNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAH--VIVMAATNRPNSIDPA-LRR- 155


                ....
gi 20129529 256 PAQF 259
Cdd:cd19519 156 FGRF 159
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 88-317 5.28e-38

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 141.05  E-value: 5.28e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   88 EDIDISWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLT 167
Cdd:PTZ00454 138 EKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGI-DPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFV 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  168 DKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRgsNDHEATAMIKTQFML-----QWDGLMSNTNicVLVLGATN 242
Cdd:PTZ00454 217 QKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKR--FDAQTGADREVQRILlellnQMDGFDQTTN--VKVIMATN 292

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529  243 RPQDLDKAILR--RMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQ 317
Cdd:PTZ00454 293 RADTLDPALLRpgRLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVRK 369
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 105-253 1.45e-37

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 133.02  E-value: 1.45e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 105 QELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTL 184
Cdd:cd19528   3 RELQELVQYPVEHPDKFLKFGM-TPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDK 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20129529 185 AKKLQPCIIFIDEIESFLRMRGSN---DHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR 253
Cdd:cd19528  82 ARAAAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN--VFIIGATNRPDIIDPAILR 151
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 100-253 4.96e-37

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 131.84  E-value: 4.96e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 100 LDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLAT 179
Cdd:cd19530   1 LDHVREELTMSILRPIKRPDIYKALGI-DLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVR 79

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20129529 180 AVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR 253
Cdd:cd19530  80 QVFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLEERSN--VFVIAATNRPDIIDPAMLR 151
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 96-254 9.40e-37

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 131.37  E-value: 9.40e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19518   1 DIGGMDSTLKELCELLIHPILPPEYFQHLGV-EPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNIC--VLVLGATNRPQDLDKAiLR 253
Cdd:cd19518  80 EKIRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAGgpVLVIGATNRPDSLDPA-LR 158


                .
gi 20129529 254 R 254
Cdd:cd19518 159 R 159
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 107-253 1.31e-34

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 125.23  E-value: 1.31e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 107 LRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTLAK 186
Cdd:cd19526   5 LEETIEWPSKYPKIFASSPL-RLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQ 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529 187 KLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILR 253
Cdd:cd19526  84 SAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGVEGLDG--VYVLAATSRPDLIDPALLR 148
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 93-317 1.93e-32

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 126.42  E-value: 1.93e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   93 SWSDIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYG 172
Cdd:PTZ00361 181 SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGI-KPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLG 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  173 ESQKLATAVFTLAKKLQPCIIFIDEIESFlrmrGSNDHEATA-----MIKTQFML--QWDGLMSNTNicVLVLGATNRPQ 245
Cdd:PTZ00361 260 DGPKLVRELFRVAEENAPSIVFIDEIDAI----GTKRYDATSggekeIQRTMLELlnQLDGFDSRGD--VKVIMATNRIE 333

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20129529  246 DLDKAILR--RMPAQFHIGVPRDCQRREILQLILQTEQLSPSVNLKELARLTIGFSGSDLRELCRHASMYRMRQ 317
Cdd:PTZ00361 334 SLDPALIRpgRIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDVDLEEFIMAKDELSGADIKAICTEAGLLALRE 407
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 96-259 7.32e-31

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 115.68  E-value: 7.32e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSRSKLwRAPKGVLLHGPPGCGKTLIAKAIAKDAGMR------FINLDVGVLTdK 169
Cdd:cd19517   1 DIGGLSHYINQLKEMVFFPLLYPEVFAKFKI-TPPRGVLFHGPPGTGKTLMARALAAECSKGgqkvsfFMRKGADCLS-K 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 170 WYGESQKLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRPQDLDK 249
Cdd:cd19517  79 WVGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLDNRGQ--VVVIGATNRPDALDP 156

                       170
                ....*....|
gi 20129529 250 AiLRRmPAQF 259
Cdd:cd19517 157 A-LRR-PGRF 164
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 106-259 1.44e-30

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 114.53  E-value: 1.44e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 106 ELRETVVLPVRHRKLFSRSklWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTLA 185
Cdd:cd19527   4 EILDTIQLPLEHPELFSSG--LRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 20129529 186 KKLQPCIIFIDEIESFLRMRGSNDHEATAM--IKTQFMLQWDGlMSNTNICVLVLGATNRPQDLDKAILRrmPAQF 259
Cdd:cd19527  82 RDAKPCVIFFDELDSLAPSRGNSGDSGGVMdrVVSQLLAELDG-MSSSGQDVFVIGATNRPDLLDPALLR--PGRF 154
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 96-261 3.13e-30

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 113.83  E-value: 3.13e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  96 DIAGLDGTIQELRETVVLPVRHRKLFSrsKLWRAPKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQ 175
Cdd:cd19523   1 DIAGLGALKAAIKEEVLWPLLRPDAFS--GLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 176 KLATAVFTLAKKLQPCIIFIDEIESFLRMRGSnDHEATAMIKTQFMLQWDGLMSNTNICVLVLGATNRPQDLDKAILRRM 255
Cdd:cd19523  79 KILQASFLAARCRQPSVLFISDLDALLSSQDD-EASPVGRLQVELLAQLDGVLGSGEDGVLVVCTTSKPEEIDESLRRYF 157


                ....*.
gi 20129529 256 PAQFHI 261
Cdd:cd19523 158 SKRLLV 163
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 129-254 1.69e-22

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 92.82  E-value: 1.69e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 129 APKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIESFL-RMRGS 207
Cdd:cd19507  30 TPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFsNADSK 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 20129529 208 NDHEATAMIKTQFmLQWdglMSNTNICVLVLGATNRPQDLDKAILRR 254
Cdd:cd19507 110 GDSGTSSRVLGTF-LTW---LQEKKKPVFVVATANNVQSLPPELLRK 152
ycf46 CHL00195
Ycf46; Provisional
 129-348 1.70e-20

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 92.78  E-value: 1.70e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  129 APKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKLQPCIIFIDEIE-SFLRMRGS 207
Cdd:CHL00195 258 TPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDkAFSNSESK 337

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  208 NDHEATAMIKTQFmLQWdglMSNTNICVLVLGATNRPQDLDKAILR--RMPAQFHIGVPRDCQRREILQLILQteQLSP- 284
Cdd:CHL00195 338 GDSGTTNRVLATF-ITW---LSEKKSPVFVVATANNIDLLPLEILRkgRFDEIFFLDLPSLEEREKIFKIHLQ--KFRPk 411

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 20129529  285 ---SVNLKELARLTIGFSGSDLREL---CRHASMYRMRQFMREKLNTG-------EEIGKDKIEwdfevkdqALQEW 348
Cdd:CHL00195 412 swkKYDIKKLSKLSNKFSGAEIEQSiieAMYIAFYEKREFTTDDILLAlkqfiplAQTEKEQIE--------ALQNW 480
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 128-262 8.85e-20

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 84.89  E-value: 8.85e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 128 RAPKGVLLHGPPGCGKTLIAKAIAK---DAGMRFINLDVGVLTDKWYGESQKLATAV---FTLAKKLQPCIIFIDEIESF 201
Cdd:cd00009  17 PPPKNLLLYGPPGTGKTTLARAIANelfRPGAPFLYLNASDLLEGLVVAELFGHFLVrllFELAEKAKPGVLFIDEIDSL 96

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529 202 LRmrgsndhEATAMIKTQFMLQWDGLMSNTNicVLVLGATNRP--QDLDKAILRRMPAQFHIG 262
Cdd:cd00009  97 SR-------GAQNALLRVLETLNDLRIDREN--VRVIGATNRPllGDLDRALYDRLDIRIVIP 150
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 130-265 3.56e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 75.10  E-value: 3.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    130 PKGVLLHGPPGCGKTLIAKAIAK-----DAGMRFINLD------------VGVLTDKWYGESQKLATAVFTLAKKLQPCI 192
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARelgppGGGVIYIDGEdileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529    193 IFIDEIESFLrmrgsnDHEATAMIKTQFMLQWDGLMSNTNIcVLVLGATNRPQDLDKAILRRMpAQFHIGVPR 265
Cdd:smart00382  82 LILDEITSLL------DAEQEALLLLLEELRLLLLLKSEKN-LTVILTTNDEKDLGPALLRRR-FDRRIVLLL 146
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 131-263 3.73e-15

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 72.91  E-value: 3.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 131 KGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVG-VLTDKWYGESQKLATAVFTLAKKLQPC--------IIFIDEIESF 201
Cdd:cd19504  36 KGILLYGPPGTGKTLMARQIGKMLNAREPKIVNGpEILNKYVGESEANIRKLFADAEEEQRRlgansglhIIIFDEIDAI 115

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 20129529 202 LRMRGS--NDHEATAMIKTQFMLQWDGLMSNTNIcvLVLGATNRPQDLDKAILRrmPAQFHIGV 263
Cdd:cd19504 116 CKQRGSmaGSTGVHDTVVNQLLSKIDGVEQLNNI--LVIGMTNRKDLIDEALLR--PGRLEVQM 175
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 131-260 2.29e-11

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 61.39  E-value: 2.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 131 KGVLLHGPPGCGKTLIAKAIAKDAGMRFINL---DVGVLTDKWYGESQKlataVFTLAKKLQP-CIIFIDEIESFLRMRG 206
Cdd:cd19512  23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMtggDVAPMGREGVTAIHK----VFDWANTSRRgLLLFVDEADAFLRKRS 98

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 20129529 207 SND-HEATAMIKTQFMLQwDGLMSNTNICVLvlgATNRPQDLDKAILRRMPAQFH 260
Cdd:cd19512  99 TEKiSEDLRAALNAFLYR-TGEQSNKFMLVL---ASNQPEQFDWAINDRIDEMVE 149
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 133-261 2.69e-11

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 62.46  E-value: 2.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAGMR---------FINLDVGVLTDKWYGESQKLATAVFTLAKKL---QPCIIF--IDEI 198
Cdd:cd19508  55 VLLHGPPGTGKTSLCKALAQKLSIRlssryrygqLIEINSHSLFSKWFSESGKLVTKMFQKIQELiddKDALVFvlIDEV 134

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 20129529 199 ESFLRMR-----GSNDHEATAMIKTqFMLQWDGLMSNTNicVLVLGATNRPQDLDKAILRRMPAQFHI 261
Cdd:cd19508 135 ESLAAARsasssGTEPSDAIRVVNA-VLTQIDRIKRYHN--NVILLTSNLLEKIDVAFVDRADIKQYI 199
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 285-321 6.45e-09

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 51.39  E-value: 6.45e-09
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 20129529   285 SVNLKELARLTIGFSGSDLRELCRHASMYRMRQFMRE 321
Cdd:pfam17862   1 DVDLEELAERTEGFSGADLEALCREAALAALRRGLEA 37
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 133-198 9.38e-08

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 53.52  E-value: 9.38e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAGMRFINL---DVGVltdkwygesqKLATAVFTLAKKL----QPCIIFIDEI 198
Cdd:COG2256  52 MILWGPPGTGKTTLARLIANATDAEFVALsavTSGV----------KDIREVIEEARERraygRRTILFVDEI 114
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 131-248 9.40e-08

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 51.37  E-value: 9.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 131 KGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWYGES--QKLATAVFTLAKKLQPCIIFIDEIE-SFLRMRGS 207
Cdd:cd19506  27 KSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEkTFYKKVPK 106

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 20129529 208 NDHEATAMIKTQFMLQWDGLMSNTNiCVLVLGATNRPQDLD 248
Cdd:cd19506 107 TEKQLDPKRLKKDLPKILKSLKPED-RVLIVGTTSRPFEAD 146
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 133-198 2.32e-07

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 52.39  E-value: 2.32e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDvGVLTdkwygeSQKLATAVFTLAKKL----QPCIIFIDEI 198
Cdd:PRK13342  39 MILWGPPGTGKTTLARIIAGATDAPFEALS-AVTS------GVKDLREVIEEARQRrsagRRTILFIDEI 101
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 86-214 5.91e-07

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 49.30  E-value: 5.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  86 TPEDIdiswsdIAGLDGTI---QELRETVVLPVRHRklFSRSKL---WR---APKGVLLHGPPGCGKTLIAKAIAKDAGM 156
Cdd:cd19498   1 TPREI------VSELDKYIigqDEAKRAVAIALRNR--WRRMQLpeeLRdevTPKNILMIGPTGVGKTEIARRLAKLAGA 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 20129529 157 RFINLDVGVLTDKWYgesqkLATAVFTLAKKLQPCIIFIDEIESFLRMRGSNDHEATA 214
Cdd:cd19498  73 PFIKVEATKFTEVGY-----VGRDVESIIRDLVEGIVFIDEIDKIAKRGGSSGPDVSR 125
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 123-261 1.55e-06

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 47.35  E-value: 1.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 123 RSKLWRapKGVLLHGPPGCGKTLIAKAIAKDAGMRF--INLDVGVLTDkwygESQKLatavfTLAKKLQPCIIFIDEIES 200
Cdd:cd19510  18 RGIPYR--RGYLLYGPPGTGKSSFIAALAGELDYDIcdLNLSEVVLTD----DRLNH-----LLNTAPKQSIILLEDIDA 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 201 FLRMRgsnDHEATAMIKTQFM--LQWDGLMSNTNICV-----LVLGATNRPQDLDKAILR--RMPAQFHI 261
Cdd:cd19510  87 AFESR---EHNKKNPSAYGGLsrVTFSGLLNALDGVAsseerIVFMTTNHIERLDPALIRpgRVDMKIYM 153
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 130-252 3.46e-06

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 46.60  E-value: 3.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 130 PKGVLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKW--------------YGESQKLATAVFTLAKKLQPCIIFI 195
Cdd:cd19505  12 SKGILLIGSIETGRSYLIKSLAANSYVPLIRISLNKLLYNKpdfgnddwidgmliLKESLHRLNLQFELAKAMSPCIIWI 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529 196 DEI------ESFLRMRGSNDHEATAMIKtqfMLQWDGLMSNTNiCVLVLGATNRPQDLDKAIL 252
Cdd:cd19505  92 PNIhelnvnRSTQNLEEDPKLLLGLLLN---YLSRDFEKSSTR-NILVIASTHIPQKVDPALI 150
RecA-like_ClpX cd19497
ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent ...
 133-198 3.74e-05

ATP-dependent Clp protease ATP-binding subunit ClpX; ClpX is a component of the ATP-dependent protease ClpXP. In ClpXP, ClpX ATPase serves to specifically recognize, unfold, and translocate protein substrates into the chamber of ClpP protease for degradation. This RecA-like_ClpX domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410905 [Multi-domain]  Cd Length: 251  Bit Score: 44.90  E-value: 3.74e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWY-GES-----QKLATAVFTLAKKLQPCIIFIDEI 198
Cdd:cd19497  53 ILLIGPTGSGKTLLAQTLAKILDVPFAIADATTLTEAGYvGEDvenilLKLLQAADYDVERAQRGIVYIDEI 124
PRK04195 PRK04195
replication factor C large subunit; Provisional
 130-155 4.47e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 45.30  E-value: 4.47e-05
                         10        20
                 ....*....|....*....|....*.
gi 20129529  130 PKGVLLHGPPGCGKTLIAKAIAKDAG 155
Cdd:PRK04195  39 KKALLLYGPPGVGKTSLAHALANDYG 64
RecA-like_Lon cd19500
lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an ...
 134-168 5.90e-05

lon protease homolog 2 peroxisomal; Lon protease (also known as Lon peptidase) is an evolutionarily conserved ATP-dependent serine protease, present in bacteria and eukaryotic mitochondria and peroxisomes, which mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Lon protease is both an ATP-dependent peptidase and a protein-activated ATPase. This RecA-like Lon domain subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410908 [Multi-domain]  Cd Length: 182  Bit Score: 43.32  E-value: 5.90e-05
                        10        20        30
                ....*....|....*....|....*....|....*
gi 20129529 134 LLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTD 168
Cdd:cd19500  41 CLVGPPGVGKTSLGKSIARALGRKFVRISLGGVRD 75
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 132-255 1.03e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 41.89  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   132 GVLLHGPPGCGKTLIAKAIAK------------DAGMRFINL----DVGVLTDKWygESQKLATAVftlakkLQPCIIFI 195
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAAalsnrpvfyvqlTRDTTEEDLfgrrNIDPGGASW--VDGPLVRAA------REGEIAVL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 20129529   196 DEIesflrmrgsnDHEATAMIKTQFMLQWDG---LMSNTNIC------VLVLGATNRP----QDLDKAILRRM 255
Cdd:pfam07728  73 DEI----------NRANPDVLNSLLSLLDERrllLPDGGELVkaapdgFRLIATMNPLdrglNELSPALRSRF 135
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 130-199 1.42e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 42.18  E-value: 1.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   130 PKGV-LLHGPPGCGKTLIAKAIAKDAGM---RFINLDVGVLTDKW--------------YGESQKLATAVftlaKKLQPC 191
Cdd:pfam07724   2 PIGSfLFLGPTGVGKTELAKALAELLFGderALIRIDMSEYMEEHsvsrligappgyvgYEEGGQLTEAV----RRKPYS 77


                  ....*...
gi 20129529   192 IIFIDEIE 199
Cdd:pfam07724  78 IVLIDEIE 85
COG1373 COG1373
Predicted ATPase, AAA+ superfamily [General function prediction only];
112-203 2.17e-04

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440984 [Multi-domain]  Cd Length: 405  Bit Score: 43.01  E-value: 2.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 112 VLPVRHRKLFSR-SKLWRAPKGVLLHGPPGCGKTLIAKAIAKD-AGMRFINLDVGVLTDKWYGESQKLATAVFTLAKKlq 189
Cdd:COG1373   1 VMIMIKRKILDKlLKLLDNRKAVVITGPRQVGKTTLLKQLAKElENILYINLDDPRLRALAEEDPDDLLEALKELYPG-- 78

                        90       100
                ....*....|....*....|
gi 20129529 190 PCIIFIDEI------ESFLR 203
Cdd:COG1373  79 KTYLFLDEIqrvpewEDALK 98
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 133-159 2.23e-04

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 42.46  E-value: 2.23e-04
                        10        20
                ....*....|....*....|....*..
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAGMRFI 159
Cdd:COG0714  34 LLLEGVPGVGKTTLAKALARALGLPFI 60
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
127-153 3.43e-04

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 41.88  E-value: 3.43e-04
                        10        20
                ....*....|....*....|....*..
gi 20129529 127 WRAPKGVLLHGPPGCGKTLIAKAIAKD 153
Cdd:COG0470  15 GRLPHALLLHGPPGIGKTTLALALARD 41
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 133-203 3.70e-04

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.79  E-value: 3.70e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAgmrfINLDVGVLtdkWYGESQKLATAVFTLAKKLQPCIIFIDEIESFLR 203
Cdd:cd01120   1 ILITGPPGSGKTTLLLQFAEQA----LLSDEPVI---FISFLDTILEAIEDLIEEKKLDIIIIDSLSSLAR 64
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
129-155 4.56e-04

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 42.26  E-value: 4.56e-04
                        10        20
                ....*....|....*....|....*..
gi 20129529 129 APKGVLLHGPPGCGKTLIAKAIAKDAG 155
Cdd:COG1224  63 AGKGILIVGPPGTGKTALAVAIARELG 89
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 133-196 4.58e-04

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 39.12  E-value: 4.58e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529   133 VLLHGPPGCGKTLIAKAIAKDAgMRFINLDV------GVLTDKWYGESQklatavftlakklQPCIIFID 196
Cdd:pfam00910   1 IWLYGPPGCGKSTLAKYLARAL-LKKLGLPKdsvysrNPDDDFWDGYTG-------------QPVVIIDD 56
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 116-199 7.33e-04

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 40.24  E-value: 7.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 116 RHRKLFSRSklwRAPKGVLL-HGPPGCGKTLIAKAIAK---DAGMRFINLDVGVLTDKWYGESQKLA-------TAVFTL 184
Cdd:cd19499  29 RARAGLSDP---NRPIGSFLfLGPTGVGKTELAKALAEllfGDEDNLIRIDMSEYMEKHSVSRLIGAppgyvgyTEGGQL 105

                        90
                ....*....|....*...
gi 20129529 185 AKKLQ---PCIIFIDEIE 199
Cdd:cd19499 106 TEAVRrkpYSVVLLDEIE 123
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 137-162 1.01e-03

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 39.34  E-value: 1.01e-03
                        10        20
                ....*....|....*....|....*.
gi 20129529 137 GPPGCGKTLIAKAIAKDAGMRFINLD 162
Cdd:COG0703   5 GMMGAGKSTVGRLLAKRLGLPFVDTD 30
clpX PRK05342
ATP-dependent Clp protease ATP-binding subunit ClpX;
133-198 1.19e-03

ATP-dependent Clp protease ATP-binding subunit ClpX;


Pssm-ID: 235422 [Multi-domain]  Cd Length: 412  Bit Score: 40.53  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529  133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDVGVLTDKWY-GES-----QKLatavftlakkLQPC----------IIFID 196
Cdd:PRK05342 111 ILLIGPTGSGKTLLAQTLARILDVPFAIADATTLTEAGYvGEDvenilLKL----------LQAAdydvekaqrgIVYID 180


                 ..
gi 20129529  197 EI 198
Cdd:PRK05342 181 EI 182
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 137-162 1.30e-03

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 39.08  E-value: 1.30e-03
                        10        20
                ....*....|....*....|....*.
gi 20129529 137 GPPGCGKTLIAKAIAKDAGMRFINLD 162
Cdd:cd00464   6 GMMGAGKTTVGRLLAKALGLPFVDLD 31
ClpX COG1219
ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein ...
 133-198 1.82e-03

ATP-dependent protease Clp, ATPase subunit ClpX [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440832 [Multi-domain]  Cd Length: 409  Bit Score: 40.03  E-value: 1.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKdagMrfinLDV-------GVLTDKWY-GES-----QKLatavftlakkLQPC-------- 191
Cdd:COG1219 112 ILLIGPTGSGKTLLAQTLAR---I----LDVpfaiadaTTLTEAGYvGEDvenilLKL----------LQAAdydvekae 174


                ....*....
gi 20129529 192 --IIFIDEI 198
Cdd:COG1219 175 rgIIYIDEI 183
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 133-198 2.14e-03

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 38.25  E-value: 2.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 20129529   133 VLLHGPPGCGKTLIAKAIAKDAGmrfINLDV--GVLTDKwygeSQKLAtAVFTlakKLQPC-IIFIDEI 198
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMG---VNIRItsGPAIER----PGDLA-AILT---NLEPGdVLFIDEI 93
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 125-152 2.62e-03

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 39.75  E-value: 2.62e-03
                        10        20
                ....*....|....*....|....*...
gi 20129529 125 KLWRAPKGVLLHGPPGCGKTLIAKAIAK 152
Cdd:COG1401 216 AALKTKKNVILAGPPGTGKTYLARRLAE 243
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 133-163 2.92e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 38.00  E-value: 2.92e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDV 163
Cdd:cd02021   2 IVVMGVSGSGKSTVGKALAERLGAPFIDGDD 32
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 129-155 3.76e-03

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 38.83  E-value: 3.76e-03
                          10        20
                  ....*....|....*....|....*..
gi 20129529   129 APKGVLLHGPPGCGKTLIAKAIAKDAG 155
Cdd:pfam06068  49 AGRAVLIAGPPGTGKTALAIAISKELG 75
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 47-152 5.61e-03

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 38.06  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 20129529    47 KYVAEEQLRKLNSSAIGAAKKFRARDFNEHEM---MIASHLVTPEDIDISWSD-------IAGLDGTIQELRETVVLPVR 116
Cdd:pfam01057  27 IAIDPDSYLRLSASPAGRRQIKNALQMAIIIMfstKTALDYLAKPEVTANFDIeenriykLLSLNGYNPAEVGSVLLAWL 106

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 20129529   117 HRKLFSRSKLWrapkgvlLHGPPGCGKTLIAKAIAK 152
Cdd:pfam01057 107 SKQFGKRNTVW-------FYGPASTGKTNLAQAIAH 135
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 137-160 5.94e-03

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 37.08  E-value: 5.94e-03
                        10        20
                ....*....|....*....|....
gi 20129529 137 GPPGCGKTLIAKAIAKDAGMRFIN 160
Cdd:cd02020   6 GPAGSGKSTVAKLLAKKLGLPYLD 29
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
131-154 8.49e-03

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 37.45  E-value: 8.49e-03
                        10        20
                ....*....|....*....|....
gi 20129529 131 KGVLLHGPPGCGKTLIAKAIAKDA 154
Cdd:COG1484 100 ENLILLGPPGTGKTHLAIALGHEA 123
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
133-163 9.52e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 36.43  E-value: 9.52e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 20129529 133 VLLHGPPGCGKTLIAKAIAKDAGMRFINLDV 163
Cdd:COG0645   2 ILVCGLPGSGKSTLARALAERLGAVRLRSDV 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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