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Conserved domains on  [gi|24586280|ref|NP_610290|]
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uncharacterized protein Dmel_CG1603, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 202-287 3.05e-15

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


:

Pssm-ID: 463144  Cd Length: 84  Bit Score: 71.16  E-value: 3.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280   202 LIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANvlftVEELKKTLEQLHVQYTLALETKQ--RGKLVGLAAR 279
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVP----VEDCKKRWKNLRDQYRRELRRKRtnSGELYKSRWY 76


                  ....*...
gi 24586280   280 YFAKCEFL 287
Cdd:pfam10545  77 YYEELSFL 84
MADF_DNA_bdg super family cl48096
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 321-408 5.16e-06

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


The actual alignment was detected with superfamily member pfam10545:

Pssm-ID: 463144  Cd Length: 84  Bit Score: 44.97  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280   321 FIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQPVVkaNETDVYIAVNKLRRWLYDAIRRLKSKELIQKCSKqeVQ 400
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDV--PVEDCKKRWKNLRDQYRRELRRKRTNSGELYKSR--WY 76


                  ....*...
gi 24586280   401 YLQMCSFL 408
Cdd:pfam10545  77 YYEELSFL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
424-583 4.07e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280 424 DKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDR------HVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLI 497
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRsspltrHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILL 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280 498 HTGERPHVC--DICGKTFRLKLLLDHHVNGVH----LNIRPYSC--NMCTKTFRKKFELANHIKGHLN--IRDKKCEYCD 567
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSfrPYNCKNPPCS 425

                       170
                ....*....|....*.
gi 24586280 568 ATFYDHSSLSRHRRSH 583
Cdd:COG5048 426 KSFNRHYNLIPHKKIH 441
 
Name Accession Description Interval E-value
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 202-287 3.05e-15

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 71.16  E-value: 3.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280   202 LIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANvlftVEELKKTLEQLHVQYTLALETKQ--RGKLVGLAAR 279
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVP----VEDCKKRWKNLRDQYRRELRRKRtnSGELYKSRWY 76


                  ....*...
gi 24586280   280 YFAKCEFL 287
Cdd:pfam10545  77 YYEELSFL 84
MADF smart00595
subfamily of SANT domain;
201-287 2.22e-13

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 65.84  E-value: 2.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280    201 HLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDrkanvlFTVEELKKTLEQLHVQYTLALETKQRGKLVGLAAR- 279
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELG------LSVEECKKRWKNLRDRYRRELKRLQNGKSGGGKKSk 74

                           90
                   ....*....|
gi 24586280    280 --YFAKCEFL 287
Cdd:smart00595  75 weYFDRLSFL 84
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 321-408 5.16e-06

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 44.97  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280   321 FIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQPVVkaNETDVYIAVNKLRRWLYDAIRRLKSKELIQKCSKqeVQ 400
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDV--PVEDCKKRWKNLRDQYRRELRRKRTNSGELYKSR--WY 76


                  ....*...
gi 24586280   401 YLQMCSFL 408
Cdd:pfam10545  77 YYEELSFL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
424-583 4.07e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280 424 DKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDR------HVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLI 497
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRsspltrHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILL 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280 498 HTGERPHVC--DICGKTFRLKLLLDHHVNGVH----LNIRPYSC--NMCTKTFRKKFELANHIKGHLN--IRDKKCEYCD 567
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSfrPYNCKNPPCS 425

                       170
                ....*....|....*.
gi 24586280 568 ATFYDHSSLSRHRRSH 583
Cdd:COG5048 426 KSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-513 5.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.36e-04
                          10        20
                  ....*....|....*....|....
gi 24586280   490 DLKVHTLIHTGERPHVCDICGKTF 513
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 202-287 3.05e-15

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 71.16  E-value: 3.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280   202 LIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDRKANvlftVEELKKTLEQLHVQYTLALETKQ--RGKLVGLAAR 279
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDVP----VEDCKKRWKNLRDQYRRELRRKRtnSGELYKSRWY 76


                  ....*...
gi 24586280   280 YFAKCEFL 287
Cdd:pfam10545  77 YYEELSFL 84
MADF smart00595
subfamily of SANT domain;
201-287 2.22e-13

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 65.84  E-value: 2.22e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280    201 HLIQAYKEHPCLWNPSDEHYQDEPARSMAYEAIMERMDrkanvlFTVEELKKTLEQLHVQYTLALETKQRGKLVGLAAR- 279
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELG------LSVEECKKRWKNLRDRYRRELKRLQNGKSGGGKKSk 74

                           90
                   ....*....|
gi 24586280    280 --YFAKCEFL 287
Cdd:smart00595  75 weYFDRLSFL 84
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 321-408 5.16e-06

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 44.97  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280   321 FIETYANYPVLYNQALPDFGSIEIRADAFKRMAKEFQPVVkaNETDVYIAVNKLRRWLYDAIRRLKSKELIQKCSKqeVQ 400
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSDV--PVEDCKKRWKNLRDQYRRELRRKRTNSGELYKSR--WY 76


                  ....*...
gi 24586280   401 YLQMCSFL 408
Cdd:pfam10545  77 YYEELSFL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
424-583 4.07e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 4.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280 424 DKRFHGDYNLRVHIVKAHEVGDLPYLCSFCPRRFDR------HVDMDRHKLRSHFERKLKCQYCEKSFAVDTDLKVHTLI 497
Cdd:COG5048 266 PTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRsspltrHLRSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILL 345

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24586280 498 HTGERPHVC--DICGKTFRLKLLLDHHVNGVH----LNIRPYSC--NMCTKTFRKKFELANHIKGHLN--IRDKKCEYCD 567
Cdd:COG5048 346 HTSISPAKEklLNSSSKFSPLLNNEPPQSLQQykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSfrPYNCKNPPCS 425

                       170
                ....*....|....*.
gi 24586280 568 ATFYDHSSLSRHRRSH 583
Cdd:COG5048 426 KSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
490-513 5.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.36e-04
                          10        20
                  ....*....|....*....|....
gi 24586280   490 DLKVHTLIHTGERPHVCDICGKTF 513
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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