NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|78707550|ref|NP_610456|]
View 

phosphorylated adaptor for RNA export, isoform A [Drosophila melanogaster]

Protein Classification

phosphorylated adapter RNA export RNA-binding domain-containing protein( domain architecture ID 10563102)

phosphorylated adapter RNA export (PHAX) RNA-binding domain-containing protein similar to PHAX protein, a phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PHAX_RNA-bd pfam10258
Phosphorylated adapter RNA export protein, RNA-binding domain; The phosphorylated adaptor for ...
 243-326 1.54e-39

Phosphorylated adapter RNA export protein, RNA-binding domain; The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterized by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains.


:

Pssm-ID: 463030  Cd Length: 84  Bit Score: 136.87  E-value: 1.54e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78707550   243 VATEMASKLYEEKDELLVRVVEVLGIDVCLELYKETQRIEADGGMMIKNGIRRRTPGGVFLFLIKHHDNITQEQQKRIFS 322
Cdd:pfam10258   1 LAKEIARRLKEPKKDLIERVVEVLGVEKALELFEETLAIEKNGGMMTADGSRRRTPGGVFLNLLKNDDSISKEEYKEIFK 80


                  ....
gi 78707550   323 EDRQ 326
Cdd:pfam10258  81 EEKE 84
 
Name Accession Description Interval E-value
PHAX_RNA-bd pfam10258
Phosphorylated adapter RNA export protein, RNA-binding domain; The phosphorylated adaptor for ...
 243-326 1.54e-39

Phosphorylated adapter RNA export protein, RNA-binding domain; The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterized by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains.


Pssm-ID: 463030  Cd Length: 84  Bit Score: 136.87  E-value: 1.54e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78707550   243 VATEMASKLYEEKDELLVRVVEVLGIDVCLELYKETQRIEADGGMMIKNGIRRRTPGGVFLFLIKHHDNITQEQQKRIFS 322
Cdd:pfam10258   1 LAKEIARRLKEPKKDLIERVVEVLGVEKALELFEETLAIEKNGGMMTADGSRRRTPGGVFLNLLKNDDSISKEEYKEIFK 80


                  ....
gi 78707550   323 EDRQ 326
Cdd:pfam10258  81 EEKE 84
 
Name Accession Description Interval E-value
PHAX_RNA-bd pfam10258
Phosphorylated adapter RNA export protein, RNA-binding domain; The phosphorylated adaptor for ...
 243-326 1.54e-39

Phosphorylated adapter RNA export protein, RNA-binding domain; The phosphorylated adaptor for RNA export (PHAX) protein transports U3 snoRNA from the nucleus after transcription. This entry represents the highly conserved U3 snoRNA-binding domain of PHAX, which is characterized by having two pairs of adjacent glycines with the sequence motif GGx12GG. This domain adopts a novel helical fold and binds non-specific single-stranded RNA and comprises five alpha-helices linked by short loops containing 1 to 4 residues, apart from helices alpha3 and 4 that are linked by 13 residues. The fold is unique to this kind of RNA binding domains which show no structural homology with other RNA-binding domains.


Pssm-ID: 463030  Cd Length: 84  Bit Score: 136.87  E-value: 1.54e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78707550   243 VATEMASKLYEEKDELLVRVVEVLGIDVCLELYKETQRIEADGGMMIKNGIRRRTPGGVFLFLIKHHDNITQEQQKRIFS 322
Cdd:pfam10258   1 LAKEIARRLKEPKKDLIERVVEVLGVEKALELFEETLAIEKNGGMMTADGSRRRTPGGVFLNLLKNDDSISKEEYKEIFK 80


                  ....
gi 78707550   323 EDRQ 326
Cdd:pfam10258  81 EEKE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH