NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19922820|ref|NP_611802|]
View 

uncharacterized protein Dmel_CG3906 [Drosophila melanogaster]

Protein Classification

Ins_allergen_rp domain-containing protein( domain architecture ID 10535966)

Ins_allergen_rp domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
 58-231 2.60e-50

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


:

Pssm-ID: 462003  Cd Length: 173  Bit Score: 161.97  E-value: 2.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922820    58 LCANFQHIRAMINQEALLNLIEVHYNCDLKFRRAMRYYNTAGFERTTQQLTDTDAYKTVLKELQSESVDTADIETVADIF 137
Cdd:pfam06757   2 LREDLQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922820   138 ---HCIILPVRQPdrnCDCKAVkhHTFVGDLLSIMPKQEVHNYVAQSQANHTNFGNFTKAVVSKQFQATLKANINKRDVV 214
Cdd:pfam06757  82 lglSGLVPPSSTL---LRTGGL--RGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERLRASPEVQ 156

                         170
                  ....*....|....*..
gi 19922820   215 KPLRTLRKNGWDIPELL 231
Cdd:pfam06757 157 RLLNKLRAHGVDVDELL 173
 
Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
 58-231 2.60e-50

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 161.97  E-value: 2.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922820    58 LCANFQHIRAMINQEALLNLIEVHYNCDLKFRRAMRYYNTAGFERTTQQLTDTDAYKTVLKELQSESVDTADIETVADIF 137
Cdd:pfam06757   2 LREDLQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922820   138 ---HCIILPVRQPdrnCDCKAVkhHTFVGDLLSIMPKQEVHNYVAQSQANHTNFGNFTKAVVSKQFQATLKANINKRDVV 214
Cdd:pfam06757  82 lglSGLVPPSSTL---LRTGGL--RGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERLRASPEVQ 156

                         170
                  ....*....|....*..
gi 19922820   215 KPLRTLRKNGWDIPELL 231
Cdd:pfam06757 157 RLLNKLRAHGVDVDELL 173
 
Name Accession Description Interval E-value
Ins_allergen_rp pfam06757
Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a ...
 58-231 2.60e-50

Insect allergen related repeat, nitrile-specifier detoxification; This family exemplifies a case of novel gene evolution. The case in point is the arms-race between plants and their infective insective herbivores in the area of the glucosinolate-myrosinase system. Brassicas have developed the glucosinolate-myrosinase system as chemical defence mechanism against the insects, and consequently the insects have adapted to produce a detoxifying molecule, nitrile-specifier protein (NSP). NSP is present in the small white butterfly Pieris rapae. NSP is structurally different from and has no amino acid homology to any known detoxifying enzymes, and it appears to have arisen by a process of domain and gene duplication of a sequence of unknown function that is widespread in insect species and referred to as insect-allergen-repeat protein. Thus this family is found either as a single domain or as a multiple repeat-domain.


Pssm-ID: 462003  Cd Length: 173  Bit Score: 161.97  E-value: 2.60e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922820    58 LCANFQHIRAMINQEALLNLIEVHYNCDLKFRRAMRYYNTAGFERTTQQLTDTDAYKTVLKELQSESVDTADIETVADIF 137
Cdd:pfam06757   2 LREDLQDFLALIPLEKIQDIVARYLLNDAEFQAAVRYLNSDEFKRLWQQLEALPEVRELLQYLEQAGLDIYDYINVLNDF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19922820   138 ---HCIILPVRQPdrnCDCKAVkhHTFVGDLLSIMPKQEVHNYVAQSQANHTNFGNFTKAVVSKQFQATLKANINKRDVV 214
Cdd:pfam06757  82 lglSGLVPPSSTL---LRTGGL--RGFLQDLLAALPRDAIRALYEEKLKTSSEFAEFVRRLRSPEFQQLLERLRASPEVQ 156

                         170
                  ....*....|....*..
gi 19922820   215 KPLRTLRKNGWDIPELL 231
Cdd:pfam06757 157 RLLNKLRAHGVDVDELL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH