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Conserved domains on  [gi|161077479|ref|NP_611966|]
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eggless [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 900-1262 1.38e-160

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


:

Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 480.63  E-value: 1.38e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  900 DISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPI 979
Cdd:cd10517     8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAATPGGQIN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  980 EEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETM 1059
Cdd:cd10517    88 PSAGYQYRRLMEKLPTGVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEDE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1060 ANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVdhsdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstq 1139
Cdd:cd10517   168 ANEEGLQYGDEYFAELDYIEVVEKLKEGYESDV----------------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1140 sseldsqeravinfnpnadldetvrensvrrlfgkDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVA 1219
Cdd:cd10517   201 -----------------------------------EEHCYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVA 245

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 161077479 1220 FFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL 1262
Cdd:cd10517   246 FFASRYIRAGTELTWDYNYEVGSVPGKVLYCYCGSSNCRGRLL 288
Tudor_SETDB1_rpt1 cd20382
first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, ...
 532-622 1.57e-40

first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, also called ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E), acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It contains two Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410453  Cd Length: 82  Bit Score: 143.96  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  532 IGTRVIAYFDGTTlsrgkdkgvVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASR 611
Cdd:cd20382     1 VGSRVVAQYKDEG---------NQVWLYAGIVAEPPKVKNRYRYLIFFDDGYAQYVTPSDVYLVCQQSKKVWEDIHEDSR 71

                          90
                  ....*....|.
gi 161077479  612 DFIQKYVEKYS 622
Cdd:cd20382    72 DFIREYLEAYP 82
Tudor_SETDB1_rpt2 cd21181
second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, ...
 630-684 3.76e-25

second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, also called ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E), acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It contains two Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410548  Cd Length: 54  Bit Score: 99.32  E-value: 3.76e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 161077479  630 CTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDkNHTEWIYRGSLRLGPVFRE 684
Cdd:cd21181     1 LKVGQLIKTEWNGKWWKARVEEVDGSLVKMLFLDD-KRTEWIYRGSTRLEPLFRE 54
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 823-879 1.13e-23

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


:

Pssm-ID: 238689  Cd Length: 60  Bit Score: 95.14  E-value: 1.13e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  823 PLAKPLLSGWERLVMRQKT---KKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDF 879
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVgkvKKHVIYKAPCGRSLRNMSEVHRYLRETCSFLTVDNFSF 60
 
Name Accession Description Interval E-value
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 900-1262 1.38e-160

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 480.63  E-value: 1.38e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  900 DISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPI 979
Cdd:cd10517     8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAATPGGQIN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  980 EEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETM 1059
Cdd:cd10517    88 PSAGYQYRRLMEKLPTGVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEDE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1060 ANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVdhsdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstq 1139
Cdd:cd10517   168 ANEEGLQYGDEYFAELDYIEVVEKLKEGYESDV----------------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1140 sseldsqeravinfnpnadldetvrensvrrlfgkDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVA 1219
Cdd:cd10517   201 -----------------------------------EEHCYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVA 245

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 161077479 1220 FFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL 1262
Cdd:cd10517   246 FFASRYIRAGTELTWDYNYEVGSVPGKVLYCYCGSSNCRGRLL 288
Tudor_SETDB1_rpt1 cd20382
first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, ...
 532-622 1.57e-40

first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, also called ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E), acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It contains two Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410453  Cd Length: 82  Bit Score: 143.96  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  532 IGTRVIAYFDGTTlsrgkdkgvVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASR 611
Cdd:cd20382     1 VGSRVVAQYKDEG---------NQVWLYAGIVAEPPKVKNRYRYLIFFDDGYAQYVTPSDVYLVCQQSKKVWEDIHEDSR 71

                          90
                  ....*....|.
gi 161077479  612 DFIQKYVEKYS 622
Cdd:cd20382    72 DFIREYLEAYP 82
Tudor_SETDB1_rpt2 cd21181
second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, ...
 630-684 3.76e-25

second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, also called ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E), acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It contains two Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410548  Cd Length: 54  Bit Score: 99.32  E-value: 3.76e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 161077479  630 CTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDkNHTEWIYRGSLRLGPVFRE 684
Cdd:cd21181     1 LKVGQLIKTEWNGKWWKARVEEVDGSLVKMLFLDD-KRTEWIYRGSTRLEPLFRE 54
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 823-879 1.13e-23

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 95.14  E-value: 1.13e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  823 PLAKPLLSGWERLVMRQKT---KKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDF 879
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVgkvKKHVIYKAPCGRSLRNMSEVHRYLRETCSFLTVDNFSF 60
Tudor_5 pfam18359
Histone methyltransferase Tudor domain 1; This is the first TUDOR domain found in SETDB1 ...
 530-591 3.61e-22

Histone methyltransferase Tudor domain 1; This is the first TUDOR domain found in SETDB1 enzymes (EC:2.1.1.43) in homosapiens, also known as Eggless in Drosophila. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4. SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase (HMT) that methylates lysine 9 on histone H3 (H3K9). The enzymatic activity of SETDB1, in association with MBD1-containing chromatin-associated factor 1 (MCAF1), converts H3K9me2 to H3K9me3 and represses subsequent transcription. SETDB1 is amplified in cancers such as melanoma and lung cancer, and increased expression of SETDB1 promotes tumorigenesis in a zebrafish melanoma model. In addition, SETDB1 is required for endogenous retrovirus silencing during early embryogenesis, inhibition of adipocyte differentiation, and differentiation of mesenchymal cells into osteoblasts. The tandem Tudor domains in the N-terminal region are involved in protein-protein interactions. The second tudor domain is pfam18385.


Pssm-ID: 465723  Cd Length: 53  Bit Score: 90.73  E-value: 3.61e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161077479   530 LTIGTRVIAYFDgttlsrgkdKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRD 591
Cdd:pfam18359    1 LPVGTRVIAKYK---------DSNGKSAYYAGVIAEPPKDLNRYRYLVFFDDGYAQYVVHKD 53
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 901-1013 1.15e-18

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 82.08  E-value: 1.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479   901 ISKGQEKMAIPLVNYYDNTLPPPC-TYAKQRIPTEGVHLNLD-----EEFLlccdceddcsdKSKCACWQLTVAGVRYcn 974
Cdd:pfam05033    1 ISKGKENVPIPVVNEVDDEPPPPDfTYITSYIYPKEFLLIIPqgcdcGDCS-----------SEKCSCAQLNGGEFRF-- 67

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 161077479   975 pkkpieeiGYQYKRLH-EHVPTGIYECNSRCKCKKNCLNR 1013
Cdd:pfam05033   68 --------PYDKDGLLvPESKPPIYECNPLCGCPPSCPNR 99
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1022-1239 6.91e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 80.84  E-value: 6.91e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479   1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEggqdagdeyfadldyievaeqlkegyesevdhsdpdaee 1101
Cdd:smart00317    2 KLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEE--------------------------------------- 42

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479   1102 dnggpDAEDDDDFRPNYHYqrkikrssrsgstqnsstqsseldsqeravinfnpnadldetvrensvrrLFGKDEAPYIm 1181
Cdd:smart00317   43 -----RPKAYDTDGAKAFY--------------------------------------------------LFDIDSDLCI- 66

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 161077479   1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDlrfpWVAFFSAAHIRSGTELTWNYNYE 1239
Cdd:smart00317   67 DARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSD 120
Tudor_4 pfam18358
Histone methyltransferase Tudor domain; This is a Tudor domain found in histone-lysine ...
 632-680 1.02e-17

Histone methyltransferase Tudor domain; This is a Tudor domain found in histone-lysine N-methyltransferase SETDB1 proteins (EC:2.1.1.43), also known as Eggless in Drosophila. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4.


Pssm-ID: 408159  Cd Length: 50  Bit Score: 77.78  E-value: 1.02e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 161077479   632 RGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNhTEWIYRGSLRLGP 680
Cdd:pfam18358    3 KGQTVKTEWNGKWWTARVLEVDASLVKVYFLSDKR-TEWIYRGSTRLEP 50
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 822-885 5.62e-11

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 59.69  E-value: 5.62e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479    822 SPLAKPLLSGWERLVMRQKT-----KKSVVYKGPCGKSLRSLAEVHRYLRAT-ENVLNVDNFDFTPDLKC 885
Cdd:smart00391    2 DPLRLPLPCGWRRETKQRKSgrsagKFDVYYISPCGKKLRSKSELARYLHKNgDLSLDLECFDFNATVPV 71
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 822-886 2.23e-09

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 55.06  E-value: 2.23e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161077479   822 SPLAKPLLSGWERLVMRQKT-----KKSVVYKGPCGKSLRSLAEVHRYLRAT-ENVLNVDNFDFTPDLKCL 886
Cdd:pfam01429    5 REDRLPLPPGWRREERQRKSgskagKVDVFYYSPTGKKLRSKSEVARYLEANgGTSPKLEDFSFTVRSEVG 75
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1171-1258 4.34e-09

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 56.12  E-value: 4.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1171 LFGKDEAPYImDAKTTGNLGRYFNHSCSPnlfvqNVFVDTHDLRFpwvaFFSAAH-IRSGTELTWNYNYEVGvvpGKVLY 1249
Cdd:COG2940    59 LFELDDDGVI-DGALGGNPARFINHSCDP-----NCEADEEDGRI----FIVALRdIAAGEELTYDYGLDYD---EEEYP 125


                  ....*....
gi 161077479 1250 CQCgaPNCR 1258
Cdd:COG2940   126 CRC--PNCR 132
 
Name Accession Description Interval E-value
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 900-1262 1.38e-160

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 480.63  E-value: 1.38e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  900 DISKGQEKMAIPLVNYYDNTLPPPCTYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTVAGVRYCNPKKPI 979
Cdd:cd10517     8 DISYGKEGVPIPCVNEIDNSSPPYVEYSKERIPGKGVNINLDPDFLVGCDCTDGCRDKSKCACQQLTIEATAATPGGQIN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  980 EEIGYQYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETM 1059
Cdd:cd10517    88 PSAGYQYRRLMEKLPTGVYECNSRCKCDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEDE 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1060 ANEGGQDAGDEYFADLDYIEVAEQLKEGYESEVdhsdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstq 1139
Cdd:cd10517   168 ANEEGLQYGDEYFAELDYIEVVEKLKEGYESDV----------------------------------------------- 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1140 sseldsqeravinfnpnadldetvrensvrrlfgkDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVA 1219
Cdd:cd10517   201 -----------------------------------EEHCYIIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVA 245

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 161077479 1220 FFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRLL 1262
Cdd:cd10517   246 FFASRYIRAGTELTWDYNYEVGSVPGKVLYCYCGSSNCRGRLL 288
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 957-1261 1.15e-84

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 275.58  E-value: 1.15e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  957 KSKCACWQLTVAGVRyCNPKKPIE-EIGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEMKLQVFKTSNRGWG 1034
Cdd:cd10541    27 KSKCACHQLTIQATA-CTPGGQDNpTAGYQYKRLEECLPTGVYECNKLCKCDPNmCQNRLVQHGLQVRLQLFKTQNKGWG 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1035 LRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEYFADLDYIEvaeqlkegyesevdhsdpdaeednggpdaeddddf 1114
Cdd:cd10541   106 IRCLDDIAKGTFVCIYAGKILTDDFADKEGLEMGDEYFANLDHIE----------------------------------- 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1115 rpnyhyqrkikrssrsgstqnsstqsseldsqeravinfnpnadldetvrensvrrlfgkdEAPYIMDAKTTGNLGRYFN 1194
Cdd:cd10541   151 -------------------------------------------------------------ESCYIIDAKLEGNLGRYLN 169

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161077479 1195 HSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRL 1261
Cdd:cd10541   170 HSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIKAGTELTWDYNYEVGSVEGKELLCCCGSNECRGRL 236
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 958-1261 2.30e-72

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 242.43  E-value: 2.30e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  958 SKCACWQLTVAGVRYCNPKKPIEEIGYQYKRLHEHVPTGIYECNSRCKCKKN-CLNRVVQFSLEMKLQVFKTSNRGWGLR 1036
Cdd:cd10523    44 LKCACLQLTARAFSKSESSPSKGGRGYKYKRLQEPIPSGLYECNVSCKCNRMlCQNRVVQHGLQVRLQVFKTEKKGWGVR 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1037 CVNDIPKGAFICIYAGHLLTETmaneggqdagdeyfadldyievaeqlkegyeseVDHSDPDAEEDNGGPDAEDDDDFRP 1116
Cdd:cd10523   124 CLDDIDKGTFVCIYAGRVLSRA---------------------------------RSPTEPLPPKLELPSENEVEVVTSW 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1117 NYHYQRKIKrssrsgstqnsstqsseldsqeravinfnpnadldetvRENSvrrlfgkdeapYIMDAKTTGNLGRYFNHS 1196
Cdd:cd10523   171 LILSKKRKL--------------------------------------RENV-----------CFLDASKEGNVGRFLNHS 201

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 161077479 1197 CSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCRLRL 1261
Cdd:cd10523   202 CCPNLFVQNVFVDTHDKNFPWVAFFTNRVVKAGTELTWDYSYDAGTSPEQEIPCLCGVNKCQKKI 266
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 958-1237 5.43e-52

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 182.19  E-value: 5.43e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  958 SKCACWQLTvagvrycnpkkpIEEIGYQYK---RLHEHvPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWG 1034
Cdd:cd10538    36 SKCACAAES------------DGIFAYTKNgllRLNNS-PPPIFECNSKCSCDDDCKNRVVQRGLQARLQVFRTSKKGWG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1035 LRCVNDIPKGAFICIYAGHLLTETMANEGGQ---DAGDEYFADLDyievaeqlkegyesevDHSDPDaeednggpdaedd 1111
Cdd:cd10538   103 VRSLEFIPKGSFVCEYVGEVITTSEADRRGKiydKSGGSYLFDLD----------------EFSDSD------------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1112 ddfrpnyhyqrkikrssrsgstqnsstqsseldsqeravinfnpnadldetvrensvrrlfgKDEAPYIMDAKTTGNLGR 1191
Cdd:cd10538   154 --------------------------------------------------------------GDGEELCVDATFCGNVSR 171

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 161077479 1192 YFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYN 1237
Cdd:cd10538   172 FINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 960-1238 1.34e-51

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 181.45  E-value: 1.34e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  960 CACWQLTVAGVRYCN-PKKPIEEIGY-QYKRLHEHVPTgIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRC 1037
Cdd:cd10545    24 CDCKNRCTDGASDCAcVKKNGGEIPYnFNGRLIRAKPA-IYECGPLCKCPPSCYNRVTQKGLRYRLEVFKTAERGWGVRS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1038 VNDIPKGAFICIYAGHLLTETMANEGGQDagDEYFADLDYIEVAEqlKEGYESEVDHSDPDAEEdnggPDAEDDddfrpn 1117
Cdd:cd10545   103 WDSIPAGSFICEYVGELLDTSEADTRSGN--DDYLFDIDNRQTNR--GWDGGQRLDVGMSDGER----SSAEDE------ 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1118 yhyqrkikrssrsgstqnsstqsseldsqeravinfnpnadldetvrensvrrlfgkDEAPYIMDAKTTGNLGRYFNHSC 1197
Cdd:cd10545   169 ---------------------------------------------------------ESSEFTIDAGSFGNVARFINHSC 191

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 161077479 1198 SPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNY 1238
Cdd:cd10545   192 SPNLFVQCVLYDHNDLRLPRVMLFAADNIPPLQELTYDYGY 232
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 987-1258 9.58e-43

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 156.68  E-value: 9.58e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  987 KRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSN-RGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQ 1065
Cdd:cd10542    53 GRLRLPPGTPIYECNSRCKCGPDCPNRVVQRGRKVPLCIFRTSNgRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGK 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1066 ---DAGDEYFADLDYievaeqlkegyesevdhsdpdaeednggpdaeDDDDfrpnyhyqrkikrssrsgstqnsstqsse 1142
Cdd:cd10542   133 iydANGRTYLFDLDY--------------------------------NDDD----------------------------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1143 ldsqeravinfnpnadldetvrensvrrlfgkdeAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFS 1222
Cdd:cd10542   152 ----------------------------------CEYTVDAAYYGNISHFINHSCDPNLAVYAVWINHLDPRLPRIAFFA 197

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 161077479 1223 AAHIRSGTELTWNYNYEVGVVP---------GKVLYCQCGAPNCR 1258
Cdd:cd10542   198 KRDIKAGEELTFDYLMTGTGGSsestipkpkDVRVPCLCGSKNCR 242
Tudor_SETDB1_rpt1 cd20382
first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, ...
 532-622 1.57e-40

first Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, also called ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E), acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It contains two Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410453  Cd Length: 82  Bit Score: 143.96  E-value: 1.57e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  532 IGTRVIAYFDGTTlsrgkdkgvVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRDVRLVCQASEKVWEDVHAASR 611
Cdd:cd20382     1 VGSRVVAQYKDEG---------NQVWLYAGIVAEPPKVKNRYRYLIFFDDGYAQYVTPSDVYLVCQQSKKVWEDIHEDSR 71

                          90
                  ....*....|.
gi 161077479  612 DFIQKYVEKYS 622
Cdd:cd20382    72 DFIREYLEAYP 82
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 994-1258 1.71e-38

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 143.63  E-value: 1.71e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  994 PTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMAneggqdagdeyfa 1073
Cdd:cd10543    64 PPLIFECNRACSCWRNCRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEA------------- 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1074 dldyievaeqlkegyesevdhsdpdaeednggpDAEDDDDfrpnYHYqrkikrssrsgstqnsstqsseldsqeravinf 1153
Cdd:cd10543   131 ---------------------------------DSREDDS----YLF--------------------------------- 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1154 npnaDLDETVRENsvrrlfgkdeapYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELT 1233
Cdd:cd10543   141 ----DLDNKDGET------------YCIDARRYGNISRFINHLCEPNLIPVRVFVEHQDLRFPRIAFFASRDIKAGEELG 204

                         250       260
                  ....*....|....*....|....*
gi 161077479 1234 WNYNYEVGVVPGKVLYCQCGAPNCR 1258
Cdd:cd10543   205 FDYGEKFWRIKGKYFTCRCGSPKCK 229
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 994-1258 8.70e-36

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 136.22  E-value: 8.70e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  994 PTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAgdeYFA 1073
Cdd:cd10535    64 PPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSEADVREEDS---YLF 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1074 DLDyievaeqlkegyesevdhsdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstqsseldsqeravinf 1153
Cdd:cd10535   141 DLD----------------------------------------------------------------------------- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1154 npnadldetvrensvrrlfGKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELT 1233
Cdd:cd10535   144 -------------------NKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMAHQDLRFPRIAFFSTRLIEAGEQLG 204

                         250       260
                  ....*....|....*....|....*
gi 161077479 1234 WNYNYEVGVVPGKVLYCQCGAPNCR 1258
Cdd:cd10535   205 FDYGERFWDIKGKLFSCRCGSPKCR 229
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 958-1258 2.41e-32

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 126.29  E-value: 2.41e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  958 SKCACWQLTVAgVRYCNPKKPIEEigyqYKRLHehvPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRC 1037
Cdd:cd10533    36 SNCLCGQLSIR-CWYDKDGRLLQE----FNKIE---PPLIFECNQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1038 VNDIPKGAFICIYAGHLLTetmaneggqdagdeyfadldyievaeqlkegyesevdhsdpDAEednggPDAEDDDDFRpn 1117
Cdd:cd10533   108 LQTIPQGTFICEYVGELIS-----------------------------------------DAE-----ADVREDDSYL-- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1118 yhyqrkikrssrsgstqnsstqsseldsqeravinfnpnADLDEtvrensvrrlfgKDEAPYIMDAKTTGNLGRYFNHSC 1197
Cdd:cd10533   140 ---------------------------------------FDLDN------------KDGEVYCIDARYYGNISRFINHLC 168

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161077479 1198 SPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLYCQCGAPNCR 1258
Cdd:cd10533   169 DPNIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK 229
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 997-1258 2.34e-31

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 123.95  E-value: 2.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  997 IYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAGDEyfaDLD 1076
Cdd:cd10544    66 VFECNSMCKCSESCQNRVVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQTKG---DMN 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1077 YIEVaeqLKEgyesevdhsdpdaeednggpdaeddddfrpnYHYQRKIKRSsrsgstqnsstqsseldsqeravinfnpn 1156
Cdd:cd10544   143 YIIV---LRE-------------------------------HLSSGKVLET----------------------------- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1157 adldetvrensvrrlfgkdeapyIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDThdlRFPWVAFFSAAHIRSGTELTWNY 1236
Cdd:cd10544   160 -----------------------FVDPTYIGNIGRFLNHSCEPNLFMVPVRVDS---MVPKLALFAARDIVAGEELSFDY 213

                         250       260       270
                  ....*....|....*....|....*....|...
gi 161077479 1237 NYEVGVVPGKVLY-----------CQCGAPNCR 1258
Cdd:cd10544   214 SGEFSNSVESVTLarqdesksrkpCLCGAENCR 246
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 997-1258 7.36e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 116.92  E-value: 7.36e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  997 IYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSN-RGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQ---DAGDEYF 1072
Cdd:cd10525    62 IYECNSRCRCGPDCPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQiydRQGATYL 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1073 ADLDYIEvaeqlkegyesevdhsdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstqsseldsqeravin 1152
Cdd:cd10525   142 FDLDYVE------------------------------------------------------------------------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1153 fnpnaDLdetvrensvrrlfgkdeapYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTEL 1232
Cdd:cd10525   149 -----DV-------------------YTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIALFATRTIRAGEEL 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 161077479 1233 TWNYNYEVGVV-------------------PGKVLY--CQCGAPNCR 1258
Cdd:cd10525   205 TFDYNMQVDPVdaestkmdsnfglaglpgsPKKRVRieCKCGVRSCR 251
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 997-1258 6.87e-27

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 110.75  E-value: 6.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  997 IYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSN-RGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQ---DAGDEYF 1072
Cdd:cd10532    60 IYECNSRCKCGPDCPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERRGQfydSKGITYL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1073 ADLDYIEvaeqlkegyesevdhsdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstqsseldsqeravin 1152
Cdd:cd10532   140 FDLDYES------------------------------------------------------------------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1153 fnpnadlDEtvrensvrrlfgkdeapYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGTEL 1232
Cdd:cd10532   147 -------DE-----------------FTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTIKAGEEL 202

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 161077479 1233 TWNYNY---------EVGVVPGKVLY---CQCGAPNCR 1258
Cdd:cd10532   203 TFDYQMkgsgdlssdSIDNSPAKKRVrtvCKCGAVTCR 240
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 985-1258 3.59e-25

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 106.12  E-value: 3.59e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  985 QYKRLHEHVPTGIYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGG 1064
Cdd:cd20073    57 EYGRVRANTGSIIYECNENCDCGINCPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRG 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1065 ---QDAGDEYFADLDYievaeqlkegYESEVDHSdpdaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstqss 1141
Cdd:cd20073   137 kkyDNVGVTYLFDLDL----------FEDQVDEY---------------------------------------------- 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1142 eldsqeravinfnpnadldetvrensvrrlfgkdeapYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFF 1221
Cdd:cd20073   161 -------------------------------------YTVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSKIYDLAFF 203

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 161077479 1222 SAAHIRSGTELTWNY-----NYEVG-VVPGKV---------LYCQCGAPNCR 1258
Cdd:cd20073   204 AIKDIPALEELTFDYsgrnnFDQLGfIGNRSNskyinlknkRPCYCGSANCR 255
Tudor_SETDB1_rpt2 cd21181
second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, ...
 630-684 3.76e-25

second Tudor domain found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1, also called ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E), acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. It contains two Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410548  Cd Length: 54  Bit Score: 99.32  E-value: 3.76e-25
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 161077479  630 CTRGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDkNHTEWIYRGSLRLGPVFRE 684
Cdd:cd21181     1 LKVGQLIKTEWNGKWWKARVEEVDGSLVKMLFLDD-KRTEWIYRGSTRLEPLFRE 54
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 928-1258 9.27e-25

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 105.48  E-value: 9.27e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  928 KQRIPTEGVHLnLDEEFLLCCDCEDDCS-DKSKCACWQLTVAGVRYCNPKKPieeigYQYK-------RLHEHVPTG--- 996
Cdd:cd19473     7 EKSILGEGVEL-ADEEFRSGCECTDDEDcMYSGCLCLQDVDPDDDRDPGKKK-----NAYHssgakkgCLRGHMLNSrlp 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  997 IYECNSRCKCKKNCLNRVVQFSLEMKLQVFKTS-NRGWGLRCVNDIPKGAFICIYAGHLLTETMANEGGQDAG-----DE 1070
Cdd:cd19473    81 IYECHEGCACSDDCPNRVVERGRKVPLQIFRTSdGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATiaqrkDV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1071 YFADLDyievaeqlkegyesevDHSDPDaeednggpdaeddddfrpnyhyqrkikrssrsgstqnsstqsseldsqerav 1150
Cdd:cd19473   161 YLFALD----------------KFSDPD---------------------------------------------------- 172

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1151 infnpnaDLDEtvrensvrRLFGkdeAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFPWVAFFSAAHIRSGT 1230
Cdd:cd19473   173 -------SLDP--------RLRG---DPYEIDGEFMSGPTRFINHSCDPNLRIFARVGDHADKHIHDLAFFAIKDIPRGT 234

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 161077479 1231 ELTWNYnyeVGVVPGKVLY------------CQCGAPNCR 1258
Cdd:cd19473   235 ELTFDY---VDGVTGLDDDagdeekekemtkCLCGSPKCR 271
HMT_MBD cd01395
Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as ...
 823-879 1.13e-23

Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated transcriptional repression. SETDB1 and other proteins in this group have a similar domain architecture. SETDB1 is a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.


Pssm-ID: 238689  Cd Length: 60  Bit Score: 95.14  E-value: 1.13e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  823 PLAKPLLSGWERLVMRQKT---KKSVVYKGPCGKSLRSLAEVHRYLRATENVLNVDNFDF 879
Cdd:cd01395     1 PLHTPLLCGFQRMKYRARVgkvKKHVIYKAPCGRSLRNMSEVHRYLRETCSFLTVDNFSF 60
Tudor_5 pfam18359
Histone methyltransferase Tudor domain 1; This is the first TUDOR domain found in SETDB1 ...
 530-591 3.61e-22

Histone methyltransferase Tudor domain 1; This is the first TUDOR domain found in SETDB1 enzymes (EC:2.1.1.43) in homosapiens, also known as Eggless in Drosophila. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4. SET domain, bifurcated 1 (SETDB1) is a histone methyltransferase (HMT) that methylates lysine 9 on histone H3 (H3K9). The enzymatic activity of SETDB1, in association with MBD1-containing chromatin-associated factor 1 (MCAF1), converts H3K9me2 to H3K9me3 and represses subsequent transcription. SETDB1 is amplified in cancers such as melanoma and lung cancer, and increased expression of SETDB1 promotes tumorigenesis in a zebrafish melanoma model. In addition, SETDB1 is required for endogenous retrovirus silencing during early embryogenesis, inhibition of adipocyte differentiation, and differentiation of mesenchymal cells into osteoblasts. The tandem Tudor domains in the N-terminal region are involved in protein-protein interactions. The second tudor domain is pfam18385.


Pssm-ID: 465723  Cd Length: 53  Bit Score: 90.73  E-value: 3.61e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161077479   530 LTIGTRVIAYFDgttlsrgkdKGVVQSAFYPGIIAEPLKQANRYRYLIFYDDGYTQYVPHRD 591
Cdd:pfam18359    1 LPVGTRVIAKYK---------DSNGKSAYYAGVIAEPPKDLNRYRYLVFFDDGYAQYVVHKD 53
Pre-SET pfam05033
Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines ...
 901-1013 1.15e-18

Pre-SET motif; This protein motif is a zinc binding motif. It contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilising SET domains.


Pssm-ID: 461530 [Multi-domain]  Cd Length: 99  Bit Score: 82.08  E-value: 1.15e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479   901 ISKGQEKMAIPLVNYYDNTLPPPC-TYAKQRIPTEGVHLNLD-----EEFLlccdceddcsdKSKCACWQLTVAGVRYcn 974
Cdd:pfam05033    1 ISKGKENVPIPVVNEVDDEPPPPDfTYITSYIYPKEFLLIIPqgcdcGDCS-----------SEKCSCAQLNGGEFRF-- 67

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 161077479   975 pkkpieeiGYQYKRLH-EHVPTGIYECNSRCKCKKNCLNR 1013
Cdd:pfam05033   68 --------PYDKDGLLvPESKPPIYECNPLCGCPPSCPNR 99
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 1022-1258 6.09e-18

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 81.53  E-value: 6.09e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLtetmaneggqdagdeyfadlDYIEVAEQLKEGYESEVDHsdpdaee 1101
Cdd:cd10531     1 KLELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVI--------------------DKKEFKERLDEYEELGKSN------- 53

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1102 dnggpdaeddddfrpnyHYQRKIKRSsrsgstqnsstqsseldsqeravinfnpnadldetvrensvrrlfgkdeapYIM 1181
Cdd:cd10531    54 -----------------FYILSLSDD---------------------------------------------------VVI 65

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161077479 1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHdlrfPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVlyCQCGAPNCR 1258
Cdd:cd10531    66 DATRKGNLSRFINHSCEPNCETQKWIVNGE----YRIGIFALRDIPAGEELTFDYNFVNYNEAKQV--CLCGAQNCR 136
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 1022-1239 6.91e-18

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 80.84  E-value: 6.91e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479   1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETMANEggqdagdeyfadldyievaeqlkegyesevdhsdpdaee 1101
Cdd:smart00317    2 KLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEE--------------------------------------- 42

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479   1102 dnggpDAEDDDDFRPNYHYqrkikrssrsgstqnsstqsseldsqeravinfnpnadldetvrensvrrLFGKDEAPYIm 1181
Cdd:smart00317   43 -----RPKAYDTDGAKAFY--------------------------------------------------LFDIDSDLCI- 66

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 161077479   1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDlrfpWVAFFSAAHIRSGTELTWNYNYE 1239
Cdd:smart00317   67 DARRKGNLARFINHSCEPNCELLFVEVNGDD----RIVIFALRDIKPGEELTIDYGSD 120
Tudor_4 pfam18358
Histone methyltransferase Tudor domain; This is a Tudor domain found in histone-lysine ...
 632-680 1.02e-17

Histone methyltransferase Tudor domain; This is a Tudor domain found in histone-lysine N-methyltransferase SETDB1 proteins (EC:2.1.1.43), also known as Eggless in Drosophila. In Drosophila, SetdB1 (Egg) is important for oogenesis and the silencing of chromosome 4.


Pssm-ID: 408159  Cd Length: 50  Bit Score: 77.78  E-value: 1.02e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 161077479   632 RGQSMTTESNGTWLYARVIDIDCSLVLMQFEGDKNhTEWIYRGSLRLGP 680
Cdd:pfam18358    3 KGQTVKTEWNGKWWTARVLEVDASLVKVYFLSDKR-TEWIYRGSTRLEP 50
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 1022-1258 3.70e-17

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 79.26  E-value: 3.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTEtmaNEGGQDAGDEYFADLDyievaeqlkegyesevdhsdpdaee 1101
Cdd:cd19174     1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSE---QEFRRRMIEQYHNHSH------------------------- 52

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1102 dnggpdaeddddfrpnyHYqrkikrssrsgstqnsstqsseldsqeraVINFNPNAdldetvrensvrrlfgkdeapyIM 1181
Cdd:cd19174    53 -----------------HY-----------------------------CLNLDSGM----------------------VI 64

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 161077479 1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDTHdlrfPWVAFFSAAHIRSGTELTWNYNYEVgVVPGKVLYCQCGAPNCR 1258
Cdd:cd19174    65 DGYRMGNEARFVNHSCDPNCEMQKWSVNGV----YRIGLFALKDIPAGEELTYDYNFHS-FNVEKQQPCKCGSPNCR 136
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 1173-1258 1.47e-16

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 77.62  E-value: 1.47e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1173 GKDEapyIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDtHDLRfpwVAFFSAAHIRSGTELTWNYNYEV-GVVPGKvlyCQ 1251
Cdd:cd19172    62 KSDE---IIDATKKGNLSRFINHSCEPNCETQKWTVN-GELR---VGFFAKRDIPAGEELTFDYQFERyGKEAQK---CY 131


                  ....*..
gi 161077479 1252 CGAPNCR 1258
Cdd:cd19172   132 CGSPNCR 138
MBD cd00122
MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of ...
 823-879 3.22e-16

MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1. The MBDs present in putative chromatin remodelling subunit, BAZ2A, and putative histone methyltransferase, CLLD8, represent two phylogenetically distinct groups within the MBD protein family.


Pssm-ID: 238069  Cd Length: 62  Bit Score: 73.90  E-value: 3.22e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 161077479  823 PLAKPLLSGWERLVMRQKT----KKSVVYKGPCGKSLRSLAEVHRYLRATEN-VLNVDNFDF 879
Cdd:cd00122     1 PLRDPLPPGWKRELVIRKSgsagKGDVYYYSPCGKKLRSKPEVARYLEKTGPsSLDLENFSF 62
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1022-1257 6.50e-16

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 75.73  E-value: 6.50e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTEtmaneggqdagDEYFADLDYievaeqlkegyesevdhsdpdaee 1101
Cdd:cd19210     3 EVEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDE-----------EECRARIRY------------------------ 47

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1102 dnggpdaeddddfrpnyhyqrkikrssrsgstqnsstqsseldSQERAVINFNpNADLDetvrensvrrlfgKDEapyIM 1181
Cdd:cd19210    48 -------------------------------------------AQEHDITNFY-MLTLD-------------KDR---II 67

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161077479 1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNYEVgVVPGKVLyCQCGAPNC 1257
Cdd:cd19210    68 DAGPKGNYARFMNHCCQPNCETQKWTVNG-DTR---VGLFALCDIKAGTELTFNYNLEC-LGNGKTV-CKCGAPNC 137
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 1022-1257 1.24e-15

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 75.04  E-value: 1.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1022 KLQVFKTSNRGWGLRCVNDIPKGAFICIYAGHLLTETmaneggqdagdeyfadldyiEVAEQLKEGYEsevdhsdpdaee 1101
Cdd:cd19173     3 PTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEE--------------------ECRRRLKKAHE------------ 50

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1102 dnggpdaEDDDDFrpnyhYQRKIkrssrsgstqnsstqsselDSQeravinfnpnadldetvrensvrrlfgkdeapYIM 1181
Cdd:cd19173    51 -------NNITNF-----YMLTL-------------------DKD--------------------------------RII 67

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 161077479 1182 DAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNYEVGVVPGKVlyCQCGAPNC 1257
Cdd:cd19173    68 DAGPKGNLSRFMNHSCQPNCETQKWTVNG-DTR---VGLFAVRDIPAGEELTFNYNLDCLGNEKKV--CRCGAPNC 137
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 1178-1258 2.03e-15

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 74.56  E-value: 2.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1178 PYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLrfpwVAFFSAAHIRSGTELTwnYNYEVGVVPGKVLYCQCGAPNC 1257
Cdd:cd10518    76 DLVIDATKKGNIARFINHSCDPNCYAKIITVDGEKH----IVIFAKRDIAPGEELT--YDYKFPIEDEEKIPCLCGAPNC 149


                  .
gi 161077479 1258 R 1258
Cdd:cd10518   150 R 150
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 1165-1257 1.97e-12

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 66.10  E-value: 1.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1165 ENSVRRLF----GKDEapyIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNYEV 1240
Cdd:cd19212    50 ENSVTNFYmltvTKDR---IIDAGPKGNYSRFMNHSCNPNCETQKWTVNG-DVR---VGLFALCDIPAGMELTFNYNLDC 122

                          90
                  ....*....|....*..
gi 161077479 1241 gVVPGKVLyCQCGAPNC 1257
Cdd:cd19212   123 -LGNGRTE-CHCGADNC 137
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 1179-1258 1.97e-12

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 66.30  E-value: 1.97e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDthdlRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVlYCQCGAPNCR 1258
Cdd:cd19171    76 WVIDATMTGGPARYINHSCNPNCVAEVVTFD----KEKKIIIISNRRIAKGEELTYDYKFDFEDDQHKI-PCLCGAPNCR 150
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 1180-1257 2.46e-12

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 65.78  E-value: 2.46e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161077479 1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNYEvgVVPGKVLYCQCGAPNC 1257
Cdd:cd19211    66 IIDAGPKGNYSRFMNHSCQPNCETQKWTVNG-DTR---VGLFAVCDIPAGTELTFNYNLD--CLGNEKTVCRCGAPNC 137
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 1171-1258 9.50e-12

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 64.28  E-value: 9.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1171 LFGKDEApYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLrfpwVAFFSAAHIRSGTELTWNYNYEVGvvPGKVLyC 1250
Cdd:cd19169    69 LFRVDDD-TIIDATKCGNLARFINHSCNPNCYAKIITVESQKK----IVIYSKRPIAVNEEITYDYKFPIE--DEKIP-C 140


                  ....*...
gi 161077479 1251 QCGAPNCR 1258
Cdd:cd19169   141 LCGAPQCR 148
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 1180-1261 2.94e-11

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 62.43  E-value: 2.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNYevgVVPGKVLYCQCGAPNCRL 1259
Cdd:cd19175    64 VIDATFKGNLSRFINHSCDPNCELQKWQVDG-ETR---IGVFAIRDIKKGEELTYDYQF---VQFGADQDCHCGSKNCRG 136


                  ..
gi 161077479 1260 RL 1261
Cdd:cd19175   137 KL 138
MBD smart00391
Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, ...
 822-885 5.62e-11

Methyl-CpG binding domain; Methyl-CpG binding domain, also known as the TAM (TTF-IIP5, ARBP, MeCP1) domain


Pssm-ID: 128673  Cd Length: 77  Bit Score: 59.69  E-value: 5.62e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479    822 SPLAKPLLSGWERLVMRQKT-----KKSVVYKGPCGKSLRSLAEVHRYLRAT-ENVLNVDNFDFTPDLKC 885
Cdd:smart00391    2 DPLRLPLPCGWRRETKQRKSgrsagKFDVYYISPCGKKLRSKSELARYLHKNgDLSLDLECFDFNATVPV 71
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 1145-1237 6.08e-11

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 61.00  E-value: 6.08e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479  1145 SQERAVINFNPNADLDETVRENSVRRLFGKDEAPYImDAKTT--GNLGRYFNHSCSPNLFVQNVFVDthdlRFPWVAFFS 1222
Cdd:pfam00856   26 TKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCI-DARALyyGNWARFINHSCDPNCEVRVVYVN----GGPRIVIFA 100

                           90
                   ....*....|....*
gi 161077479  1223 AAHIRSGTELTWNYN 1237
Cdd:pfam00856  101 LRDIKPGEELTIDYG 115
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 1180-1258 2.06e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 57.72  E-value: 2.06e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161077479 1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDlrfpWVAFFSAAHIRSGTELTWNYNYEVGvVPGKVLYCQCGAPNCR 1258
Cdd:cd19206    77 VVDATMHGNAARFINHSCEPNCYSRVINIDGQK----HIVIFAMRKIYRGEELTYDYKFPIE-DASNKLPCNCGAKKCR 150
MBD pfam01429
Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one ...
 822-886 2.23e-09

Methyl-CpG binding domain; The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase.


Pssm-ID: 396147 [Multi-domain]  Cd Length: 76  Bit Score: 55.06  E-value: 2.23e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161077479   822 SPLAKPLLSGWERLVMRQKT-----KKSVVYKGPCGKSLRSLAEVHRYLRAT-ENVLNVDNFDFTPDLKCL 886
Cdd:pfam01429    5 REDRLPLPPGWRREERQRKSgskagKVDVFYYSPTGKKLRSKSEVARYLEANgGTSPKLEDFSFTVRSEVG 75
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 1189-1237 2.96e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 54.56  E-value: 2.96e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 161077479 1189 LGRYFNHSCSPNLFVQNVFVDTHdlrfPWVAFFSAAHIRSGTELTWNYN 1237
Cdd:cd08161    28 LARFINHSCEPNCEFEEVYVGGK----PRVFIVALRDIKAGEELTVDYG 72
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1171-1258 4.34e-09

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 56.12  E-value: 4.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1171 LFGKDEAPYImDAKTTGNLGRYFNHSCSPnlfvqNVFVDTHDLRFpwvaFFSAAH-IRSGTELTWNYNYEVGvvpGKVLY 1249
Cdd:COG2940    59 LFELDDDGVI-DGALGGNPARFINHSCDP-----NCEADEEDGRI----FIVALRdIAAGEELTYDYGLDYD---EEEYP 125


                  ....*....
gi 161077479 1250 CQCgaPNCR 1258
Cdd:COG2940   126 CRC--PNCR 132
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 1171-1258 6.08e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 56.25  E-value: 6.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1171 LFGKDEApYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDlrfpWVAFFSAAHIRSGTELTWNYNYEVGVVPgkvLYC 1250
Cdd:cd19170    69 MFRIDDD-EVVDATMHGNAARFINHSCEPNCYSRVVNIDGKK----HIVIFALRRILRGEELTYDYKFPIEDVK---IPC 140


                  ....*...
gi 161077479 1251 QCGAPNCR 1258
Cdd:cd19170   141 TCGSKKCR 148
PreSET smart00468
N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal ...
 900-1005 1.16e-08

N-terminal to some SET domains; A Cys-rich putative Zn2+-binding domain that occurs N-terminal to some SET domains. Function is unknown. Unpublished.


Pssm-ID: 128744 [Multi-domain]  Cd Length: 98  Bit Score: 53.57  E-value: 1.16e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479    900 DISKGQEKMAIPLVNYYDNTLPPPC-TYAKQRIPTEGVHLNLDEEFLLCCDCEDDCSDKSKCACWQLTvagvrycnpkkp 978
Cdd:smart00468    3 DISNGKENVPVPLVNEVDEDPPPPDfEYISEYIYGQGVPIDRSPSPLVGCSCSGDCSSSNKCECARKN------------ 70

                            90       100
                    ....*....|....*....|....*...
gi 161077479    979 IEEIGY-QYKRLHEHVPTGIYECNSRCK 1005
Cdd:smart00468   71 GGEFAYeLNGGLRLKRKPLIYECNSRCS 98
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 1171-1258 2.22e-08

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 54.35  E-value: 2.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1171 LFGKDEaPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLrfpwVAFFSAAHIRSGTELTWNYNYEVGVVPgkvLYC 1250
Cdd:cd20072    69 LFRIDD-DTVVDATKKGNIARFINHCCDPNCTAKIIKVEGEKR----IVIYAKRDIAAGEELTYDYKFPREEDK---IPC 140


                  ....*...
gi 161077479 1251 QCGAPNCR 1258
Cdd:cd20072   141 LCGAPNCR 148
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 1177-1239 3.14e-08

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 53.11  E-value: 3.14e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 161077479 1177 APYIMDAKTTGNLGRYFNHSCSPNLFVQNVFvdthdLRFPWVAFFSAAH-IRSGTELTWNYNYE 1239
Cdd:cd10522    61 DILVIDAGKKGNLTRFINHSDQPNLELIVRT-----LKGEQHIGFVAIRdIKPGEELFISYGPK 119
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 1180-1258 6.44e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 53.10  E-value: 6.44e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161077479 1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDlrfpWVAFFSAAHIRSGTELTWNYNYEVGVVPGKvLYCQCGAPNCR 1258
Cdd:cd19207    77 VVDATMHGNAARFINHSCEPNCYSRVIHVEGQK----HIVIFALRKIYRGEELTYDYKFPIEDASNK-LPCNCGAKRCR 150
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 1179-1258 7.57e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 53.16  E-value: 7.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLrfpwVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLyCQCGAPNCR 1258
Cdd:cd19209    78 HVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDK----IIIISSRRIPKGEELTYDYQFDFEDDQHKIP-CHCGAWNCR 152
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 1179-1258 1.19e-07

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 52.71  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDthdlRFPWVAFFSAAHIRSGTELTWNYNYEVGVVPGKVLyCQCGAPNCR 1258
Cdd:cd19208    77 HVIDATLTGGPARYINHSCAPNCVAEVVTFE----KGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKIP-CHCGAVNCR 151
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 1180-1258 4.07e-07

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 50.82  E-value: 4.07e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 161077479 1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLrfpwVAFFSAAHIRSGTELTWNYNYEvgvVPGKVLYCQCGAPNCR 1258
Cdd:cd19205    78 IIDATKCGNFARFINHSCNPNCYAKVITVESQKK----IVIYSKQHINVNEEITYDYKFP---IEDVKIPCLCGSENCR 149
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 1180-1258 4.20e-07

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 50.79  E-value: 4.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1180 IMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLrfpwVAFFSAAHIRSGTELTWNYNY--EVGVVPgkvlyCQCGAPNC 1257
Cdd:cd19204    78 IIDATKCGNLARFINHCCTPNCYAKVITIESQKK----IVIYSKQPIGVNEEITYDYKFpiEDNKIP-----CLCGTENC 148


                  .
gi 161077479 1258 R 1258
Cdd:cd19204   149 R 149
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 1179-1238 9.49e-07

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 48.78  E-value: 9.49e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDtHDLRfpwVAFFSAAHIRSGTELTWNYNY 1238
Cdd:cd10519    62 FVVDATRKGNKIRFANHSSNPNCYAKVMMVN-GDHR---IGIFAKRDIEAGEELFFDYGY 117
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 1173-1238 1.08e-06

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 48.81  E-value: 1.08e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 161077479 1173 GKDEAPYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDTHDLRFpwvAFFSAAHIRSGTELT--WNYNY 1238
Cdd:cd10529    63 GFEGLPLCVDARKYGNEARFIRRSCRPNAELRHVVVSNGELRL---FIFALKDIRKGTEITipFDYDY 127
MeCP2_MBD cd01396
MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the ...
 827-884 9.21e-06

MeCP2, MBD1, MBD2, MBD3, and MBD4 are members of a protein family that share the methyl-CpG-binding domain (MBD). The MBD, consists of about 70 residues and is defined as the minimal region required for binding to methylated DNA by a methyl-CpG-binding protein which binds specifically to methylated DNA. The MBD can recognize a single symmetrically methylated CpG either as naked DNA or within chromatin. MeCP2, MBD1 and MBD2 (and likely MBD3) form complexes with histone deacetylase and are involved in histone deacetylase-dependent repression of transcription. MBD4 is an endonuclease that forms a complex with the DNA mismatch-repair protein MLH1.


Pssm-ID: 238690  Cd Length: 77  Bit Score: 44.67  E-value: 9.21e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 161077479  827 PLLSGWER-LVMR--QKTKKS-VVYKGPCGKSLRSLAEVHRYLRATEN-VLNVDNFDFTPDLK 884
Cdd:cd01396     6 RLPPGWKReLVPRksGSAGKFdVYYISPTGKKFRSKVELARYLEKNGPtSLDLSDFDFTVPKK 68
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 1192-1236 7.60e-05

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 43.52  E-value: 7.60e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 161077479 1192 YFNHSCSPNLFVqnVFVDTHDLRfpwvaFFSAAHIRSGTELTWNY 1236
Cdd:cd20071    58 LLNHSCDPNAVV--VFDGNGTLR-----VRALRDIKAGEELTISY 95
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 1178-1233 5.32e-04

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 42.39  E-value: 5.32e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 161077479 1178 PYIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDthDLRFPWVAFFSAAHIRSGTELT 1233
Cdd:cd19183    66 PLYIDTRRSGSVARFIRRSCRPNAELVTVASD--SGSVLKFVLYASRDISPGEEIT 119
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 1179-1236 1.11e-03

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 40.64  E-value: 1.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDA-KTTGNLGRYFNHSC-SPNLFVQNVFVDTHdlrfPWVAFFSAAHIRSGTELTWNY 1236
Cdd:cd10528    83 YCVDAtKESGRLGRLINHSKkKPNLKTKLLVIDGV----PHLILVAKRDIKPGEELLYDY 138
HAT_MBD cd01397
Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as ...
 827-881 1.77e-03

Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The Drosophila melanogaster toutatis protein, a putative subunit of the chromatin-remodeling complex, and other such proteins in this group share a similar domain architecture with BAZ2A, as does the Caenorhabditis elegans flectin homolog.


Pssm-ID: 238691 [Multi-domain]  Cd Length: 73  Bit Score: 38.15  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161077479  827 PLLSGWERLVmRQKT-----KKSVVYKGPCGKSLRSLAEVHRYL-RATENVLNVDNFDFTP 881
Cdd:cd01397     5 PLELGWRRET-RIRGlggriQGEVAYYAPCGKKLRQYPEVIKYLsKNGISLLSRENFSFSA 64
Tudor_SGF29_rpt2 cd20394
second Tudor domain found in SAGA-associated factor 29 (SGF29) and similar proteins; SGF29, ...
 533-592 2.87e-03

second Tudor domain found in SAGA-associated factor 29 (SGF29) and similar proteins; SGF29, also called coiled-coil domain-containing protein 101, or SAGA complex-associated factor 29, is a chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes, like the TFTC-HAT, ATAC or STAGA complexes. It specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). SGF29 contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410465  Cd Length: 60  Bit Score: 37.20  E-value: 2.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161077479  533 GTRVIAYFDGTTlsrgkdkgvvqsAFYPGIIAEPLKQANRYRYLIFYDDGYT-QYVPHRDV 592
Cdd:cd20394     4 GTRVLALYPQTT------------CFYPATVVSPPTRPSDDYSLLFEDDEYAdGYSPPREV 52
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 1179-1238 3.52e-03

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 38.74  E-value: 3.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNY 1238
Cdd:cd19218    65 FVVDATRKGNKIRFANHSVNPNCYAKVMMVNG-DHR---IGIFAKRAIQTGEELFFDYRY 120
Tudor_53BP1 cd20383
Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins; ...
 532-592 4.24e-03

Tudor domain found in tumor suppressor TP53-binding protein 1 (53BP1) and similar proteins; 53BP1, also called p53-binding protein 1 (p53BP1), is a double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics, and class-switch recombination (CSR) during antibody genesis. It plays a key role in the repair of DSBs in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. It is recruited to DSB sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2), two histone marks that are present at DSB sites. 53BP1 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410454  Cd Length: 52  Bit Score: 36.47  E-value: 4.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 161077479  532 IGTRVIAyfdgttlsRGKDKGVvqsaFYPGIIAEPLKqanRYRYLIFYDDGYTQYVPHRDV 592
Cdd:cd20383     1 VGTRVFA--------KWSSDGY----YYPGIITRVLG---DGKYKVLFDDGYERDVKGKDI 46
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 1179-1238 5.69e-03

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 38.51  E-value: 5.69e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 161077479 1179 YIMDAKTTGNLGRYFNHSCSPNLFVQNVFVDThDLRfpwVAFFSAAHIRSGTELTWNYNY 1238
Cdd:cd19217    67 FVVDATRKGNKIRFANHSVNPNCYAKVVMVNG-DHR---IGIFAKRAIQQGEELFFDYRY 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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