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Conserved domains on  [gi|24762781|ref|NP_611979|]
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painless, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
495-746 5.29e-19

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 87.32  E-value: 5.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   495 FYLNFLIYSLFTASIITYTLlKFHESDQRALTAFFGLLSWLGISYLILRECIQWIMSPV--RYFWSITNIMEVALITLSI 572
Cdd:pfam00520   2 RYFELFILLLILLNTIFLAL-ETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   573 FTCMESSFdkETQRVLAVFTILLVsMEFCLLVGSLPVLSISTHMLMlrEVSNSFLKSFTLYSIFVLTFSLCFYILFGKSV 652
Cdd:pfam00520  81 ISLVLSSV--GSLSGLRVLRLLRL-LRLLRLIRRLEGLRTLVNSLI--RSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   653 eedqsksatpcpplgkKEGKDEEQGFNTFTKPIEAVIKTIVMLTGE-----FDAGSIQFTSIYTYLIFLLFVIFMTIVLF 727
Cdd:pfam00520 156 ----------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgwgdiMYDTIDGKGEFWAYIYFVSFIILGGFLLL 219
                         250
                  ....*....|....*....
gi 24762781   728 NLLNGLAVSDTQVIKAQAE 746
Cdd:pfam00520 220 NLFIAVIIDNFQELTERTE 238
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
2-182 1.76e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   2 DFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTpGCRDFIEACIDHGSQVNYINKKlDKA 81
Cdd:COG0666  45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN-GDLEIVKLLLEAGADVNARDKD-GET 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781  82 AISYAADSRDPGNLAALLKYrpGNKVQVDRKYGQlTPLNSLAKNltdeNAPDVyscMQLLLDYGASPNIVDQGEFTPLHH 161
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEA--GADVNAQDNDGN-TPLHLAAAN----GNLEI---VKLLLEAGADVNARDNDGETPLHL 192
                       170       180
                ....*....|....*....|.
gi 24762781 162 VlrkskVKAGKKELIQLFLDH 182
Cdd:COG0666 193 A-----AENGHLEIVKLLLEA 208
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
243-406 4.57e-07

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 243 LQNLKGGADNqlNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRpgRANEANLVETAVIYGNWQALERLLK---EP 319
Cdd:COG0666  71 LLLLAAGADI--NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEagaDV 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 320 NLR----LTPdskLLNAVIGRldeppydgssHQRCFELLINSDrVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYI 395
Cdd:COG0666 147 NAQdndgNTP---LHLAAANG----------NLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212
                       170
                ....*....|.
gi 24762781 396 GSKSAFGTLPI 406
Cdd:COG0666 213 NAKDNDGKTAL 223
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
495-746 5.29e-19

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 87.32  E-value: 5.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   495 FYLNFLIYSLFTASIITYTLlKFHESDQRALTAFFGLLSWLGISYLILRECIQWIMSPV--RYFWSITNIMEVALITLSI 572
Cdd:pfam00520   2 RYFELFILLLILLNTIFLAL-ETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   573 FTCMESSFdkETQRVLAVFTILLVsMEFCLLVGSLPVLSISTHMLMlrEVSNSFLKSFTLYSIFVLTFSLCFYILFGKSV 652
Cdd:pfam00520  81 ISLVLSSV--GSLSGLRVLRLLRL-LRLLRLIRRLEGLRTLVNSLI--RSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   653 eedqsksatpcpplgkKEGKDEEQGFNTFTKPIEAVIKTIVMLTGE-----FDAGSIQFTSIYTYLIFLLFVIFMTIVLF 727
Cdd:pfam00520 156 ----------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgwgdiMYDTIDGKGEFWAYIYFVSFIILGGFLLL 219
                         250
                  ....*....|....*....
gi 24762781   728 NLLNGLAVSDTQVIKAQAE 746
Cdd:pfam00520 220 NLFIAVIIDNFQELTERTE 238
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
438-746 9.81e-10

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 62.41  E-value: 9.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   438 IDYKNLMRQERDSGLNQLqdemapIAF--IAESKEMRH--LLQHPLiSSFLFLKWHRL-SVIFYLNFLIYSLFtasIITY 512
Cdd:TIGR00870 299 YWLEELDGWRRKQSVLEL------IVVfvIGLKFPELSdmYLIAPL-SRLGQFKWKPFiKFIFHSASYLYFLY---LIIF 368
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   513 TLLKFHE---SDQRALTAFFGLLSWLGI---SYLILRECIQWIMSPVR-YFWSITNIME-------VALITLSI------ 572
Cdd:TIGR00870 369 TSVAYYRptrTDLRVTGLQQTPLEMLIVtwvDGLRLGEEKLIWLGGIFeYIHQLWNILDfgmnsfyLATFLDRPfailfv 448
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   573 ---FTCMESSFDKETQRVLAVftillVSMEFCLLVGSLPVLSIST---HM----LML-REVSNSFLKSFTLYSIFVLTFS 641
Cdd:TIGR00870 449 tqaFLVLREHWLRFDPTLIEE-----ALFAFALVLSWLNLLYIFRgnqHLgplqIMIgRMILGDILRFLFIYAVVLFGFA 523
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   642 LCFYILFgksvEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLtGEFDAGSIQFTSIYTYLIFLLFVIF 721
Cdd:TIGR00870 524 CGLNQLY----QYYDELKLNECSNPHARSCEKQGNAYSTLFETSQELFWAIIGL-GDLLANEHKFTEFVGLLLFGAYNVI 598
                         330       340
                  ....*....|....*....|....*
gi 24762781   722 MTIVLFNLLNGLAVSDTQVIKAQAE 746
Cdd:TIGR00870 599 MYILLLNMLIAMMGNTYQLIADDAD 623
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-182 1.76e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   2 DFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTpGCRDFIEACIDHGSQVNYINKKlDKA 81
Cdd:COG0666  45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN-GDLEIVKLLLEAGADVNARDKD-GET 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781  82 AISYAADSRDPGNLAALLKYrpGNKVQVDRKYGQlTPLNSLAKNltdeNAPDVyscMQLLLDYGASPNIVDQGEFTPLHH 161
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEA--GADVNAQDNDGN-TPLHLAAAN----GNLEI---VKLLLEAGADVNARDNDGETPLHL 192
                       170       180
                ....*....|....*....|.
gi 24762781 162 VlrkskVKAGKKELIQLFLDH 182
Cdd:COG0666 193 A-----AENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
243-406 4.57e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 243 LQNLKGGADNqlNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRpgRANEANLVETAVIYGNWQALERLLK---EP 319
Cdd:COG0666  71 LLLLAAGADI--NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEagaDV 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 320 NLR----LTPdskLLNAVIGRldeppydgssHQRCFELLINSDrVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYI 395
Cdd:COG0666 147 NAQdndgNTP---LHLAAANG----------NLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212
                       170
                ....*....|.
gi 24762781 396 GSKSAFGTLPI 406
Cdd:COG0666 213 NAKDNDGKTAL 223
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
468-738 2.22e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 51.42  E-value: 2.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 468 SKEMRH--LLQHPLiSSFLFLKWHRLSV-IFYLNFLIYSLFtasIITYTLLKFHE-----SDQRALTAFFG--------L 531
Cdd:cd21882 274 KREARHqmLVQEPL-NELLQEKWDRYGRpYFCFNFACYLLY---MIIFTVCAYYRplkdrPANQEAKATFGdsirlvgeI 349
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 532 LSWLGISYLILREcIQ--WIMSPVRYFWSITNIMEVALITLSIFTCMeSSFDKETQRVLAVftillVSMEFCLLVGSLPV 609
Cdd:cd21882 350 LTVLGGVYILLGE-IPyfFRRRLSRWFGFLDSYFEILFITQALLVLL-SMVLRFMETEGYV-----VPLVFSLVLGWCNV 422
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 610 L------------SISTHMLMLREVsnsfLKSFTLYSIFVLTFSLCFYILFgksveedqsksatpcpplgkKEGKDEEQG 677
Cdd:cd21882 423 LyytrgfqmlgiyTVMIQKMILRDL----MRFCWVYLVFLFGFASAFVILF--------------------QTEDPNKLG 478
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24762781 678 --FNTFTKPIEAVIKTIVMLTGEFDAgSIQFTSIYTyLIFLLFVIFMTIVLFNLLNGLaVSDT 738
Cdd:cd21882 479 efRDYPDALLELFKFTIGMGDLPFNE-NVDFPFVYL-ILLLAYVILTYLLLLNMLIAL-MGET 538
Ank_2 pfam12796
Ankyrin repeats (3 copies);
135-192 1.79e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24762781   135 YSCMQLLLDYGASPNIVDQGEFTPLHHVlrkskVKAGKKELIQLFLDHPELDIDSYRN 192
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLA-----AKNGHLEIVKLLLEHADVNLKDNGR 62
PHA02878 PHA02878
ankyrin repeat protein; Provisional
42-177 2.20e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   42 DRHTSIYEKALSTPGCRDFIEACI-----DHGSQVNYINKKLDKAAISYAADSRDpgnlaallkyrpgnkvqvdrkygql 116
Cdd:PHA02878 126 KNIQTIDLVYIDKKSKDDIIEAEItklllSYGADINMKDRHKGNTALHYATENKD------------------------- 180
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24762781  117 tplnslaknltdenapdvYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKvKAGKKELIQ 177
Cdd:PHA02878 181 ------------------QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYN-KPIVHILLE 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
303-398 2.86e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.79  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   303 AVIYGNWQALERLLK---EPNLRLTPDSKLLNAVIGRldeppydgsSHQRCFELLInsDRVDINEADSGRLvPLFFAVKY 379
Cdd:pfam12796   4 AAKNGNLELVKLLLEngaDANLQDKNGRTALHLAAKN---------GHLEIVKLLL--EHADVNLKDNGRT-ALHYAARS 71
                          90
                  ....*....|....*....
gi 24762781   380 RNTSAMQKLLKNGAYIGSK 398
Cdd:pfam12796  72 GHLEIVKLLLEKGADINVK 90
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
495-746 5.29e-19

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 87.32  E-value: 5.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   495 FYLNFLIYSLFTASIITYTLlKFHESDQRALTAFFGLLSWLGISYLILRECIQWIMSPV--RYFWSITNIMEVALITLSI 572
Cdd:pfam00520   2 RYFELFILLLILLNTIFLAL-ETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILDFVVVLPSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   573 FTCMESSFdkETQRVLAVFTILLVsMEFCLLVGSLPVLSISTHMLMlrEVSNSFLKSFTLYSIFVLTFSLCFYILFGKSV 652
Cdd:pfam00520  81 ISLVLSSV--GSLSGLRVLRLLRL-LRLLRLIRRLEGLRTLVNSLI--RSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   653 eedqsksatpcpplgkKEGKDEEQGFNTFTKPIEAVIKTIVMLTGE-----FDAGSIQFTSIYTYLIFLLFVIFMTIVLF 727
Cdd:pfam00520 156 ----------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgwgdiMYDTIDGKGEFWAYIYFVSFIILGGFLLL 219
                         250
                  ....*....|....*....
gi 24762781   728 NLLNGLAVSDTQVIKAQAE 746
Cdd:pfam00520 220 NLFIAVIIDNFQELTERTE 238
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
438-746 9.81e-10

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 62.41  E-value: 9.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   438 IDYKNLMRQERDSGLNQLqdemapIAF--IAESKEMRH--LLQHPLiSSFLFLKWHRL-SVIFYLNFLIYSLFtasIITY 512
Cdd:TIGR00870 299 YWLEELDGWRRKQSVLEL------IVVfvIGLKFPELSdmYLIAPL-SRLGQFKWKPFiKFIFHSASYLYFLY---LIIF 368
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   513 TLLKFHE---SDQRALTAFFGLLSWLGI---SYLILRECIQWIMSPVR-YFWSITNIME-------VALITLSI------ 572
Cdd:TIGR00870 369 TSVAYYRptrTDLRVTGLQQTPLEMLIVtwvDGLRLGEEKLIWLGGIFeYIHQLWNILDfgmnsfyLATFLDRPfailfv 448
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   573 ---FTCMESSFDKETQRVLAVftillVSMEFCLLVGSLPVLSIST---HM----LML-REVSNSFLKSFTLYSIFVLTFS 641
Cdd:TIGR00870 449 tqaFLVLREHWLRFDPTLIEE-----ALFAFALVLSWLNLLYIFRgnqHLgplqIMIgRMILGDILRFLFIYAVVLFGFA 523
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   642 LCFYILFgksvEEDQSKSATPCPPLGKKEGKDEEQGFNTFTKPIEAVIKTIVMLtGEFDAGSIQFTSIYTYLIFLLFVIF 721
Cdd:TIGR00870 524 CGLNQLY----QYYDELKLNECSNPHARSCEKQGNAYSTLFETSQELFWAIIGL-GDLLANEHKFTEFVGLLLFGAYNVI 598
                         330       340
                  ....*....|....*....|....*
gi 24762781   722 MTIVLFNLLNGLAVSDTQVIKAQAE 746
Cdd:TIGR00870 599 MYILLLNMLIAMMGNTYQLIADDAD 623
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-182 1.76e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   2 DFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTpGCRDFIEACIDHGSQVNYINKKlDKA 81
Cdd:COG0666  45 LALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN-GDLEIVKLLLEAGADVNARDKD-GET 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781  82 AISYAADSRDPGNLAALLKYrpGNKVQVDRKYGQlTPLNSLAKNltdeNAPDVyscMQLLLDYGASPNIVDQGEFTPLHH 161
Cdd:COG0666 123 PLHLAAYNGNLEIVKLLLEA--GADVNAQDNDGN-TPLHLAAAN----GNLEI---VKLLLEAGADVNARDNDGETPLHL 192
                       170       180
                ....*....|....*....|.
gi 24762781 162 VlrkskVKAGKKELIQLFLDH 182
Cdd:COG0666 193 A-----AENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-202 3.94e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.81  E-value: 3.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   2 DFNNCGFIDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTpGCRDFIEACIDHGSQVNYINKKlDKA 81
Cdd:COG0666  78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN-GNLEIVKLLLEAGADVNAQDND-GNT 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781  82 AISYAADSRDPGNLAALLKYrpGNKVQVDRKYGQlTPLNSLAKNltdeNAPDVyscMQLLLDYGASPNIVDQGEFTPLHH 161
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEA--GADVNARDNDGE-TPLHLAAEN----GHLEI---VKLLLEAGADVNAKDNDGKTALDL 225
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24762781 162 VlrkskVKAGKKELIQLFLDHPELDIDSYRNGEVRRLLQAQ 202
Cdd:COG0666 226 A-----AENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
243-406 4.57e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 52.65  E-value: 4.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 243 LQNLKGGADNqlNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRpgRANEANLVETAVIYGNWQALERLLK---EP 319
Cdd:COG0666  71 LLLLAAGADI--NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEagaDV 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 320 NLR----LTPdskLLNAVIGRldeppydgssHQRCFELLINSDrVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYI 395
Cdd:COG0666 147 NAQdndgNTP---LHLAAANG----------NLEIVKLLLEAG-ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV 212
                       170
                ....*....|.
gi 24762781 396 GSKSAFGTLPI 406
Cdd:COG0666 213 NAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-182 7.36e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.88  E-value: 7.36e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   9 IDPQAQLAGALAKQDIRQFVAALDSGALADLQDDRHTSIYEKALSTPGCRDFIEACIDHGSQVNYINKKLDKAAISYAAD 88
Cdd:COG0666  17 LLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781  89 SRDPGNLAALLKYrpGNKVQVDRKYGQlTPLNSLAKNltdeNAPDVyscMQLLLDYGASPNIVDQGEFTPLHHVlrkskV 168
Cdd:COG0666  97 NGDLEIVKLLLEA--GADVNARDKDGE-TPLHLAAYN----GNLEI---VKLLLEAGADVNAQDNDGNTPLHLA-----A 161
                       170
                ....*....|....
gi 24762781 169 KAGKKELIQLFLDH 182
Cdd:COG0666 162 ANGNLEIVKLLLEA 175
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
468-738 2.22e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 51.42  E-value: 2.22e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 468 SKEMRH--LLQHPLiSSFLFLKWHRLSV-IFYLNFLIYSLFtasIITYTLLKFHE-----SDQRALTAFFG--------L 531
Cdd:cd21882 274 KREARHqmLVQEPL-NELLQEKWDRYGRpYFCFNFACYLLY---MIIFTVCAYYRplkdrPANQEAKATFGdsirlvgeI 349
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 532 LSWLGISYLILREcIQ--WIMSPVRYFWSITNIMEVALITLSIFTCMeSSFDKETQRVLAVftillVSMEFCLLVGSLPV 609
Cdd:cd21882 350 LTVLGGVYILLGE-IPyfFRRRLSRWFGFLDSYFEILFITQALLVLL-SMVLRFMETEGYV-----VPLVFSLVLGWCNV 422
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 610 L------------SISTHMLMLREVsnsfLKSFTLYSIFVLTFSLCFYILFgksveedqsksatpcpplgkKEGKDEEQG 677
Cdd:cd21882 423 LyytrgfqmlgiyTVMIQKMILRDL----MRFCWVYLVFLFGFASAFVILF--------------------QTEDPNKLG 478
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24762781 678 --FNTFTKPIEAVIKTIVMLTGEFDAgSIQFTSIYTyLIFLLFVIFMTIVLFNLLNGLaVSDT 738
Cdd:cd21882 479 efRDYPDALLELFKFTIGMGDLPFNE-NVDFPFVYL-ILLLAYVILTYLLLLNMLIAL-MGET 538
Ank_2 pfam12796
Ankyrin repeats (3 copies);
135-192 1.79e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.25  E-value: 1.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24762781   135 YSCMQLLLDYGASPNIVDQGEFTPLHHVlrkskVKAGKKELIQLFLDHPELDIDSYRN 192
Cdd:pfam12796  10 LELVKLLLENGADANLQDKNGRTALHLA-----AKNGHLEIVKLLLEHADVNLKDNGR 62
TRPV2 cd22197
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely ...
462-733 2.75e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 2; TRPV2 is closely related to TRPV1, sharing high sequence identity (>50%), but TRPV2 shows a higher temperature threshold and sensitivity for activation than TRPV1. TRPV2 can be stimulated by ligands or lipids, and is involved in osmosensation and mechanosensation. TRPV2 is expressed in both neuronal and non-neuronal tissues, and it has been implicated in diverse physiological and pathophysiological processes, including cardiac-structure maintenance, innate immunity, and cancer. TRPV2 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411981 [Multi-domain]  Cd Length: 640  Bit Score: 44.85  E-value: 2.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 462 IAFIAESKEMRHLLQHPLISSFLFLKWHRLSVIFYLNFLIYSLFtasIITYTLLKFHESDQ------RALTAFFGLLSWL 535
Cdd:cd22197 290 IAFHSKSPNRHRMVVLEPLNKLLQEKWDRLVSRFYFNFLCYLVY---MFIFTVVAYHQPLLdqppipPLKATAGGSMLLL 366
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 536 GiSYLILRECIQWIMSPVRYFW----SITNIM-----EV-----ALIT-LSIFTCMESSfdkETQRVLAVFTILLVSMEF 600
Cdd:cd22197 367 G-HILILLGGIYLLLGQLWYFWrrrlFIWISFmdsyfEIlfllqALLTvLSQVLYFMGS---EWYLPLLVFSLVLGWLNL 442
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 601 CLLVGSLPVLSISTHML---MLREVsnsfLKSFTLYSIFVLTFSLCFYILFGKSVEEDQSKSATPCPPLGKKEGKDEEQG 677
Cdd:cd22197 443 LYYTRGFQHTGIYSVMIqkvILRDL----LRFLLVYLVFLFGFAVALVSLSREAPSPKAPEDNNSTVTEQPTVGQEEEPA 518
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24762781 678 F--NTFTKPIEAVIKTIVMLTGEFDAgSIQFTSIYTYLIfLLFVIFMTIVLFNLLNGL 733
Cdd:cd22197 519 PyrSILDASLELFKFTIGMGELAFQE-QLRFRGVVLLLL-LAYVLLTYVLLLNMLIAL 574
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
240-405 3.09e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.79  E-value: 3.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 240 AEYLQNLKGGADNQLNAHQEEYFGLLQESIKRGRQRAFDVILSTGMDINSRpgRANEANLVETAVIYGNWQALERLLK-- 317
Cdd:COG0666  33 LLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK--DDGGNTLLHAAARNGDLEIVKLLLEag 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 318 -EPNLRLTPDSKLLNAVIGRldeppydgsSHQRCFELLINSDrVDINEADSGRLVPLFFAVKYRNTSAMQKLLKNGAYIG 396
Cdd:COG0666 111 aDVNARDKDGETPLHLAAYN---------GNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN 180

                ....*....
gi 24762781 397 SKSAFGTLP 405
Cdd:COG0666 181 ARDNDGETP 189
PHA02878 PHA02878
ankyrin repeat protein; Provisional
42-177 2.20e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 2.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   42 DRHTSIYEKALSTPGCRDFIEACI-----DHGSQVNYINKKLDKAAISYAADSRDpgnlaallkyrpgnkvqvdrkygql 116
Cdd:PHA02878 126 KNIQTIDLVYIDKKSKDDIIEAEItklllSYGADINMKDRHKGNTALHYATENKD------------------------- 180
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24762781  117 tplnslaknltdenapdvYSCMQLLLDYGASPNIVDQGEFTPLHHVLRKSKvKAGKKELIQ 177
Cdd:PHA02878 181 ------------------QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYN-KPIVHILLE 222
Ank_2 pfam12796
Ankyrin repeats (3 copies);
303-398 2.86e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.79  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781   303 AVIYGNWQALERLLK---EPNLRLTPDSKLLNAVIGRldeppydgsSHQRCFELLInsDRVDINEADSGRLvPLFFAVKY 379
Cdd:pfam12796   4 AAKNGNLELVKLLLEngaDANLQDKNGRTALHLAAKN---------GHLEIVKLLL--EHADVNLKDNGRT-ALHYAARS 71
                          90
                  ....*....|....*....
gi 24762781   380 RNTSAMQKLLKNGAYIGSK 398
Cdd:pfam12796  72 GHLEIVKLLLEKGADINVK 90
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
468-733 9.24e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 39.79  E-value: 9.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 468 SKEMRH--LLQHPLiSSFLFLKWHR-LSVIFYLNFLIYSLFtasIITYTLLKFHESDQRALTAFFG------------LL 532
Cdd:cd22196 297 ETPNRHemLLVEPL-NKLLQDKWDKfVKRIFYFNFFVYFIY---MIIFTLAAYYRPVNKTPPFPIEnttgeylrltgeII 372
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 533 SWLGISYLILREcIQWIMSPvRYFWS---ITNIMEVALITLSIFTcMESSFDKETQRVLAVftillVSMEFCLLVGSLPV 609
Cdd:cd22196 373 SVSGGVYFFFRG-IQYFLQR-RPSLKkliVDSYCEILFFVQSLFL-LASTVLYFCGRNEYV-----AFMVISLALGWANV 444
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24762781 610 L------------SISTHMLMLREVsnsfLKSFTLYSIFVLTFSLCFYILfgksVEEDQSKSATPCPPlGKKEGKDEEQG 677
Cdd:cd22196 445 LyytrgfqqmgiySVMIQKMILRDI----CRFLFVYLVFLFGFSAALVTL----IEDGPPKGDVNTSQ-KECVCKSGYNS 515
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24762781 678 FNTFTKPIEAVIK-TIVMltgefdaGSIQFTSIYTY---LIFLL--FVIFMTIVLFNLLNGL 733
Cdd:cd22196 516 YNSLYSTCLELFKfTIGM-------GDLEFTENYKFkevFIFLLisYVILTYILLLNMLIAL 570
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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