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Conserved domains on  [gi|24654848|ref|NP_612054|]
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uncharacterized protein Dmel_CG13894 [Drosophila melanogaster]

Protein Classification

DNA-binding domain-containing protein( domain architecture ID 10659618)

DNA-binding domain-containing protein containing a Tc5 transposase-like DNA-binding domain; similar to Chaetomium globosum chaetoglobosin A biosynthesis cluster protein C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 6-82 1.80e-16

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 214951  Cd Length: 80  Bit Score: 74.39  E-value: 1.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654848      6 RCCIIGCLSNSRQHPSMQFFAFPRPENPFHKLWKEAC-HASLRRIVPFKKPVVCALHFDPSVLG--GRRLQSNALPTLRL 82
Cdd:smart00980   1 KCCVPGCGNRSKKNPGLSFFRFPKEDPELRKKWLENLgLPDDPNRKPKKRSRICSRHFEPDDFDnsGRRLKPGAVPTLFL 80
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
104-165 3.25e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


:

Pssm-ID: 197828  Cd Length: 66  Bit Score: 67.32  E-value: 3.25e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654848    104 RKCAYINAVVYEWLVRANinpQLRGSITHGMIKDKAENARQVIGSTSFIADNRWLNRFRETH 165
Cdd:smart00674   2 RLYPLLEKALYEWILRQE---ALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRH 60
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 6-82 1.80e-16

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 74.39  E-value: 1.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654848      6 RCCIIGCLSNSRQHPSMQFFAFPRPENPFHKLWKEAC-HASLRRIVPFKKPVVCALHFDPSVLG--GRRLQSNALPTLRL 82
Cdd:smart00980   1 KCCVPGCGNRSKKNPGLSFFRFPKEDPELRKKWLENLgLPDDPNRKPKKRSRICSRHFEPDDFDnsGRRLKPGAVPTLFL 80
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
104-165 3.25e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 67.32  E-value: 3.25e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654848    104 RKCAYINAVVYEWLVRANinpQLRGSITHGMIKDKAENARQVIGSTSFIADNRWLNRFRETH 165
Cdd:smart00674   2 RLYPLLEKALYEWILRQE---ALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRH 60
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 7-80 1.34e-13

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 66.02  E-value: 1.34e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654848     7 CCIIGCLSNSRQHPSMQFFAFPRPENPFHKlWKEACHasLRRIVPFKKPVVCALHFDPS----VLGGRRLQSNALPTL 80
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPKDPERRKK-WLNACK--RKDLPPPSNSYVCSLHFEENdfekSGGKRKLKPGAIPTL 75
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
107-165 1.61e-06

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 45.31  E-value: 1.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654848   107 AYINAVVYEWLVRAninpQLRG-SITHGMIKDKAE---NARQVIGSTSFIADNRWLNRFRETH 165
Cdd:pfam03221   2 PDLEKALYEWILQL----RARGiPITGPMIREKALelaQLAADLGEPDFKASKGWLDRFKKRH 60
 
Name Accession Description Interval E-value
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 6-82 1.80e-16

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 74.39  E-value: 1.80e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654848      6 RCCIIGCLSNSRQHPSMQFFAFPRPENPFHKLWKEAC-HASLRRIVPFKKPVVCALHFDPSVLG--GRRLQSNALPTLRL 82
Cdd:smart00980   1 KCCVPGCGNRSKKNPGLSFFRFPKEDPELRKKWLENLgLPDDPNRKPKKRSRICSRHFEPDDFDnsGRRLKPGAVPTLFL 80
CENPB smart00674
Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;
104-165 3.25e-14

Putative DNA-binding domain in centromere protein B, mouse jerky and transposases;


Pssm-ID: 197828  Cd Length: 66  Bit Score: 67.32  E-value: 3.25e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654848    104 RKCAYINAVVYEWLVRANinpQLRGSITHGMIKDKAENARQVIGSTSFIADNRWLNRFRETH 165
Cdd:smart00674   2 RLYPLLEKALYEWILRQE---ALGIPISGEDIREKALEILQRLGLENFKASKGWLTRFKKRH 60
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 7-80 1.34e-13

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 66.02  E-value: 1.34e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654848     7 CCIIGCLSNSRQHPSMQFFAFPRPENPFHKlWKEACHasLRRIVPFKKPVVCALHFDPS----VLGGRRLQSNALPTL 80
Cdd:pfam05485   1 CSVPGCTNRKKKNPRTSFHKFPKDPERRKK-WLNACK--RKDLPPPSNSYVCSLHFEENdfekSGGKRKLKPGAIPTL 75
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
24-83 5.94e-10

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 55.01  E-value: 5.94e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654848     24 FFAFPRpENPFHKLWKEACHASLRrIVPFKKPVVCALHFDPSVLGGR-RLQSNALPTLRLE 83
Cdd:smart00692   1 LFRFPK-DPELLKKWEHNLRLSPD-EKKLKNSRICSRHFEPECFGKRrRLKPGAVPTLELG 59
HTH_Tnp_Tc5 pfam03221
Tc5 transposase DNA-binding domain;
107-165 1.61e-06

Tc5 transposase DNA-binding domain;


Pssm-ID: 460850  Cd Length: 63  Bit Score: 45.31  E-value: 1.61e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654848   107 AYINAVVYEWLVRAninpQLRG-SITHGMIKDKAE---NARQVIGSTSFIADNRWLNRFRETH 165
Cdd:pfam03221   2 PDLEKALYEWILQL----RARGiPITGPMIREKALelaQLAADLGEPDFKASKGWLDRFKKRH 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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