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Conserved domains on  [gi|2491778665|ref|NP_620179|]
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NLR family, apoptosis inhibitory protein 6 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 766-872 4.77e-48

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


:

Pssm-ID: 436120  Cd Length: 106  Bit Score: 166.69  E-value: 4.77e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  766 EDQDLGLYYLRQINSPLKAMSIYHTFLRYvSNHPSSKAGPKVISHLLQLVDEKESPENTSENEDYMKLHPETLLWSQCLR 845
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 2491778665  846 GLLQLSPESFSLFISERLLNIALNFAY 872
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 464-618 6.07e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 6.07e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  464 SVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLnrFQLVFYLSLRSIRADQ---GLADIICAQLLEAGGCISEVslSSGIQ 540
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSEV--WAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  541 HLQHQVLFLLDDYSGMDSLPQALDT----------LITKNYLSRTCLLMAVHTNRVRDIRPYLET--VLQIKEFPFYNTV 608
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGQLDGpcpvltllssLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 2491778665  609 YILKKIFSHD 618
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 1.68e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


:

Pssm-ID: 197595  Cd Length: 71  Bit Score: 120.89  E-value: 1.68e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491778665   159 EEARLESFEDWPFYAHgTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS 229
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 280-346 2.50e-29

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


:

Pssm-ID: 237989  Cd Length: 69  Bit Score: 111.59  E-value: 2.50e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665  280 LRMDTFKDWPHESPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:cd00022      2 ARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 1.19e-20

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


:

Pssm-ID: 459891  Cd Length: 68  Bit Score: 86.94  E-value: 1.19e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665   63 RLKTFVTY--DTFRSWTPQEMAAAGFYYTGVRHGVQCFCCSLILFATRLRKVPIEVHRKLQPECEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1050-1339 4.95e-10

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 4.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1050 LNKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSGTSQIPDQLFHNLDKFLGLKELSVRLDGTQDMLSVLPGEFPNLH 1129
Cdd:COG4886     17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1130 HMEKLSIHTSTE-SDLSKLVKLIQNSPNLHDF--------HLKCDFLSNC--ESLMAALASCKKLREIEFSGRCFEAVPf 1198
Cdd:COG4886     97 NLTELDLSGNEElSNLTNLESLDLSGNQLTDLpeelanltNLKELDLSNNqlTDLPEPLGNLTNLKSLDLSNNQLTDLP- 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1199 vNILSNFASLKILNLRNQQFPDketsekFAQALGSLRNLEELHLpTGDGIHQVAKPIvrrclqlpclrvlvfaetlddds 1278
Cdd:COG4886    176 -EELGNLTNLKELDLSNNQITD------LPEPLGNLTNLEELDL-SGNQLTDLPEPL----------------------- 224

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2491778665 1279 vleiakgatsGGFQNLENLDLTLNhKITEegyrnfFQALDNLPNLQNLDIS----RHIPECIQVQ 1339
Cdd:COG4886    225 ----------ANLTNLETLDLSNN-QLTD------LPELGNLTNLEELDLSnnqlTDLPPLANLT 272
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 766-872 4.77e-48

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 166.69  E-value: 4.77e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  766 EDQDLGLYYLRQINSPLKAMSIYHTFLRYvSNHPSSKAGPKVISHLLQLVDEKESPENTSENEDYMKLHPETLLWSQCLR 845
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 2491778665  846 GLLQLSPESFSLFISERLLNIALNFAY 872
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 464-618 6.07e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 6.07e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  464 SVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLnrFQLVFYLSLRSIRADQ---GLADIICAQLLEAGGCISEVslSSGIQ 540
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSEV--WAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  541 HLQHQVLFLLDDYSGMDSLPQALDT----------LITKNYLSRTCLLMAVHTNRVRDIRPYLET--VLQIKEFPFYNTV 608
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGQLDGpcpvltllssLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 2491778665  609 YILKKIFSHD 618
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 1.68e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 120.89  E-value: 1.68e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491778665   159 EEARLESFEDWPFYAHgTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS 229
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 4.75e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 119.30  E-value: 4.75e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2491778665  162 RLESFEDWPFYAHGT-SPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 160-229 6.22e-31

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 116.21  E-value: 6.22e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  160 EARLESFEDWPfYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS 229
Cdd:cd00022      1 EARLKTFKNWP-ISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 280-346 2.50e-29

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 111.59  E-value: 2.50e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665  280 LRMDTFKDWPHESPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:cd00022      2 ARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-346 4.12e-29

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 111.21  E-value: 4.12e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2491778665  281 RMDTFKDWPHE--SPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:pfam00653    1 RLATFENWPHSnkSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 277-346 4.90e-29

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 110.87  E-value: 4.90e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665   277 NEGLRMDTFKDWPHESPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVR 70
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 1.19e-20

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 86.94  E-value: 1.19e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665   63 RLKTFVTY--DTFRSWTPQEMAAAGFYYTGVRHGVQCFCCSLILFATRLRKVPIEVHRKLQPECEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-127 3.19e-20

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 85.78  E-value: 3.19e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665   61 AKRLKTFVTYDTFRSWTPQEMAAAGFYYTGVRHGVQCFCCSLILFATRLRKVPIEVHRKLQPECEFL 127
Cdd:cd00022      1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFV 67
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
457-919 9.77e-18

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 89.48  E-value: 9.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  457 EVFANLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRfqLVFYLSLRSIRADQGLADIICAQLLEAGGcisevSLS 536
Cdd:COG5635    174 ELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGG-----EPE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  537 SGIQHL--QHQVLFLLDdysGMDSLPQALDTLITKNYLSRtcLLMAVHTNRV----RDI---RPYLE--TVLQIKEFPFY 605
Cdd:COG5635    247 DALERLlrNGRLLLLLD---GLDEVPDEADRDEVLNQLRR--FLERYPKARViitsRPEgydSSELEgfEVLELAPLSDE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  606 NTVYILKKIFSHDIIRVRRFINYFGFHEYLQGIHKTPLFVAgVCADWLQNPSDQPFQDVTIFKSYMQYLFLKHKATAGPL 685
Cdd:COG5635    322 QIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLT-LLALLLRERGELPDTRAELYEQFVELLLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  686 QATVSS-------CGHLALTGLFSSSFEFSSDDLieagvdeDEELSTCLMSKFTAQRL---------------RPVYRFL 743
Cdd:COG5635    401 IYRELSreelrelLSELALAMQENGRTEFAREEL-------EEILREYLGRRKDAEALldelllrtgllvergEGRYSFA 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  744 SPLFQEFLAAMRLSELLGSDSQEdqdlglyylrQINSPLKAMSIYHTFLRYVSNHPSSKAGPKVISHLLQLVDEKESPEN 823
Cdd:COG5635    474 HRSFQEYLAARALVEELDEELLE----------LLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALALA 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  824 TSENEDYMKLHPETLLWSQCLRGLLQLSPESFSLFISERLLNIALNFAYQSNTVAACSPVILQFLQGRTLDLKVLNLQYF 903
Cdd:COG5635    544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLA 623

                          490
                   ....*....|....*.
gi 2491778665  904 WDHPETLLLLKSIQVL 919
Cdd:COG5635    624 LLLLLLLLLLAELLLL 639
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1050-1339 4.95e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 4.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1050 LNKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSGTSQIPDQLFHNLDKFLGLKELSVRLDGTQDMLSVLPGEFPNLH 1129
Cdd:COG4886     17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1130 HMEKLSIHTSTE-SDLSKLVKLIQNSPNLHDF--------HLKCDFLSNC--ESLMAALASCKKLREIEFSGRCFEAVPf 1198
Cdd:COG4886     97 NLTELDLSGNEElSNLTNLESLDLSGNQLTDLpeelanltNLKELDLSNNqlTDLPEPLGNLTNLKSLDLSNNQLTDLP- 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1199 vNILSNFASLKILNLRNQQFPDketsekFAQALGSLRNLEELHLpTGDGIHQVAKPIvrrclqlpclrvlvfaetlddds 1278
Cdd:COG4886    176 -EELGNLTNLKELDLSNNQITD------LPEPLGNLTNLEELDL-SGNQLTDLPEPL----------------------- 224

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2491778665 1279 vleiakgatsGGFQNLENLDLTLNhKITEegyrnfFQALDNLPNLQNLDIS----RHIPECIQVQ 1339
Cdd:COG4886    225 ----------ANLTNLETLDLSNN-QLTD------LPELGNLTNLEELDLSnnqlTDLPPLANLT 272
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1080-1329 2.83e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 2.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1080 QSLEVSGTSQIPDQLFHNLDK---FLGLKELSVRLDGTQDMLSVLPgEFPNLHHMEkLSIHTSTEsDLSKLVKLIQNSPN 1156
Cdd:cd00116     33 NTLGEEAAKALASALRPQPSLkelCLSLNETGRIPRGLQSLLQGLT-KGCGLQELD-LSDNALGP-DGCGVLESLLRSSS 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1157 LHDFHL------------KCDFL-------------------SNCESLMAALASCKKLREIEFS-----GRCFEAVpfVN 1200
Cdd:cd00116    110 LQELKLnnnglgdrglrlLAKGLkdlppaleklvlgrnrlegASCEALAKALRANRDLKELNLAnngigDAGIRAL--AE 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1201 ILSNFASLKILNLRNQQFPDKETSeKFAQALGSLRNLEELHLptgdgihqvakpivRRCLqlpclrvlvfaetLDDDSVL 1280
Cdd:cd00116    188 GLKANCNLEVLDLNNNGLTDEGAS-ALAETLASLKSLEVLNL--------------GDNN-------------LTDAGAA 239

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2491778665 1281 EIAKgATSGGFQNLENLDLTLNHkITEEGYRNFFQALDNLPNLQNLDIS 1329
Cdd:cd00116    240 ALAS-ALLSPNISLLTLSLSCND-ITDDGAKDLAEVLAEKESLLELDLR 286
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 452-567 6.23e-03

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 39.23  E-value: 6.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  452 ALTIPEVFANLSSVMCVEGEAGSGKTTFLKRIafLWASGCC------PLLNRFQLVFYLSLRSIrADQGLADIICAQLLE 525
Cdd:cd03238     10 NLQNLDVSIPLNVLVVVTGVSGSGKSTLVNEG--LYASGKArlisflPKFSRNKLIFIDQLQFL-IDVGLGYLTLGQKLS 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2491778665  526 --AGGCISEVSLSSGIQHLQHQVLFLLDDYS-GMDslPQALDTLI 567
Cdd:cd03238     87 tlSGGELQRVKLASELFSEPPGTLFILDEPStGLH--QQDINQLL 129
 
Name Accession Description Interval E-value
NLRC4_HD pfam17889
NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and ...
 766-872 4.77e-48

NLRC4 helical domain; This is a helical domain found in NLRC4, Nucleotide-binding and oligomerization domain-like receptor (NLR) proteins. Structural and functional studies indicate that the helical domain HD2 repressively contacted a conserved and functionally important alpha-helix of the NBD (nucleotide binding domain) in Swiss:Q3UP24. Furthermore, the HD2 domain was shown to cap the N-terminal side of the LRR (leucine-rich repeat) domain via extensive interactions. Other family members carrying this domain include baculoviral IAP repeat-containing protein 1 (Birc1) also known as neuronal apoptosis inhibitory protein (Naip).


Pssm-ID: 436120  Cd Length: 106  Bit Score: 166.69  E-value: 4.77e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  766 EDQDLGLYYLRQINSPLKAMSIYHTFLRYvSNHPSSKAGPKVISHLLQLVDEKESPENTSENEDYMKLHPETLLWSQCLR 845
Cdd:pfam17889    1 EDQDLGLYYLKQINSILKAVSRYNNFLLY-TCHSSTKAGPKIVSHLLHLVDHKESLENLSENDDYLKHHPETSLLMQNIR 79

                           90       100
                   ....*....|....*....|....*..
gi 2491778665  846 GLLQLSPESFSLFISERLLNIALNFAY 872
Cdd:pfam17889   80 SLWQLSPELYLSSVSEHLLSLALEIAY 106
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 464-618 6.07e-38

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 140.13  E-value: 6.07e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  464 SVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLnrFQLVFYLSLRSIRADQ---GLADIICAQLLEAGGCISEVslSSGIQ 540
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQG--FDFVFFLPCRELSRSGnarSLADLLFSQWPEPAAPVSEV--WAVIL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  541 HLQHQVLFLLDDYSGMDSLPQALDT----------LITKNYLSRTCLLMAVHTNRVRDIRPYLET--VLQIKEFPFYNTV 608
Cdd:pfam05729   77 ELPERLLLILDGLDELVSDLGQLDGpcpvltllssLLRKKLLPGASLLLTVRPDALRDLRRGLEEprYLEVRGFSESDRK 156

                          170
                   ....*....|
gi 2491778665  609 YILKKIFSHD 618
Cdd:pfam05729  157 QYVRKYFSDE 166
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 159-229 1.68e-32

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 120.89  E-value: 1.68e-32
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2491778665   159 EEARLESFEDWPFYAHgTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS 229
Cdd:smart00238    2 EEARLKTFQNWPYNSK-CTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVRN 71
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 162-228 4.75e-32

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 119.30  E-value: 4.75e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2491778665  162 RLESFEDWPFYAHGT-SPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQ 228
Cdd:pfam00653    1 RLATFENWPHSNKSPpTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 160-229 6.22e-31

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 116.21  E-value: 6.22e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  160 EARLESFEDWPfYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLQS 229
Cdd:cd00022      1 EARLKTFKNWP-ISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVLL 69
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 280-346 2.50e-29

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 111.59  E-value: 2.50e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665  280 LRMDTFKDWPHESPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:cd00022      2 ARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFVL 68
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 281-346 4.12e-29

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 111.21  E-value: 4.12e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2491778665  281 RMDTFKDWPHE--SPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:pfam00653    1 RLATFENWPHSnkSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFLK 68
BIR smart00238
Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis ...
 277-346 4.90e-29

Baculoviral inhibition of apoptosis protein repeat; Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. Acts as a direct inhibitor of caspase enzymes.


Pssm-ID: 197595  Cd Length: 71  Bit Score: 110.87  E-value: 4.90e-29
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665   277 NEGLRMDTFKDWPHESPMAVEALVKAGLFYTGKKDIVQCFSCGGCMENWKEGDDPIEDHTKFFPNCVFLQ 346
Cdd:smart00238    1 SEEARLKTFQNWPYNSKCTPEQLAEAGFYYTGVGDEVKCFFCGGELDNWEPGDDPWEEHKKWSPNCPFVR 70
BIR pfam00653
Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein ...
 63-127 1.19e-20

Inhibitor of Apoptosis domain; BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.


Pssm-ID: 459891  Cd Length: 68  Bit Score: 86.94  E-value: 1.19e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665   63 RLKTFVTY--DTFRSWTPQEMAAAGFYYTGVRHGVQCFCCSLILFATRLRKVPIEVHRKLQPECEFL 127
Cdd:pfam00653    1 RLATFENWphSNKSPPTPEELAEAGFYYTGTGDRVQCFYCGLELDGWEEGDDPWEEHKKHSPDCPFL 67
BIR cd00022
Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis ...
 61-127 3.19e-20

Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. In yeast, BIR domains are involved in regulating cytokinesis. This novel fold is stabilized by zinc tetrahedrally coordinated by one histidine and three cysteine residues and resembles a classical zinc finger.


Pssm-ID: 237989  Cd Length: 69  Bit Score: 85.78  E-value: 3.19e-20
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2491778665   61 AKRLKTFVTYDTFRSWTPQEMAAAGFYYTGVRHGVQCFCCSLILFATRLRKVPIEVHRKLQPECEFL 127
Cdd:cd00022      1 EARLKTFKNWPISLKVTPEKLAEAGFYYTGRGDEVKCFFCGLELKNWEPGDDPWEEHKRWSPNCPFV 67
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
457-919 9.77e-18

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 89.48  E-value: 9.77e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  457 EVFANLSSVMCVEGEAGSGKTTFLKRIAFLWASGCCPLLNRfqLVFYLSLRSIRADQGLADIICAQLLEAGGcisevSLS 536
Cdd:COG5635    174 ELLEAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEDP--IPILIELRDLAEEASLEDLLAEALEKRGG-----EPE 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  537 SGIQHL--QHQVLFLLDdysGMDSLPQALDTLITKNYLSRtcLLMAVHTNRV----RDI---RPYLE--TVLQIKEFPFY 605
Cdd:COG5635    247 DALERLlrNGRLLLLLD---GLDEVPDEADRDEVLNQLRR--FLERYPKARViitsRPEgydSSELEgfEVLELAPLSDE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  606 NTVYILKKIFSHDIIRVRRFINYFGFHEYLQGIHKTPLFVAgVCADWLQNPSDQPFQDVTIFKSYMQYLFLKHKATAGPL 685
Cdd:COG5635    322 QIEEFLKKWFEATERKAERLLEALEENPELRELARNPLLLT-LLALLLRERGELPDTRAELYEQFVELLLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  686 QATVSS-------CGHLALTGLFSSSFEFSSDDLieagvdeDEELSTCLMSKFTAQRL---------------RPVYRFL 743
Cdd:COG5635    401 IYRELSreelrelLSELALAMQENGRTEFAREEL-------EEILREYLGRRKDAEALldelllrtgllvergEGRYSFA 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  744 SPLFQEFLAAMRLSELLGSDSQEdqdlglyylrQINSPLKAMSIYHTFLRYVSNHPSSKAGPKVISHLLQLVDEKESPEN 823
Cdd:COG5635    474 HRSFQEYLAARALVEELDEELLE----------LLAEHLEDPRWREVLLLLAGLLDDVKQIKELIDALLARDDAAALALA 543

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  824 TSENEDYMKLHPETLLWSQCLRGLLQLSPESFSLFISERLLNIALNFAYQSNTVAACSPVILQFLQGRTLDLKVLNLQYF 903
Cdd:COG5635    544 AALLLALLLALALLALLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLA 623

                          490
                   ....*....|....*.
gi 2491778665  904 WDHPETLLLLKSIQVL 919
Cdd:COG5635    624 LLLLLLLLLLAELLLL 639
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1050-1339 4.95e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 4.95e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1050 LNKTSVTKCSMSRLELSRAEQELLLTLPALQSLEVSGTSQIPDQLFHNLDKFLGLKELSVRLDGTQDMLSVLPGEFPNLH 1129
Cdd:COG4886     17 LLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLT 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1130 HMEKLSIHTSTE-SDLSKLVKLIQNSPNLHDF--------HLKCDFLSNC--ESLMAALASCKKLREIEFSGRCFEAVPf 1198
Cdd:COG4886     97 NLTELDLSGNEElSNLTNLESLDLSGNQLTDLpeelanltNLKELDLSNNqlTDLPEPLGNLTNLKSLDLSNNQLTDLP- 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1199 vNILSNFASLKILNLRNQQFPDketsekFAQALGSLRNLEELHLpTGDGIHQVAKPIvrrclqlpclrvlvfaetlddds 1278
Cdd:COG4886    176 -EELGNLTNLKELDLSNNQITD------LPEPLGNLTNLEELDL-SGNQLTDLPEPL----------------------- 224

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2491778665 1279 vleiakgatsGGFQNLENLDLTLNhKITEegyrnfFQALDNLPNLQNLDIS----RHIPECIQVQ 1339
Cdd:COG4886    225 ----------ANLTNLETLDLSNN-QLTD------LPELGNLTNLEELDLSnnqlTDLPPLANLT 272
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1058-1359 3.45e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 51.33  E-value: 3.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1058 CSMSRLELSRAEQELLLTLPALQSLEVSGTSQIPdQLFHNLDKFLGLKELSVRLDGTQDMLSVLpgefpNLHHMEKLSIH 1137
Cdd:COG5238     98 EEVSPVALAETATAVATPPPDLRRIMAKTLEDSL-ILYLALPRRINLIQVLKDPLGGNAVHLLG-----LAARLGLLAAI 171

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1138 TSTESDLSKlvkliqnspNLHDFHLKCDFLSN--CESLMAALASCKKLREIEFSGRCF---EAVPFVNILSNFASLKILN 1212
Cdd:COG5238    172 SMAKALQNN---------SVETVYLGCNQIGDegIEELAEALTQNTTVTTLWLKRNPIgdeGAEILAEALKGNKSLTTLD 242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1213 LRNQQFPDKETSEkFAQALGSLRNLEELHLpTGDGI-HQVAKPIVRRCLQLPCLRVLVFAET-LDDDSVLEIAKGATsgG 1290
Cdd:COG5238    243 LSNNQIGDEGVIA-LAEALKNNTTVETLYL-SGNQIgAEGAIALAKALQGNTTLTSLDLSVNrIGDEGAIALAEGLQ--G 318

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2491778665 1291 FQNLENLDLTLNhKITEEGYRNFFQALDNLPNLQNLDISRHipeciQVQASTVKALGQCVSRLPSLTRL 1359
Cdd:COG5238    319 NKTLHTLNLAYN-GIGAQGAIALAKALQENTTLHSLDLSDN-----QIGDEGAIALAKYLEGNTTLREL 381
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1080-1329 2.83e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 47.74  E-value: 2.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1080 QSLEVSGTSQIPDQLFHNLDK---FLGLKELSVRLDGTQDMLSVLPgEFPNLHHMEkLSIHTSTEsDLSKLVKLIQNSPN 1156
Cdd:cd00116     33 NTLGEEAAKALASALRPQPSLkelCLSLNETGRIPRGLQSLLQGLT-KGCGLQELD-LSDNALGP-DGCGVLESLLRSSS 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1157 LHDFHL------------KCDFL-------------------SNCESLMAALASCKKLREIEFS-----GRCFEAVpfVN 1200
Cdd:cd00116    110 LQELKLnnnglgdrglrlLAKGLkdlppaleklvlgrnrlegASCEALAKALRANRDLKELNLAnngigDAGIRAL--AE 187

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1201 ILSNFASLKILNLRNQQFPDKETSeKFAQALGSLRNLEELHLptgdgihqvakpivRRCLqlpclrvlvfaetLDDDSVL 1280
Cdd:cd00116    188 GLKANCNLEVLDLNNNGLTDEGAS-ALAETLASLKSLEVLNL--------------GDNN-------------LTDAGAA 239

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 2491778665 1281 EIAKgATSGGFQNLENLDLTLNHkITEEGYRNFFQALDNLPNLQNLDIS 1329
Cdd:cd00116    240 ALAS-ALLSPNISLLTLSLSCND-ITDDGAKDLAEVLAEKESLLELDLR 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1073-1330 3.01e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 3.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1073 LLTLPALQSLEVSGT--SQIPDQLFhNLDKflgLKELSvrLDGTQdmLSVLPGEFPNLHHMEKLSIHTSTESDLSKLVKL 1150
Cdd:COG4886    178 LGNLTNLKELDLSNNqiTDLPEPLG-NLTN---LEELD--LSGNQ--LTDLPEPLANLTNLETLDLSNNQLTDLPELGNL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1151 iqnspnlhdfhlkcdflsnceslmaalascKKLREIEFSGRCFEAVPFvniLSNFASLKILNLRNQQFPDketsekfaqa 1230
Cdd:COG4886    250 ------------------------------TNLEELDLSNNQLTDLPP---LANLTNLKTLDLSNNQLTD---------- 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1231 lgslRNLEELHLPTGDGIHQVAKPIVRRCLQLPCLRVLVFAETLDDDSVLEIAKGATSGGFQNLENLDLTLNHKITEEGY 1310
Cdd:COG4886    287 ----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                          250       260
                   ....*....|....*....|
gi 2491778665 1311 RNFFQALDNLPNLQNLDISR 1330
Cdd:COG4886    363 LTLLLTLGLLGLLEATLLTL 382
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 1107-1330 1.07e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1107 LSVRLDGTQDMLSVLPGEFPNLHHME--KLSIHTSTESDLSKLVKLIQNSPNLHDFHLKCDFL----SNCESLMAALASC 1180
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCLQvlRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETgripRGLQSLLQGLTKG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1181 KKLREIEFS--GRCFEAVPFVNILSNFASLKILNLRNQQFPDkeTSEKF-AQALGSLR-NLEELHLP----TGDGIHQVA 1252
Cdd:cd00116     81 CGLQELDLSdnALGPDGCGVLESLLRSSSLQELKLNNNGLGD--RGLRLlAKGLKDLPpALEKLVLGrnrlEGASCEALA 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1253 K--PIVRRclqlpcLRVLVFAET-LDDDSVLEIAKGATSggFQNLENLDLTLNhKITEEGYRNFFQALDNLPNLQNLDIS 1329
Cdd:cd00116    159 KalRANRD------LKELNLANNgIGDAGIRALAEGLKA--NCNLEVLDLNNN-GLTDEGASALAETLASLKSLEVLNLG 229


                   .
gi 2491778665 1330 R 1330
Cdd:cd00116    230 D 230
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 1072-1270 5.05e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 40.00  E-value: 5.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1072 LLLTLPALQSLEVSGTSQIPDQLFHNLDKFlglkELSV--RLDGTQDMLSvlpgefpNLHHMEKLSIHTSTESDLSKLVK 1149
Cdd:cd09293      4 LLFILHKLGQITQSNISQLLRILHSGLEWL----ELYMcpISDPPLDQLS-------NCNKLKKLILPGSKLIDDEGLIA 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665 1150 LIQNSPNLHDFHLK-CDFLSNcESLMAALASCKKLREIEFsGRCFEAvpfvnILSNFASLKIL-----NLRNQQFPDKET 1223
Cdd:cd09293     73 LAQSCPNLQVLDLRaCENITD-SGIVALATNCPKLQTINL-GRHRNG-----HLITDVSLSALgknctFLQTVGFAGCDV 145

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2491778665 1224 SEKFAQALGSLR--NLEELHLPTGDGIHQVAKPIVRRCLQLPCLRVLVF 1270
Cdd:cd09293    146 TDKGVWELASGCskSLERLSLNNCRNLTDQSIPAILASNYFPNLSVLEF 194
ABC_UvrA cd03238
ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in ...
 452-567 6.23e-03

ATP-binding cassette domain of the excision repair protein UvrA; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep ATP-dependent reaction that requires the UvrA, UvrB, and UvrC proteins. Both UvrA and UvrB are ATPases, with UvrA having two ATP binding sites, which have the characteristic signature of the family of ABC proteins, and UvrB having one ATP binding site that is structurally related to that of helicases.


Pssm-ID: 213205 [Multi-domain]  Cd Length: 176  Bit Score: 39.23  E-value: 6.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2491778665  452 ALTIPEVFANLSSVMCVEGEAGSGKTTFLKRIafLWASGCC------PLLNRFQLVFYLSLRSIrADQGLADIICAQLLE 525
Cdd:cd03238     10 NLQNLDVSIPLNVLVVVTGVSGSGKSTLVNEG--LYASGKArlisflPKFSRNKLIFIDQLQFL-IDVGLGYLTLGQKLS 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 2491778665  526 --AGGCISEVSLSSGIQHLQHQVLFLLDDYS-GMDslPQALDTLI 567
Cdd:cd03238     87 tlSGGELQRVKLASELFSEPPGTLFILDEPStGLH--QQDINQLL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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