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Conserved domains on  [gi|24664423|ref|NP_648739|]
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uncharacterized protein Dmel_CG18649, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CobT2 super family cl34772
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-91 3.60e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG4547:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 40.16  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664423  24 DIDDLEDLEEDKR--------------IADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQ 89
Cdd:COG4547 180 DLDRLAELLDDQAafaravrdllrdldLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDA 259


                ..
gi 24664423  90 DE 91
Cdd:COG4547 260 EE 261
 
Name Accession Description Interval E-value
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-91 3.60e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 40.16  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664423  24 DIDDLEDLEEDKR--------------IADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQ 89
Cdd:COG4547 180 DLDRLAELLDDQAafaravrdllrdldLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDA 259


                ..
gi 24664423  90 DE 91
Cdd:COG4547 260 EE 261
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 23-71 8.79e-05

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 39.13  E-value: 8.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 24664423    23 VDIDDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPED 71
Cdd:pfam05327 215 VELEDLDDDEDEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDE 263
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 24-92 6.07e-04

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 36.90  E-value: 6.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24664423   24 DIDDLEDLEEDKRiADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQDEE 92
Cdd:PRK05901 138 DDDDLDDDDIDDD-DDDEDDDEDDDDDDVDDEDEEKKEAKELEKLSDDDDFVWDEDDSEALRQARKDAK 205
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 32-84 1.15e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 36.13  E-value: 1.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24664423     32 EEDKRIADEQDNANDDEK---DDEDSNEPESDDDLDEPESPEDDSQNNDDSESDES 84
Cdd:TIGR00927  833 GEQELNAENQGEAKQDEKgvdGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEE 888
 
Name Accession Description Interval E-value
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-91 3.60e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 40.16  E-value: 3.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664423  24 DIDDLEDLEEDKR--------------IADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQ 89
Cdd:COG4547 180 DLDRLAELLDDQAafaravrdllrdldLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDA 259


                ..
gi 24664423  90 DE 91
Cdd:COG4547 260 EE 261
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 26-92 6.22e-05

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 39.78  E-value: 6.22e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24664423  26 DDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQDEE 92
Cdd:COG4547 209 EELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESDEMA 275
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 23-71 8.79e-05

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 39.13  E-value: 8.79e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 24664423    23 VDIDDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPED 71
Cdd:pfam05327 215 VELEDLDDDEDEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDE 263
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 27-92 1.73e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 38.24  E-value: 1.73e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24664423  27 DLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQDEE 92
Cdd:COG4547 206 DLAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAES 271
RRN3 pfam05327
RNA polymerase I specific transcription initiation factor RRN3; This family consists of ...
 23-87 2.04e-04

RNA polymerase I specific transcription initiation factor RRN3; This family consists of several eukaryotic proteins which are homologous to the yeast RRN3 protein. RRN3 is one of the RRN genes specifically required for the transcription of rDNA by RNA polymerase I (Pol I) in Saccharomyces cerevisiae.


Pssm-ID: 461623  Cd Length: 548  Bit Score: 38.36  E-value: 2.04e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24664423    23 VDI-DDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQY 87
Cdd:pfam05327 211 VEIqVELEDLDDDEDEELLEQLDEDDDDDDDDDSDDDSDSSDDGLDDDEEDDEVQRIKKIKELVEK 276
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 31-84 4.69e-04

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 37.22  E-value: 4.69e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 24664423    31 LEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDES 84
Cdd:pfam04931 623 LDARENPEGQQELFEDEDEDEEDDDEEEDDDDEDDEDSEEDDDEDDDDEDEEDD 676
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 29-85 4.73e-04

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 37.22  E-value: 4.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24664423    29 EDLEEDKRI-ADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESI 85
Cdd:pfam04931 627 ENPEGQQELfEDEDEDEEDDDEEEDDDDEDDEDSEEDDDEDDDDEDEEDDDDEDVDEI 684
DNA_pol_phi pfam04931
DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7. ...
 21-83 5.02e-04

DNA polymerase phi; This family includes the fifth essential DNA polymerase in yeast EC:2.7.7.7. Pol5p is localized exclusively to the nucleolus and binds near or at the enhancer region of rRNA-encoding DNA repeating units.


Pssm-ID: 461488  Cd Length: 765  Bit Score: 37.22  E-value: 5.02e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24664423    21 NPVDIDDLEDLEEDkriaDEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDE 83
Cdd:pfam04931 628 NPEGQQELFEDEDE----DEEDDDEEEDDDDEDDEDSEEDDDEDDDDEDEEDDDDEDVDEIDE 686
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 24-92 6.07e-04

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 36.90  E-value: 6.07e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24664423   24 DIDDLEDLEEDKRiADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQDEE 92
Cdd:PRK05901 138 DDDDLDDDDIDDD-DDDEDDDEDDDDDDVDDEDEEKKEAKELEKLSDDDDFVWDEDDSEALRQARKDAK 205
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 32-84 1.15e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 36.13  E-value: 1.15e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24664423     32 EEDKRIADEQDNANDDEK---DDEDSNEPESDDDLDEPESPEDDSQNNDDSESDES 84
Cdd:TIGR00927  833 GEQELNAENQGEAKQDEKgvdGGGGSDGGDSEEEEEEEEEEEEEEEEEEEEEEEEE 888
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 29-85 1.35e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 35.72  E-value: 1.35e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24664423   29 EDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESI 85
Cdd:PRK13108 377 GDLAGQAPAAHQVDAEAASAAPEEPAALASEAHDETEPEVPEKAAPIPDPAKPDELA 433
PTZ00482 PTZ00482
membrane-attack complex/perforin (MACPF) Superfamily; Provisional
 24-85 1.85e-03

membrane-attack complex/perforin (MACPF) Superfamily; Provisional


Pssm-ID: 240433 [Multi-domain]  Cd Length: 844  Bit Score: 35.61  E-value: 1.85e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24664423   24 DIDDLEDLEEDKRiaDEQDNANDDEKDDEDSNEPESDDdldepESPEDDSQNNDDSESDESI 85
Cdd:PTZ00482  90 DDDEFDFLYEDDE--DDAGNATSGESSTDDDSLLELPD-----RDEDADTQANNDQTNDFDQ 144
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-92 7.10e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 34.00  E-value: 7.10e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24664423  24 DIDDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQYNQDEE 92
Cdd:COG4547 217 EEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEEGESEAAEAESDEMAEEAEGEDSEE 285
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 24-83 8.32e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 33.81  E-value: 8.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24664423   24 DIDDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDE 83
Cdd:PRK05901 123 DIDVLNQADDDDDDDDDDDLDDDDIDDDDDDEDDDEDDDDDDVDDEDEEKKEAKELEKLS 182
PRK05901 PRK05901
RNA polymerase sigma factor; Provisional
 16-86 9.92e-03

RNA polymerase sigma factor; Provisional


Pssm-ID: 235640 [Multi-domain]  Cd Length: 509  Bit Score: 33.43  E-value: 9.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24664423   16 ATVSANPVDIDDLEDLEEDKRIADEQDNANDDEKDDEDSNEPESDDDLDEPESPEDDSQNNDDSESDESIQ 86
Cdd:PRK05901 103 SKKAEKKNALDKDDDLNYVKDIDVLNQADDDDDDDDDDDLDDDDIDDDDDDEDDDEDDDDDDVDDEDEEKK 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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