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Conserved domains on  [gi|21355345|ref|NP_648954|]
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PAPS transporter 2 [Drosophila melanogaster]

Protein Classification

DMT family transporter( domain architecture ID 12093821)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; such as yeast UDP-N-acetylglucosamine transporter YEA4 and vertebrate UDP-xylose and UDP-N-acetylglucosamine transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 61-364 1.67e-104

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


:

Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 310.77  E-value: 1.67e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345    61 QFLLSCAGVFFLYILYGYLQELIFTVEGfKPYGWFLTLVQFGYYIGFGLVERRLEgyrisggSFWNIePEPRCIPMRTYL 140
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDI-------FTSKF-LKPRKIPLKTYV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   141 ILAALTLGTMGLSNSSLGY-LNYPTQVIFKCCKLIPVLVGSILIQGKRYGLLDFAAATCMCIGLAWFTL-------ADSQ 212
Cdd:pfam08449  72 ILVALFFITSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSV 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   213 MTPNFNLLGVAMISGALLCDAAIGNVQEKAMREFKAPSSEVVFYSYGLGFVYlfvIMLVTGNFFSGFAFCLEHPVETF-- 290
Cdd:pfam08449 152 VSPNFFLIGIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPF---FLLLQGDLFSAVQFCSQSPDKAVls 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21355345   291 -----GYGFLFSLSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSK 364
Cdd:pfam08449 229 lpsmlFYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 61-364 1.67e-104

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 310.77  E-value: 1.67e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345    61 QFLLSCAGVFFLYILYGYLQELIFTVEGfKPYGWFLTLVQFGYYIGFGLVERRLEgyrisggSFWNIePEPRCIPMRTYL 140
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDI-------FTSKF-LKPRKIPLKTYV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   141 ILAALTLGTMGLSNSSLGY-LNYPTQVIFKCCKLIPVLVGSILIQGKRYGLLDFAAATCMCIGLAWFTL-------ADSQ 212
Cdd:pfam08449  72 ILVALFFITSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSV 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   213 MTPNFNLLGVAMISGALLCDAAIGNVQEKAMREFKAPSSEVVFYSYGLGFVYlfvIMLVTGNFFSGFAFCLEHPVETF-- 290
Cdd:pfam08449 152 VSPNFFLIGIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPF---FLLLQGDLFSAVQFCSQSPDKAVls 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21355345   291 -----GYGFLFSLSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSK 364
Cdd:pfam08449 229 lpsmlFYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 139-367 5.64e-08

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 53.69  E-value: 5.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345 139 YLILAALTLGTMGLSNSSLgyLNYpTQVIFkccklipVLVGSILIQGKRYGLLDFAAATCMCIGLAWFTLADSQMTPNFn 218
Cdd:COG0697  79 AFLLFFLALQYTPAALAAL--LLA-LAPLF-------VALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGS- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345 219 LLGVAMISGALLCdAAIGNVQEKAMREfKAPSSEVVFYSYGLGFVYLFVIMLVTGnffsgfafcLEHPVETFGYGFLFSL 298
Cdd:COG0697 148 LLGDLLALLAALS-WALYTVLTRRLSR-RLDPLTLTFWQMLVGALLLLPLALLTG---------LPLPLSAAAWLALLYL 216

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355345 299 ---SGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSKRNK 367
Cdd:COG0697 217 glfGTALAYLLWFRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERRR 288
 
Name Accession Description Interval E-value
UAA pfam08449
UAA transporter family; This family includes transporters with a specificity for ...
 61-364 1.67e-104

UAA transporter family; This family includes transporters with a specificity for UDP-N-acetylglucosamine.


Pssm-ID: 462479 [Multi-domain]  Cd Length: 307  Bit Score: 310.77  E-value: 1.67e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345    61 QFLLSCAGVFFLYILYGYLQELIFTVEGfKPYGWFLTLVQFGYYIGFGLVERRLEgyrisggSFWNIePEPRCIPMRTYL 140
Cdd:pfam08449   1 QFLLAVSGVFGGCCSNGVLQELIMKVEP-GPFGNLLTFAQFLFYALEGLPESIDI-------FTSKF-LKPRKIPLKTYV 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   141 ILAALTLGTMGLSNSSLGY-LNYPTQVIFKCCKLIPVLVGSILIQGKRYGLLDFAAATCMCIGLAWFTL-------ADSQ 212
Cdd:pfam08449  72 ILVALFFITSVLNNEALKYdISYPTHIIFRSSKLIPVMIMGILILGKRYSKLQYLSAFLVTLGIIIFTLfsakdkvADSV 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   213 MTPNFNLLGVAMISGALLCDAAIGNVQEKAMREFKAPSSEVVFYSYGLGFVYlfvIMLVTGNFFSGFAFCLEHPVETF-- 290
Cdd:pfam08449 152 VSPNFFLIGIAMLSGALLLDAFLGNYQEKTYKKYGKHSKEMLFYSHLLSLPF---FLLLQGDLFSAVQFCSQSPDKAVls 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21355345   291 -----GYGFLFSLSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSK 364
Cdd:pfam08449 229 lpsmlFYLLLNVLTQYVCIRGVFILISEFGALTVTLVTTLRKFVSLLLSILLFGNPFTLQHWVGTLLVFLGTFLYSYSK 307
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 139-367 5.64e-08

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 53.69  E-value: 5.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345 139 YLILAALTLGTMGLSNSSLgyLNYpTQVIFkccklipVLVGSILIQGKRYGLLDFAAATCMCIGLAWFTLADSQMTPNFn 218
Cdd:COG0697  79 AFLLFFLALQYTPAALAAL--LLA-LAPLF-------VALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGS- 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345 219 LLGVAMISGALLCdAAIGNVQEKAMREfKAPSSEVVFYSYGLGFVYLFVIMLVTGnffsgfafcLEHPVETFGYGFLFSL 298
Cdd:COG0697 148 LLGDLLALLAALS-WALYTVLTRRLSR-RLDPLTLTFWQMLVGALLLLPLALLTG---------LPLPLSAAAWLALLYL 216

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21355345 299 ---SGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVYSKRNK 367
Cdd:COG0697 217 glfGTALAYLLWFRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERRR 288
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 219-362 4.88e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 39.87  E-value: 4.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355345   219 LLGVAMISGALLCDAAIGNVQEKAMREFkaPSSEVVFYSYGLGFVYLFVIMLVTGNFFSGfafclehPVETFGYGFLFS- 297
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRI--SPLTLTFWRFLIAGILLLPFALFTGGKLVI-------PLKSWLALLYLGv 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21355345   298 LSGYLGIQFVLALVRSSGAPIAATVTTARKAVTIAFSFVLFSKPFTLQYLWSGLIVVLGIYLNVY 362
Cdd:pfam00892  72 LGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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