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Conserved domains on  [gi|21358419|ref|NP_649748|]
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TBP-associated factor 7, isoform A [Drosophila melanogaster]

Protein Classification

transcription initiation factor TFIID subunit 7 family protein( domain architecture ID 10519876)

transcription initiation factor TFIID subunit 7 (TAF7) family protein is a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Gene Ontology:  GO:0005669
PubMed:  35700575|16407123

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAFII55_N pfam04658
TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the ...
 55-213 3.86e-72

TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown. The conserved region is situated towards the N-terminus of the protein.


:

Pssm-ID: 461382  Cd Length: 160  Bit Score: 225.47  E-value: 3.86e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419    55 LESQFIMRVPKE-LADTVHEAINAGTIKDRLTIQLDPDLRYGEVRIDDQILYTKLVDLPTVVESYKTIDNKSFYKSADIC 133
Cdd:pfam04658   1 IEEQFILRLPPDeDADYLRKAIESGDIKDDLSIKFLKDGRRAVVRIGGQLYAAKLVDLPTIIESMKTIDKKNFYKTADIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419   134 QILIC--KEEREDETEKESPNKNKKKDPNKVDKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEApeIEKEVKHLLRIDNE 211
Cdd:pfam04658  81 QMLLVlgPIKNEEEAKTEPLPEEPPPKKEVKDKKYQYPHGLTPPLKNVRKRRFRKRLKKKEIEA--VEKEVKRLLRADAE 158


                  ..
gi 21358419   212 AV 213
Cdd:pfam04658 159 AE 160
 
Name Accession Description Interval E-value
TAFII55_N pfam04658
TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the ...
 55-213 3.86e-72

TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown. The conserved region is situated towards the N-terminus of the protein.


Pssm-ID: 461382  Cd Length: 160  Bit Score: 225.47  E-value: 3.86e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419    55 LESQFIMRVPKE-LADTVHEAINAGTIKDRLTIQLDPDLRYGEVRIDDQILYTKLVDLPTVVESYKTIDNKSFYKSADIC 133
Cdd:pfam04658   1 IEEQFILRLPPDeDADYLRKAIESGDIKDDLSIKFLKDGRRAVVRIGGQLYAAKLVDLPTIIESMKTIDKKNFYKTADIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419   134 QILIC--KEEREDETEKESPNKNKKKDPNKVDKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEApeIEKEVKHLLRIDNE 211
Cdd:pfam04658  81 QMLLVlgPIKNEEEAKTEPLPEEPPPKKEVKDKKYQYPHGLTPPLKNVRKRRFRKRLKKKEIEA--VEKEVKRLLRADAE 158


                  ..
gi 21358419   212 AV 213
Cdd:pfam04658 159 AE 160
TAF7 cd08047
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and ...
 56-220 2.72e-61

TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; The TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and are involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new, unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. TAF7 is involved in the regulation of the transition from PIC assembly to initiation and elongation. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers.


Pssm-ID: 173966  Cd Length: 162  Bit Score: 197.49  E-value: 2.72e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419  56 ESQFIMRVPKELADTVHEAINAGTIKDRL-TIQLDPDLRYGEVRIDDQILYTKLVDLPTVVESYKTIDNKSFYKSADICQ 134
Cdd:cd08047   1 EEQFILRLPPDVADRLRKAIEEGDSNEKLlSITLFEDSRRAVVRINGQKYPAKLVDLPTIIESHKTLDKKNLYKTADISQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419 135 ILICKEEREDETEKESPNKNKKKDpnkvDKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEAPEIEKEVKHLLRIDNEAVR 214
Cdd:cd08047  81 MLIVYEPDDSEKEAKEAKLDKKDK----PKKFEYPHGLTPPMKNVRKRRFRKTPSKKIAEIEEVEKEVKRLLKEDTEAVS 156


                ....*.
gi 21358419 215 VDYEII 220
Cdd:cd08047 157 VEYEVI 162
Taf7 COG5414
TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation ...
 44-326 2.81e-23

TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation complex [Transcription];


Pssm-ID: 227701  Cd Length: 392  Bit Score: 101.32  E-value: 2.81e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419  44 AEHKARDDGVELESQFIMRV-PKELADTVHEAINAGTIKDrLTIQLDpDLRYGEVRIDDQILYTKLVDLPTVVESYKTID 122
Cdd:COG5414  61 SEASDIEDDPLIEQQFILRLhPSIQIEHVVDLGESGDYSG-ITIKIK-DDRSAVVTHNNKKYPAILVDLPCIIESNKSMD 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419 123 NKSFYKSADICQILICKEEREDETEKESPNKNKKkdpnkvdKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEapEIEKEV 202
Cdd:COG5414 139 SKQHYKVADISQMLVALEAVYHENSFLNKHLKKE-------REYYYLHGLSPPLKYVRARRFRKKSSKIEIE--EVEKKV 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419 203 KHLLRIDNEAVRVDYEIINEEDKPMDELEQSDIKPYNDADDDLQDESTMHASEKTIMEMSS-------------QRHLQV 269
Cdd:COG5414 210 DDLLEKDMKAESVSVVLKDEKELARQERVSSWENFKEEPGEPLSRPALKKEKQGAEEEGEEgmseedldvgaaeIENKEV 289

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21358419 270 ESDDDEASNFPSHRAPNMGVAVHDIFGEEVSSTDDEDEPDRGNNTMQRRVMEESSRL 326
Cdd:COG5414 290 SEGDKEQQQEEVENAEAHKEEVQSDRPDEIGEEKEEDDENEENERHTELLADELNEL 346
 
Name Accession Description Interval E-value
TAFII55_N pfam04658
TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the ...
 55-213 3.86e-72

TAFII55 protein conserved region; The general transcription factor, TFIID, consists of the TATA-binding protein (TBP) associated with a series of TBP-associated factors (TAFs) that together participate in the assembly of the transcription preinitiation complex. TAFII55 binds to TAFII250 and inhibits it acetyltransferase activity. The exact role of TAFII55 is currently unknown. The conserved region is situated towards the N-terminus of the protein.


Pssm-ID: 461382  Cd Length: 160  Bit Score: 225.47  E-value: 3.86e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419    55 LESQFIMRVPKE-LADTVHEAINAGTIKDRLTIQLDPDLRYGEVRIDDQILYTKLVDLPTVVESYKTIDNKSFYKSADIC 133
Cdd:pfam04658   1 IEEQFILRLPPDeDADYLRKAIESGDIKDDLSIKFLKDGRRAVVRIGGQLYAAKLVDLPTIIESMKTIDKKNFYKTADIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419   134 QILIC--KEEREDETEKESPNKNKKKDPNKVDKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEApeIEKEVKHLLRIDNE 211
Cdd:pfam04658  81 QMLLVlgPIKNEEEAKTEPLPEEPPPKKEVKDKKYQYPHGLTPPLKNVRKRRFRKRLKKKEIEA--VEKEVKRLLRADAE 158


                  ..
gi 21358419   212 AV 213
Cdd:pfam04658 159 AE 160
TAF7 cd08047
TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and ...
 56-220 2.72e-61

TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; The TATA Binding Protein (TBP) Associated Factor 7 (TAF7) is one of several TAFs that bind TBP and are involved in forming the Transcription Factor IID (TFIID) complex. TFIID is one of seven General Transcription Factors (GTF) (TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and TFIID) that are involved in accurate initiation of transcription by RNA polymerase II in eukaryotes. TFIID plays an important role in the recognition of promoter DNA and assembly of the preinitiation complex. TFIID complex is composed of the TBP and at least 13 TAFs. TAFs are named after their electrophoretic mobility in polyacrylamide gels in different species. A new, unified nomenclature has been suggested for the pol II TAFs to show the relationship between TAF orthologs and paralogs. Several hypotheses are proposed for TAFs functions such as serving as activator-binding sites, core-promoter recognition or a role in essential catalytic activity. Each TAF, with the help of a specific activator, is required only for expression of subset of genes and is not universally involved for transcription as are GTFs. TAF7 is involved in the regulation of the transition from PIC assembly to initiation and elongation. In yeast and human cells, TAFs have been found as components of other complexes besides TFIID. Several TAFs interact via histone-fold (HFD) motifs; the HFD is the interaction motif involved in heterodimerization of the core histones and their assembly into nucleosome octamers.


Pssm-ID: 173966  Cd Length: 162  Bit Score: 197.49  E-value: 2.72e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419  56 ESQFIMRVPKELADTVHEAINAGTIKDRL-TIQLDPDLRYGEVRIDDQILYTKLVDLPTVVESYKTIDNKSFYKSADICQ 134
Cdd:cd08047   1 EEQFILRLPPDVADRLRKAIEEGDSNEKLlSITLFEDSRRAVVRINGQKYPAKLVDLPTIIESHKTLDKKNLYKTADISQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419 135 ILICKEEREDETEKESPNKNKKKDpnkvDKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEAPEIEKEVKHLLRIDNEAVR 214
Cdd:cd08047  81 MLIVYEPDDSEKEAKEAKLDKKDK----PKKFEYPHGLTPPMKNVRKRRFRKTPSKKIAEIEEVEKEVKRLLKEDTEAVS 156


                ....*.
gi 21358419 215 VDYEII 220
Cdd:cd08047 157 VEYEVI 162
Taf7 COG5414
TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation ...
 44-326 2.81e-23

TATA-binding protein-associated factor Taf7, part of the TFIID transcription initiation complex [Transcription];


Pssm-ID: 227701  Cd Length: 392  Bit Score: 101.32  E-value: 2.81e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419  44 AEHKARDDGVELESQFIMRV-PKELADTVHEAINAGTIKDrLTIQLDpDLRYGEVRIDDQILYTKLVDLPTVVESYKTID 122
Cdd:COG5414  61 SEASDIEDDPLIEQQFILRLhPSIQIEHVVDLGESGDYSG-ITIKIK-DDRSAVVTHNNKKYPAILVDLPCIIESNKSMD 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419 123 NKSFYKSADICQILICKEEREDETEKESPNKNKKkdpnkvdKKYLFPHGITPPCKNVRKRRFRKTLKKKNVEapEIEKEV 202
Cdd:COG5414 139 SKQHYKVADISQMLVALEAVYHENSFLNKHLKKE-------REYYYLHGLSPPLKYVRARRFRKKSSKIEIE--EVEKKV 209

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21358419 203 KHLLRIDNEAVRVDYEIINEEDKPMDELEQSDIKPYNDADDDLQDESTMHASEKTIMEMSS-------------QRHLQV 269
Cdd:COG5414 210 DDLLEKDMKAESVSVVLKDEKELARQERVSSWENFKEEPGEPLSRPALKKEKQGAEEEGEEgmseedldvgaaeIENKEV 289

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21358419 270 ESDDDEASNFPSHRAPNMGVAVHDIFGEEVSSTDDEDEPDRGNNTMQRRVMEESSRL 326
Cdd:COG5414 290 SEGDKEQQQEEVENAEAHKEEVQSDRPDEIGEEKEEDDENEENERHTELLADELNEL 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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