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Conserved domains on  [gi|24644979|ref|NP_649770|]
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uncharacterized protein Dmel_CG7800 [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
SCOP:  4003523

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-482 1.91e-14

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 1.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  68 LELENCDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNItrlsnecFKGLAQLWLLSLPGNGI 147
Cdd:COG4886  53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQL 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 148 QGLPWDvFQNLPELLHLDLSGNRIETLHENIFtGVPKLEMLLLNGNPLTWIaPTSLKSLSNLRLLDMSNCgPLPDLSLPg 227
Cdd:COG4886 126 TDLPEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-QITDLPEP- 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 228 ahtlildnsgvqrldiLGSVHKLQarknhiteiklpdkssviELDLHSNLLTatDIPKLLTGMWRLQRLDLSENIIgiya 307
Cdd:COG4886 201 ----------------LGNLTNLE------------------ELDLSGNQLT--DLPEPLANLTNLETLDLSNNQL---- 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 308 aagsDNTSELFILPNLMYMNLSANRLTRLHFDSPIPweRLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELT 387
Cdd:COG4886 241 ----TDLPELGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 388 PWKPHPSLKEVALYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPTCKPCIPDARDFPTSISADTNQTIDTKVN 467
Cdd:COG4886 315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
                       410
                ....*....|....*
gi 24644979 468 PLSNDTYQWNVWNVL 482
Cdd:COG4886 395 TTTAGVLLLTLALLD 409
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-482 1.91e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 1.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  68 LELENCDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNItrlsnecFKGLAQLWLLSLPGNGI 147
Cdd:COG4886  53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQL 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 148 QGLPWDvFQNLPELLHLDLSGNRIETLHENIFtGVPKLEMLLLNGNPLTWIaPTSLKSLSNLRLLDMSNCgPLPDLSLPg 227
Cdd:COG4886 126 TDLPEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-QITDLPEP- 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 228 ahtlildnsgvqrldiLGSVHKLQarknhiteiklpdkssviELDLHSNLLTatDIPKLLTGMWRLQRLDLSENIIgiya 307
Cdd:COG4886 201 ----------------LGNLTNLE------------------ELDLSGNQLT--DLPEPLANLTNLETLDLSNNQL---- 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 308 aagsDNTSELFILPNLMYMNLSANRLTRLHFDSPIPweRLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELT 387
Cdd:COG4886 241 ----TDLPELGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 388 PWKPHPSLKEVALYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPTCKPCIPDARDFPTSISADTNQTIDTKVN 467
Cdd:COG4886 315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
                       410
                ....*....|....*
gi 24644979 468 PLSNDTYQWNVWNVL 482
Cdd:COG4886 395 TTTAGVLLLTLALLD 409
LRR_8 pfam13855
Leucine rich repeat;
87-147 2.14e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.14e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644979    87 PYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGI 147
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
59-196 2.13e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  59 LKLMPNLRTLEL-ENCDSpdfTMNDLNQLPYLTSLQLRRGNLLGLhdEHFSKWPNMKILMLGGNNITRLSN--------- 128
Cdd:cd21340  20 LSLCKNLKVLYLyDNKIT---KIENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEGlenltnlee 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 129 ------------------ECFKGLAQ-LWLLSLPGNGIQGLpwDVFQNLPELLHLDLSGNRIETLHE--NIFTGVPKLEM 187
Cdd:cd21340  95 lhienqrlppgekltfdpRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRE 172

                ....*....
gi 24644979 188 LLLNGNPLT 196
Cdd:cd21340 173 LDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
157-379 4.93e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  157 NLPELLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLS-NLRLLDMSN---CGPLPDLSLPGAHTLI 232
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSsSLRYLNLSNnnfTGSIPRGSIPNLETLD 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  233 LDN---SGVQRLDIlGSVHKLQArknhiteiklpdkssvieLDLHSNLLTAtDIPKLLTGMWRLQRLDLSEN-IIGiyaa 308
Cdd:PLN00113 147 LSNnmlSGEIPNDI-GSFSSLKV------------------LDLGGNVLVG-KIPNSLTNLTSLEFLTLASNqLVG---- 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24644979  309 agsDNTSELFILPNLMYMNLSANRLTrlhfdSPIPWE-----RLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGN 379
Cdd:PLN00113 203 ---QIPRELGQMKSLKWIYLGYNNLS-----GEIPYEiggltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR smart00370
Leucine-rich repeats, outliers;
158-181 4.96e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.96e-03
                           10        20
                   ....*....|....*....|....
gi 24644979    158 LPELLHLDLSGNRIETLHENIFTG 181
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-482 1.91e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 1.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  68 LELENCDSPDFTMNDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNItrlsnecFKGLAQLWLLSLPGNGI 147
Cdd:COG4886  53 LSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQL 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 148 QGLPWDvFQNLPELLHLDLSGNRIETLHENIFtGVPKLEMLLLNGNPLTWIaPTSLKSLSNLRLLDMSNCgPLPDLSLPg 227
Cdd:COG4886 126 TDLPEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNN-QITDLPEP- 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 228 ahtlildnsgvqrldiLGSVHKLQarknhiteiklpdkssviELDLHSNLLTatDIPKLLTGMWRLQRLDLSENIIgiya 307
Cdd:COG4886 201 ----------------LGNLTNLE------------------ELDLSGNQLT--DLPEPLANLTNLETLDLSNNQL---- 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 308 aagsDNTSELFILPNLMYMNLSANRLTRLHFDSPIPweRLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELT 387
Cdd:COG4886 241 ----TDLPELGNLTNLEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 388 PWKPHPSLKEVALYDNKFQPKGYKNITKFFNEIGVNVLEKTQYSQSNNTTPTCKPCIPDARDFPTSISADTNQTIDTKVN 467
Cdd:COG4886 315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLL 394
                       410
                ....*....|....*
gi 24644979 468 PLSNDTYQWNVWNVL 482
Cdd:COG4886 395 TTTAGVLLLTLALLD 409
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
64-392 5.50e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.81  E-value: 5.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  64 NLRTLELENCDSPDFTMNDLNQLPYLTSLQLRrgnllglHDEHFSKWPNMKILMLGGNNITRLSNEcFKGLAQLWLLSLP 143
Cdd:COG4886  73 LLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLS 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 144 GNGIQGLPwDVFQNLPELLHLDLSGNRIETLHENIFtGVPKLEMLLLNGNPLTWIaPTSLKSLSNLRLLDMSNCG----P 219
Cdd:COG4886 145 NNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQltdlP 221
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 220 LPDLSLPGAHTLILDNSGVQRLDILGSVHKLQ---ARKNHITEI-KLPDKSSVIELDLHSNLLTATDIPKLLTGMWRLQR 295
Cdd:COG4886 222 EPLANLTNLETLDLSNNQLTDLPELGNLTNLEeldLSNNQLTDLpPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSL 301
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 296 LDLSENIIGIYAAAGSDNTSELFILPNLMYMNLSANRLTRLHFDSPIPWERLTHLDASYNRIYAPAKVGIDEAFNLQSLH 375
Cdd:COG4886 302 LLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLT 381
                       330
                ....*....|....*..
gi 24644979 376 LEGNYINNFELTPWKPH 392
Cdd:COG4886 382 LALLLLTLLLLLLTTTA 398
LRR_8 pfam13855
Leucine rich repeat;
87-147 2.14e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 2.14e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644979    87 PYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGI 147
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
140-195 8.50e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.53  E-value: 8.50e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24644979   140 LSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPL 195
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
111-171 9.89e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.89e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24644979   111 PNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRI 171
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
59-196 2.13e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  59 LKLMPNLRTLEL-ENCDSpdfTMNDLNQLPYLTSLQLRRGNLLGLhdEHFSKWPNMKILMLGGNNITRLSN--------- 128
Cdd:cd21340  20 LSLCKNLKVLYLyDNKIT---KIENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVEGlenltnlee 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 129 ------------------ECFKGLAQ-LWLLSLPGNGIQGLpwDVFQNLPELLHLDLSGNRIETLHE--NIFTGVPKLEM 187
Cdd:cd21340  95 lhienqrlppgekltfdpRSLAALSNsLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRE 172

                ....*....
gi 24644979 188 LLLNGNPLT 196
Cdd:cd21340 173 LDLTGNPVC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-301 1.65e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 1.65e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  44 TKLTEFHMDSCE----KKVLKLMPNLRTLELENCDSPDFTmNDLNQLPYLTSLQLRRGNLLGLHDEhFSKWPNMKILMLG 119
Cdd:COG4886 159 TNLKSLDLSNNQltdlPEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLS 236
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 120 GNNITRLSNecFKGLAQLWLLSLPGNGIQGLPwdVFQNLPELLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIA 199
Cdd:COG4886 237 NNQLTDLPE--LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 200 PTSLKSLSNLRLLDMSNCGPLPDLSLPGAHTLILDNSGVQRLDILGSVHKLQARKNHITEIKLPDKSSVIELDLHSNLLT 279
Cdd:COG4886 313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
                       250       260
                ....*....|....*....|..
gi 24644979 280 ATDIPKLLTGMWRLQRLDLSEN 301
Cdd:COG4886 393 LLTTTAGVLLLTLALLDAVNTE 414
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
157-379 4.93e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 4.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  157 NLPELLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLS-NLRLLDMSN---CGPLPDLSLPGAHTLI 232
Cdd:PLN00113  67 NSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDDIFTTSsSLRYLNLSNnnfTGSIPRGSIPNLETLD 146
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  233 LDN---SGVQRLDIlGSVHKLQArknhiteiklpdkssvieLDLHSNLLTAtDIPKLLTGMWRLQRLDLSEN-IIGiyaa 308
Cdd:PLN00113 147 LSNnmlSGEIPNDI-GSFSSLKV------------------LDLGGNVLVG-KIPNSLTNLTSLEFLTLASNqLVG---- 202
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24644979  309 agsDNTSELFILPNLMYMNLSANRLTrlhfdSPIPWE-----RLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGN 379
Cdd:PLN00113 203 ---QIPRELGQMKSLKWIYLGYNNLS-----GEIPYEiggltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-419 9.05e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 9.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 120 GNNITRLSNECFKGLAQLWLLSLPGNGIQGLPWDVFQNLPELLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIA 199
Cdd:COG4886   9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 200 PTSLKSLSNLRLLDMSNCGPLPDLSlpgahtlildnsGVQRLDIlgsvhklqaRKNHITEI--KLPDKSSVIELDLHSNL 277
Cdd:COG4886  89 LTDLGDLTNLTELDLSGNEELSNLT------------NLESLDL---------SGNQLTDLpeELANLTNLKELDLSNNQ 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 278 LtaTDIPKLLTGMWRLQRLDLSEN-IIGIYAAAG----------SDN-----TSELFILPNLMYMNLSANRLTRLhfDSP 341
Cdd:COG4886 148 L--TDLPEPLGNLTNLKSLDLSNNqLTDLPEELGnltnlkeldlSNNqitdlPEPLGNLTNLEELDLSGNQLTDL--PEP 223
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24644979 342 IP-WERLTHLDASYNRIYAPAKVGidEAFNLQSLHLEGNYINnfELTPWKPHPSLKEVALYDNKFQPKGYKNITKFFNE 419
Cdd:COG4886 224 LAnLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLT--DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298
LRR_8 pfam13855
Leucine rich repeat;
159-217 1.26e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.26e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 24644979   159 PELLHLDLSGNRIETLHENIFTGVPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSNC 217
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
81-379 1.51e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979   81 NDLNQLPYLTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNITRLSNECFKGLAQLWLLSLPGNGIQGlpwdvfqNLPE 160
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSG-------EIPE 302
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  161 LLhLDLSGNRIETLHENIFTG--------VPKLEMLLLNGNPLTWIAPTSLKSLSNLRLLDMSN---CGPLPDLSLPGAH 229
Cdd:PLN00113 303 LV-IQLQNLEILHLFSNNFTGkipvaltsLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTnnlTGEIPEGLCSSGN 381
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  230 --TLILDNSGVQ-----RLDILGSVHKLQARKNHITE------IKLPdksSVIELDLHSNLLTAtDIPKLLTGMWRLQRL 296
Cdd:PLN00113 382 lfKLILFSNSLEgeipkSLGACRSLRRVRLQDNSFSGelpsefTKLP---LVYFLDISNNNLQG-RINSRKWDMPSLQML 457
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  297 DLSENII--GIYAAAGSDNTSELFI---------------LPNLMYMNLSANRLTRLHFDSPIPWERLTHLDASYNRIYA 359
Cdd:PLN00113 458 SLARNKFfgGLPDSFGSKRLENLDLsrnqfsgavprklgsLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSG 537
                        330       340
                 ....*....|....*....|
gi 24644979  360 PAKVGIDEAFNLQSLHLEGN 379
Cdd:PLN00113 538 QIPASFSEMPVLSQLDLSQN 557
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
131-334 1.89e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 1.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 131 FKGLAQLWLLSLPGNGIQGLPWDVFQNL---PELLHLDLSGNRIETLHENIFTGV-----PKLEMLLLNGNPLTWIAPTS 202
Cdd:cd00116  77 LTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRGLRLLAKGlkdlpPALEKLVLGRNRLEGASCEA 156
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 203 ----LKSLSNLRLLDMSNCGplpdLSLPGAHTL---ILDNSGVQRLDIlgsvhklqaRKNHITEIK-------LPDKSSV 268
Cdd:cd00116 157 lakaLRANRDLKELNLANNG----IGDAGIRALaegLKANCNLEVLDL---------NNNGLTDEGasalaetLASLKSL 223
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 269 IELDLHSNLLTATDIPKLLTGMW----RLQRLDLSENIIGiyAAAGSDNTSELFILPNLMYMNLSANRLT 334
Cdd:cd00116 224 EVLNLGDNNLTDAGAAALASALLspniSLLTLSLSCNDIT--DDGAKDLAEVLAEKESLLELDLRGNKFG 291
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
230-404 8.95e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.54  E-value: 8.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  230 TLILDNSGVQRL--DILGSVHKLQARKNHITEI--KLPDKSSVIELDLHSnlltATDIPKLLTGMwrLQRLDLSENIIgi 305
Cdd:PRK15370 203 TLILDNNELKSLpeNLQGNIKTLYANSNQLTSIpaTLPDTIQEMELSINR----ITELPERLPSA--LQSLDLFHNKI-- 274
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  306 yaAAGSDNTSElfilpNLMYMNLSANRLTRL--HFDSPIpwerlTHLDASYNRIYA-PAKVgideAFNLQSLHLEGNYIN 382
Cdd:PRK15370 275 --SCLPENLPE-----ELRYLSVYDNSIRTLpaHLPSGI-----THLNVQSNSLTAlPETL----PPGLKTLEAGENALT 338
                        170       180
                 ....*....|....*....|..
gi 24644979  383 NFeltPWKPHPSLKEVALYDNK 404
Cdd:PRK15370 339 SL---PASLPPELQVLDVSKNQ 357
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
118-418 2.52e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  118 LGGNNITRLSNECFKGLAQLWLLSLPGNGIQG-LPWDVFQNLPELLHLDLSGNRietlheniFTG------VPKLEMLLL 190
Cdd:PLN00113  76 LSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNN--------FTGsiprgsIPNLETLDL 147
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  191 NGNPLTWIAPTSLKSLSNLRLLDMSNCgplpdlSLPGAHTLILDNsgvqrldiLGSVHKLQARKNHIT---EIKLPDKSS 267
Cdd:PLN00113 148 SNNMLSGEIPNDIGSFSSLKVLDLGGN------VLVGKIPNSLTN--------LTSLEFLTLASNQLVgqiPRELGQMKS 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  268 VIELDLHSNLLTAtDIPKLLTGMWRLQRLDLseniigIYAAAGSDNTSELFILPNLMYMNLSANRLTrlhfdSPIP---- 343
Cdd:PLN00113 214 LKWIYLGYNNLSG-EIPYEIGGLTSLNHLDL------VYNNLTGPIPSSLGNLKNLQYLFLYQNKLS-----GPIPpsif 281
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24644979  344 -WERLTHLDASYNRIYAPAKVGIDEAFNLQSLHLEGNYINNFELTPWKPHPSLKEVALYDNKFQPKGYKNITKFFN 418
Cdd:PLN00113 282 sLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNN 357
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
78-296 1.93e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.01  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  78 FTMNDLNQLPYLTSLQLRRGNLLGLHdEHFSKWPNMKILMLGGNNITRLSNECF----KGLAQLWLLSLPGNGI--QGLP 151
Cdd:COG5238 176 ALQNNSVETVYLGCNQIGDEGIEELA-EALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIgdEGVI 254
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 152 --WDVFQNLPELLHLDLSGNRIETLH----ENIFTGVPKLEMLLLNGNPLT---WIA-PTSLKSLSNLRLLDMSNCGplp 221
Cdd:COG5238 255 alAEALKNNTTVETLYLSGNQIGAEGaialAKALQGNTTLTSLDLSVNRIGdegAIAlAEGLQGNKTLHTLNLAYNG--- 331
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 222 dLSLPGAHTL---ILDNSGVQRLDILG-------------------SVHKLQARKNHITE------IKLPDKSSVIELDL 273
Cdd:COG5238 332 -IGAQGAIALakaLQENTTLHSLDLSDnqigdegaialakylegntTLRELNLGKNNIGKqgaealIDALQTNRLHTLIL 410
                       250       260
                ....*....|....*....|...
gi 24644979 274 HSNLLTATDIPKLLTGMWRLQRL 296
Cdd:COG5238 411 DGNLIGAEAQQRLEQLLERIKSV 433
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
115-336 1.24e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 41.69  E-value: 1.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  115 ILMLGGNNITRLSnECFKglAQLWLLSLPGNGIQGLPwdvfQNLPELLHLDLSGNRIETLHenifTGVPKLEMLLLNGNP 194
Cdd:PRK15387 205 VLNVGESGLTTLP-DCLP--AHITTLVIPDNNLTSLP----ALPPELRTLEVSGNQLTSLP----VLPPGLLELSIFSNP 273
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  195 LTWIaPTSLKSLSNLRLLDmSNCGPLPDLSlPGAHTLILDNSGVQRLDILGS-VHKLQARKNHITEI-KLPdkSSVIELD 272
Cdd:PRK15387 274 LTHL-PALPSGLCKLWIFG-NQLTSLPVLP-PGLQELSVSDNQLASLPALPSeLCKLWAYNNQLTSLpTLP--SGLQELS 348
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  273 LHSNLLTA-TDIPKLLTGMW----RLQRLDLSENIIGIYAAAGSDNTSeLFILPN-LMYMNLSANRLTRL 336
Cdd:PRK15387 349 VSDNQLASlPTLPSELYKLWaynnRLTSLPALPSGLKELIVSGNRLTS-LPVLPSeLKELMVSGNRLTSL 417
LRR smart00370
Leucine-rich repeats, outliers;
158-181 4.96e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.96e-03
                           10        20
                   ....*....|....*....|....
gi 24644979    158 LPELLHLDLSGNRIETLHENIFTG 181
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
158-181 4.96e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 4.96e-03
                           10        20
                   ....*....|....*....|....
gi 24644979    158 LPELLHLDLSGNRIETLHENIFTG 181
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
82-357 5.92e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 5.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979  82 DLNQLPY--LTSLQLRRGNLLGLHDEHFSKWPNMKILMLGGNNItrlSNECFKGLA-------QLWLLSLPGNGI--QGL 150
Cdd:COG5238 149 DPLGGNAvhLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQI---GDEGIEELAealtqntTVTTLWLKRNPIgdEGA 225
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 151 P--WDVFQNLPELLHLDLSGNRIetlheniftGVPKLEMLLlngnpltwiapTSLKSLSNLRLLDMSncgplpdLSLPGA 228
Cdd:COG5238 226 EilAEALKGNKSLTTLDLSNNQI---------GDEGVIALA-----------EALKNNTTVETLYLS-------GNQIGA 278
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24644979 229 HTLILDNSGVQRLDilgSVHKLQARKNHITEI-------KLPDKSSVIELDLHSNLLTATDIPKLLTGMW---RLQRLDL 298
Cdd:COG5238 279 EGAIALAKALQGNT---TLTSLDLSVNRIGDEgaialaeGLQGNKTLHTLNLAYNGIGAQGAIALAKALQentTLHSLDL 355
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24644979 299 SENIIGIYAAAG-----SDNTSELFIlpNLMYMNLSA------------NRLTRLHFDS-PIPWERLTHLDASYNRI 357
Cdd:COG5238 356 SDNQIGDEGAIAlakylEGNTTLREL--NLGKNNIGKqgaealidalqtNRLHTLILDGnLIGAEAQQRLEQLLERI 430
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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