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Conserved domains on  [gi|24647326|ref|NP_650516|]
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GATAe, isoform A [Drosophila melanogaster]

Protein Classification

GATA-type transcription factor( domain architecture ID 10078896)

GATA-type transcription factor binds to the DNA consensus sequence [AT]GATA[AG] and may function as a transcription factor/regulator

CATH:  3.30.50.10
Gene Ontology:  GO:0003700|GO:0006357|GO:0008270|GO:0043565
PubMed:  31574210
SCOP:  4003617

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 538-589 3.66e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


:

Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 87.04  E-value: 3.66e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24647326 538 TCANCQTNSTTLWRRN-NEGNPVCNACGLYYKLHNMNRPLSMKKEG-IQKRKRK 589
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
GAT1 super family cl35034
GATA Zn-finger-containing transcription factor [Transcription];
533-644 5.69e-03

GATA Zn-finger-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5641:

Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 39.85  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647326 533 RRNGVTCANCQTNSTTlwrRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPKNNggapmhraplPSMSQGvnl 612
Cdd:COG5641 348 KRSNATCMNCSSTPTN---KILSPPTTSNSPGAQVKLPNQTRSTGATKKKITRRRMNSGKI----------PALSSS--- 411

                        90       100       110
                ....*....|....*....|....*....|..
gi 24647326 613 maNSPLYPSQVPVSMLNSQLNSQQNSSPELHD 644
Cdd:COG5641 412 --MKNPVPKEFSPLIPQSTESETPSQSKSSLT 441
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 538-589 3.66e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 87.04  E-value: 3.66e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24647326 538 TCANCQTNSTTLWRRN-NEGNPVCNACGLYYKLHNMNRPLSMKKEG-IQKRKRK 589
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
534-583 5.18e-18

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 78.23  E-value: 5.18e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24647326    534 RNGVTCANCQTNSTTLWRRNNEGN-PVCNACGLYYKLHN-MNRPLSMKKEGI 583
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGgLKRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 539-570 3.81e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.88  E-value: 3.81e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 24647326   539 CANCQTNSTTLWRRNNEGNP-VCNACGLYYKLH 570
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
538-640 2.47e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 60.27  E-value: 2.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647326 538 TCANCQTNSTTLWRR-----NNEGNPVCNACGLYYKLHNMNR-PLSMKKEGIQKRKRKPKNNGGAP-MHRAPLPSMSQG- 609
Cdd:COG5641 160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSRSSHNNNDSnGENANTESIGNSs 239

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647326 610 VNLMANSPLYPSQVPVSMLNSQLNSQQNSSP 640
Cdd:COG5641 240 ASKLTKSWEERPQGRQLLSDAGSLSPRSNNP 270
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
533-644 5.69e-03

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 39.85  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647326 533 RRNGVTCANCQTNSTTlwrRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPKNNggapmhraplPSMSQGvnl 612
Cdd:COG5641 348 KRSNATCMNCSSTPTN---KILSPPTTSNSPGAQVKLPNQTRSTGATKKKITRRRMNSGKI----------PALSSS--- 411

                        90       100       110
                ....*....|....*....|....*....|..
gi 24647326 613 maNSPLYPSQVPVSMLNSQLNSQQNSSPELHD 644
Cdd:COG5641 412 --MKNPVPKEFSPLIPQSTESETPSQSKSSLT 441
 
Name Accession Description Interval E-value
ZnF_GATA cd00202
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ...
 538-589 3.66e-21

Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C


Pssm-ID: 238123 [Multi-domain]  Cd Length: 54  Bit Score: 87.04  E-value: 3.66e-21
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 24647326 538 TCANCQTNSTTLWRRN-NEGNPVCNACGLYYKLHNMNRPLSMKKEG-IQKRKRK 589
Cdd:cd00202   1 ACSNCGTTTTPLWRRGpSGGSTLCNACGLYWKKHGVMRPLSKRKKDqIKRRNRK 54
ZnF_GATA smart00401
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
534-583 5.18e-18

zinc finger binding to DNA consensus sequence [AT]GATA[AG];


Pssm-ID: 214648 [Multi-domain]  Cd Length: 52  Bit Score: 78.23  E-value: 5.18e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24647326    534 RNGVTCANCQTNSTTLWRRNNEGN-PVCNACGLYYKLHN-MNRPLSMKKEGI 583
Cdd:smart00401   1 GSGRSCSNCGTTETPLWRRGPSGNkTLCNACGLYYKKHGgLKRPLSLKKDGI 52
GATA pfam00320
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ...
 539-570 3.81e-13

GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.


Pssm-ID: 425605 [Multi-domain]  Cd Length: 36  Bit Score: 63.88  E-value: 3.81e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 24647326   539 CANCQTNSTTLWRRNNEGNP-VCNACGLYYKLH 570
Cdd:pfam00320   1 CSNCGTTKTPLWRRGPNGNRtLCNACGLYYKKK 33
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
538-640 2.47e-09

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 60.27  E-value: 2.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647326 538 TCANCQTNSTTLWRR-----NNEGNPVCNACGLYYKLHNMNR-PLSMKKEGIQKRKRKPKNNGGAP-MHRAPLPSMSQG- 609
Cdd:COG5641 160 VCSNCKTTSTPLWRRassesSLPGNNLCNACGLYLKLHGSPRaPISLKSDSIKSRSSRSSHNNNDSnGENANTESIGNSs 239

                        90       100       110
                ....*....|....*....|....*....|.
gi 24647326 610 VNLMANSPLYPSQVPVSMLNSQLNSQQNSSP 640
Cdd:COG5641 240 ASKLTKSWEERPQGRQLLSDAGSLSPRSNNP 270
GAT1 COG5641
GATA Zn-finger-containing transcription factor [Transcription];
533-644 5.69e-03

GATA Zn-finger-containing transcription factor [Transcription];


Pssm-ID: 227928 [Multi-domain]  Cd Length: 498  Bit Score: 39.85  E-value: 5.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24647326 533 RRNGVTCANCQTNSTTlwrRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPKNNggapmhraplPSMSQGvnl 612
Cdd:COG5641 348 KRSNATCMNCSSTPTN---KILSPPTTSNSPGAQVKLPNQTRSTGATKKKITRRRMNSGKI----------PALSSS--- 411

                        90       100       110
                ....*....|....*....|....*....|..
gi 24647326 613 maNSPLYPSQVPVSMLNSQLNSQQNSSPELHD 644
Cdd:COG5641 412 --MKNPVPKEFSPLIPQSTESETPSQSKSSLT 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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