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Conserved domains on  [gi|24647582|ref|NP_650591|]
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uncharacterized protein Dmel_CG3995 [Drosophila melanogaster]

Protein Classification

zf-BED and GT1 domain-containing protein( domain architecture ID 11139454)

zf-BED and GT1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-BED pfam02892
BED zinc finger;
6-47 3.29e-12

BED zinc finger;


:

Pssm-ID: 427043  Cd Length: 44  Bit Score: 60.07  E-value: 3.29e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 24647582     6 SEIWCFFRAV--DDTFAVCNICKAKLSYKTTTTNLSKHMNRMHP 47
Cdd:pfam02892   1 SKVWKYFRELplDETKAVCRYCGKILSRGGGTSNLIRHLRRKHP 44
GT1 super family cl23759
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 73-144 2.73e-03

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


The actual alignment was detected with superfamily member pfam13873:

Pssm-ID: 474047  Cd Length: 78  Bit Score: 36.11  E-value: 2.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24647582    73 KPRNSTQE-LILLEFVKKHPRLLQNPTWETRGN--LESLWEELSSELNSHGPPRKDIATWRRALKDWKRFILRKV 144
Cdd:pfam13873   2 KKNFSEEEkEVLVELVEKRKHILEGKKSDAATWkaKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKL 76
 
Name Accession Description Interval E-value
zf-BED pfam02892
BED zinc finger;
6-47 3.29e-12

BED zinc finger;


Pssm-ID: 427043  Cd Length: 44  Bit Score: 60.07  E-value: 3.29e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 24647582     6 SEIWCFFRAV--DDTFAVCNICKAKLSYKTTTTNLSKHMNRMHP 47
Cdd:pfam02892   1 SKVWKYFRELplDETKAVCRYCGKILSRGGGTSNLIRHLRRKHP 44
ZnF_BED smart00614
BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and ...
 7-47 6.76e-09

BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and transposases


Pssm-ID: 214746 [Multi-domain]  Cd Length: 50  Bit Score: 51.27  E-value: 6.76e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 24647582      7 EIWCFFRAV-----DDTFAVCNICKAKLSYKTT--TTNLSKHMNRMHP 47
Cdd:smart00614   1 KVWKHFTLIlekdnGKQRAKCKYCGKKLSRSSKggTSNLRRHLRRKHP 48
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 73-144 2.73e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 36.11  E-value: 2.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24647582    73 KPRNSTQE-LILLEFVKKHPRLLQNPTWETRGN--LESLWEELSSELNSHGPPRKDIATWRRALKDWKRFILRKV 144
Cdd:pfam13873   2 KKNFSEEEkEVLVELVEKRKHILEGKKSDAATWkaKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKL 76
 
Name Accession Description Interval E-value
zf-BED pfam02892
BED zinc finger;
6-47 3.29e-12

BED zinc finger;


Pssm-ID: 427043  Cd Length: 44  Bit Score: 60.07  E-value: 3.29e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 24647582     6 SEIWCFFRAV--DDTFAVCNICKAKLSYKTTTTNLSKHMNRMHP 47
Cdd:pfam02892   1 SKVWKYFRELplDETKAVCRYCGKILSRGGGTSNLIRHLRRKHP 44
ZnF_BED smart00614
BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and ...
 7-47 6.76e-09

BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and transposases


Pssm-ID: 214746 [Multi-domain]  Cd Length: 50  Bit Score: 51.27  E-value: 6.76e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 24647582      7 EIWCFFRAV-----DDTFAVCNICKAKLSYKTT--TTNLSKHMNRMHP 47
Cdd:smart00614   1 KVWKHFTLIlekdnGKQRAKCKYCGKKLSRSSKggTSNLRRHLRRKHP 48
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 73-144 2.73e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 36.11  E-value: 2.73e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24647582    73 KPRNSTQE-LILLEFVKKHPRLLQNPTWETRGN--LESLWEELSSELNSHGPPRKDIATWRRALKDWKRFILRKV 144
Cdd:pfam13873   2 KKNFSEEEkEVLVELVEKRKHILEGKKSDAATWkaKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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