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Conserved domains on  [gi|24649025|ref|NP_651054|]
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uncharacterized protein Dmel_CG5376 [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-186 1.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649025     23 QEEVRQPEQPQNELLDMVFTLESE---KQALLEESRKRIGALRKDFEEAKAENERLKRRVVQLEQSLkqsvmlggTDAPK 99
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEELEEEleqLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKEL--------TELEA 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649025    100 SRQEQEELLLKAKTLLFEKTKVNKQQEQQISVLRTQVDSIKDVLQVTKDMLQLKTAECDHTQARLEKSQQWIKAEQDKCV 179
Cdd:TIGR02168  762 EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841


                   ....*..
gi 24649025    180 LTEKKLA 186
Cdd:TIGR02168  842 DLEEQIE 848
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-186 1.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649025     23 QEEVRQPEQPQNELLDMVFTLESE---KQALLEESRKRIGALRKDFEEAKAENERLKRRVVQLEQSLkqsvmlggTDAPK 99
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEELEEEleqLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKEL--------TELEA 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649025    100 SRQEQEELLLKAKTLLFEKTKVNKQQEQQISVLRTQVDSIKDVLQVTKDMLQLKTAECDHTQARLEKSQQWIKAEQDKCV 179
Cdd:TIGR02168  762 EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841


                   ....*..
gi 24649025    180 LTEKKLA 186
Cdd:TIGR02168  842 DLEEQIE 848
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 23-186 1.19e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649025     23 QEEVRQPEQPQNELLDMVFTLESE---KQALLEESRKRIGALRKDFEEAKAENERLKRRVVQLEQSLkqsvmlggTDAPK 99
Cdd:TIGR02168  690 EEKIAELEKALAELRKELEELEEEleqLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKEL--------TELEA 761

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24649025    100 SRQEQEELLLKAKTLLFEKTKVNKQQEQQISVLRTQVDSIKDVLQVTKDMLQLKTAECDHTQARLEKSQQWIKAEQDKCV 179
Cdd:TIGR02168  762 EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLE 841


                   ....*..
gi 24649025    180 LTEKKLA 186
Cdd:TIGR02168  842 DLEEQIE 848
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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