NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|24649230|ref|NP_651129|]
View 

uncharacterized protein Dmel_CG13829 [Drosophila melanogaster]

Protein Classification

vacuolar ATPase assembly integral membrane protein VMA21( domain architecture ID 10559582)

vacuolar ATPase assembly integral membrane protein VMA21 is required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
VMA21 pfam09446
VMA21-like domain; This presumed short domain appears to contain two potential transmembrane ...
 138-197 1.41e-09

VMA21-like domain; This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localized in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase.


:

Pssm-ID: 462801  Cd Length: 64  Bit Score: 52.15  E-value: 1.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24649230   138 IVLLLMSYCSLIIGFPIATFFALKFVVLKSYAHI---NADIISTICTVVAVHAAVGFYIYRAI 197
Cdd:pfam09446   2 VIKKLLIFSILMVLLPIAIFFGFKNFVFDGYFGLsssDSTTYSGILAVIVVNVVLAAYIYRAY 64
VMA21 super family cl09685
VMA21-like domain; This presumed short domain appears to contain two potential transmembrane ...
 62-109 1.71e-06

VMA21-like domain; This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localized in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase.


The actual alignment was detected with superfamily member pfam09446:

Pssm-ID: 462801  Cd Length: 64  Bit Score: 44.07  E-value: 1.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24649230    62 PVVIFVIFKFLIMEPLYGNSDDNVGIGSGVATVIVMHVLVTGYILRLI 109
Cdd:pfam09446  17 PIAIFFGFKNFVFDGYFGLSSSDSTTYSGILAVIVVNVVLAAYIYRAY 64
 
Name Accession Description Interval E-value
VMA21 pfam09446
VMA21-like domain; This presumed short domain appears to contain two potential transmembrane ...
 138-197 1.41e-09

VMA21-like domain; This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localized in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase.


Pssm-ID: 462801  Cd Length: 64  Bit Score: 52.15  E-value: 1.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24649230   138 IVLLLMSYCSLIIGFPIATFFALKFVVLKSYAHI---NADIISTICTVVAVHAAVGFYIYRAI 197
Cdd:pfam09446   2 VIKKLLIFSILMVLLPIAIFFGFKNFVFDGYFGLsssDSTTYSGILAVIVVNVVLAAYIYRAY 64
VMA21 pfam09446
VMA21-like domain; This presumed short domain appears to contain two potential transmembrane ...
 62-109 1.71e-06

VMA21-like domain; This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localized in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase.


Pssm-ID: 462801  Cd Length: 64  Bit Score: 44.07  E-value: 1.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24649230    62 PVVIFVIFKFLIMEPLYGNSDDNVGIGSGVATVIVMHVLVTGYILRLI 109
Cdd:pfam09446  17 PIAIFFGFKNFVFDGYFGLSSSDSTTYSGILAVIVVNVVLAAYIYRAY 64
 
Name Accession Description Interval E-value
VMA21 pfam09446
VMA21-like domain; This presumed short domain appears to contain two potential transmembrane ...
 138-197 1.41e-09

VMA21-like domain; This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localized in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase.


Pssm-ID: 462801  Cd Length: 64  Bit Score: 52.15  E-value: 1.41e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24649230   138 IVLLLMSYCSLIIGFPIATFFALKFVVLKSYAHI---NADIISTICTVVAVHAAVGFYIYRAI 197
Cdd:pfam09446   2 VIKKLLIFSILMVLLPIAIFFGFKNFVFDGYFGLsssDSTTYSGILAVIVVNVVLAAYIYRAY 64
VMA21 pfam09446
VMA21-like domain; This presumed short domain appears to contain two potential transmembrane ...
 62-109 1.71e-06

VMA21-like domain; This presumed short domain appears to contain two potential transmembrane helices. VMA21 is localized in the ER where it is needed as an accessory factor for assembly of the V0 component of the vacuolar ATPase.


Pssm-ID: 462801  Cd Length: 64  Bit Score: 44.07  E-value: 1.71e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24649230    62 PVVIFVIFKFLIMEPLYGNSDDNVGIGSGVATVIVMHVLVTGYILRLI 109
Cdd:pfam09446  17 PIAIFFGFKNFVFDGYFGLSSSDSTTYSGILAVIVVNVVLAAYIYRAY 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH