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Conserved domains on  [gi|21356671|ref|NP_651393|]
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astrocytic leucine-rich repeat molecule [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-426 8.35e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 8.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 100 SLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFlGADNLATLHLQGNQLKQLGNhSFHALKEVKELSLAENQLEQISlG 179
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-E 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 180 VFSGMRKLMDLNLAGNRLDALPrGVFDRNLNLTKLNLARNRFTAFESELLKLQPVfTQLDISGNIFQELTlnftmldvai 259
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNL-ETLDLSNNQLTDLP---------- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 260 ahscDLRRLTVygvIHELDLHNNSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHELPEglFK 339
Cdd:COG4886 245 ----ELGNLTN---LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL--LI 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 340 KQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNNWNCDFLQLLMSSFVKRKDISFMEDITAPELVDDYVDGIACWY 419
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                ....*..
gi 21356671 420 ESDKQSK 426
Cdd:COG4886 396 TTAGVLL 402
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-426 8.35e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 8.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 100 SLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFlGADNLATLHLQGNQLKQLGNhSFHALKEVKELSLAENQLEQISlG 179
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-E 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 180 VFSGMRKLMDLNLAGNRLDALPrGVFDRNLNLTKLNLARNRFTAFESELLKLQPVfTQLDISGNIFQELTlnftmldvai 259
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNL-ETLDLSNNQLTDLP---------- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 260 ahscDLRRLTVygvIHELDLHNNSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHELPEglFK 339
Cdd:COG4886 245 ----ELGNLTN---LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL--LI 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 340 KQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNNWNCDFLQLLMSSFVKRKDISFMEDITAPELVDDYVDGIACWY 419
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                ....*..
gi 21356671 420 ESDKQSK 426
Cdd:COG4886 396 TTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
138-197 4.99e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 4.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   138 NLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRL 197
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-354 7.34e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 7.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  84 LFDTFPDLQVLRMENCSLETFEKPQFEGA----SNLMSLFLGYNRLKDIPKNI------FLGADNLATLHLQGNQLKQLG 153
Cdd:cd00116  18 LLPKLLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 154 NHSFHALkeVKELSLAENQLEQISLGvfsgmrklmdlnlaGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESE----LL 229
Cdd:cd00116  98 CGVLESL--LRSSSLQELKLNNNGLG--------------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 230 KLQPVFTQLDISGNIFQELtlNFTMLDVAIAHSCDLRRLtvygvihelDLHNNSLREMPHIPLAANVSS------LDLSH 303
Cdd:cd00116 162 RANRDLKELNLANNGIGDA--GIRALAEGLKANCNLEVL---------DLNNNGLTDEGASALAETLASlkslevLNLGD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 21356671 304 NPLGNlqgnplrrftsllrlnlsaTGAHELPEGLFKKQSHLQMLDISGNSI 354
Cdd:cd00116 231 NNLTD-------------------AGAAALASALLSPNISLLTLSLSCNDI 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
115-337 8.61e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 8.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  115 LMSLFLGYNRLKDIPKNIflgADNLATLHLQGNQLKQLGnhsfHALKE-VKELSLAENQLEQISLGVFSGmrkLMDLNLA 193
Cdd:PRK15370 201 ITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIP----ATLPDtIQEMELSINRITELPERLPSA---LQSLDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  194 GNRLDALPRGVFDrnlNLTKLNLARNRFTAFESELlklQPVFTQLDISGNIFQELTLNFTM-LDVAIAHSCDLRRL--TV 270
Cdd:PRK15370 271 HNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPgLKTLEAGENALTSLpaSL 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356671  271 YGVIHELDLHNNSLREMPHIpLAANVSSLDLSHNPLGNLQGN-PlrrfTSLLRLNLSATGAHELPEGL 337
Cdd:PRK15370 345 PPELQVLDVSKNQITVLPET-LPPTITTLDVSRNALTNLPENlP----AALQIMQASRNNLVRLPESL 407
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
100-426 8.35e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 8.35e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 100 SLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFlGADNLATLHLQGNQLKQLGNhSFHALKEVKELSLAENQLEQISlG 179
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-E 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 180 VFSGMRKLMDLNLAGNRLDALPrGVFDRNLNLTKLNLARNRFTAFESELLKLQPVfTQLDISGNIFQELTlnftmldvai 259
Cdd:COG4886 177 ELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLANLTNL-ETLDLSNNQLTDLP---------- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 260 ahscDLRRLTVygvIHELDLHNNSLREMPHIPLAANVSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHELPEglFK 339
Cdd:COG4886 245 ----ELGNLTN---LEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLEL--LI 315

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 340 KQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNNWNCDFLQLLMSSFVKRKDISFMEDITAPELVDDYVDGIACWY 419
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395


                ....*..
gi 21356671 420 ESDKQSK 426
Cdd:COG4886 396 TTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
138-197 4.99e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 4.99e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   138 NLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRL 197
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
162-221 2.33e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 2.33e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   162 EVKELSLAENQLEQISLGVFSGMRKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRF 221
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
185-377 6.08e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 6.08e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 185 RKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGNIFQELTLNFTMLDVAIAHSCD 264
Cdd:COG4886   9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 265 LRRLTVYGVIHELDLHNNslremPHIPLAANVSSLDLSHNPLGNLqGNPLRRFTSLLRLNLSATGAHELPEGLfKKQSHL 344
Cdd:COG4886  89 LTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPL-GNLTNL 161

                       170       180       190
                ....*....|....*....|....*....|...
gi 21356671 345 QMLDISGNSIYSLKITIfDSLKALQYFYFQQNN 377
Cdd:COG4886 162 KSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 84-354 7.34e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 7.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  84 LFDTFPDLQVLRMENCSLETFEKPQFEGA----SNLMSLFLGYNRLKDIPKNI------FLGADNLATLHLQGNQLKQLG 153
Cdd:cd00116  18 LLPKLLCLQVLRLEGNTLGEEAAKALASAlrpqPSLKELCLSLNETGRIPRGLqsllqgLTKGCGLQELDLSDNALGPDG 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 154 NHSFHALkeVKELSLAENQLEQISLGvfsgmrklmdlnlaGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESE----LL 229
Cdd:cd00116  98 CGVLESL--LRSSSLQELKLNNNGLG--------------DRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 230 KLQPVFTQLDISGNIFQELtlNFTMLDVAIAHSCDLRRLtvygvihelDLHNNSLREMPHIPLAANVSS------LDLSH 303
Cdd:cd00116 162 RANRDLKELNLANNGIGDA--GIRALAEGLKANCNLEVL---------DLNNNGLTDEGASALAETLASlkslevLNLGD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 21356671 304 NPLGNlqgnplrrftsllrlnlsaTGAHELPEGLFKKQSHLQMLDISGNSI 354
Cdd:cd00116 231 NNLTD-------------------AGAAALASALLSPNISLLTLSLSCNDI 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
115-337 8.61e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 8.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  115 LMSLFLGYNRLKDIPKNIflgADNLATLHLQGNQLKQLGnhsfHALKE-VKELSLAENQLEQISLGVFSGmrkLMDLNLA 193
Cdd:PRK15370 201 ITTLILDNNELKSLPENL---QGNIKTLYANSNQLTSIP----ATLPDtIQEMELSINRITELPERLPSA---LQSLDLF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  194 GNRLDALPRGVFDrnlNLTKLNLARNRFTAFESELlklQPVFTQLDISGNIFQELTLNFTM-LDVAIAHSCDLRRL--TV 270
Cdd:PRK15370 271 HNKISCLPENLPE---ELRYLSVYDNSIRTLPAHL---PSGITHLNVQSNSLTALPETLPPgLKTLEAGENALTSLpaSL 344

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21356671  271 YGVIHELDLHNNSLREMPHIpLAANVSSLDLSHNPLGNLQGN-PlrrfTSLLRLNLSATGAHELPEGL 337
Cdd:PRK15370 345 PPELQVLDVSKNQITVLPET-LPPTITTLDVSRNALTNLPENlP----AALQIMQASRNNLVRLPESL 407
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 133-372 6.11e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.25  E-value: 6.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 133 FLGADNLATLHLQGNQLKQLGNHSF-HALKE---VKELSLAENQL-EQISLGVFS---GMRKLMDLNLAGNRLDAlpRGV 204
Cdd:COG5238 176 ALQNNSVETVYLGCNQIGDEGIEELaEALTQnttVTTLWLKRNPIgDEGAEILAEalkGNKSLTTLDLSNNQIGD--EGV 253

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 205 ------FDRNLNLTKLNLARNRFTA----FESELLKLQPVFTQLDISGNIFQELTLnftmldVAIAHScdlrrLTVYGVI 274
Cdd:COG5238 254 ialaeaLKNNTTVETLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIGDEGA------IALAEG-----LQGNKTL 322

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 275 HELDLHNNSLREMPHIPLAA------NVSSLDLSHNPLGN---------LQGNPLRRFTSLLRLNLSATGAHELPEGLFK 339
Cdd:COG5238 323 HTLNLAYNGIGAQGAIALAKalqentTLHSLDLSDNQIGDegaialakyLEGNTTLRELNLGKNNIGKQGAEALIDALQT 402

                       250       260       270
                ....*....|....*....|....*....|....
gi 21356671 340 KQshLQMLDISGNSI-YSLKITIFDSLKALQYFY 372
Cdd:COG5238 403 NR--LHTLILDGNLIgAEAQQRLEQLLERIKSVY 434
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-326 1.43e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 1.43e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 142 LHLQGNQLKQLGNhsFHALKEVKELSLAENQLEQISLgvFSGMRKLMDLNLAGNR------LDALPrgvfdrnlNLTKLN 215
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQiekienLENLV--------NLKKLY 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 216 LARNRFTAFESelLKLQPVFTQLDISGnifQELTLNFTML-DVAIAHSCdLRRLTVygviheLDLHNNSLREMphIPLAA 294
Cdd:cd21340  75 LGGNRISVVEG--LENLTNLEELHIEN---QRLPPGEKLTfDPRSLAAL-SNSLRV------LNISGNNIDSL--EPLAP 140

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 21356671 295 --NVSSLDLSHNPLGNLQ--GNPLRRFTSLLRLNLS 326
Cdd:cd21340 141 lrNLEQLDASNNQISDLEelLDLLSSWPSLRELDLT 176
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 114-331 1.48e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  114 NLMSLFLGYNRLKD-IPKNifLGA-DNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLE-QISLGVFSgMRKLMDL 190
Cdd:PLN00113 381 NLFKLILFSNSLEGeIPKS--LGAcRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQML 457

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  191 NLAGNR-LDALPRgvFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGN-----IFQELTlnftmldvaiahSCd 264
Cdd:PLN00113 458 SLARNKfFGGLPD--SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENklsgeIPDELS------------SC- 522

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21356671  265 lRRLTvygvihELDLHNNSLREmpHIPLAAN----VSSLDLSHNPL-GNLQGNpLRRFTSLLRLNLSATGAH 331
Cdd:PLN00113 523 -KKLV------SLDLSHNQLSG--QIPASFSempvLSQLDLSQNQLsGEIPKN-LGNVESLVQVNISHNHLH 584
LRR_8 pfam13855
Leucine rich repeat;
91-149 3.44e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 3.44e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21356671    91 LQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLKDIPKNIFLGADNLATLHLQGNQL 149
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 107-354 4.32e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.99  E-value: 4.32e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  107 PQFEGASNLMSLFLGYNRLKD-IPKNIFlGADNLATLHLQGNQLKQLGNHSFHALKEVKELSLAENQLEQISLGVFSGMR 185
Cdd:PLN00113 254 SSLGNLKNLQYLFLYQNKLSGpIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLP 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  186 KLMDLNLAGNRLDA-LPRGVFDRNlNLTKLNLARNRFTAFESEllklqpvftQLDISGNIFQeLTLNFTMLDVAIAHS-- 262
Cdd:PLN00113 333 RLQVLQLWSNKFSGeIPKNLGKHN-NLTVLDLSTNNLTGEIPE---------GLCSSGNLFK-LILFSNSLEGEIPKSlg 401

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  263 -C-DLRRL---------------TVYGVIHELDLHNNSLR--------EMPHIPL-----------------AANVSSLD 300
Cdd:PLN00113 402 aCrSLRRVrlqdnsfsgelpsefTKLPLVYFLDISNNNLQgrinsrkwDMPSLQMlslarnkffgglpdsfgSKRLENLD 481

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 21356671  301 LSHNPLGNLQGNPLRRFTSLLRLNLSA---TGahELPEGLfKKQSHLQMLDISGNSI 354
Cdd:PLN00113 482 LSRNQFSGAVPRKLGSLSELMQLKLSEnklSG--EIPDEL-SSCKKLVSLDLSHNQL 535
LRR_8 pfam13855
Leucine rich repeat;
185-243 7.86e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 7.86e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 21356671   185 RKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQPVFTQLDISGN 243
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 125-353 1.99e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.10  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   125 LKDIPKNifLGADNLATLHLQGNQLKQL--GNHSFHAL-----------KEVKELSLAENqLEQISLGVFSG-------- 183
Cdd:PLN03210  601 LRCMPSN--FRPENLVKLQMQGSKLEKLwdGVHSLTGLrnidlrgsknlKEIPDLSMATN-LETLKLSDCSSlvelpssi 677

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   184 --MRKLMDLNLAG-NRLDALPRGVfdrNL-NLTKLNLAR-NRFTAFeselLKLQPVFTQLDISGNIFQELTLNFTMLDVA 258
Cdd:PLN03210  678 qyLNKLEDLDMSRcENLEILPTGI---NLkSLYRLNLSGcSRLKSF----PDISTNISWLDLDETAIEEFPSNLRLENLD 750

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   259 IAHSCDLRRLTVYGviheldlhnnslREMPHIPLAANVS----SLDLSHNPLGNLQGNPLRRFTSLLRLNL-SATGAHEL 333
Cdd:PLN03210  751 ELILCEMKSEKLWE------------RVQPLTPLMTMLSpsltRLFLSDIPSLVELPSSIQNLHKLEHLEIeNCINLETL 818

                         250       260
                  ....*....|....*....|
gi 21356671   334 PEGLfkKQSHLQMLDISGNS 353
Cdd:PLN03210  819 PTGI--NLESLESLDLSGCS 836
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 94-243 2.29e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 2.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  94 LRMENCSLETFEKpqFEGASNLMSLFLGYNRLKDIPKniFLGADNLATLHLQGNQ------------LKQL---GNH--- 155
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQiekienlenlvnLKKLylgGNRisv 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 156 --SFHALKEVKELSLAENQL---EQISLGVFSGM---RKLMDLNLAGNRLDAL-PRGVFDrnlNLTKLNLARNRFTAFE- 225
Cdd:cd21340  83 veGLENLTNLEELHIENQRLppgEKLTFDPRSLAalsNSLRVLNISGNNIDSLePLAPLR---NLEQLDASNNQISDLEe 159

                       170
                ....*....|....*....
gi 21356671 226 -SELLKLQPVFTQLDISGN 243
Cdd:cd21340 160 lLDLLSSWPSLRELDLTGN 178
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 156-354 5.36e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 5.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 156 SFHALKEVKELSLAENQLEQISLGVFSGMRKLMD-----LNLAGNRLDALPRGVF----DRNLNLTKLNLARNRFTAFES 226
Cdd:COG5238 146 VLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNnsvetVYLGCNQIGDEGIEELaealTQNTTVTTLWLKRNPIGDEGA 225

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671 227 ----ELLKLQPVFTQLDISGNIFQELTLnftmldVAIAHScdlrrLTVYGVIHELDLHNNSLREMPHIPLA------ANV 296
Cdd:COG5238 226 eilaEALKGNKSLTTLDLSNNQIGDEGV------IALAEA-----LKNNTTVETLYLSGNQIGAEGAIALAkalqgnTTL 294

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21356671 297 SSLDLSHNPLGN---------LQGNPLRRFTSLLRLNLSATGAHELPEGLfKKQSHLQMLDISGNSI 354
Cdd:COG5238 295 TSLDLSVNRIGDegaialaegLQGNKTLHTLNLAYNGIGAQGAIALAKAL-QENTTLHSLDLSDNQI 360
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-202 1.01e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671  74 NSSIAKIPHLlfDTFPDLQVLRMENCSLETFEkpQFEGASNLMSLFLGYNRL-------KDiPKNIFLGADNLATLHLQG 146
Cdd:cd21340  55 NNQIEKIENL--ENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLppgekltFD-PRSLAALSNSLRVLNISG 129

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 21356671 147 NQLKQLgnHSFHALKEVKELSLAENQLEQIS--LGVFSGMRKLMDLNLAGNRLDALPR 202
Cdd:cd21340 130 NNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
318-377 4.03e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.03e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21356671   318 TSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKITIFDSLKALQYFYFQQNN 377
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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