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Conserved domains on  [gi|22129199|ref|NP_667043|]
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olfactory receptor family 2 subfamily N member 1 [Mus musculus]

Protein Classification

family 2 olfactory receptor( domain architecture ID 11610423)

family 2 olfactory receptor is a G-protein coupled receptor (GPCR) that plays a central role in olfaction, the sense of smell; GPCRs transmit physiological signals from the outside of the cell to the inside via G proteins by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 5.19e-158

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


:

Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 441.68  E-value: 5.19e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 5.19e-158

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 441.68  E-value: 5.19e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-305 5.17e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 143.80  E-value: 5.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199    35 YPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   115 LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIKTACGEKET 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   195 NELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAI--SMYLQPPSSITKDQPK 272
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIglSMVHRFGHNVPPLLQI 244
                         250       260       270
                  ....*....|....*....|....*....|...
gi 22129199   273 FMALFYGVVTPTLNPFIYTLRNKDVKGALGNLF 305
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
 
Name Accession Description Interval E-value
7tmA_OR2B-like cd15947
olfactory receptor subfamily 2B and related proteins, member of the class A family of ...
25-294 5.19e-158

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320613 [Multi-domain]  Cd Length: 270  Bit Score: 441.68  E-value: 5.19e-158
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15947   1 MPLFVVVLIFYLLTLLGNTAIILLSLLDPRLHTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15947  81 LWLGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15947 161 IKLACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVLRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15947 241 SYSQDQGKFISLFYTVVTPTLNPLIYTLRN 270
7tmA_OR10A-like cd15225
olfactory receptor subfamily 10A and related proteins, member of the class A family of ...
25-301 3.97e-132

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320353  Cd Length: 277  Bit Score: 376.41  E-value: 3.97e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15225   1 LLLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15225  81 LFLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15225 161 LKLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPSAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15225 241 SYSPETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR2W-like cd15434
olfactory receptor subfamily 2W and related proteins, member of the class A family of ...
27-301 3.01e-127

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320551 [Multi-domain]  Cd Length: 277  Bit Score: 364.39  E-value: 3.01e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15434   3 LSVVVLIFYLLTLVGNTTIILVSCLDSRLHTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15434  83 LGGTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15434 163 LACVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAVLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSV 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15434 243 SQDQGKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277
7tmA_OR2B2-like cd15432
olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...
25-301 1.37e-126

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320549 [Multi-domain]  Cd Length: 277  Bit Score: 362.57  E-value: 1.37e-126
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15432   1 MVLFVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15432  81 LGLGSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPAL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15432 161 LKLSCVDTTANEAELFVISVLLLLIPLGLILISYIFIVRAVLRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15432 241 NSSHDRGKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277
7tmA_OR cd13954
olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...
25-294 5.17e-125

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320092 [Multi-domain]  Cd Length: 270  Bit Score: 358.33  E-value: 5.17e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd13954   1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd13954  81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd13954 161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPSAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd13954 241 SYSSDLDKVVSVFYTVVTPMLNPIIYSLRN 270
7tmA_OR2-like cd15237
olfactory receptor family 2 and related proteins, member of the class A family of ...
25-294 9.76e-124

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320365 [Multi-domain]  Cd Length: 270  Bit Score: 355.05  E-value: 9.76e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15237   1 ILLFILFLLIYLLTLLGNGLIILLIWLDSRLHTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15237  81 LALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15237 161 LKLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATILRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15237 241 THSPDQDKMISVFYTIVTPMLNPLIYSLRN 270
7tmA_OR5V1-like cd15231
olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...
27-301 1.00e-115

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320359 [Multi-domain]  Cd Length: 277  Bit Score: 335.00  E-value: 1.00e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15231   3 LFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFVS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15231  83 FVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15231 163 LSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTILKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSGY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15231 243 SLDKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277
7tmA_OR13H-like cd15431
olfactory receptor subfamily 13H and related proteins, member of the class A family of ...
26-294 7.50e-115

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320548 [Multi-domain]  Cd Length: 269  Bit Score: 332.27  E-value: 7.50e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15431   2 ILFVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEAtVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15431  82 FLGITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIPV-LTMPLHFCGPNVINHFFCEVQALL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15431 161 KLACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVLRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSK 240
                       250       260
                ....*....|....*....|....*....
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15431 241 SSSDQDKIISVFYGVVTPMLNPLIYSLRN 269
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
27-301 2.07e-114

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 331.44  E-value: 2.07e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15421   3 LFSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15421  83 LGGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15421 163 LSCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVLRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYH 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15421 243 SPEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277
7tmA_OR5-like cd15230
olfactory receptor family 5 and related proteins, member of the class A family of ...
26-294 9.35e-112

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320358  Cd Length: 270  Bit Score: 324.46  E-value: 9.35e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15230   2 PLFVLFLLIYLITLVGNLGMIVLIRIDSRLHTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15230  82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15230 162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITILRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241
                       250       260
                ....*....|....*....|....*....
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15230 242 YSLDQDKVVSVFYTVVIPMLNPLIYSLRN 270
7tmA_OR2F-like cd15429
olfactory receptor subfamily 2F and related proteins, member of the class A family of ...
27-301 1.85e-111

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320546 [Multi-domain]  Cd Length: 277  Bit Score: 324.35  E-value: 1.85e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15429   3 LFVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15429  83 LGGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15429 163 LACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAILRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15429 243 SALQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277
7tmA_OR5AP2-like cd15943
olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...
11-301 4.16e-109

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320609 [Multi-domain]  Cd Length: 295  Bit Score: 318.92  E-value: 4.16e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  11 EFILLGFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTK 90
Cdd:cd15943   1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNLGMIVLIRLDSRLHTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAENK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  91 TISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCG 170
Cdd:cd15943  81 TISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPFCG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 171 HNKLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLL 250
Cdd:cd15943 161 SNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAILRIHSSEGRRKAFSTCASHLMAVTI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129199 251 FYGPAISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15943 241 FYGTTLFMYLRPSSSYSLDQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDAL 291
7tmA_OR2A-like cd15420
olfactory receptor subfamily 2A and related proteins, member of the class A family of ...
27-301 3.02e-108

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320542 [Multi-domain]  Cd Length: 277  Bit Score: 315.81  E-value: 3.02e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15420   3 LFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15420  83 LAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15420 163 LACADTWINEILIFAGCVFILLGPFSLILISYLHILAAILKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSSN 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15420 243 SAEQEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277
7tmA_OR11A-like cd15911
olfactory receptor subfamily 11A and related proteins, member of the class A family of ...
25-294 6.74e-108

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320577  Cd Length: 270  Bit Score: 314.81  E-value: 6.74e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15911   1 ILLFLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15911  81 GSLAATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15911 161 LKLSCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTGRQKAFSTCSSHLIVVTIFYGTLIIVYVVPST 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15911 241 NTSRDLNKVFSLFYTVLTPLVNPLIYSLRN 270
7tmA_OR1_7-like cd15918
olfactory receptor families 1, 7, and related proteins, member of the class A family of ...
27-294 4.30e-107

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320584 [Multi-domain]  Cd Length: 270  Bit Score: 312.63  E-value: 4.30e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15918   3 LFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15918  83 FGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15918 163 LSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPSAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSSH 242
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15918 243 SASKDSVAAVMYTVVTPMLNPFIYSLRN 270
7tmA_OR6C-like cd15912
olfactory receptor subfamily 6C and related proteins, member of the class A family of ...
25-294 1.67e-106

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320578  Cd Length: 270  Bit Score: 311.34  E-value: 1.67e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15912   1 ILLFLLLLLTYLLTLLGNLLIITITLVDHRLHTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15912  81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15912 161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPSASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15912 241 SSSLDLNKVVALLNTVVTPLLNPFIYTLRN 270
7tmA_OR5AK3-like cd15408
olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...
12-298 3.20e-106

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320530  Cd Length: 287  Bit Score: 311.18  E-value: 3.20e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  12 FILLGFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKT 91
Cdd:cd15408   1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  92 ISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGH 171
Cdd:cd15408  81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 172 NKLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd15408 161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATILRMRSAEGRHKAFSTCASHLTAVTLF 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 252 YGPAISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVK 298
Cdd:cd15408 241 YGSLAFMYLRPSSRYSLDLDKVASVFYTVVIPMLNPLIYSLRNKEVK 287
7tmA_OR2Y-like cd15433
olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...
27-301 8.70e-106

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320550 [Multi-domain]  Cd Length: 277  Bit Score: 309.80  E-value: 8.70e-106
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15433   3 LFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15433  83 LGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15433 163 LACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVLRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHRY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15433 243 SQAHGKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277
7tmA_OR5D-like cd15410
olfactory receptor subfamily 5D and related proteins, member of the class A family of ...
12-305 2.53e-105

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320532  Cd Length: 294  Bit Score: 309.20  E-value: 2.53e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  12 FILLGFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKT 91
Cdd:cd15410   1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNLGMIVLIKIDPKLHTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAEDKA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  92 ISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGH 171
Cdd:cd15410  81 ISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 172 NKLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd15410 161 NVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTILRIRSAEGRQKAFSTCASHLTAITIF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129199 252 YGPAISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGALGNLF 305
Cdd:cd15410 241 HGTILFMYCRPSSSYSLDTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKLI 294
7tmA_OR1A-like cd15235
olfactory receptor subfamily 1A and related proteins, member of the class A family of ...
26-301 2.94e-105

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320363 [Multi-domain]  Cd Length: 278  Bit Score: 308.38  E-value: 2.94e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15235   3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15235  83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15235 163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPSAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15235 243 YSADKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278
7tmA_OR13-like cd15430
olfactory receptor family 13 and related proteins, member of the class A family of ...
27-294 5.65e-104

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320547 [Multi-domain]  Cd Length: 270  Bit Score: 305.06  E-value: 5.65e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15430   3 LFVLCLIMYLVILLGNGVLIIITILDSHLHTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLSLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15430  83 MGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15430 163 LACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTILRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKSKN 242
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15430 243 AQISDKLITLFYGVVTPMLNPIIYSLRN 270
7tmA_OR14-like cd15227
olfactory receptor family 14 and related proteins, member of the class A family of ...
28-294 1.31e-103

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320355  Cd Length: 270  Bit Score: 303.99  E-value: 1.31e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  28 FIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIM 107
Cdd:cd15227   4 FVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 108 GGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIKT 187
Cdd:cd15227  84 AASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 188 ACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSIT 267
Cdd:cd15227 164 SCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPSAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSDSP 243
                       250       260
                ....*....|....*....|....*..
gi 22129199 268 KDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15227 244 SLLDLLLSVFYSVVPPTLNPIIYSLRN 270
7tmA_OR8H-like cd15411
olfactory receptor subfamily 8H and related proteins, member of the class A family of ...
25-301 7.52e-103

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320533 [Multi-domain]  Cd Length: 279  Bit Score: 302.31  E-value: 7.52e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15411   1 VPLFVLFLVIYVITVMGNLGMILLIRADSQLHTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15411  81 IALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15411 161 LKLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTILKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15411 241 SYSLGQDKVASVFYTVVIPMLNPLIYSLRNKEVKNAL 277
7tmA_OR12D-like cd15915
olfactory receptor subfamily 12D and related proteins, member of the class A family of ...
27-294 7.52e-103

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320581 [Multi-domain]  Cd Length: 271  Bit Score: 301.92  E-value: 7.52e-103
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15915   3 LFVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15915  83 LGSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIG-HAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15915 163 LACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIIsFLLLKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSG 242
                       250       260
                ....*....|....*....|....*....
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15915 243 DSLEQDRIVALLYTVVTPVLNPLIYTLRN 271
7tmA_OR2D-like cd15428
olfactory receptor subfamily 2D and related proteins, member of the class A family of ...
27-301 3.56e-102

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320545 [Multi-domain]  Cd Length: 277  Bit Score: 300.55  E-value: 3.56e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15428   3 LFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15428  83 FGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15428 163 LASTDTHQAEMAMFIMCVFTLVLPVLLILASYTRIIYTVFGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMRPKSST 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15428 243 SKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277
7tmA_OR9K2-like cd15419
olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...
25-302 3.55e-100

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320541  Cd Length: 279  Bit Score: 295.37  E-value: 3.55e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15419   1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15419  81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15419 161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTILRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPGA 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGALG 302
Cdd:cd15419 241 VSSPEQSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALK 278
7tmA_OR2_unk cd15424
olfactory receptor family 2, unknown subfamily, member of the class A family of ...
27-301 2.37e-99

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320544 [Multi-domain]  Cd Length: 277  Bit Score: 293.57  E-value: 2.37e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15424   3 LFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIALS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15424  83 LGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15424 163 LACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVLQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPRSGS 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15424 243 TPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277
7tmA_OR5C1-like cd15945
olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...
12-301 5.16e-99

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320611  Cd Length: 292  Bit Score: 293.19  E-value: 5.16e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  12 FILLGFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKT 91
Cdd:cd15945   1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  92 ISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGH 171
Cdd:cd15945  81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 172 NKLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd15945 161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVLKIRSAEGRFKAFSTCASHLTAVGLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 22129199 252 YGPAISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15945 241 YGTLLFMYLRPSSSYSLDTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEAL 290
7tmA_OR8S1-like cd15229
olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...
26-301 6.89e-99

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320357 [Multi-domain]  Cd Length: 277  Bit Score: 292.19  E-value: 6.89e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15229   2 FLFLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15229  82 FFAGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15229 162 PLSCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTILRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSA 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15229 242 SSSVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277
7tmA_OR5A1-like cd15417
olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...
25-301 1.65e-98

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320539  Cd Length: 279  Bit Score: 291.47  E-value: 1.65e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15417   1 IILFVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15417  81 SGMGLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15417 161 LSLSCSDTFISQVVLFLVAVLFGVFSVLVVLISYGYIISTILKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15417 241 SHSQDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDAL 277
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
25-294 6.89e-96

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 284.15  E-value: 6.89e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15232   1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15232  81 TWSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15232 161 LLLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSILRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSS 240
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15232 241 SYSPEKDKVVAVLYSVVTPTLNPLIYSLRN 270
7tmA_OR5M-like cd15412
olfactory receptor subfamily 5M and related proteins, member of the class A family of ...
25-301 1.21e-95

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320534  Cd Length: 279  Bit Score: 283.91  E-value: 1.21e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15412   1 PLLFVLFLVIYLITLLGNLGMILLIRLDSRLHTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15412  81 IALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15412 161 IKLSCSDTYVKETAMFIVAGFNLSSSLLIILISYLFILIAILRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLRPPS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15412 241 EESVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQAL 277
7tmA_OR8D-like cd15406
olfactory receptor subfamily 8D and related proteins, member of the class A family of ...
16-301 2.71e-93

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320528 [Multi-domain]  Cd Length: 290  Bit Score: 278.48  E-value: 2.71e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  16 GFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYM 95
Cdd:cd15406   1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  96 RCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLD 175
Cdd:cd15406  81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 176 HLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPA 255
Cdd:cd15406 161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSILRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129199 256 ISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15406 241 IFMYLKPSSSSSMTQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNAL 286
7tmA_OR4-like cd15226
olfactory receptor family 4 and related proteins, member of the class A family of ...
25-294 2.86e-93

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320354 [Multi-domain]  Cd Length: 267  Bit Score: 277.55  E-value: 2.86e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15226   1 LFLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15226  81 HFFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNEL-------ALSVVCIFLLavplcliLASYASIGHAVFKiKSSEGRKKAFGTCSSHLIVVLLFYGPAIS 257
Cdd:cd15226 161 IKLACTDTYVLELmvvansgLISLVCFLLL-------LISYIVILVTVRK-HSSGGSSKALSTCSAHITVVVLFFGPCIF 232
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 258 MYLQPPSSITKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15226 233 IYVWPFSTFPVD--KFLAVFYTVITPLLNPIIYTLRN 267
7tmA_OR5AR1-like cd15944
olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...
12-305 7.39e-93

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320610 [Multi-domain]  Cd Length: 294  Bit Score: 277.44  E-value: 7.39e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  12 FILLGFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKT 91
Cdd:cd15944   1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  92 ISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGH 171
Cdd:cd15944  81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 172 NKLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd15944 161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAILRMRSAEGRRKAFSTCASHFTGVTLF 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129199 252 YGPAISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGALGNLF 305
Cdd:cd15944 241 YGTVIFMYLRPTSVYSLDQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKLI 294
7tmA_OR7-like cd15234
olfactory receptor family 7 and related proteins, member of the class A family of ...
26-301 4.95e-91

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320362 [Multi-domain]  Cd Length: 277  Bit Score: 272.14  E-value: 4.95e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15234   2 LLFGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15234  82 LFGGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLqppSS 265
Cdd:cd15234 162 KLACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPSSGGKYKAFSTCGSHLSVVSLFYGTGLGVYI---SS 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129199 266 ITKDQPKFMA---LFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15234 239 AVTHSSRKTAvasVMYTVVTPMLNPFIYSLRNKDMKGAL 277
7tmA_OR5P-like cd15416
olfactory receptor subfamily 5P and related proteins, member of the class A family of ...
25-301 5.45e-91

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320538 [Multi-domain]  Cd Length: 279  Bit Score: 272.32  E-value: 5.45e-91
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15416   1 IILFVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15416  81 ATFGTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15416 161 LKLSCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAILRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15416 241 SYSMDQNKVVSVFYMVVIPMLNPLIYSLRNKEVKGAL 277
7tmA_OR10G-like cd15916
olfactory receptor subfamily 10G and related proteins, member of the class A family of ...
26-301 1.07e-90

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320582 [Multi-domain]  Cd Length: 276  Bit Score: 271.24  E-value: 1.07e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGS-STKTISYMRCVVQLYFF 104
Cdd:cd15916   2 LLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEpGGKVISFGGCVAQLYFF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15916  82 HFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPPL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15916 162 LKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAILRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPGS 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDqpKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15916 242 KEALD--GVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276
7tmA_OR5H-like cd15409
olfactory receptor subfamily 5H and related proteins, member of the class A family of ...
26-301 1.61e-90

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320531 [Multi-domain]  Cd Length: 279  Bit Score: 271.20  E-value: 1.61e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15409   2 PLFLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15409  82 FSATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15409 162 KISCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTILKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSL 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15409 242 YALDQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDAL 277
7tmA_OR1330-like cd15946
olfactory receptor 1330 and related proteins, member of the class A family of ...
27-294 1.91e-89

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320612  Cd Length: 270  Bit Score: 267.81  E-value: 1.91e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15946   3 LFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFLA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15946  83 LGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15946 163 LACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAILKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSNY 242
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15946 243 SPERDKKISLFYNVFTALLNPVIYSLRN 270
7tmA_OR4A-like cd15939
olfactory receptor 4A and related proteins, member of the class A family of ...
27-294 4.37e-89

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320605 [Multi-domain]  Cd Length: 267  Bit Score: 266.77  E-value: 4.37e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15939   3 CFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15939  83 FGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACgeKETNELALSVVC----IFLLAvpLCLILASYASIGHAVfKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQP 262
Cdd:cd15939 163 LAC--TDTYVIGLLVVAnsglICLLS--FLILLISYIVILYSL-RTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRP 237
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129199 263 PSSITKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15939 238 VTTFPID--KVVAVFYTIITPMLNPLIYTLRN 267
7tmA_OR10D-like cd15228
olfactory receptor subfamily 10D and related proteins, member of the class A family of ...
27-301 1.53e-88

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320356 [Multi-domain]  Cd Length: 275  Bit Score: 265.83  E-value: 1.53e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15228   3 LFVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15228  83 LGSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15228 163 LACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISILKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSP 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPkfMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15228 243 VLVTP--VQIFNNVVTPMLNPLIYTLRNKEVKAAL 275
7tmA_OR11G-like cd15913
olfactory receptor OR11G and related proteins, member of the class A family of ...
27-294 2.40e-88

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320579  Cd Length: 270  Bit Score: 264.95  E-value: 2.40e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15913   3 LFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFFS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15913  83 LGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFLWFLIPVVLISQLPFCGPNIIDHFLCDPGPLLA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15913 163 LSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAVLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGSGN 242
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15913 243 STGMQKIVTLFYSVVTPLLNPLIYSLRN 270
7tmA_OR8K-like cd15413
olfactory receptor subfamily 8K and related proteins, member of the class A family of ...
26-301 2.72e-88

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320535  Cd Length: 279  Bit Score: 265.34  E-value: 2.72e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15413   2 PLFGLFLVIYLTTVMGNLGMIILTRLDSRLQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLAFFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15413  82 TFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDLPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15413 162 ALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAILRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQPKSS 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15413 242 HSLDTDKMASVFYTLVIPMLNPLIYSLRNKEVKDAL 277
7tmA_OR6B-like cd15224
olfactory receptor subfamily 6B and related proteins, member of the class A family of ...
27-294 4.82e-88

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320352  Cd Length: 270  Bit Score: 264.53  E-value: 4.82e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15224   3 LFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15224  83 LACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLLN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15224 163 LSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPSATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAIS 242
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15224 243 SFDSNKLVSVLYTVVTPLLNPIIYCLRN 270
7tmA_OR5G-like cd15414
olfactory receptor subfamily 5G and related proteins, member of the class A family of ...
25-302 4.49e-86

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320536 [Multi-domain]  Cd Length: 285  Bit Score: 260.05  E-value: 4.49e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15414   1 IPLFLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15414  81 GLFVAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15414 161 LSLSCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAILRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGALG 302
Cdd:cd15414 241 SSSLDLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALR 278
7tmA_OR6N-like cd15914
olfactory receptor OR6N and related proteins, member of the class A family of ...
27-294 2.05e-85

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320580 [Multi-domain]  Cd Length: 270  Bit Score: 257.68  E-value: 2.05e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15914   3 LFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFHS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15914  83 LGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLLS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15914 163 LACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVLKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKSY 242
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15914 243 SLDYDRAIAVVYAVLTPFFNPIIYSLRN 270
7tmA_OR5J-like cd15415
olfactory receptor subfamily 5J and related proteins, member of the class A family of ...
26-301 9.63e-85

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320537 [Multi-domain]  Cd Length: 279  Bit Score: 256.19  E-value: 9.63e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15415   2 PLFMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15415  82 VFVTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSS 265
Cdd:cd15415 162 KLSCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAILRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQ 241
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 266 ITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15415 242 YSLEQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDAL 277
7tmA_OR8B-like cd15405
olfactory receptor subfamily 8B and related proteins, member of the class A family of ...
25-301 5.79e-84

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320527 [Multi-domain]  Cd Length: 277  Bit Score: 254.26  E-value: 5.79e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15405   1 IPLFFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15405  81 CFFVISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15405 161 LQLSCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNILHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15405 241 VGSVNQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277
7tmA_OR4E-like cd15940
olfactory receptor 4E and related proteins, member of the class A family of ...
25-294 8.35e-84

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320606 [Multi-domain]  Cd Length: 267  Bit Score: 253.52  E-value: 8.35e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15940   1 LAFFMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15940  81 HLFACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKE-------TNELALSVVCIFLLavplcliLASYASIGHAVFKIkSSEGRKKAFGTCSSHLIVVLLFYGPAIS 257
Cdd:cd15940 161 IKLACTDTYlidilivSNSGLISLVCFVAL-------LGSYIVILVSLRKR-STEGRRKALSTCASHLTVVTLFFGPCIF 232
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 258 MYLQPPSSITKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15940 233 IYTRPSTSFSED--KVVSVFYTVVTPLLNPIIYTLRN 267
7tmA_OR9G-like cd15418
olfactory receptor subfamily 9G and related proteins, member of the class A family of ...
24-301 2.65e-83

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320540 [Multi-domain]  Cd Length: 281  Bit Score: 252.78  E-value: 2.65e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  24 ELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYF 103
Cdd:cd15418   1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 104 FHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPI 183
Cdd:cd15418  81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 184 LIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPP 263
Cdd:cd15418 161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAILRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 264 SSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15418 241 SSHTPDRDKVVALFYTVVNPLLNPLIYSLRNKDVKEAL 278
7tmA_OR5B-like cd15407
olfactory receptor subfamily 5B and related proteins, member of the class A family of ...
25-301 1.54e-82

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320529  Cd Length: 279  Bit Score: 250.80  E-value: 1.54e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15407   1 IPLFIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15407  81 VVFATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15407 161 LALSCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITILRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15407 241 SHSMDTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAF 277
7tmA_OR4D-like cd15936
olfactory receptor 4D and related proteins, member of the class A family of ...
25-294 8.75e-82

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320602 [Multi-domain]  Cd Length: 267  Bit Score: 248.40  E-value: 8.75e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15936   1 FFLFLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15936  81 HFTGGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIghaVFKIKS--SEGRKKAFGTCSSHLIVVLLFYGPAISMYLQP 262
Cdd:cd15936 161 IKLACTDTFLLELLMVSNSGLVTLLIFFILLISYTVI---LVKIRThvTEGKRKALSTCASQITVVTLIFVPCIYIYARP 237
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129199 263 PSSITKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15936 238 FQTFPMD--KAVSVLYTVITPMLNPMIYTLRN 267
7tmA_OR3A-like cd15233
olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...
27-301 1.85e-80

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320361 [Multi-domain]  Cd Length: 277  Bit Score: 245.47  E-value: 1.85e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15233   3 LFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFHL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15233  83 LAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLFQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15233 163 LSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVLRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSVY 242
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 267 TKDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15233 243 SSDKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277
7tmA_OR1E-like cd15236
olfactory receptor subfamily 1E and related proteins, member of the class A family of ...
28-301 4.30e-79

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320364 [Multi-domain]  Cd Length: 277  Bit Score: 241.98  E-value: 4.30e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  28 FIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIM 107
Cdd:cd15236   4 FALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFFIFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 108 GGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIKT 187
Cdd:cd15236  84 GCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVALLKL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 188 ACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSIT 267
Cdd:cd15236 164 SCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPSTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSSNNS 243
                       250       260       270
                ....*....|....*....|....*....|....
gi 22129199 268 KDQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15236 244 SDKDIVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277
7tmA_OR10S1-like cd15941
olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...
27-301 9.81e-79

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320607 [Multi-domain]  Cd Length: 277  Bit Score: 240.91  E-value: 9.81e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHS-PMYFFLTNLSFLDMCYTTSIVPQMLTNL-GSSTKTISYMRCVVQLYFF 104
Cdd:cd15941   3 FFLLFLLIYLLTVLGNLLILLTIGSDPHLHGlPMYHFLGHLSFLDACLSSVTVPKVLAGLlTLSGRTISFEGCVVQLYAF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15941  83 HFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPPV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15941 163 LKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVLRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPSS 242
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDqpKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15941 243 SQAGA--GAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277
7tmA_OR10G6-like cd15942
olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...
25-301 2.19e-78

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320608  Cd Length: 275  Bit Score: 240.03  E-value: 2.19e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15942   1 APLFLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15942  81 HFLGCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAM 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15942 161 LKLACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAILKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGS 240
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 22129199 265 SITKDqpKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15942 241 QDPLD--GVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275
7tmA_OR4Q2-like cd15938
olfactory receptor 4Q2 and related proteins, member of the class A family of ...
27-294 1.46e-72

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320604 [Multi-domain]  Cd Length: 265  Bit Score: 224.75  E-value: 1.46e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15938   3 LFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFLHF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIK 186
Cdd:cd15938  83 VGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPVIK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLLAVPLCLILASYASIghaVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPSSI 266
Cdd:cd15938 163 LACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTI---LVTIRSTEGRRKALSTCASHLMVVTLFFGPCIFIYARPFSTF 239
                       250       260
                ....*....|....*....|....*...
gi 22129199 267 TKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15938 240 PVD--KHVSVLYNVITPMLNPLIYTLRN 265
7tmA_OR4Q3-like cd15935
olfactory receptor 4Q3 and related proteins, member of the class A family of ...
25-294 2.41e-69

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320601 [Multi-domain]  Cd Length: 268  Bit Score: 216.55  E-value: 2.41e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDP-CLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYF 103
Cdd:cd15935   1 LLLFVLVLACYAAILLGNLLIVVTVHADPhLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 104 FHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPI 183
Cdd:cd15935  81 LHFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 184 LIKTACGEKETNELaLSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPP 263
Cdd:cd15935 161 VIKLACMDTYVVEV-LMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPF 239
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129199 264 SSITKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15935 240 SSSSVD--KVASVFYTLITPALNPLIYTLRN 268
7tmA_OR4N-like cd15937
olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...
25-294 3.89e-68

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320603  Cd Length: 267  Bit Score: 213.45  E-value: 3.89e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15937   1 LLLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPIL 184
Cdd:cd15937  81 HFLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLAVPLCLILASYASIgHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15937 161 IKLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFL-LAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFR 239
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 265 SITKDqpKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15937 240 SFPMD--KVVAVFHTVIFPLLNPMIYTLRN 267
7tmA_OR56-like cd15223
olfactory receptor family 56 and related proteins, member of the class A family of ...
21-301 7.93e-64

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320351 [Multi-domain]  Cd Length: 279  Bit Score: 202.91  E-value: 7.93e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  21 PWLELPLFIILLVtyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQ 100
Cdd:cd15223   1 HWLSLPFLLLYLV----ALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 101 LYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCE 180
Cdd:cd15223  77 MFFIHFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 181 IPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYL 260
Cdd:cd15223 157 HMALVSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAVLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129199 261 QPPSSITK--DQPKFMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15223 237 TYRFGKTIppDVHVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279
7tmA_OR51_52-like cd15917
olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...
22-295 1.38e-57

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341351  Cd Length: 275  Bit Score: 186.73  E-value: 1.38e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVtyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15917   2 WLSIPFCAMYLV----ALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15917  78 FFIHSFTAMESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYL- 260
Cdd:cd15917 158 MAVVKLACGDTRVNSIYGLFVALLIVGFDLLFIALSYVLILRAVLQLPSKEARLKALSTCGSHICVILIFYTPALFSFLt 237
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 261 -QPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNK 295
Cdd:cd15917 238 hRFGHHVPPHVHILLANLYLLLPPMLNPIVYGVRTK 273
7tmA_OR52E-like cd15952
olfactory receptor subfamily 52E and related proteins, member of the class A family of ...
22-297 1.18e-56

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320618  Cd Length: 274  Bit Score: 184.12  E-value: 1.18e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIIllvtYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15952   2 WIGFPFCAV----YLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15952  78 FFIHTFTGMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETN-ELALSVVCIFLLAVplCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYL 260
Cdd:cd15952 158 MGIAKLACASIRINiIYGLFAISVLVLDV--ILIALSYVLILRAVFRLPSHDARLKALSTCGSHVCVILAFYTPALFSFL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129199 261 ------QPPSSITkdqpKFMALFYGVVTPTLNPFIYTLRNKDV 297
Cdd:cd15952 236 thrfghNIPRYIH----ILLANLYVVLPPMLNPVIYGVRTKQI 274
7tmA_OR52I-like cd15950
olfactory receptor subfamily 52I and related proteins, member of the class A family of ...
22-297 5.73e-56

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320616  Cd Length: 275  Bit Score: 182.61  E-value: 5.73e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIIllvtYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15950   2 WIAIPFCSM----YVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15950  78 FFVHSFTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAI-SMYL 260
Cdd:cd15950 158 MAVVKLACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVLGLSSKEARLKAFSTCGSHVCVILLFYIPGLlSIYT 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 261 QP-PSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDV 297
Cdd:cd15950 238 QRfGQGVPPHTQVLLADLYLLVPPMLNPIIYGMRTKQI 275
7tmA_OR52B-like cd15221
olfactory receptor subfamily 52B and related proteins, member of the class A family of ...
22-295 7.60e-53

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320349  Cd Length: 275  Bit Score: 174.40  E-value: 7.60e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIIllvtYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15221   2 WISIPFCSM----YIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRncilLVSTVWLTGI--SYAVSEATVTL--QLPLCGHNKLDHL 177
Cdd:cd15221  78 FFVHFVFVTESAILLAMAFDRYVAICYPLRYTTILTHS----VIGKIGVAAVarSFCIVFPFVFLlkRLPYCGHNVIPHT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 178 VCEIPILIKTACGEketnelaLSVVCIFLLAVPL-------CLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLL 250
Cdd:cd15221 154 YCEHMGIARLACAD-------ITVNIWYGLTVALltvgldvVLIAVSYALILRAVFRLPSKDARLKALSTCGSHVCVILM 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 251 FYGPAISMYL--QPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNK 295
Cdd:cd15221 227 FYTPAFFSFLthRFGRHIPRHVHILLANLYVLVPPMLNPIVYGVKTK 273
7tmA_OR51-like cd15222
olfactory receptor family 51 and related proteins, member of the class A family of ...
21-295 1.07e-50

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320350  Cd Length: 275  Bit Score: 168.83  E-value: 1.07e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  21 PWLELPLFIIllvtYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQ 100
Cdd:cd15222   1 HWISIPFCLL----YLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 101 LYFFHIMGGTEC-VLLAlMSFDRYVAICKPLHYTLimnqrncILLVSTVWLTGISYAVSEATVTLQLPL-------CGHN 172
Cdd:cd15222  77 MFFIHTFSFMESsVLLA-MAFDRFVAICNPLRYAS-------ILTNSRIAKIGLAIVLRSVLLLLPLPFllkrlpfCHSN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 173 KLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFY 252
Cdd:cd15222 149 VLSHSYCLHQDVMKLACSDTRVNSIYGLFVVLSTMGLDSLLILLSYVLILKTVLGIASREERLKALNTCVSHICAVLIFY 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129199 253 GPAISM-----YLQPPSSITKdqpKFMALFYGVVTPTLNPFIYTLRNK 295
Cdd:cd15222 229 VPMIGLsmvhrFGKHASPLVH---VLMANVYLLVPPVLNPIIYSVKTK 273
7tmA_OR52R_52L-like cd15951
olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...
22-297 3.56e-48

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320617  Cd Length: 275  Bit Score: 162.52  E-value: 3.56e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVtyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15951   2 WISIPFCIMYAV----ALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15951  78 FFIHSFSTMESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQ 261
Cdd:cd15951 158 MAVVKLACADTRVSRAYGLSVAFLVGGLDVIFIAVSYIQILRAVFKLPSKEARLKTFGTCGSHICVILVFYIPALFSFLT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22129199 262 --------PPSSItkdqpkFMALFYGVVTPTLNPFIYTLRNKDV 297
Cdd:cd15951 238 hrfghnvpPHVHI------LIANVYLLVPPMLNPIIYGVRTKQI 275
7tmA_OR52P-like cd15953
olfactory receptor subfamily 52P and related proteins, member of the class A family of ...
22-295 1.08e-46

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 341354  Cd Length: 275  Bit Score: 158.58  E-value: 1.08e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15953   2 WISIPFCLMYIVT----LLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15953  78 FFIHTLSIMESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQ 261
Cdd:cd15953 158 MAVVKLACGDTTINRIYGLVVALLVVGLDLLLIALSYALIIRAVLRLSSKKARQKALNTCTAHICVILMSYTPALFSFLT 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129199 262 -------PPSSITkdqpkFMALFYGVVTPTLNPFIYTLRNK 295
Cdd:cd15953 238 hrfgqgiAPHIHI-----ILANLYLLVPPMLNPIIYGVKTK 273
7tmA_OR52K-like cd15948
olfactory receptor subfamily 52K and related proteins, member of the class A family of ...
21-298 4.79e-46

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320614 [Multi-domain]  Cd Length: 277  Bit Score: 156.99  E-value: 4.79e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  21 PWLELPLfiilLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQ 100
Cdd:cd15948   2 PWISIPF----CSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 101 LYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRncilLVSTVWLTGISYAVSEAT----VTLQLPLCGHNKLDH 176
Cdd:cd15948  78 MFFLHSFSIMESAVLLAMAFDRYVAICNPLRYATILTNS----VITKIGLAALARAVTLMTplpfLLRRLPYCRSHVIAH 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 177 LVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAI 256
Cdd:cd15948 154 CYCEHMAVVKLACGDTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASKEEQLKAFGTCGSHICAILVFYTPVV 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 22129199 257 --SMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDVK 298
Cdd:cd15948 234 lsSTMHRFARHVAPHVHILLANFYLLFPPMMNPIVYGVKTKQIR 277
7tm_4 pfam13853
Olfactory receptor; The members of this family are transmembrane olfactory receptors.
35-305 5.17e-41

Olfactory receptor; The members of this family are transmembrane olfactory receptors.


Pssm-ID: 404695  Cd Length: 278  Bit Score: 143.80  E-value: 5.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199    35 YPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVL 114
Cdd:pfam13853   5 YLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIMESAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   115 LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIKTACGEKET 194
Cdd:pfam13853  85 LLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCADIKV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   195 NELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAI--SMYLQPPSSITKDQPK 272
Cdd:pfam13853 165 NNIYGLFVVTSTFGIDSLLIVLSYGLILRTVLGIASREGRLKALNTCGSHVCAVLAFYTPMIglSMVHRFGHNVPPLLQI 244
                         250       260       270
                  ....*....|....*....|....*....|...
gi 22129199   273 FMALFYGVVTPTLNPFIYTLRNKDVKGALGNLF 305
Cdd:pfam13853 245 MMANAYLFFPPVLNPIVYSVKTKQIRDCVKRML 277
7tmA_OR52W-like cd15956
olfactory receptor subfamily 52W and related proteins, member of the class A family of ...
22-297 6.01e-41

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320622 [Multi-domain]  Cd Length: 275  Bit Score: 143.47  E-value: 6.01e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVtyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15956   2 WLSLPFCFIYVL----SLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15956  78 FLVHAFSAMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYL- 260
Cdd:cd15956 158 MAVVKLACGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSPEARGKAFSTCSAHICVILFFYIPGLLSVLm 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 261 -QPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDV 297
Cdd:cd15956 238 hRFGHSVPSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275
7tmA_OR52M-like cd15949
olfactory receptor subfamily 52M and related proteins, member of the class A family of ...
9-298 5.83e-40

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320615  Cd Length: 292  Bit Score: 141.45  E-value: 5.83e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   9 PEEFILLGFADRPWLELPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSS 88
Cdd:cd15949   1 PSTFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  89 TKTISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPL 168
Cdd:cd15949  81 SNEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPW 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 169 CGHNKLDHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVV 248
Cdd:cd15949 161 YRTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLATSEARLKTFGTCVSHVCAI 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 22129199 249 LLFYGPAISMYL--------QPPSSItkdqpkFMALFYGVVTPTLNPFIYTLRNKDVK 298
Cdd:cd15949 241 LAFYVPIAVSSLihrfgqnvPPPTHI------LLANFYLLIPPMLNPIVYGVRTKQIQ 292
7tmA_OR52N-like cd15954
olfactory receptor subfamily 52N and related proteins, member of the class A family of ...
22-297 7.39e-39

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320620  Cd Length: 276  Bit Score: 138.03  E-value: 7.39e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVtyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15954   2 WISIPFCFMYII----AMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15954  78 FFVHTFTGMESGVLMLMALDRYVAICYPLRYATILTNPVITKAGLATFLRGVMLIIPFPLLTKRLPYCRGNFIPHTYCDH 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQ 261
Cdd:cd15954 158 MSVVKLACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSSKEARSKAFSTCTAHICAIVITYTPAFFTFFA 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129199 262 ---PPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDV 297
Cdd:cd15954 238 hrfGGHHITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
41-290 1.10e-37

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 134.35  E-value: 1.10e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199    41 GNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLT-NLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMS 119
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVyYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   120 FDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNkldHLVCEIPILIKTACgeketNELAL 199
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGN---VTVCFIDFPEDLSK-----PVSYT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199   200 SVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGR-------KKAFGTCSSHLIVVLLFYGPAISMYLQPPSSITKDQPK 272
Cdd:pfam00001 153 LLISVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrRKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSR 232
                         250       260
                  ....*....|....*....|....
gi 22129199   273 FM------ALFYGVVTPTLNPFIY 290
Cdd:pfam00001 233 LLdkalsvTLWLAYVNSCLNPIIY 256
7tmA_OR52A-like cd15955
olfactory receptor subfamily 52A and related proteins, member of the class A family of ...
22-297 1.25e-33

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320621 [Multi-domain]  Cd Length: 276  Bit Score: 124.50  E-value: 1.25e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVtyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15955   2 WIGIPFCIMFLL----AVLGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQM 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRncillvstvWLTGISYAVSEATVTLQLPLCGHNKL------- 174
Cdd:cd15955  78 FFIHTLQAFESGILLAMALDRYVAICHPLRHSSILTPQ---------VLLGIGVLVVVRAVVLIIPCPLLIKLrlhhfrs 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 175 ---DHLVCEIPILIKTACGEKETNELALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd15955 149 tviSHSYCEHMAVVKLAADDVRVNKIYGLFVAFSILGFDIIFITTSYALIFRAVFRLPQKEARLKAFNTCTAHIFVFLLF 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 22129199 252 YGPAISMYL--QPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRNKDV 297
Cdd:cd15955 229 YTLAFFSFFahRFGHHVAPYVHILLSNLYLLVPPVLNPIVYGVKTKQI 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
27-294 9.80e-26

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 103.14  E-value: 9.80e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVseatvtlqLPLCGHNKLDHlvceIPILIK 186
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLAL--------PPLLGWGVYDY----GGYCCC 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 187 TACGEKETNELALSVVCIFLL-AVPLCLILASYASIGHAVFK--------------IKSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd00637 149 CLCWPDLTLSKAYTIFLFVLLfLLPLLVIIVCYVRIFRKLRRhrrrirssssnssrRRRRRRERKVTKTLLIVVVVFLLC 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 252 YGPAISMYL----QPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd00637 229 WLPYFILLLldvfGPDPSPLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
25-301 2.60e-16

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 77.22  E-value: 2.60e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd14967   4 VFLSLIILVT----VFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVseatvtlqLPLcghnKLDHLVCEIPIL 184
Cdd:cd14967  80 VLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISL--------PPL----VGWRDETQPSVV 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLavPLCLILASYASIghavFKIKSSEgrKKAFGTCSshlIVVLLFY---GPAISMYL- 260
Cdd:cd14967 148 DCECEFTPNKIYVLVSSVISFFI--PLLIMIVLYARI----FRVARRE--LKAAKTLA---IIVGAFLlcwLPFFIIYLv 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 22129199 261 ---QPPSSITkdqPKFMALFY--GVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd14967 217 safCPPDCVP---PILYAVFFwlGYLNSALNPIIYALFNRDFRRAF 259
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
26-236 7.78e-14

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 70.17  E-value: 7.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15012   1 IFIILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLT----GISYAVSEATVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15012  81 LSYTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTsavyNTPYFVFSQTVEILVTQDGQEEEICVLDRE 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129199 182 PILIKtacgeketneLALSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEGRKK 236
Cdd:cd15012 161 MFNSK----------LYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRK 205
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
40-221 4.52e-10

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 59.53  E-value: 4.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  40 IGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMS 119
Cdd:cd14969  16 VLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAVTFLGLVSISTLAALA 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 120 FDRYVAICKPLHYTlIMNQRNCILLVSTVWLTGISYAVseatvtlqLPLCGHNKLdhlvceIPILIKTACG----EKETN 195
Cdd:cd14969  96 FERYLVIVRPLKAF-RLSKRRALILIAFIWLYGLFWAL--------PPLFGWSSY------VPEGGGTSCSvdwySKDPN 160
                       170       180
                ....*....|....*....|....*..
gi 22129199 196 ELALSVVC-IFLLAVPLCLILASYASI 221
Cdd:cd14969 161 SLSYIVSLfVFCFFLPLAIIIFCYYKI 187
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
26-222 6.98e-09

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 55.74  E-value: 6.98e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15001   1 PVIIVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPL---HYTLIMNQRNCILLvstVWLTGISYAVSEATVTLQLPLCGHNKLDHLVCEIp 182
Cdd:cd15001  81 LSFICSVLTLTAISIERYYVILHPMkakSFCTIGRARKVALL---IWILSAILASPVLFGQGLVRYESENGVTVYHCQK- 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 22129199 183 iliktACGEKETNELALSVVCIFLLAVPLCLILASYASIG 222
Cdd:cd15001 157 -----AWPSTLYSRLYVVYLAIVIFFIPLIVMTFAYARDT 191
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
29-295 2.16e-08

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 54.53  E-value: 2.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPT----AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSS-------TKTISYMR 96
Cdd:cd14993   1 IVLIVLYVVvfllALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFCMPlTLLENVYRPwvfgevlCKAVPYLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  97 CVVQlyffhimgGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISyavseatvtLQLPLCGHNKLDH 176
Cdd:cd14993  81 GVSV--------SASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAII---------IMLPLLVVYELEE 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 177 LVCEIPILI-KTACGEKETNE---LALSVVC-IFLLAVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSH------- 244
Cdd:cd14993 144 IISSEPGTItIYICTEDWPSPelrKAYNVALfVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGSANSTSSRRilrskkk 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22129199 245 -----LIVVLLF-------YGPAISMYLQPPSSITKDQPKFM----ALFYGVVTPTLNPFIYTLRNK 295
Cdd:cd14993 224 varmlIVVVVLFalswlpyYVLSILLDFGPLSSEESDENFLLilpfAQLLGYSNSAINPIIYCFMSK 290
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
26-300 2.69e-08

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 53.86  E-value: 2.69e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAmIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15052   3 AALLLLLLVIATI-GGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVGLLVMPlSILTELFGGVWPLPLVLCLLWVTLD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSeatvtlqLPLCGHNKLDHLVceipIL 184
Cdd:cd15052  82 VLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWL--ISIGIS-------SPIPVLGIIDTTN----VL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACGEKETNELALSVVCIFLLavPLCLILASYAsighavFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPP- 263
Cdd:cd15052 149 NNGTCVLFNPNFVIYGSIVAFFI--PLLIMVVTYA------LTIRLLSNEQKASKVLGIVFAVFVICWCPFFITNILTGl 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129199 264 --SSITKDQPKFMALF--YGVVTPTLNPFIYTLRNKDVKGA 300
Cdd:cd15052 221 ceECNCRISPWLLSVFvwLGYVSSTINPIIYTIFNKTFRRA 261
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
38-301 3.65e-08

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 53.45  E-value: 3.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd14972  12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLVSLTPSPATWLLRKGSLVLSLLASAYSLLAI 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 mSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVseatvtlqLPLCGHNKLDhlvCEIPILIKTACGEKETNEL 197
Cdd:cd14972  92 -AVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLAL--------LPVLGWNCVL---CDQESCSPLGPGLPKSYLV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 198 ALSVVCIFLLAVPLCLILASYASIGHAVFKIK----------SSEGRKKAFgTCSSHLIVVLLFYGPAISMYLQ----PP 263
Cdd:cd14972 160 LILVFFFIALVIIVFLYVRIFWCLWRHANAIAarqeaavpaqPSTSRKLAK-TVVIVLGVFLVCWLPLLILLVLdvlcPS 238
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 264 SSITKDQPKFMALFyGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd14972 239 VCDIQAVFYYFLVL-ALLNSAINPIIYAFRLKEMRRAV 275
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
22-303 3.86e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 53.37  E-value: 3.86e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSSTKTISYMRCVVQ 100
Cdd:cd15305   2 WPALLILIIIILT----IGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPvSLIAILYDYAWPLPRYLCPIW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 101 LYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISyavseatVTLQLPLCGhnkldhLVCE 180
Cdd:cd15305  78 ISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIG-------ISMPIPVIG------LQDD 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 181 IPILIKTACGEKETNELALSVVCIFLlaVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGP----AI 256
Cdd:cd15305 145 EKVFVNGTCVLNDENFVLIGSFVAFF--IPLIIMVITYCLTIQVLQRQQAINNERRASKVLGIVFFLFLIMWCPffitNI 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 22129199 257 SMYLQPPSSITKDQPKFMALFY--GVVTPTLNPFIYTLRNKDVKGALGN 303
Cdd:cd15305 223 LSVLCKEACDQKLMEELLNVFVwvGYVSSGINPLVYTLFNKTYRRAFSN 271
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
29-225 1.33e-07

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 51.95  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCvvQLYFF--HI 106
Cdd:cd15083   5 IFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILNCPLMVISSFSGRWIFGKTGC--DMYGFsgGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCGHNK--LDHLV--CEIP 182
Cdd:cd15083  83 FGIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLP--------PLFGWSRyvLEGLLtsCSFD 154
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 22129199 183 ILIKTAcgekeTNELALSVVCIFLLAVPLCLILASYASIGHAV 225
Cdd:cd15083 155 YLSRDD-----ANRSYVICLLIFGFVLPLLIIIYCYSFIFRAV 192
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
38-301 4.50e-07

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 50.28  E-value: 4.50e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd15326  14 AIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTASILSLCA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 MSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTgisyavseATVTLQLPLCGHNK---LDHLVCEIPiliktacgEKET 194
Cdd:cd15326  94 ISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVL--------STVISIGPLLGWKEpapPDDKVCEIT--------EEPF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 195 NELALSVVCIFllaVPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAI-----SMYLQPPSSITKd 269
Cdd:cd15326 158 YALFSSLGSFY---IPLIVILVMYCRVYIVALKFSREKKAAKTLGIVVGMFILCWLPFFIALplgslFSHLKPPETLFK- 233
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129199 270 qpkfMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15326 234 ----IIFWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
38-231 5.01e-07

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 50.37  E-value: 5.01e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTtSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd14970  14 GLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFL-LGLPFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIFCLTV 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 MSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNklDHLVCEIPiliktacgEKETNEL 197
Cdd:cd14970  93 MSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGT--ISCNLQWP--------DPPDYWG 162
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 22129199 198 ALSVVCIFLL--AVPLCLILASYASIghaVFKIKSS 231
Cdd:cd14970 163 RVFTIYTFVLgfAVPLLVITVCYSLI---IRRLRSS 195
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
23-223 8.12e-07

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 49.74  E-value: 8.12e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  23 LELPLFIILLVTyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPqmLTnLGSSTKTISYMRCVVQLY 102
Cdd:cd15394   2 LIIPLYSLVVLV---GVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATCVP--LT-LAYAFEPRGWVFGRFMCY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 103 FFHIMGGTEcVLLALMSF-----DRYVAICKPLHYTLIMnqRNCILLVSTVWLTGISYAVSEATVTLQLPLCGHnklDHL 177
Cdd:cd15394  76 FVFLMQPVT-VYVSVFTLtaiavDRYYVTVYPLRRRISR--RTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGL---DFS 149
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 22129199 178 VCEipilikTACGEKETNELALSvvCIFLL---AVPLCLILASYASIGH 223
Cdd:cd15394 150 ICE------EFWFGQEKQRLAYA--CSTLLityVLPLLAISLSYLRISV 190
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
21-165 1.65e-06

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 48.60  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  21 PWLELPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRC--- 97
Cdd:cd15058   1 PGLLLLLALIILAI----VVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWCelw 76
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 22129199  98 -VVQLYFFHIMGGTECVLlalmSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSEATVTLQ 165
Cdd:cd15058  77 tSVDVLCVTASIETLCVI----AVDRYIAITRPLRYQVLLTKRRARVIVCVVWI--VSALVSFVPIMNQ 139
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
39-251 3.39e-06

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 47.85  E-value: 3.39e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  39 MIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALM 118
Cdd:cd14971  15 LVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQQVSMHASIFTLVAM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 119 SFDRYVAICKPLHYTLIMNQRNCILLVSTVWltGISYAVSeatvtlqLPLCGHNKLDHLVCEipilIKTACGEKETN--- 195
Cdd:cd14971  95 SLDRFLAVVYPLRSLHIRTPRNALAASGCIW--VVSLAVA-------APVLALHRLRNYTPG----NRTVCSEAWPSrah 161
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22129199 196 ELALsVVCIFLLA--VPLCLILASYASIGHAVFKI--------KSSEGRKKafgTCSSHLIVVLLF 251
Cdd:cd14971 162 RRAF-ALCTFLFGylLPLLLICVCYAAMLRHLWRVavrpvlseGSRRAKRK---VTRLVLVVVVLF 223
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
39-301 3.42e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 47.58  E-value: 3.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  39 MIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALM 118
Cdd:cd15325  15 VLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCII 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 119 SFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCGHNK---LDHLVCEIpiliktacgEKETN 195
Cdd:cd15325  95 SIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIG--------PLFGWKEpapEDETICQI---------TEEPG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 196 ELALSVVCIFLLavPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFY---GPAISMY--LQPPSSITKdq 270
Cdd:cd15325 158 YALFSALGSFYL--PLAIILVMYCRVYVVALKFSREKKAAKTLGIVVGCFVLCWLPFflvMPIGSIFpaYKPSDTVFK-- 233
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129199 271 pkfMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15325 234 ---ITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
27-156 5.66e-06

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 47.07  E-value: 5.66e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSSTKTISYMRCVV-----Q 100
Cdd:cd15005   7 LGLILCVS----LAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLACFPfVMASVRHGSGWIYGALSCKViaflaV 82
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129199 101 LYFFHIMggtecVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYA 156
Cdd:cd15005  83 LFCFHSA-----FTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMA 133
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
40-223 6.61e-06

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 46.83  E-value: 6.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  40 IGNIAIILVSILDPCLHSPMYFFLTNLSFLD--MCYTTsiVP-QMLTNlgsstktisymrcvvqLYFFHIMGGTECVL-- 114
Cdd:cd15203  16 VGNLLVIYVVLRNKSMQTVTNIFILNLAVSDllLCLVS--LPfTLIYT----------------LTKNWPFGSILCKLvp 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 115 -------------LALMSFDRYVAICKPLHYtlIMNQRNCILLVSTVWLtgISYAVSeatvtlqLPLCGHNKLDHLVCEI 181
Cdd:cd15203  78 slqgvsifvstltLTAIAIDRYQLIVYPTRP--RMSKRHALLIIALIWI--LSLLLS-------LPLAIFQELSDVPIEI 146
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 22129199 182 PILIKTACGEKETNELALSV----VCIFLLAVPLCLILASYASIGH 223
Cdd:cd15203 147 LPYCGYFCTESWPSSSSRLIytisVLVLQFVIPLLIISFCYFRISL 192
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
30-254 8.80e-06

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 46.31  E-value: 8.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  30 ILLVTYPTAMIGNIAIILVSILDPCLH----SPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15365   2 LFPFVYIFVIVISIPSNCISLYVSCLQirkkNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYavseATVTLQLPLCGHNKLDHLVCEIPILI 185
Cdd:cd15365  82 TNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICF----NAVILTWEDSFHESSSHTLCYDKFPL 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22129199 186 ktacgEKETNELALSVVCIFLLaVPLCLILASYASIGHAVFKIKSSEG--RKKAFGTCSSHLIVVLLFYGP 254
Cdd:cd15365 158 -----EDWQARLNLFRICLGYL-LPLLIILFCYWKIYQAVRSNQATEDqeKKKIFKLLLLITVTFVICFTP 222
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
23-150 8.95e-06

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 46.20  E-value: 8.95e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  23 LELPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSSTKTISYMRCVVqL 101
Cdd:cd15067   2 LGVVLSLFCLVT----VAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMPfSILHEMTGGYWLFGRDWCDV-W 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15067  77 HSFDVLASTASILnLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWI 126
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
38-300 9.75e-06

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 46.33  E-value: 9.75e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd15062  14 AIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 MSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCGHNK---LDHLVCEIpiliktacgEKET 194
Cdd:cd15062  94 ISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIG--------PLLGWKEpapADEQACGV---------NEEP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 195 NELALSVVCIFLLavPLCLILASYASIGHAVFKIKSSEGRKKAFGtcsshlIVVLLFYGPAISMYLQPP-----SSITKD 269
Cdd:cd15062 157 GYVLFSSLGSFYL--PLAIILVMYCRVYVVAFKFSREKKAAKTLG------IVVGAFVLCWFPFFVVLPlgslfSTLKPP 228
                       250       260       270
                ....*....|....*....|....*....|..
gi 22129199 270 QPKFMALFY-GVVTPTLNPFIYTLRNKDVKGA 300
Cdd:cd15062 229 EPVFKVVFWlGYFNSCLNPIIYPCSSREFKRA 260
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
28-251 1.02e-05

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 46.26  E-value: 1.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  28 FIILLV---TYPTAMIGNIAIILVSILDPCL--HSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLY 102
Cdd:cd15098   1 VIVPVVfglIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 103 FFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL----TGISYAVSEATVTlqlplcGHNKLDHlv 178
Cdd:cd15098  81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVlslaMASPVAVHQDLVH------HWTASNQ-- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 179 ceipilikTACGEKETNELA--LSVVCIFLL--AVPLCLILASYASIGHAVFKiKSSEGRKKAFG----TCSSHLIVVLL 250
Cdd:cd15098 153 --------TFCWENWPEKQQkpVYVVCTFVFgyLLPLLLITFCYAKVLNHLHK-KLKNMSKKSERskkkTAQTVLVVVVV 223

                .
gi 22129199 251 F 251
Cdd:cd15098 224 F 224
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
37-227 1.18e-05

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 46.16  E-value: 1.18e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  37 TAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIvpqmltnlGSSTKTISYMR---------CvvQLYFF--H 105
Cdd:cd15337  13 LGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVN--------GFPLKTISSFNkkwiwgkvaC--ELYGFagG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVseatvtlqLPLCGHNKLdhlvceIPILI 185
Cdd:cd15337  83 IFGFMSITTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSI--------PPFFGWGRY------VPEGF 148
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129199 186 KTACG----EKETNELaLSVVCIFLL--AVPLCLILASYASIGHAVFK 227
Cdd:cd15337 149 QTSCTfdylSRDLNNR-LFILGLFIFgfLCPLLIIIFCYVNIIRAVRN 195
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
26-222 1.29e-05

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 46.19  E-value: 1.29e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd14979   2 LVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNFWWQYPWAFGDGGCKLYYFLF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAvseatvtlqLPLCGHNKLDHLVCEIPIL 184
Cdd:cd14979  82 EACTYATVLtIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCA---------IPILFLMGIQYLNGPLPGP 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 22129199 185 IK--TACG--EKETNELALSVVCIFL-LAVPLCLILASYASIG 222
Cdd:cd14979 153 VPdsAVCTlvVDRSTFKYVFQVSTFIfFVLPMFVISILYFRIG 195
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
42-301 1.42e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 45.96  E-value: 1.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  42 NIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMSFD 121
Cdd:cd15076  18 NAIVLFVTIKYKKLRQPLNYILVNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGWSLAFLAFE 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 122 RYVAICKPLHyTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCGHNKLdhlvceIPILIKTACG-------EKET 194
Cdd:cd15076  98 RYIVICKPFG-NFRFGSKHALGAVVATWIIGIGVSLP--------PFFGWSRY------IPEGLQCSCGpdwytvgTKYR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 195 NELALSVVCIFLLAVPLCLILASYASIGHAVFKI----KSSEGRKKAFGTCSSHLIVVL----LFYGP--AISMYLQPPS 264
Cdd:cd15076 163 SEYYTWFLFIFCFIVPLSIIIFSYSQLLGALRAVaaqqQESASTQKAEREVSRMVVVMVgsfcLCYVPyaALAMYMVNNR 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129199 265 SITKDQpKFMAL--FYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15076 243 DHGLDL-RLVTIpaFFSKSSCVYNPIIYCFMNKQFRACI 280
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
22-165 1.65e-05

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 45.69  E-value: 1.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSSTKTISYMRCVVQ 100
Cdd:cd15304   2 WPALLTVIVIILT----IAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVW 77
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22129199 101 LYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATVTLQ 165
Cdd:cd15304  78 IYLDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQ 142
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-155 1.86e-05

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 45.32  E-value: 1.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  39 MIGNIAIILVsILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNL-----GSSTKTISYMRCVVQLYFFHIMGGTECV 113
Cdd:cd14978  15 IIGNILNLVV-LTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYiadysSSFLSYFYAYFLPYIYPLANTFQTASVW 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129199 114 LLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISY 155
Cdd:cd14978  94 LTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLL 135
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
22-306 2.22e-05

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 45.33  E-value: 2.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVTYptamiGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15307   3 WALLALVLVLGTAA-----GNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGHFPLSSEHCLTWI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatVTLQLPLCGHNKLDHLVCEI 181
Cdd:cd15307  78 CLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLP---LSLMYSKDHASVLVNGTCQI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 182 PILIKTACGeketnelalSVVCIFllaVPLCLILASYASIGHAVFKIKSSEGR-----KKAFGTCSSHLIVVLLFYGPAI 256
Cdd:cd15307 155 PDPVYKLVG---------SIVCFY---IPLGVMLLTYCLTVRLLARQRSRHGRiirleQKATKVLGVVFFTFVILWSPFF 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 22129199 257 SMYLQPPSSITKDQPKFMALF-----YGVVTPTLNPFIYTLRNKDVKGALGNLFK 306
Cdd:cd15307 223 VLNLLPTVCAECEERISHWVFdvvtwLGYASSMVNPIFYTIFNKVFRQAFKKVLL 277
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
29-225 2.33e-05

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 45.04  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPT----AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLD-----MCYTTSIVPQMLTN---LGSST-KTISYM 95
Cdd:cd15392   1 VIIILMYSTifvlAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDilmavFCVPFSFIALLILQywpFGEFMcPVVNYL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  96 RCV-VQLYFFhimggtecvLLALMSFDRYVAICKPLhyTLIMNQRNCILLVSTVWLTGISYAVSEATVT-LQLPLCGHNK 173
Cdd:cd15392  81 QAVsVFVSAF---------TLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAITSrLFEDSNASCG 149
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22129199 174 ldhlvceipiliKTACGE---KETNELALSVVCIFL-LAVPLCLILASYASIGHAV 225
Cdd:cd15392 150 ------------QYICTEswpSDTNRYIYSLVLMILqYFVPLAVLVFTYTRIGIVV 193
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
30-150 2.56e-05

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 45.20  E-value: 2.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  30 ILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTT-SIVPQMLTNLGSSTKTISYM-RCVVQLYFFHIM 107
Cdd:cd15385   6 VLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVAFfQVLPQLCWDITYRFYGPDFLcRIVKHLQVLGMF 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129199 108 GGTecVLLALMSFDRYVAICKPLHyTLIMNQRNCILLVSTVWL 150
Cdd:cd15385  86 AST--YMLVMMTADRYIAICHPLK-TLQQPTKRSYLMIGSAWA 125
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
40-254 3.65e-05

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 44.56  E-value: 3.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  40 IGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI-MGGTeCVLLALM 118
Cdd:cd14982  16 LGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYInMYGS-ILFLTCI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 119 SFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgisyavseATVTLQLPLCGHNKLDHLVCEIPILIKTACGEKETNELA 198
Cdd:cd14982  95 SVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWI---------LVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAAPI 165
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 199 LSVVCIFLLAVPLCLILASYASIGHAVFKIKSSEG----RKKAFGTCSSHLIVVLLFYGP 254
Cdd:cd14982 166 VLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQksvrKRKALRMILIVLAVFLVCFLP 225
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
115-292 4.50e-05

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 44.08  E-value: 4.50e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 115 LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSEATVTLQLPLCGHNKLDHLVCEIPILIktacgeket 194
Cdd:cd15055  91 LVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWF--VSALYSSVLLYDNLNQPGLIRYNSCYGECVVVV--------- 159
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 195 NELALSVVCIFLLAVPLCLILASYASIG----------HAVFKIKSSEGRKKAFGTCSSH--------LIVVLL------ 250
Cdd:cd15055 160 NFIWGVVDLVLTFILPCTVMIVLYMRIFvvarsqaraiRSHTAQVSLEGSSKKVSKKSERkaaktlgiVVGVFLlcwlpy 239
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 22129199 251 FYGPAISMYLQPPSSITkdqPKFMALFYgvVTPTLNPFIYTL 292
Cdd:cd15055 240 YIVSLVDPYISTPSSVF---DVLIWLGY--FNSCLNPLIYAL 276
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
25-232 4.61e-05

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 44.24  E-value: 4.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNlgsstktisymrcVVQLYFF 104
Cdd:cd15134   1 IPITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILGLPFELYT-------------IWQQYPW 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 hIMGGTECVLLALM---------------SFDRYVAICKPLHYTLIMNQRNCILLVSTVWL----TGISYAVSEATVTLQ 165
Cdd:cd15134  68 -VFGEVFCKLRAFLsemssyasvltitafSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIiafvCALPFAIQTRIVYLE 146
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 22129199 166 LPLCGHNKL-DHLVCEIPILIktacgEKETNELALSvvCIFLLAVPLCLILASYASIGhavFKIKSSE 232
Cdd:cd15134 147 YPPTSGEALeESAFCAMLNEI-----PPITPVFQLS--TFLFFIIPMIAIIVLYVLIG---LQLRRST 204
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
104-153 4.81e-05

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 44.34  E-value: 4.81e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129199 104 FHIMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGI 153
Cdd:cd15057  79 FDIMCSTASILnLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSA 129
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
22-302 4.85e-05

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 44.05  E-value: 4.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELplfIILLVTYPTaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTNLGSSTKTISYMRCVVQ 100
Cdd:cd15306   2 WAAL---LILMVIIPT-IGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPiALLTILFEAMWPLPLVLCPIW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 101 LYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqLPLCGHNKLDHLVCE 180
Cdd:cd15306  78 LFLDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIP-------VPIKGIETDVDNPNN 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 181 IPILIKTacgEKETNELALSVVCIFLlaVPLCLILASYASIGHAVFK--IKSSEGRKKAFGtcsshlIVVLLFYGPAISM 258
Cdd:cd15306 151 ITCVLTK---ERFGDFILFGSLAAFF--TPLAIMIVTYFLTIHALRKqtITNEQRASKVLG------IVFFLFLLMWCPF 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129199 259 YLQPPSSITKDQ------PKFMALF--YGVVTPTLNPFIYTLRNKDVKGALG 302
Cdd:cd15306 220 FITNITSVLCDScnqttlQMLMEIFvwIGYVSSGVNPLVYTLFNKTFRDAFG 271
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
29-150 5.22e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 43.90  E-value: 5.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPTAMIGN---IAIILVSILDPClhSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15104   4 VILAVLSPLIITGNllvIVALLKLIRKKD--TKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVI 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15104  82 TSCAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWL 126
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
38-301 6.20e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 43.78  E-value: 6.20e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPqmLTNLGSSTKTISYMRCVVQLYFFHIMggTECVLLAL 117
Cdd:cd14968  14 SVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVL--TQSSIFSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 M--SFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVseatvtlqLPLCGHNKlDHLVCEIPILIKTACGEKETN 195
Cdd:cd14968  90 LaiAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPMFGWNN-GAPLESGCGEGGIQCLFEEVI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 196 ELALSVVCIFLLAV--PLCLILASYASIGHAVFK----IKSSEG-------RKKAFGTCSSHLIVVLLFygpAIS----- 257
Cdd:cd14968 161 PMDYMVYFNFFACVlvPLLIMLVIYLRIFRVIRKqlrqIESLLRsrrsrstLQKEVKAAKSLAIILFLF---ALCwlplh 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129199 258 -----MYLQPPSSItkdqPKFMALFYGVVTPT---LNPFIYTLRNKDVKGAL 301
Cdd:cd14968 238 iinciTLFCPECKV----PKILTYIAILLSHAnsaVNPIVYAYRIRKFRQTF 285
7tmA_MC3R cd15352
melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G ...
38-153 6.22e-05

melanocortin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320474 [Multi-domain]  Cd Length: 272  Bit Score: 43.72  E-value: 6.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTS-----IVPQMLTN--LGSSTKTISYMRCVVQLYFFHIMGGT 110
Cdd:cd15352  14 SLLENILVILAVVKNKNLHSPMYFFLCSLAVADMLVSVSnsletIMIAVLNSgyLVISDQFIQHMDNVFDSMICISLVAS 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129199 111 ECVLLALmSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGI 153
Cdd:cd15352  94 ICNLLAI-AVDRYVTIFYALRYHSIMTVRKALVLIAVIWVVCI 135
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
38-244 6.79e-05

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 43.80  E-value: 6.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd15074  14 STLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCSINTLTA 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 MSFDRYVAICKPLHYTLIMNQRNCILLVStVWLTGISYAVSeatvtlqlPLCGHNKLdhlvceIPILIKTAC------GE 191
Cdd:cd15074  94 ISIYRYLKICHPPYGPKLSRRHVCIVIVA-IWLYALFWAVA--------PLVGWGSY------GPEPFGTSCsidwtgAS 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129199 192 KETNELALSVVCIFL-LAVPLCLILASYASIghaVFKIKSSEGRKKAFGTCSSH 244
Cdd:cd15074 159 ASVGGMSYIISIFIFcYLLPVLIIVFSYVKI---IRKVKSSRKRVAGFDSRSKR 209
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
23-294 6.98e-05

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 43.49  E-value: 6.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  23 LELPLFIILLVtyptamIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTK-TISYMRCVVQL 101
Cdd:cd15053   5 LFLLLLPLLTV------FGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNGGKwYLGPILCDIYI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSeatvtlqLPL-CGHNKLDHLVCE 180
Cdd:cd15053  79 AMDVMCSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWV--VSAAIA-------CPLlFGLNNVPYRDPE 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 181 IpiliktaCGEKETNELALSVVCIFLLAVPLCLILasYASIGHAVFKikssegRKKAFGTCSSHLIVVLLFYGP------ 254
Cdd:cd15053 150 E-------CRFYNPDFIIYSSISSFYIPCIVMLLL--YYRIFRALRR------EKKATKTLAIVLGVFLFCWLPfftlni 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 22129199 255 --AISMYLQPPSSITKDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd15053 215 lnAICPKLQNQSCHVGPALFSLTTWLGYVNSFLNPIIYTIFN 256
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
29-301 7.07e-05

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 43.75  E-value: 7.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMG 108
Cdd:cd15327   5 VFLAIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 109 GTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCGHNkldhlvcEIPILIKTA 188
Cdd:cd15327  85 TASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIG--------PLLGWK-------EPPPPDESI 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 189 CGEKETNELAL-SVVCIFLLavPLCLILASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLL---FYGPAISMY--LQP 262
Cdd:cd15327 150 CSITEEPGYALfSSLFSFYL--PLMVILVMYFRVYVVALKFSREKKAAKTLAIVVGVFILCWFpffFVLPLGSFFpaLKP 227
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 22129199 263 PSSITKdqpkfMALFYGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15327 228 SEMVFK-----VIFWLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
27-300 9.49e-05

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 43.09  E-value: 9.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFfHI 106
Cdd:cd15064   7 LSLIILAT----ILGNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISL-DV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCG---HNKLDHLVCEIp 182
Cdd:cd15064  82 TCCTASILhLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLP--------PLFGwrtPDSEDPSECLI- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 183 iliktacgEKETNELALSVVCIFLlaVPLCLILASYASIGHAVFKikssegRKKAFGTCSSHLIVVLLFYGPAISMYLQP 262
Cdd:cd15064 153 --------SQDIGYTIFSTFGAFY--IPLLLMLILYWKIYRAAAR------ERKAAKTLGIILGAFIVCWLPFFLVALIV 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 22129199 263 PSSITKDQPKFMA---LFYGVVTPTLNPFIYTLRNKDVKGA 300
Cdd:cd15064 217 PLCSHCWIPLALKsffLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_MC5R cd15354
melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G ...
38-149 1.03e-04

melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320476 [Multi-domain]  Cd Length: 270  Bit Score: 43.00  E-value: 1.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTS-----IVPQMLTN--LGSSTKTISYMRCVVQLYFFHIMGGT 110
Cdd:cd15354  14 SLLENILVILAIVKNKNLHSPMYFFVCSLAVADMLVSVSnawetITIYLLNNrhLVIEDAFVRHIDNVFDSLICISVVAS 93
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 22129199 111 ECVLLALmSFDRYVAICKPLHYTLIMNQRNCILLVSTVW 149
Cdd:cd15354  94 MCSLLAI-AVDRYVTIFYALRYHNIMTVRRAGIIIACIW 131
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
40-153 1.05e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 43.05  E-value: 1.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  40 IGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTN--------LGsstKTISYMRCVVQLYFFHimggTE 111
Cdd:cd14997  16 LGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVLLVCMPVALVEtwarepwlLG---EFMCKLVPFVELTVAH----AS 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22129199 112 CVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGI 153
Cdd:cd14997  89 VLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLAL 130
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
25-150 1.19e-04

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 43.06  E-value: 1.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTypTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15048   3 LAVLISVLIL--VTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVGLVSMPFYIPYTLTGKWPFGKVFCKAWLVVD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 105 HIMGgTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15048  81 YTLC-TASALtIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWI 126
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
27-227 1.26e-04

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 42.95  E-value: 1.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIvPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15079   6 IYIFLGIV---SLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKM-PIFIYNSFYEGWALGPLGCQIYAFLGSL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLiMNQRNCILLVSTVWLTGISYAVseatvtlqLPLC-GHNKLdhlvceIPILI 185
Cdd:cd15079  82 SGIGSIWTNAAIAYDRYNVIVKPLNGNP-LTRGKALLLILFIWLYALPWAL--------LPLLfGWGRY------VPEGF 146
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 186 KTACGE---KETNELALSVVCIFLLA--VPLCLILASYASIGHAVFK 227
Cdd:cd15079 147 LTSCSFdylTRDWNTRSFVATIFVFAyvIPLIIIIYCYSFIVKAVFA 193
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
26-150 1.87e-04

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 42.34  E-value: 1.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTN--LGSSTKTISYmrCVVQLYF 103
Cdd:cd15065   1 LIGIFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVALLVMTFAVVNdlLGYWLFGETF--CNIWISF 78
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 22129199 104 fHIMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15065  79 -DVMCSTASILnLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWI 125
7tmA_MC4R cd15353
melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G ...
38-149 2.03e-04

melanocortin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320475 [Multi-domain]  Cd Length: 269  Bit Score: 42.20  E-value: 2.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTS-----IVPQMLTNLGSSTKTISY-MRCVVQLYFFHIMGGTE 111
Cdd:cd15353  14 SLLENILVIAAIAKNKNLHSPMYFFICSLAVADMLVSVSngsetVVITLLNGNDTDAQSFTVnIDNVIDSVICSSLLASI 93
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 22129199 112 CVLLALmSFDRYVAICKPLHYTLIMNQRNCILLVSTVW 149
Cdd:cd15353  94 CSLLSI-AVDRYFTIFYALQYHNIMTVRRAGVIITCIW 130
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
27-296 2.74e-04

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 41.58  E-value: 2.74e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFfHI 106
Cdd:cd15061   5 FLILAIIF---TIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISL-DV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 107 MGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTgisyavseATVTLQLPLCGHNKldhlvcEIPILI 185
Cdd:cd15061  81 LLCTASILnLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVI--------SLLITSPPLVGPSW------HGRRGL 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 186 KTACGEKETNELALSVVCIFLLavPLCLILASYASIghavFKIKSSEgrKKAFGTCSshlIVVLLF---YGPAISMYLQP 262
Cdd:cd15061 147 GSCYYTYDKGYRIYSSMGSFFL--PLLLMLFVYLRI----FRVIAKE--RKTAKTLA---IVVGCFivcWLPFFIMYLIE 215
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 263 P--SSITKDQPKFMALFYGVVTPTLNPFIYTLRNKD 296
Cdd:cd15061 216 PfcDCQFSEALSTAFTWLGYFNSVINPFIYAFYNKD 251
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
22-229 3.19e-04

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 41.61  E-value: 3.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVTyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDM-----CYTTSIVPQMLTN--LGSSTktisy 94
Cdd:cd15206   1 ELIIPLYSVIFLL---AVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLllavfCMPFTLVGQLLRNfiFGEVM----- 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  95 mrCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTG----ISYAVSEATVTLQLPlCG 170
Cdd:cd15206  73 --CKLIPYFQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSflimSPILVFSNLIPMSRP-GG 149
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22129199 171 HnkldhlvceipiliktACGEKETNELALSVVCIFLLA----VPLCLILASYASIGHAVFKIK 229
Cdd:cd15206 150 H----------------KCREVWPNEIAEQAWYVFLDLmllvIPGLVMSVAYGLISWTLLEAK 196
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
38-156 3.22e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 41.86  E-value: 3.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNL-GSSTKTISYMRCVVQLYFFHIMGGTECVLLA 116
Cdd:cd15217  14 SLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADTIRSAVCFPFVLVSIrNGSAWTYSVLSCKIVAFMAVLFCFHAAFMLF 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 22129199 117 LMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYA 156
Cdd:cd15217  94 CISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMA 133
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
27-156 3.48e-04

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 41.57  E-value: 3.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIIlVSILD-PCLHSPMYFFLTNLSFLDMCyttsivpqmltnLGSSTKTISYMRCVVQLYFF- 104
Cdd:cd15312   3 MYLFMAGAILLTVFGNLMVI-ISISHfKQLHSPTNFLILSLAITDFL------------LGFLVMPYSMVRSVESCWYFg 69
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22129199 105 ----------HIMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYA 156
Cdd:cd15312  70 dlfckihsslDMMLSTTSIFhLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSVPCLFA 132
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
39-298 3.83e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 41.46  E-value: 3.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  39 MIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALM 118
Cdd:cd15323  15 IVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVLFCTSSIVHLCAI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 119 SFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTG--ISY----AVSEATVTLQLPLCGHNkldhlvceipiliktacgeK 192
Cdd:cd15323  95 SLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISavISFppliSMYRDPEGDVYPQCKLN-------------------D 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 193 ETNELALSvvCIFLLAVPLCLILASYASIghavfkIKSSEGRKKAFGTCSSHLI-VVLLFYGP---AISMYLQPPSSITK 268
Cdd:cd15323 156 ETWYILSS--CIGSFFAPCLIMILVYIRI------YRVAKAREKRFTFVLAVVMgVFVVCWFPfffSYSLYGICREACEV 227
                       250       260       270
                ....*....|....*....|....*....|.
gi 22129199 269 DQPKFMALFY-GVVTPTLNPFIYTLRNKDVK 298
Cdd:cd15323 228 PEPLFKFFFWiGYCNSSLNPVIYTIFNQDFR 258
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
38-304 4.30e-04

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 41.39  E-value: 4.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMcyttsivpqMLTNLGSstkTISYMRcvvQLYFFHIMGGTECVL--- 114
Cdd:cd15084  24 ASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADL---------LVTLFGS---SVSFSN---NIVGFFVFGKTMCEFegf 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 115 ------------LALMSFDRYVAICKPLHyTLIMNQRNCILLVSTVWLTGISYAVSeatvtlqlPLCGHNKLdhlvceIP 182
Cdd:cd15084  89 mvsltgivglwsLAILAFERYLVICKPMG-DFRFQQRHAVSGCAFTWGWSLLWTSP--------PLFGWSSY------VP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 183 ILIKTACGEK----ETNE----LALSVVCiflLAVPLCLILASYASIGHAVFKI----KSSEGRKKAFGTCSSHLIVV-- 248
Cdd:cd15084 154 EGLRTSCGPNwytgGTNNnsyiLALFVTC---FALPLSTIIFSYSNLLLTLRAVaaqqKESETTQRAEKEVTRMVIAMvm 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 22129199 249 --LLFYGPAISMYLQppSSITKD---QPKFMAL--FYGVVTPTLNPFIYTLRNKDVKGALGNL 304
Cdd:cd15084 231 afLICWLPYATFAMV--VATNKDvviQPTLASLpsYFSKTATVYNPIIYVFMNKQFRSCLLEL 291
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
42-295 4.73e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 40.99  E-value: 4.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  42 NIAIILVSILDPCLHSPMYFFLTNLSFLDM----CYTTSIVpqmLTNLGSSTkTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd15085  18 NVLVIAVTLKNPQLRNPINIFILNLSFSDLmmalCGTTIVT---VTNYEGYF-YLGDAFCIFQGFAVNYFGIVSLWSLTL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 118 MSFDRYVAICKPLHYTLIMNQRNCILLVsTVWLTGISYAVSeatvtlqlPLCGHNKLDhlvceiPILIKTAC--GEKETN 195
Cdd:cd15085  94 LAYERYNVVCKPMGGLKLSTKRGYQGLL-FIWLFCLFWAVA--------PLFGWSSYG------PEGVQTSCsiGWEERS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 196 ELALSVVCIFLLA---VPLCLILASYASIGHAVFKIKSS---EGRKK-----------------AFGTC--SSHLIVVLL 250
Cdd:cd15085 159 WSNYSYLILYFLMcfvIPVAIIGFSYGNVLRSLHKLNKKieqQGGKNcpeeeeravimvlamviAFLICwlPYTVFALIV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22129199 251 FYGPAISMylqPPSSITkdqpkfMALFYGVVTPTLNPFIYTLRNK 295
Cdd:cd15085 239 VVNPELSI---SPLAAT------MPTYFAKTSPVYNPIIYIFLNK 274
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
42-301 6.36e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 40.53  E-value: 6.36e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  42 NIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNlGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMSFD 121
Cdd:cd15102  18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLS-GARTLRLSPAQWFLREGSMFVALSASVFSLLAIAIE 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 122 RYVAICKPLHYTLIMNQRnCILLVSTVWLTGISYAVseatvtlqLPLCGHNKLDHL-VCE--IPILIKtacgeketnelA 198
Cdd:cd15102  97 RHLTMAKMKPYGASKTSR-VLLLIGACWLISLLLGG--------LPILGWNCLGALdACStvLPLYSK-----------H 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 199 LSVVCIFLLAVPLCLILASYASIGHAV----FKIKSSEGRKKAFGTCSSHLIVVLLF---YGPAISMYLQPPSSITKDQP 271
Cdd:cd15102 157 YVLFCVTIFAGILAAIVALYARIYCLVrasgRKATRASASPRSLALLKTVLIVLLVFiacWGPLFILLLLDVACPVKTCP 236
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 22129199 272 ------KFMALfyGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15102 237 ilykadWFLAL--AVLNSALNPIIYTLRSRELRRAV 270
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
27-294 8.05e-04

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 40.49  E-value: 8.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCytTSIVPQMLTNLGSSTKTISYMR--CVVQLYFF 104
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLL--ASLVVLVLFFLLGLTEASSRPQalCYLIYLLW 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTgisyavseATVTLQLPLCGHNKlDHLVCEIPIL 184
Cdd:cd14964  79 YGANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGV--------SLLLSIPPLVGKGA-IPRYNTLTGS 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 IKTACgekeTNELALSVVCIFLLAVPLCLILASYASIGHAVFKI-------------KSSEGRKKAFGTCSSHLIVVLLF 251
Cdd:cd14964 150 CYLIC----TTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRvrairsaaslntdKNLKATKSLLILVITFLLCWLPF 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 22129199 252 YGPAISMYLQPPSSITkDQPKFMALFYGVVTPTLNPFIYTLRN 294
Cdd:cd14964 226 SIVFILHALVAAGQGL-NLLSILANLLAVLASTLNPFIYCLGN 267
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
29-156 1.01e-03

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 40.14  E-value: 1.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTI-SYMRCVVQLYFFHIM 107
Cdd:cd15212   5 LVLLAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPFAFLTLFSRPGWLfGDRLCLANGFFNACF 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129199 108 GGTECVLLALMSFDRYVAICKPLHYTliMNQRNCILLVSTVWLTGISYA 156
Cdd:cd15212  85 GIVSTLTMTLISFDRYYAIVRQPQGK--IGRRRALQLLAAAWLTALGFS 131
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
28-150 1.03e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 40.10  E-value: 1.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  28 FIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCY-TTSIVPQMLTNLGSS-------TKTISYMRCVV 99
Cdd:cd15197   4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVgLINVLTDIIWRITVEwragdfaCKVIRYLQVVV 83
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 22129199 100 qLYffhimgGTECVLLALmSFDRYVAICKPLHYTliMNQRNCILLVSTVWL 150
Cdd:cd15197  84 -TY------ASTYVLVAL-SIDRYDAICHPMNFS--QSGRQARVLICVAWI 124
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
38-159 1.20e-03

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 39.80  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTT-SIVPQMLTNLGSSTKTISYM-RCVVQLYFFHIMGGTecVLL 115
Cdd:cd15387  14 ALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfQVLPQLIWDITFRFYGPDFLcRLVKYLQVVGMFAST--YML 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129199 116 ALMSFDRYVAICKPLHYtliMNQRNCILLVSTVWLTGISYAVSE 159
Cdd:cd15387  92 LLMSIDRCLAICQPLRS---LHRRSDRVYVLFSWLLSLVFSIPQ 132
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
28-157 1.28e-03

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 39.70  E-value: 1.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  28 FIILLVTYpTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLD--MCYTTSivPQMLTNLGSSTKTISYMRCvvQLYFF- 104
Cdd:cd15336   5 SVILIIGI-TGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDflMSLTQS--PIFFVNSLHKRWIFGEKGC--ELYAFc 79
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 22129199 105 -HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAV 157
Cdd:cd15336  80 gALFGITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSL 133
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
25-301 1.39e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 39.54  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15322   1 LTLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSEATVTLQLPLCGHNKLDhlVCEIpil 184
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWV--ISAVISFPPLITIEKKSGQPEGP--ICKI--- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 185 iktacgEKETNELALSVVCIFLLavPLCLILASYASIghavFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQPPS 264
Cdd:cd15322 154 ------NDEKWYIISSCIGSFFA--PCLIMVLVYIRI----YQIAKNREKRFTFVLAVVIGVFVICWFPFFFTYTLTAVC 221
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 22129199 265 SITKDQPKFMALF-YGVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15322 222 DCSVPETLFKFFFwFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
115-155 1.46e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 39.67  E-value: 1.46e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 22129199 115 LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTG--ISY 155
Cdd:cd15066  90 LCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPalISF 132
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
62-254 1.66e-03

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 39.29  E-value: 1.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  62 FLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNC 141
Cdd:cd15160  38 YLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFA 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 142 ILLVSTVWL--TGISYAVseatvtlqlplcghnkLDHLVCEIPILIKTACGEK---ETNELALSVVCIFL-LAVPLCLIL 215
Cdd:cd15160 118 LKVSASIWVleLGTHSVF----------------LGHDELFRDEPNHTLCYEKypmEGWQASYNYARFLVgFLIPLSLIL 181
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22129199 216 ASYASIGHAVFKIKSSEGRKKA--FGTCSSHLIVVLLFYGP 254
Cdd:cd15160 182 FFYRRVLRAVRQSPSLEREEKRkiIGLLLSIVVIFLLCFLP 222
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
39-309 1.98e-03

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 39.05  E-value: 1.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  39 MIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQML-TNLGSSTKTISYMRCVVqLYFFHIMGGTECVL-LA 116
Cdd:cd15308  15 IAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLALLVLPLYVySEFQGGVWTLSPVLCDA-LMTMDVMLCTASIFnLC 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 117 LMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSEATvtlqlpLCGHNkldhlvcEIPILIKTACGEKETNE 196
Cdd:cd15308  94 AISVDRFIAVSVPLNYNRRQGSVRQLLLISATWI--LSFAVASPV------IFGLN-------NVPNRDPAVCKLEDNNY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 197 LALSVVCIFLLAVPLCLIL--ASYASIGHAVFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLqPPSSITkdqpkfM 274
Cdd:cd15308 159 VVYSSVCSFFIPCPVMLVLycAMFRGLGRERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCSI-PPQLIS------I 231
                       250       260       270
                ....*....|....*....|....*....|....*
gi 22129199 275 ALFYGVVTPTLNPFIYTLRNKDvkgalgnlFKNIF 309
Cdd:cd15308 232 VTWLGYVNSALNPVIYTVFNAE--------FRNVF 258
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
28-150 2.20e-03

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 39.02  E-value: 2.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  28 FIILLVtyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIM 107
Cdd:cd15063   9 FLNVLV-----VLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWM 83
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 22129199 108 GGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15063  84 CTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWV 126
7tmA_MCR cd15103
melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
42-149 2.32e-03

melanocortin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320231 [Multi-domain]  Cd Length: 270  Bit Score: 39.01  E-value: 2.32e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  42 NIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTS-----IVPQMLTN--LGSSTKTISYMRCVVQLYFFHIMGGTECVL 114
Cdd:cd15103  18 NILVILAIAKNKNLHSPMYFFICSLAVADMLVSVSnaletIVIILLNNgyLVPRDSFEQHIDNVIDSMICSSLLASICSL 97
                        90       100       110
                ....*....|....*....|....*....|....*
gi 22129199 115 LALmSFDRYVAICKPLHYTLIMNQRNCILLVSTVW 149
Cdd:cd15103  98 LAI-AVDRYITIFYALRYHSIMTVRRAGVIITAIW 131
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
30-150 2.37e-03

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 39.01  E-value: 2.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  30 ILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTT-SIVPQMLTNL-----GSS--TKTISYMRcVVQL 101
Cdd:cd15386   6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfQVLPQLIWEItyrfqGPDllCRAVKYLQ-VLSM 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 22129199 102 YFFHIMggtecvlLALMSFDRYVAICKPLHyTLIMNQRNCILLVSTVWL 150
Cdd:cd15386  85 FASTYM-------LIMMTVDRYIAVCHPLR-TLQQPSRQAYLMIGATWL 125
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
29-298 2.66e-03

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 38.80  E-value: 2.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMG 108
Cdd:cd17790   9 ILSLVT----VTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIGAFSMNLYTTYILMGHWALGTVACDLWLALDYVAS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 109 GTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLtgISYAVSEATVTLQLPLCGHNKLDHLVCEIPILikta 188
Cdd:cd17790  85 NASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWL--ISFVLWAPAILFWQYLVGERTVLAGQCYIQFL---- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 189 cgEKETNELALSVVCIFLlavPLCLILASYASIGHAVFKikssegRKKAFGTCSSHLIVVLLFYGPAISMYLQppSSITK 268
Cdd:cd17790 159 --SQPIITFGTAIAAFYL---PVTIMIILYWRIYRETIK------EKKAARTLSAILLAFILTWTPYNIMVLV--STFCK 225
                       250       260       270
                ....*....|....*....|....*....|....
gi 22129199 269 D--QPKFMALFYGV--VTPTLNPFIYTLRNKDVK 298
Cdd:cd17790 226 DcvPKTLWELGYWLcyVNSTVNPMCYALCNKSFR 259
7tmA_S1PR2_Edg5 cd15347
sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial ...
26-298 2.84e-03

sphingosine-1-phosphate receptor subtype 2 (S1PR2 or S1P2), also called endothelial differentiation gene 5 (Edg5), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320469 [Multi-domain]  Cd Length: 266  Bit Score: 38.64  E-value: 2.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  26 PLFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNlGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15347   2 VASIFIVILCCIIVLENLLVLIAVARNKKFHSAMFFFIGNLAFSDLLAGVAFIANILLS-GSVTFRLTPVQWFIREGTAF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHYTlimNQRNC--ILLVSTVWLTGIsyavseatVTLQLPLCGHNKLDHLVCEIPI 183
Cdd:cd15347  81 ITLSASVFSLLAIAIERHVAITKVKLYG---SDKNCrmVLLIGACWVISI--------VLGGLPILGWNCIGNLEDCSTV 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 184 LiktacgEKETNELALSVVCIFLLavplcLILASYASIGHAVFKIKSSEGRKKA------FGTCSSHLIVVLLFYGPAIS 257
Cdd:cd15347 150 L------PLYSKHYILFVVTIFSI-----ILLSIVILYVRIYCIVRSSHAEMAApqtlalLKTVTIVLGVFIVCWLPAFI 218
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 22129199 258 MYLQPPSSITKDQPKF--MALFYGVVT--PTLNPFIYTLRNKDVK 298
Cdd:cd15347 219 ILLLDTSCKVKSCPILykADYFFSVATlnSALNPVIYTLRSKDMR 263
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
27-155 2.85e-03

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 38.58  E-value: 2.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVP-QMLTnlgsSTKTISYMR---CVVQLY 102
Cdd:cd15317   3 IYIVLVLAMLITVSGNLVVIISISHFKQLHSPTNMLVLSLATADFLLGLCVMPfSMIR----TVETCWYFGdlfCKFHTG 78
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22129199 103 FFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISY 155
Cdd:cd15317  79 LDLLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIY 131
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
102-162 2.93e-03

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 38.69  E-value: 2.93e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22129199 102 YFFHIMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAVSEATV 162
Cdd:cd15356  82 YFVRDICSYATVLnIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPMAFI 143
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
104-149 2.95e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 38.78  E-value: 2.95e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 104 FHIMGGTECVL-LALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVW 149
Cdd:cd15319  79 FDIMCSTASILnLCVISVDRYWAISSPFRYERKMTQRVALVMISVAW 125
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
38-150 3.18e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 38.61  E-value: 3.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPqmLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLAL 117
Cdd:cd15070  14 AVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLA 91
                        90       100       110
                ....*....|....*....|....*....|...
gi 22129199 118 MSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15070  92 IAVDRYLRVKLTVRYRIVTTQRRIWLALGLCWL 124
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
27-150 3.20e-03

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 38.61  E-value: 3.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDM-CYTTSIVPQMLTNlGSSTKTISYMRCVVQLYFFH 105
Cdd:cd15075   3 LSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLgTTVFGGLLSVVTN-AVGYFNLGRVGCVLEGFAVA 81
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 22129199 106 IMGGTECVLLALMSFDRYVAICKPLHyTLIMNQRNCILLVSTVWL 150
Cdd:cd15075  82 FFGIAALCTVAVIAVDRLFVVCKPLG-TLTFQTRHALAGIASSWL 125
7tmA_MC1R cd15351
melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G ...
38-157 3.38e-03

melanocortin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The melanocortin receptor (MCR) subfamily is a member of the class A family of seven-transmembrane G-protein coupled receptors. MCRs bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. There are five known subtypes of the MCR subfamily. MC1R is involved in regulating skin pigmentation and hair color. ACTH (adrenocorticotropic hormone) is the only endogenous ligand for MC2R, which shows low sequence similarity with other melanocortin receptors. Mutations in MC2R cause familial glucocorticoid deficiency type 1, in which patients have elevated plasma ACTH and low cortisol levels. MC3R is expressed in many parts of the brain and peripheral tissues and involved in the regulation of energy homeostasis. MC4R is expressed primarily in the central nervous system and involved in both eating behavior and sexual function. MC5R is widely expressed in peripheral tissues and is mainly involved in the regulation of exocrine gland function.


Pssm-ID: 320473 [Multi-domain]  Cd Length: 271  Bit Score: 38.62  E-value: 3.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQ----MLTN---LGSSTKTISYMRCVVQLYFFHIMGGT 110
Cdd:cd15351  14 SLVENILVVVAIAKNRNLHSPMYYFICCLAVSDMLVSVSNLIEtlfmLLLEhgvLVCRAPMLQHMDNVIDTMICSSVVSS 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 22129199 111 ECVLLALmSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYAV 157
Cdd:cd15351  94 LSFLGAI-AVDRYITIFYALRYHSIMTLQRAVNAIAGIWLASTVSST 139
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
55-252 3.73e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 38.35  E-value: 3.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  55 LHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLhytl 134
Cdd:cd15081  43 LRHPLNWILVNLAIADLGETVIASTISVVNQIFGYFILGHPMCVLEGFTVSVCGITGLWSLTIISWERWVVVCKPF---- 118
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 135 imnqrNCILLVSTVWLTGISYAVSEATVTLQLPLCGHNKLdhlvceIPILIKTACGEK----------ETNELALSVVCI 204
Cdd:cd15081 119 -----GNIKFDGKLAIVGIIFSWVWSAVWCAPPIFGWSRY------WPHGLKTSCGPDvfsgssdpgvQSYMIVLMITCC 187
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 22129199 205 FLlavPLCLILASYASIGHAVFKI----KSSEGRKKAFGTCSSHLIVVLLFY 252
Cdd:cd15081 188 II---PLAIIILCYLQVWLAIRAVaqqqKESESTQKAEKEVSRMVVVMIFAY 236
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
29-130 3.98e-03

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 38.51  E-value: 3.98e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTtsiVPQMLTNLGSSTkTISYM------RCVVQLY 102
Cdd:cd14986   5 AVLGVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVA---FFTVLTQIIWEA-TGEWVagdvlcRIVKYLQ 80
                        90       100
                ....*....|....*....|....*...
gi 22129199 103 FFHIMGGTecVLLALMSFDRYVAICKPL 130
Cdd:cd14986  81 VVGLFAST--YILVSMSLDRYQAIVKPM 106
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
27-150 4.67e-03

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 38.22  E-value: 4.67e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  27 LFIILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHI 106
Cdd:cd15209   3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 22129199 107 MGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15209  83 SVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWL 126
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
38-156 5.08e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 38.09  E-value: 5.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  38 AMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNL-GSSTKTISYMRCVVQLYFFHIMGGTECVLLA 116
Cdd:cd15218  14 SVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILRSAICFPFVFTSVkNGSTWTYGTLTCKVIAFLGVLSCFHTAFMLF 93
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 22129199 117 LMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGISYA 156
Cdd:cd15218  94 CISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMA 133
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
39-301 5.21e-03

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 37.98  E-value: 5.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  39 MIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALM 118
Cdd:cd15321  21 IFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCTSSIVHLCAI 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 119 SFDRYVAICKPLHYTLIMNQRNCILLVSTVWLTGisyavseATVTLQlPLCGHNKLDHLVCEIPiliktacgEKETNELA 198
Cdd:cd15321 101 SLDRYWSVSRAIEYNSKRTPRRIKCIILIVWLIA-------AVISLP-PLIYKGKQKDEQGGLP--------QCKLNEEA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 199 L----SVVCIFLlaVPLCLILASYASIghavFKIKSSEGRKKAFGTCSSHLIVVLLFYGPAISMYLQP--PSSITKDQPK 272
Cdd:cd15321 165 WyilsSSIGSFF--APCLIMILVYLRI----YLIAKNREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAicPELCKVPHSL 238
                       250       260       270
                ....*....|....*....|....*....|
gi 22129199 273 FMALFY-GVVTPTLNPFIYTLRNKDVKGAL 301
Cdd:cd15321 239 FQFFFWiGYCNSSLNPVIYTIFNQDFRRAF 268
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
29-154 5.57e-03

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 37.88  E-value: 5.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  29 IILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMG 108
Cdd:cd15301   5 IVAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIGVISMPLFTVYTALGYWPLGYEVCDTWLAIDYLAS 84
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129199 109 GTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWltGIS 154
Cdd:cd15301  85 NASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAW--IIS 128
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
40-149 5.59e-03

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 37.66  E-value: 5.59e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  40 IGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMS 119
Cdd:cd15096  16 IGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLVYVTAYASVYTLVLMS 95
                        90       100       110
                ....*....|....*....|....*....|
gi 22129199 120 FDRYVAICKPLHYTLIMNQRNCILLVSTVW 149
Cdd:cd15096  96 LDRYLAVVHPITSMSIRTERNTLIAIVGIW 125
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
30-150 7.50e-03

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 37.58  E-value: 7.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  30 ILLVTYPTAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGG 109
Cdd:cd15377   6 VYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLY 85
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 22129199 110 TECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15377  86 GSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWL 126
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
53-156 8.03e-03

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 37.50  E-value: 8.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  53 PCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFFHIMGGTECVLLALMSFDRYVAICKPLHY 132
Cdd:cd15097  30 QSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLTMYASSFTLAAVSVDRYLAIRYPLRS 109
                        90       100
                ....*....|....*....|....
gi 22129199 133 TLIMNQRNCILLVSTVWLTGISYA 156
Cdd:cd15097 110 RELRTPRNAVAAIALIWGLSLLFA 133
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
22-223 8.07e-03

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 37.37  E-value: 8.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  22 WLELPLFIILLVTyptAMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQL 101
Cdd:cd15208   1 WVLIALYILVFIV---GLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIICLPATLLVDVTETWFFGQVLCKIIP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199 102 YFFHIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQ-RNCILLvstVWLTGISYAVSEATV-TLQLPLCGHNKLDHLvc 179
Cdd:cd15208  78 YLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRaRVSILI---IWIVSLLIMIPQAIVmECSRVVPLANKTILL-- 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 22129199 180 eipilikTACGEKETNELALSV--VCIFLLA--VPLCLILASYASIGH 223
Cdd:cd15208 153 -------TVCDERWSDSIYQKVyhICFFLVTylLPLCLMILAYFQIFR 193
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
25-150 8.52e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 37.16  E-value: 8.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22129199  25 LPLFIILLVTyptaMIGNIAIILVSILDPCLHSPMYFFLTNLSFLDMCYTTSIVPQMLTNLGSSTKTISYMRCVVQLYFF 104
Cdd:cd15324   5 LVVVVIILVT----IVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGSTWCAFYLALD 80
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 22129199 105 HIMGGTECVLLALMSFDRYVAICKPLHYTLIMNQRNCILLVSTVWL 150
Cdd:cd15324  81 VLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWV 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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