NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27544933|ref|NP_689920|]
View 

solute carrier family 25 member 16 isoform a [Homo sapiens]

Protein Classification

ADP/ATP carrier family protein( domain architecture ID 1000309)

ADP/ATP carrier family protein may provide transport for nucleotides, amino acids, carboxylic acids, fatty acids, cofactors, or inorganic ions across a membrane; similar to mitochondrial adenine nucleotide carriers

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PTZ00169 super family cl36523
ADP/ATP transporter on adenylate translocase; Provisional
 36-330 8.57e-29

ADP/ATP transporter on adenylate translocase; Provisional


The actual alignment was detected with superfamily member PTZ00169:

Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 112.55  E-value: 8.57e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHH--------YKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYG 107
Cdd:PTZ00169   7 FATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIpeiksgkvPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  108 AIQFmAFEHY----------KTLITTKLGISghvhrLMAGSMAGMTAVICTYPLDMVRVRLAFQV--KGEHSYTGIIHAF 175
Cdd:PTZ00169  87 AFNF-AFKDYfknmfpkynqKTDFWKFFGVN-----ILSGGLAGASSLLIVYPLDFARTRLASDIgkGGDREFTGLFDCL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  176 KTIYaKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVglshaptLLGrpSSDNPNVLvlkthvnllcggVAGAIAQ 255
Cdd:PTZ00169 161 MKIS-KQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKAL-------LFG--NDKNTNIL------------YKWAVAQ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  256 T-------ISYPFDVTRRRMQLGTVLPEFEKCL--TMRDTMKYVYGHHGIrKGLYRGLSLNYIRCIpSQAVAFTTYELMK 326
Cdd:PTZ00169 219 TvtilaglISYPFDTVRRRMMMMSGRKAKSEIQytGTLDCWKKILKNEGL-GGFFKGAWANVLRGA-GGALVLVFYDELQ 296


                 ....
gi 27544933  327 QFFH 330
Cdd:PTZ00169 297 KLLK 300
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 36-330 8.57e-29

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 112.55  E-value: 8.57e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHH--------YKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYG 107
Cdd:PTZ00169   7 FATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIpeiksgkvPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  108 AIQFmAFEHY----------KTLITTKLGISghvhrLMAGSMAGMTAVICTYPLDMVRVRLAFQV--KGEHSYTGIIHAF 175
Cdd:PTZ00169  87 AFNF-AFKDYfknmfpkynqKTDFWKFFGVN-----ILSGGLAGASSLLIVYPLDFARTRLASDIgkGGDREFTGLFDCL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  176 KTIYaKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVglshaptLLGrpSSDNPNVLvlkthvnllcggVAGAIAQ 255
Cdd:PTZ00169 161 MKIS-KQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKAL-------LFG--NDKNTNIL------------YKWAVAQ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  256 T-------ISYPFDVTRRRMQLGTVLPEFEKCL--TMRDTMKYVYGHHGIrKGLYRGLSLNYIRCIpSQAVAFTTYELMK 326
Cdd:PTZ00169 219 TvtilaglISYPFDTVRRRMMMMSGRKAKSEIQytGTLDCWKKILKNEGL-GGFFKGAWANVLRGA-GGALVLVFYDELQ 296


                 ....
gi 27544933  327 QFFH 330
Cdd:PTZ00169 297 KLLK 300
Mito_carr pfam00153
Mitochondrial carrier protein;
33-125 1.22e-27

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 103.50  E-value: 1.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933    33 DFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY--KHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQ 110
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGksKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIY 81

                          90
                  ....*....|....*
gi 27544933   111 FMAFEHYKTLITTKL 125
Cdd:pfam00153  82 FGTYETLKRLLLKKL 96
 
Name Accession Description Interval E-value
PTZ00169 PTZ00169
ADP/ATP transporter on adenylate translocase; Provisional
 36-330 8.57e-29

ADP/ATP transporter on adenylate translocase; Provisional


Pssm-ID: 240302 [Multi-domain]  Cd Length: 300  Bit Score: 112.55  E-value: 8.57e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHH--------YKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYG 107
Cdd:PTZ00169   7 FATDFLMGGISAAISKTAVAPIERVKMLIQTQDSIpeiksgkvPRYSGIVNCFRRVSKEQGVLSLWRGNTANVIRYFPTQ 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  108 AIQFmAFEHY----------KTLITTKLGISghvhrLMAGSMAGMTAVICTYPLDMVRVRLAFQV--KGEHSYTGIIHAF 175
Cdd:PTZ00169  87 AFNF-AFKDYfknmfpkynqKTDFWKFFGVN-----ILSGGLAGASSLLIVYPLDFARTRLASDIgkGGDREFTGLFDCL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  176 KTIYaKEGGFFGFYRGLMPTILGMAPYAGVSFFTFGTLKSVglshaptLLGrpSSDNPNVLvlkthvnllcggVAGAIAQ 255
Cdd:PTZ00169 161 MKIS-KQTGFLSLYQGFGVSVQGIIVYRGAYFGLYDSAKAL-------LFG--NDKNTNIL------------YKWAVAQ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  256 T-------ISYPFDVTRRRMQLGTVLPEFEKCL--TMRDTMKYVYGHHGIrKGLYRGLSLNYIRCIpSQAVAFTTYELMK 326
Cdd:PTZ00169 219 TvtilaglISYPFDTVRRRMMMMSGRKAKSEIQytGTLDCWKKILKNEGL-GGFFKGAWANVLRGA-GGALVLVFYDELQ 296


                 ....
gi 27544933  327 QFFH 330
Cdd:PTZ00169 297 KLLK 300
Mito_carr pfam00153
Mitochondrial carrier protein;
33-125 1.22e-27

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 103.50  E-value: 1.22e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933    33 DFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY--KHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQ 110
Cdd:pfam00153   2 ELSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGksKGRGILDCFKKIYKEEGIRGLYKGLLPNLLRVAPAAAIY 81

                          90
                  ....*....|....*
gi 27544933   111 FMAFEHYKTLITTKL 125
Cdd:pfam00153  82 FGTYETLKRLLLKKL 96
Mito_carr pfam00153
Mitochondrial carrier protein;
131-214 1.52e-24

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 95.42  E-value: 1.52e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   131 VHRLMAGSMAGMTAVICTYPLDMVRVRLAFQ-VKGEHSYTGIIHAFKTIYaKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209
Cdd:pfam00153   6 LASLLAGGIAGAIAVTVTYPLDVVKTRLQVQgGSGKSKGRGILDCFKKIY-KEEGIRGLYKGLLPNLLRVAPAAAIYFGT 84


                  ....*
gi 27544933   210 FGTLK 214
Cdd:pfam00153  85 YETLK 89
Mito_carr pfam00153
Mitochondrial carrier protein;
238-330 2.01e-21

Mitochondrial carrier protein;


Pssm-ID: 395101 [Multi-domain]  Cd Length: 96  Bit Score: 86.94  E-value: 2.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   238 LKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQLGTVLPEfEKCLTMRDTMKYVYGHHGIRkGLYRGLSLNYIRCIPSQAV 317
Cdd:pfam00153   3 LSFLASLLAGGIAGAIAVTVTYPLDVVKTRLQVQGGSGK-SKGRGILDCFKKIYKEEGIR-GLYKGLLPNLLRVAPAAAI 80

                          90
                  ....*....|...
gi 27544933   318 AFTTYELMKQFFH 330
Cdd:pfam00153  81 YFGTYETLKRLLL 93
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 37-267 1.26e-09

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 58.01  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHykhlgVFSALRAvpqkegflgLYKGNGAMMIRIFPYGAIQFMAFEH 116
Cdd:PTZ00168   4 FHNLVTGALSGVIVDAVLYPIDSIKTNIQAKKSF-----SFSDIKK---------LYSGILPTLVGTVPASAFFYCFYEL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  117 YKTLITTK-LGISGHVHRLMAGSMAGMTAVICTYPLDMVRVRLafQVKGEHSytgIIHAFKTIYAKEGGFFGFYRGLMPT 195
Cdd:PTZ00168  70 SKKLLTEYrENISKTNLYLISTSIAEITACIVRLPFEIVKQNM--QVSGNIS---VLKTIYEITQREGLPSFLGKSYFVM 144

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27544933  196 ILGMAPYAGVSFFTFGTLKSVGLSHaptlLGRPSSDNPNVlvlkthVNLLCGGVAGAIAQTISYPFDVTRRR 267
Cdd:PTZ00168 145 IVREIPFDCIQYFLWETLKEKAKKD----FGKFSKKYPSI------TSAICGGLAGGIAGFLTTPVDVIKSR 206
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 130-270 3.90e-05

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 44.53  E-value: 3.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  130 HVHRLMAGSMAGMTAVICTYPLDMVRVRLafQVKGEHSYTGIIHafktiyakeggffgFYRGLMPTILGMAPyAGVSFFT 209
Cdd:PTZ00168   3 HFHNLVTGALSGVIVDAVLYPIDSIKTNI--QAKKSFSFSDIKK--------------LYSGILPTLVGTVP-ASAFFYC 65

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27544933  210 FGTLksvglshAPTLLgrpSSDNPNVLvlKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQL 270
Cdd:PTZ00168  66 FYEL-------SKKLL---TEYRENIS--KTNLYLISTSIAEITACIVRLPFEIVKQNMQV 114
PTZ00168 PTZ00168
mitochondrial carrier protein; Provisional
 45-210 2.06e-04

mitochondrial carrier protein; Provisional


Pssm-ID: 185494 [Multi-domain]  Cd Length: 259  Bit Score: 42.22  E-value: 2.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933   45 IAGCCAKTTVAPLDRVKVLLQAHNHhykhLGVFSALRAVPQKEGFLG-LYKGNGAMMIRIFPYGAIQFMAFEHYKTLITT 123
Cdd:PTZ00168  93 IAEITACIVRLPFEIVKQNMQVSGN----ISVLKTIYEITQREGLPSfLGKSYFVMIVREIPFDCIQYFLWETLKEKAKK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27544933  124 KLG----ISGHVHRLMAGSMAGMTAVICTYPLDMVRVRlafQVKGEHSYtgiIHAFKTIyaKEGGFFGFYRGLMPTIL-- 197
Cdd:PTZ00168 169 DFGkfskKYPSITSAICGGLAGGIAGFLTTPVDVIKSR---QIIYGKSY---IETVTEI--AEEGYLTFYKGCCFRSSyl 240

                        170
                 ....*....|....*.
gi 27544933  198 ---GMAPYAGVSFFTF 210
Cdd:PTZ00168 241 ffgGLIFFGSLRFFSF 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH