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Conserved domains on  [gi|24429572|ref|NP_722516|]
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transcription initiation factor TFIID subunit 1-like [Homo sapiens]

Protein Classification

transcription initiation factor TFIID subunit 1( domain architecture ID 10557979)

transcription initiation factor TFIID subunit 1 (TAF1) is part of the TFIID complex that plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription

CATH:  1.20.920.10
Gene Symbol:  TAF1
Gene Ontology:  GO:0005669|GO:0017025|GO:0006366|GO:0001091|GO:0004402|GO:0008270|GO:0070577
PubMed:  11686293|16205117|33787465|11179890|12665246|11911891|15382140
SCOP:  4000871

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3591 pfam12157
Protein of unknown function (DUF3591); This domain is found in eukaryotes and is typically ...
 584-1047 0e+00

Protein of unknown function (DUF3591); This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.


:

Pssm-ID: 463476 [Multi-domain]  Cd Length: 456  Bit Score: 694.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    584 WNLSNDEYYFPK----QQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGalsqpGPHSVQPLL 659
Cdd:pfam12157    1 FNISNDEAYEILkenhQSKVRSTLGNLAIEHSLPALKLQLPFYKTKLSKRELRSFHRPRLQFPPNG-----GPEIVFSKL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    660 KHIKKKakmreqerQASGGGELFFMRTPQDLTGKD-GDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY 738
Cdd:pfam12157   76 KHRKKK--------KDKGKDISELFKTTKDLSLRDtSNLVLLEYSEEYPPLLSNFGMGSKLINYYRKKDAKDTSRPKLEI 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    739 GETVYC---HTSPF--LGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQG----YYIRELVDIFVVGQQCPLFE 809
Cdd:pfam12157  148 GETHVLdpqDKSPFwnFGSVEPGETVPTLYNNMFRAPIFKHKPKSTDFLLIRSTTGgeskYYLRNIDNLFVVGQTFPVVE 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    810 VPGPNSRRANMHIRDFLQVFIYRLFWKSKDRprRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRL 889
Cdd:pfam12157  228 VPGPHSRKVTNFSKNRLKMIAYRLFRKSKDG--RIKIEDITKHFPDQNEMQNRQRLKEFMDYQRTGDDQGFWKLKPGDRL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    890 PTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSffAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEV 969
Cdd:pfam12157  306 PDEEEIRKMVTPEDVCLYESMQVGQQRLKDAGYGEKD--APEEEDEDDDESKIELEQQLAPWNTTKNFINATQGKAMLQL 383

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572    970 TGVADPTGCGEGFSYVKIPNKPTQQKDDkepqAVKKTVTGTDADlRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDV 1047
Cdd:pfam12157  384 HGEGDPTGRGEGFSFLRTSMKGGFLKAG----ETKKDVTGTDAD-RKLSGGHSYNVARQQGVYEEEIKRIWRWQKISL 456
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1526-1638 2.75e-57

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 193.63  E-value: 2.75e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1526 FSFILDNIVTQKMMAvPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPE 1605
Cdd:cd05511    1 LSFILDEIVNELKNL-PDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPD 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 24429572 1606 SQYTKTAQEIVNICYQTITEYDEHLTQLEKDIC 1638
Cdd:cd05511   80 SVYTKKAKEMLELAEELLAEREEKLTQLEKNIN 112
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1404-1515 1.07e-54

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 185.93  E-value: 1.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1404 LSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05511    1 LSFILDEIVNELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 24429572 1484 SLTQISQSMLDLCDEKLKEKEDKLARLEKAIN 1515
Cdd:cd05511   81 VYTKKAKEMLELAEELLAEREEKLTQLEKNIN 112
zf-CCHC_6 pfam15288
Zinc knuckle; This Zinc knuckle is found in FAM90A mammalian proteins.
 1280-1315 1.75e-13

Zinc knuckle; This Zinc knuckle is found in FAM90A mammalian proteins.


:

Pssm-ID: 464616 [Multi-domain]  Cd Length: 42  Bit Score: 66.25  E-value: 1.75e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24429572   1280 KLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMT 1315
Cdd:pfam15288    1 RVKCKNCGAFGHTARSKRCPIKCWNGALVPQPLGSK 36
TBP-binding pfam09247
TATA box-binding protein binding; Members of this family adopt a structure consisting of three ...
 34-85 6.31e-12

TATA box-binding protein binding; Members of this family adopt a structure consisting of three alpha helices and a beta-hairpin. They bind to TATA box-binding protein (TBP), inhibiting TBP interaction with the TATA element, thereby resulting in shutting down of gene transcription.


:

Pssm-ID: 462723  Cd Length: 59  Bit Score: 62.28  E-value: 6.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24429572     34 PFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEE 85
Cdd:pfam09247    8 GLDLTGFLFGNIDEHGQLEDDDILDEESKRHLSSLSKLGLGSFLSEIIDDEE 59
CobT2 super family cl34772
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 1711-1821 1.24e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG4547:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 46.71  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1711 LGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGtvQQPEASvlyedllisEGEDDEEDAGSDEEGDNPFSAIQ 1790
Cdd:COG4547  207 LAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEG--AEAEDA---------EASGDDAEEGESEAAEAESDEMA 275

                         90       100       110
                 ....*....|....*....|....*....|.
gi 24429572 1791 LSESGSDSDVGYGGIRPKQPFMLQHASGEHK 1821
Cdd:COG4547  276 EEAEGEDSEEPGEPWRPNAPPPDDPADPDYK 306
 
Name Accession Description Interval E-value
DUF3591 pfam12157
Protein of unknown function (DUF3591); This domain is found in eukaryotes and is typically ...
 584-1047 0e+00

Protein of unknown function (DUF3591); This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.


Pssm-ID: 463476 [Multi-domain]  Cd Length: 456  Bit Score: 694.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    584 WNLSNDEYYFPK----QQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGalsqpGPHSVQPLL 659
Cdd:pfam12157    1 FNISNDEAYEILkenhQSKVRSTLGNLAIEHSLPALKLQLPFYKTKLSKRELRSFHRPRLQFPPNG-----GPEIVFSKL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    660 KHIKKKakmreqerQASGGGELFFMRTPQDLTGKD-GDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY 738
Cdd:pfam12157   76 KHRKKK--------KDKGKDISELFKTTKDLSLRDtSNLVLLEYSEEYPPLLSNFGMGSKLINYYRKKDAKDTSRPKLEI 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    739 GETVYC---HTSPF--LGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQG----YYIRELVDIFVVGQQCPLFE 809
Cdd:pfam12157  148 GETHVLdpqDKSPFwnFGSVEPGETVPTLYNNMFRAPIFKHKPKSTDFLLIRSTTGgeskYYLRNIDNLFVVGQTFPVVE 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    810 VPGPNSRRANMHIRDFLQVFIYRLFWKSKDRprRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRL 889
Cdd:pfam12157  228 VPGPHSRKVTNFSKNRLKMIAYRLFRKSKDG--RIKIEDITKHFPDQNEMQNRQRLKEFMDYQRTGDDQGFWKLKPGDRL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    890 PTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSffAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEV 969
Cdd:pfam12157  306 PDEEEIRKMVTPEDVCLYESMQVGQQRLKDAGYGEKD--APEEEDEDDDESKIELEQQLAPWNTTKNFINATQGKAMLQL 383

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572    970 TGVADPTGCGEGFSYVKIPNKPTQQKDDkepqAVKKTVTGTDADlRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDV 1047
Cdd:pfam12157  384 HGEGDPTGRGEGFSFLRTSMKGGFLKAG----ETKKDVTGTDAD-RKLSGGHSYNVARQQGVYEEEIKRIWRWQKISL 456
TAF1 COG5179
Transcription initiation factor TFIID, subunit TAF1 [Transcription];
579-1309 4.70e-99

Transcription initiation factor TFIID, subunit TAF1 [Transcription];


Pssm-ID: 227506 [Multi-domain]  Cd Length: 968  Bit Score: 343.58  E-value: 4.70e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  579 EVKDPWNLSNDEYY----FPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPplkKYSFgalsQPGPHS 654
Cdd:COG5179  355 ELKGKFNISNDKYYgilkKTHQSKVRNTLSTLGIQHSLPALRLDPPFYKNNHTKEELRNFHRP---RFMV----RPGSNI 427

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  655 VQPLLKHIKKKAKMREQERqasgggELFfmRTPQDLTGKDGD-LILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGA 733
Cdd:COG5179  428 VFSTLEARKRNKDKGKDVQ------EII--KTAGELTVGDTSpFSLFEYSEEEPFFLSNPGMASLLNNYYRKSNEQDEYR 499

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  734 PDCKYGETVYCHT---SPF--LGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQG-----YYIRELVDIFVVGQ 803
Cdd:COG5179  500 PKLDVGEYHVLDVqdpSPFwnFGDVEPGTIIPTLYNNMIRAPVFKHSSGGTDFLLIVESSNsgemsLYLRNINHLFCVGQ 579

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  804 QCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRmeDIKKAFPSHSESSIRKRLKLCADFKRTGMDsNWWVL 883
Cdd:COG5179  580 TFPVEEVPGPHSRKVTVFCKNRLKMAAFRLFNSKEGGSLRIS--QLDKHFPDQSEGQKRQWLKEFMDYVKDGPD-GVWVL 656

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  884 KSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYgEKSFFAPEEENEEdfqmkiddEVHAAPWNTTRAFIAAMKG 963
Cdd:COG5179  657 KPSEALLDEEDLRSLVTPENICQYESMLAGERKLEDSGY-KTVNEDDDEENEE--------EMLLPPWCLTRNFINATQG 727

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  964 KCLLEVTGVADPTGCGEGFSYVKIpnkptqqkddkepqavkktvtgtdadlrrlSLKNAkqlLRKFGVPEEEIKklsrwe 1043
Cdd:COG5179  728 RAMLELSGPGDPTGIGEGFSFRKT------------------------------SMKGG---FEKSGSPVENRK------ 768

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1044 vidvvrTMSTEQAHSgegpmskfargsrFSVAEHQERYKEECQRIFDLQNKVLSStevlstdtdsisaedSDFEEMGKni 1123
Cdd:COG5179  769 ------SSNKKNTHI-------------YNVAQQQSAYKEEIDRIWSKQLASLSI---------------VNFEEPFD-- 812

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1124 enmlqnkktSSQLSReweeqerkelrrmllvagsaasgnNHRDDV-TASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCE 1202
Cdd:COG5179  813 ---------ESFINR------------------------RHREEVkNADLLRETTMLSEKTLLIVRRTRDENGTSYREVE 859

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1203 TVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLK 1282
Cdd:COG5179  860 RISDPRVIKAYLKARKQDKEDVNKLDTSKINNKEISEKQKKLLQLELANLEKSQQRRAARQNSKNGSDLAGKGRKNTTRT 939

                        730       740
                 ....*....|....*....|....*..
gi 24429572 1283 CGACGAIGHMRTNKFCPLYYQTNVPPS 1309
Cdd:COG5179  940 CGNCGQVGHMKTNKACPKFSSKDNPAS 966
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1526-1638 2.75e-57

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 193.63  E-value: 2.75e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1526 FSFILDNIVTQKMMAvPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPE 1605
Cdd:cd05511    1 LSFILDEIVNELKNL-PDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPD 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 24429572 1606 SQYTKTAQEIVNICYQTITEYDEHLTQLEKDIC 1638
Cdd:cd05511   80 SVYTKKAKEMLELAEELLAEREEKLTQLEKNIN 112
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1404-1515 1.07e-54

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 185.93  E-value: 1.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1404 LSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05511    1 LSFILDEIVNELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 24429572 1484 SLTQISQSMLDLCDEKLKEKEDKLARLEKAIN 1515
Cdd:cd05511   81 VYTKKAKEMLELAEELLAEREEKLTQLEKNIN 112
BROMO smart00297
bromo domain;
1519-1626 1.39e-30

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 116.99  E-value: 1.39e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    1519 DDDDQVAFSFILDNIVTQKMMAvPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANS 1598
Cdd:smart00297    1 DPKLQKKLQELLKAVLDKLDSH-PLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNA 79

                            90       100
                    ....*....|....*....|....*...
gi 24429572    1599 VKYNGPESQYTKTAQEIVNICYQTITEY 1626
Cdd:smart00297   80 RTYNGPDSEVYKDAKKLEKFFEKKLREL 107
BROMO smart00297
bromo domain;
1397-1502 4.95e-27

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 106.98  E-value: 4.95e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    1397 RTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSA 1476
Cdd:smart00297    1 DPKLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*.
gi 24429572    1477 TYNGPKHSLTQISQSMLDLCDEKLKE 1502
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLRE 106
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1534-1614 1.26e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 90.45  E-value: 1.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572   1534 VTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQ 1613
Cdd:pfam00439    4 ILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAE 83


                   .
gi 24429572   1614 E 1614
Cdd:pfam00439   84 K 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1451-1636 2.00e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 95.26  E-value: 2.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1451 ENVRK-CLYPSREEFREHL--ELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKainplldddDQVAFS 1527
Cdd:COG5076   81 ENVGGiTYSPFEKNRPESLrfDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRKTPKIEDELLYA---------DNKAIA 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1528 FILDNIVTQKmmAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQ 1607
Cdd:COG5076  152 KFKKQLFLRD--GRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSS 229

                        170       180
                 ....*....|....*....|....*....
gi 24429572 1608 YTKTAQEIVNICYQTITEYDEHLTQLEKD 1636
Cdd:COG5076  230 VYVDAKELEKYFLKLIEEIPEEMLELSIK 258
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1408-1490 9.20e-17

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 76.58  E-value: 9.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572   1408 LESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQ 1487
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYK 80


                   ...
gi 24429572   1488 ISQ 1490
Cdd:pfam00439   81 AAE 83
zf-CCHC_6 pfam15288
Zinc knuckle; This Zinc knuckle is found in FAM90A mammalian proteins.
 1280-1315 1.75e-13

Zinc knuckle; This Zinc knuckle is found in FAM90A mammalian proteins.


Pssm-ID: 464616 [Multi-domain]  Cd Length: 42  Bit Score: 66.25  E-value: 1.75e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24429572   1280 KLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMT 1315
Cdd:pfam15288    1 RVKCKNCGAFGHTARSKRCPIKCWNGALVPQPLGSK 36
TBP-binding pfam09247
TATA box-binding protein binding; Members of this family adopt a structure consisting of three ...
 34-85 6.31e-12

TATA box-binding protein binding; Members of this family adopt a structure consisting of three alpha helices and a beta-hairpin. They bind to TATA box-binding protein (TBP), inhibiting TBP interaction with the TATA element, thereby resulting in shutting down of gene transcription.


Pssm-ID: 462723  Cd Length: 59  Bit Score: 62.28  E-value: 6.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24429572     34 PFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEE 85
Cdd:pfam09247    8 GLDLTGFLFGNIDEHGQLEDDDILDEESKRHLSSLSKLGLGSFLSEIIDDEE 59
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 1711-1821 1.24e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 46.71  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1711 LGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGtvQQPEASvlyedllisEGEDDEEDAGSDEEGDNPFSAIQ 1790
Cdd:COG4547  207 LAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEG--AEAEDA---------EASGDDAEEGESEAAEAESDEMA 275

                         90       100       110
                 ....*....|....*....|....*....|.
gi 24429572 1791 LSESGSDSDVGYGGIRPKQPFMLQHASGEHK 1821
Cdd:COG4547  276 EEAEGEDSEEPGEPWRPNAPPPDDPADPDYK 306
 
Name Accession Description Interval E-value
DUF3591 pfam12157
Protein of unknown function (DUF3591); This domain is found in eukaryotes and is typically ...
 584-1047 0e+00

Protein of unknown function (DUF3591); This domain is found in eukaryotes and is typically between 445 to 462 amino acids in length. Most members are annotated as being transcription initiation factor TFIID subunit 1, and this region is the conserved central portion of these proteins.


Pssm-ID: 463476 [Multi-domain]  Cd Length: 456  Bit Score: 694.29  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    584 WNLSNDEYYFPK----QQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGalsqpGPHSVQPLL 659
Cdd:pfam12157    1 FNISNDEAYEILkenhQSKVRSTLGNLAIEHSLPALKLQLPFYKTKLSKRELRSFHRPRLQFPPNG-----GPEIVFSKL 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    660 KHIKKKakmreqerQASGGGELFFMRTPQDLTGKD-GDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKY 738
Cdd:pfam12157   76 KHRKKK--------KDKGKDISELFKTTKDLSLRDtSNLVLLEYSEEYPPLLSNFGMGSKLINYYRKKDAKDTSRPKLEI 147

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    739 GETVYC---HTSPF--LGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQG----YYIRELVDIFVVGQQCPLFE 809
Cdd:pfam12157  148 GETHVLdpqDKSPFwnFGSVEPGETVPTLYNNMFRAPIFKHKPKSTDFLLIRSTTGgeskYYLRNIDNLFVVGQTFPVVE 227

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    810 VPGPNSRRANMHIRDFLQVFIYRLFWKSKDRprRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRL 889
Cdd:pfam12157  228 VPGPHSRKVTNFSKNRLKMIAYRLFRKSKDG--RIKIEDITKHFPDQNEMQNRQRLKEFMDYQRTGDDQGFWKLKPGDRL 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    890 PTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSffAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEV 969
Cdd:pfam12157  306 PDEEEIRKMVTPEDVCLYESMQVGQQRLKDAGYGEKD--APEEEDEDDDESKIELEQQLAPWNTTKNFINATQGKAMLQL 383

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572    970 TGVADPTGCGEGFSYVKIPNKPTQQKDDkepqAVKKTVTGTDADlRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDV 1047
Cdd:pfam12157  384 HGEGDPTGRGEGFSFLRTSMKGGFLKAG----ETKKDVTGTDAD-RKLSGGHSYNVARQQGVYEEEIKRIWRWQKISL 456
TAF1 COG5179
Transcription initiation factor TFIID, subunit TAF1 [Transcription];
579-1309 4.70e-99

Transcription initiation factor TFIID, subunit TAF1 [Transcription];


Pssm-ID: 227506 [Multi-domain]  Cd Length: 968  Bit Score: 343.58  E-value: 4.70e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  579 EVKDPWNLSNDEYY----FPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPplkKYSFgalsQPGPHS 654
Cdd:COG5179  355 ELKGKFNISNDKYYgilkKTHQSKVRNTLSTLGIQHSLPALRLDPPFYKNNHTKEELRNFHRP---RFMV----RPGSNI 427

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  655 VQPLLKHIKKKAKMREQERqasgggELFfmRTPQDLTGKDGD-LILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGA 733
Cdd:COG5179  428 VFSTLEARKRNKDKGKDVQ------EII--KTAGELTVGDTSpFSLFEYSEEEPFFLSNPGMASLLNNYYRKSNEQDEYR 499

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  734 PDCKYGETVYCHT---SPF--LGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQG-----YYIRELVDIFVVGQ 803
Cdd:COG5179  500 PKLDVGEYHVLDVqdpSPFwnFGDVEPGTIIPTLYNNMIRAPVFKHSSGGTDFLLIVESSNsgemsLYLRNINHLFCVGQ 579

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  804 QCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRmeDIKKAFPSHSESSIRKRLKLCADFKRTGMDsNWWVL 883
Cdd:COG5179  580 TFPVEEVPGPHSRKVTVFCKNRLKMAAFRLFNSKEGGSLRIS--QLDKHFPDQSEGQKRQWLKEFMDYVKDGPD-GVWVL 656

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  884 KSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYgEKSFFAPEEENEEdfqmkiddEVHAAPWNTTRAFIAAMKG 963
Cdd:COG5179  657 KPSEALLDEEDLRSLVTPENICQYESMLAGERKLEDSGY-KTVNEDDDEENEE--------EMLLPPWCLTRNFINATQG 727

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572  964 KCLLEVTGVADPTGCGEGFSYVKIpnkptqqkddkepqavkktvtgtdadlrrlSLKNAkqlLRKFGVPEEEIKklsrwe 1043
Cdd:COG5179  728 RAMLELSGPGDPTGIGEGFSFRKT------------------------------SMKGG---FEKSGSPVENRK------ 768

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1044 vidvvrTMSTEQAHSgegpmskfargsrFSVAEHQERYKEECQRIFDLQNKVLSStevlstdtdsisaedSDFEEMGKni 1123
Cdd:COG5179  769 ------SSNKKNTHI-------------YNVAQQQSAYKEEIDRIWSKQLASLSI---------------VNFEEPFD-- 812

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1124 enmlqnkktSSQLSReweeqerkelrrmllvagsaasgnNHRDDV-TASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCE 1202
Cdd:COG5179  813 ---------ESFINR------------------------RHREEVkNADLLRETTMLSEKTLLIVRRTRDENGTSYREVE 859

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1203 TVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLK 1282
Cdd:COG5179  860 RISDPRVIKAYLKARKQDKEDVNKLDTSKINNKEISEKQKKLLQLELANLEKSQQRRAARQNSKNGSDLAGKGRKNTTRT 939

                        730       740
                 ....*....|....*....|....*..
gi 24429572 1283 CGACGAIGHMRTNKFCPLYYQTNVPPS 1309
Cdd:COG5179  940 CGNCGQVGHMKTNKACPKFSSKDNPAS 966
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1526-1638 2.75e-57

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 193.63  E-value: 2.75e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1526 FSFILDNIVTQKMMAvPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPE 1605
Cdd:cd05511    1 LSFILDEIVNELKNL-PDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPD 79

                         90       100       110
                 ....*....|....*....|....*....|...
gi 24429572 1606 SQYTKTAQEIVNICYQTITEYDEHLTQLEKDIC 1638
Cdd:cd05511   80 SVYTKKAKEMLELAEELLAEREEKLTQLEKNIN 112
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1404-1515 1.07e-54

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 185.93  E-value: 1.07e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1404 LSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05511    1 LSFILDEIVNELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 24429572 1484 SLTQISQSMLDLCDEKLKEKEDKLARLEKAIN 1515
Cdd:cd05511   81 VYTKKAKEMLELAEELLAEREEKLTQLEKNIN 112
BROMO smart00297
bromo domain;
1519-1626 1.39e-30

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 116.99  E-value: 1.39e-30
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    1519 DDDDQVAFSFILDNIVTQKMMAvPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANS 1598
Cdd:smart00297    1 DPKLQKKLQELLKAVLDKLDSH-PLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNA 79

                            90       100
                    ....*....|....*....|....*...
gi 24429572    1599 VKYNGPESQYTKTAQEIVNICYQTITEY 1626
Cdd:smart00297   80 RTYNGPDSEVYKDAKKLEKFFEKKLREL 107
BROMO smart00297
bromo domain;
1397-1502 4.95e-27

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 106.98  E-value: 4.95e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572    1397 RTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSA 1476
Cdd:smart00297    1 DPKLQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNAR 80

                            90       100
                    ....*....|....*....|....*.
gi 24429572    1477 TYNGPKHSLTQISQSMLDLCDEKLKE 1502
Cdd:smart00297   81 TYNGPDSEVYKDAKKLEKFFEKKLRE 106
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1522-1623 4.05e-26

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 103.99  E-value: 4.05e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1522 DQVAFSFILDNIVTQKMmavPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKY 1601
Cdd:cd04369    1 LKKKLRSLLDALKKLKR---DLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTY 77

                         90       100
                 ....*....|....*....|..
gi 24429572 1602 NGPESQYTKTAQEIVNICYQTI 1623
Cdd:cd04369   78 NGPGSPIYKDAKKLEKLFEKLL 99
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1404-1500 2.33e-23

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 96.29  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1404 LSSILESIINDMRDLpnTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd04369    5 LRSLLDALKKLKRDL--SEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGS 82

                         90
                 ....*....|....*..
gi 24429572 1484 SLTQISQSMLDLCDEKL 1500
Cdd:cd04369   83 PIYKDAKKLEKLFEKLL 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1542-1626 3.60e-23

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 95.70  E-value: 3.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1542 PDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQ 1621
Cdd:cd05509   17 KSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWK 96


                 ....*
gi 24429572 1622 TITEY 1626
Cdd:cd05509   97 KLKEL 101
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1534-1614 1.26e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 90.45  E-value: 1.26e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572   1534 VTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQ 1613
Cdd:pfam00439    4 ILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYKAAE 83


                   .
gi 24429572   1614 E 1614
Cdd:pfam00439   84 K 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1451-1636 2.00e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 95.26  E-value: 2.00e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1451 ENVRK-CLYPSREEFREHL--ELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKainplldddDQVAFS 1527
Cdd:COG5076   81 ENVGGiTYSPFEKNRPESLrfDEIVFLAIESVTPESGLGSLLMAHLKTSVKKRKTPKIEDELLYA---------DNKAIA 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1528 FILDNIVTQKmmAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQ 1607
Cdd:COG5076  152 KFKKQLFLRD--GRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSS 229

                        170       180
                 ....*....|....*....|....*....
gi 24429572 1608 YTKTAQEIVNICYQTITEYDEHLTQLEKD 1636
Cdd:COG5076  230 VYVDAKELEKYFLKLIEEIPEEMLELSIK 258
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1423-1615 2.45e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 95.26  E-value: 2.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1423 PFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKE 1502
Cdd:COG5076  168 IFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKLIEE 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1503 KEDKLARLEKAINPLLDDDDQVAfsfILDNivtqkMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQ 1582
Cdd:COG5076  248 IPEEMLELSIKPGREEREERESV---LITN-----SQAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYR 319

                        170       180       190
                 ....*....|....*....|....*....|...
gi 24429572 1583 SRESFLDDVNLILANSVKYNGPESQYTKTAQEI 1615
Cdd:COG5076  320 PEETFVRDAKLFFDNCVMYNGEVTDYYKNANVL 352
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 1535-1623 2.72e-20

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 87.44  E-value: 2.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1535 TQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQE 1614
Cdd:cd05508   11 ALERMKQPGAEPFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAAKA 90


                 ....*....
gi 24429572 1615 IVNICYQTI 1623
Cdd:cd05508   91 IVKICEQEM 99
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 1526-1606 1.50e-18

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 82.42  E-value: 1.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1526 FSFILDNIVTQkmmavPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPE 1605
Cdd:cd05503    5 CETILDEMEAH-----EDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDD 79


                 .
gi 24429572 1606 S 1606
Cdd:cd05503   80 S 80
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1408-1502 4.49e-18

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 81.06  E-value: 4.49e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1408 LESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQ 1487
Cdd:cd05509    6 LKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYK 85

                         90
                 ....*....|....*
gi 24429572 1488 ISQSMLDLCDEKLKE 1502
Cdd:cd05509   86 CANKLEKFFWKKLKE 100
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 1530-1606 2.74e-17

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 79.41  E-value: 2.74e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24429572 1530 LDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPES 1606
Cdd:cd05510   12 LDKVLNELKTYTEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSDPS 88
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1408-1490 9.20e-17

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 76.58  E-value: 9.20e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572   1408 LESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQ 1487
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIYK 80


                   ...
gi 24429572   1488 ISQ 1490
Cdd:pfam00439   81 AAE 83
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 1534-1618 4.14e-16

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 75.27  E-value: 4.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1534 VTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPES----QYT 1609
Cdd:cd05505    8 ILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSyvlsCMR 87


                 ....*....
gi 24429572 1610 KTAQEIVNI 1618
Cdd:cd05505   88 KTEQCCVNL 96
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 1404-1500 7.93e-16

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 74.73  E-value: 7.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1404 LSSILESIINDMRdLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05508    4 LSKLLKFALERMK-QPGAEPFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDH 82

                         90
                 ....*....|....*..
gi 24429572 1484 SLTQISQSMLDLCDEKL 1500
Cdd:cd05508   83 KLTQAAKAIVKICEQEM 99
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 1542-1606 8.23e-16

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 75.12  E-value: 8.23e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24429572 1542 PDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPES 1606
Cdd:cd05504   28 KDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHT 92
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 1408-1506 1.61e-15

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 74.40  E-value: 1.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1408 LESIINDMRDL-PNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNG-PKHSL 1485
Cdd:cd05510   12 LDKVLNELKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdPSHPL 91

                         90       100
                 ....*....|....*....|.
gi 24429572 1486 TQISQSMLDLCDEKLKEKEDK 1506
Cdd:cd05510   92 RRHANFMKKKAEHLLKLIPDI 112
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 1409-1479 2.64e-15

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 73.18  E-value: 2.64e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24429572 1409 ESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYN 1479
Cdd:cd05503    6 ETILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFN 76
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1529-1618 5.45e-15

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 72.06  E-value: 5.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1529 ILDNIVTQKMMAVPDSWpFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQY 1608
Cdd:cd05513    5 ALEQLIRQLQRKDPHGF-FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIY 83

                         90
                 ....*....|
gi 24429572 1609 TKTAQEIVNI 1618
Cdd:cd05513   84 YKAAKKLLHS 93
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 1528-1615 9.45e-15

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 71.58  E-value: 9.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1528 FILDNIVTQKMMavPDSWPFHHPVN--KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPE 1605
Cdd:cd05500    8 FLLSSIRSLKRL--KDARPFLVPVDpvKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPE 85

                         90
                 ....*....|
gi 24429572 1606 SQYTKTAQEI 1615
Cdd:cd05500   86 HPVSQMGKRL 95
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1519-1625 2.63e-14

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 71.21  E-value: 2.63e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1519 DDDDQVAfsfILDNIVTQKMMAVPDSW--PFHHPVNKK-FVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLIL 1595
Cdd:cd05529   21 IRDEERE---RLISGLDKLLLSLQLEIaeYFEYPVDLRaWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLIL 97

                         90       100       110
                 ....*....|....*....|....*....|
gi 24429572 1596 ANSVKYNGPESQYTKTAQEIVNICYQTITE 1625
Cdd:cd05529   98 SNAETFNEPNSEIAKKAKRLSDWLLRILSS 127
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 1393-1484 3.08e-14

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 70.50  E-value: 3.08e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1393 IHRRRT-DPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELI 1471
Cdd:cd05504    1 RRRSEGrHHGPLNLSALEQLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLV 80

                         90
                 ....*....|...
gi 24429572 1472 VKNSATYNgPKHS 1484
Cdd:cd05504   81 FSNCFLYN-PEHT 92
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 1544-1625 3.61e-14

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 70.14  E-value: 3.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1544 SWPFHHPVN--KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQ 1621
Cdd:cd05497   23 AWPFQQPVDavKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEKLFLQ 102


                 ....
gi 24429572 1622 TITE 1625
Cdd:cd05497  103 KLAQ 106
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 1537-1618 6.89e-14

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 69.28  E-value: 6.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1537 KMMAVPDSWPFHHPVNKKF--VPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQE 1614
Cdd:cd05506   11 KLMKHKWGWVFNAPVDVVAlgLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHTMAKE 90


                 ....
gi 24429572 1615 IVNI 1618
Cdd:cd05506   91 LLKI 94
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1553-1614 8.94e-14

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 68.81  E-value: 8.94e-14
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24429572 1553 KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQE 1614
Cdd:cd05522   34 KAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVL 95
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 1546-1603 1.58e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 68.54  E-value: 1.58e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572 1546 PFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNG 1603
Cdd:cd05528   23 AFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNP 80
zf-CCHC_6 pfam15288
Zinc knuckle; This Zinc knuckle is found in FAM90A mammalian proteins.
 1280-1315 1.75e-13

Zinc knuckle; This Zinc knuckle is found in FAM90A mammalian proteins.


Pssm-ID: 464616 [Multi-domain]  Cd Length: 42  Bit Score: 66.25  E-value: 1.75e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 24429572   1280 KLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMT 1315
Cdd:pfam15288    1 RVKCKNCGAFGHTARSKRCPIKCWNGALVPQPLGSK 36
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 1547-1612 5.60e-13

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 66.65  E-value: 5.60e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1547 FHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTA 1612
Cdd:cd05512   22 FSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAA 87
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 1410-1483 6.68e-13

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 66.53  E-value: 6.68e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24429572 1410 SIINDMRDLPNT---HPFHTPVNAKVVK--DYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05498    7 GILKELFSKKHKayaWPFYKPVDPEALGlhDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDH 85
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 1543-1614 7.79e-13

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 66.55  E-value: 7.79e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24429572 1543 DSWPFHHPVnKKFVPDYYKMIVNPVDLETIRKNI---SKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQE 1614
Cdd:cd05502   21 LSLPFHEPV-SPSVPNYYKIIKTPMDLSLIRKKLqpkSPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKE 94
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 1529-1604 1.31e-12

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 65.38  E-value: 1.31e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572 1529 ILDNIVTQKMMAVpdSWPFHHPVNKKF--VPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGP 1604
Cdd:cd05499    8 VLKELMKPKHSAY--NWPFLDPVDPVAlnIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPE 83
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 1404-1492 1.69e-12

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 65.46  E-value: 1.69e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1404 LSSILESIINDMRDLPnthpFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05528    8 LRDVLKRLASDKRFNA----FTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRD 83


                 ....*....
gi 24429572 1484 SLTQISQSM 1492
Cdd:cd05528   84 PADKLIRSR 92
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 1409-1499 2.29e-12

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 64.66  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1409 ESIINDMRDLPNTHPFHTPVNAKV--VKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLT 1486
Cdd:cd05506    6 GTLLRKLMKHKWGWVFNAPVDVVAlgLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVH 85

                         90
                 ....*....|...
gi 24429572 1487 QISQSMLDLCDEK 1499
Cdd:cd05506   86 TMAKELLKIFETR 98
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 1552-1612 3.48e-12

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 64.63  E-value: 3.48e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24429572 1552 NKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTA 1612
Cdd:cd05515   32 SKSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDA 92
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 1545-1604 6.14e-12

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 63.84  E-value: 6.14e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24429572 1545 WPFHHPVN--KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGP 1604
Cdd:cd05498   22 WPFYKPVDpeALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPP 83
TBP-binding pfam09247
TATA box-binding protein binding; Members of this family adopt a structure consisting of three ...
 34-85 6.31e-12

TATA box-binding protein binding; Members of this family adopt a structure consisting of three alpha helices and a beta-hairpin. They bind to TATA box-binding protein (TBP), inhibiting TBP interaction with the TATA element, thereby resulting in shutting down of gene transcription.


Pssm-ID: 462723  Cd Length: 59  Bit Score: 62.28  E-value: 6.31e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 24429572     34 PFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEE 85
Cdd:pfam09247    8 GLDLTGFLFGNIDEHGQLEDDDILDEESKRHLSSLSKLGLGSFLSEIIDDEE 59
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 1553-1607 7.82e-12

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 63.23  E-value: 7.82e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24429572 1553 KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQ 1607
Cdd:cd05518   33 KKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQ 87
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 1542-1623 1.09e-11

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 63.23  E-value: 1.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1542 PDSWPFHHPVNKKF--VPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNIC 1619
Cdd:cd05495   20 PESLPFRQPVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKLAEVF 99


                 ....
gi 24429572 1620 YQTI 1623
Cdd:cd05495  100 EQEI 103
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 1541-1612 1.68e-11

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 62.36  E-value: 1.68e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24429572 1541 VPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTA 1612
Cdd:cd05520   21 QLLAEPFLKLPSKRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDA 92
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 1404-1480 2.73e-11

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 61.65  E-value: 2.73e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24429572 1404 LSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNG 1480
Cdd:cd05512    2 LEVLLRKTLDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNA 78
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 1410-1487 3.16e-11

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 61.56  E-value: 3.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1410 SIINDMRDLPNTHPFHTPVNAkvVK----DYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSL 1485
Cdd:cd05500   11 SSIRSLKRLKDARPFLVPVDP--VKlnipHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPV 88


                 ..
gi 24429572 1486 TQ 1487
Cdd:cd05500   89 SQ 90
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 1423-1502 5.11e-11

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 61.28  E-value: 5.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1423 PFHTPVNAkvVK----DYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE 1498
Cdd:cd05497   25 PFQQPVDA--VKlnlpDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEKLFLQ 102


                 ....
gi 24429572 1499 KLKE 1502
Cdd:cd05497  103 KLAQ 106
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 1409-1491 9.91e-11

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 60.24  E-value: 9.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1409 ESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGP-KHSLTQ 1487
Cdd:cd05505    6 EEILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENgSYVLSC 85


                 ....
gi 24429572 1488 ISQS 1491
Cdd:cd05505   86 MRKT 89
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1524-1621 1.82e-10

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 59.71  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1524 VAFSFILDNIVTQKM-MAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYN 1602
Cdd:cd05525    5 QVLKEICDAIITYKDsNGQSLAIPFINLPSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYY 84

                         90
                 ....*....|....*....
gi 24429572 1603 GPESQYTKTAQEIVNICYQ 1621
Cdd:cd05525   85 GRKSPIGRDVCRLRKAYYQ 103
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 1423-1502 2.51e-10

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 59.23  E-value: 2.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1423 PFHTPVnAKVVKDYYKIITRPMDLQTLRENVRKCL---YPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEK 1499
Cdd:cd05502   24 PFHEPV-SPSVPNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQ 102


                 ...
gi 24429572 1500 LKE 1502
Cdd:cd05502  103 LKE 105
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 1546-1623 1.76e-09

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 56.60  E-value: 1.76e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572 1546 PFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTI 1623
Cdd:cd05507   23 VFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAVEMQREVMSQI 100
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1424-1481 1.82e-09

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 56.65  E-value: 1.82e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 24429572 1424 FHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGP 1481
Cdd:cd05513   22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKP 79
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 1546-1607 5.16e-09

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 55.51  E-value: 5.16e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24429572 1546 PFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQ 1607
Cdd:cd05516   27 VFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSL 88
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1411-1484 8.82e-09

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 55.16  E-value: 8.82e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24429572 1411 IINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHS 1484
Cdd:cd05496   13 LVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTPNKRS 86
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 1547-1602 8.95e-09

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 54.65  E-value: 8.95e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1547 FHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYN 1602
Cdd:cd05519   27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYN 82
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 1404-1479 1.05e-08

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 54.74  E-value: 1.05e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1404 LSSILESIINDMRDLpnTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYN 1479
Cdd:cd05516   10 VDVVIKYKDSDGRQL--AEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFN 83
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 1409-1483 2.57e-08

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 53.44  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1409 ESIINDMRDLPNTH---PFHTPVN--AKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05499    6 EEVLKELMKPKHSAynwPFLDPVDpvALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGT 85
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 1553-1628 3.62e-08

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 53.11  E-value: 3.62e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1553 KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDE 1628
Cdd:cd05524   35 RRNEPEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSARNEVLS 110
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 1536-1630 4.73e-08

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 52.83  E-value: 4.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1536 QKMMAVPDSWPFHHPVNKKF--VPDYYKMIVNPVDLETIRKNISK-------HKYQSRESFLDDVNLILANSvkynGPES 1606
Cdd:cd05494   13 KRHRRNEDAWPFLEPVNPPRrgAPDYRDVIKRPMSFGTKVNNIVEtgardleDLQIVQEDPADKQIDDEGRR----SPSN 88

                         90       100
                 ....*....|....*....|....*.
gi 24429572 1607 QYTKTA--QEIVNICYQTITEYDEHL 1630
Cdd:cd05494   89 IYAVEAleQLIVFQCKQVKGLKQKRH 114
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1533-1602 4.76e-08

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 53.23  E-value: 4.76e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1533 IVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYN 1602
Cdd:cd05496   12 ELVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 1416-1479 2.21e-07

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 50.90  E-value: 2.21e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1416 RDLPNTHPFHTPVNAKV--VKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYN 1479
Cdd:cd05495   17 KQDPESLPFRQPVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYN 82
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 1553-1615 4.10e-07

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 50.13  E-value: 4.10e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24429572 1553 KKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEI 1615
Cdd:cd05517   33 KVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAI 95
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1547-1613 5.60e-07

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 49.63  E-value: 5.60e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24429572 1547 FHHPVNKKFVPDYYKMIVNPVDLETIRKNISkhKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQ 1613
Cdd:cd05521   28 FNVLPLRKDYPDYYKIIKNPLSLNTVKKRLP--HYTNAQEFVNDLAQIPWNARLYNTKGSVIYKYAL 92
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 1431-1479 1.63e-05

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 45.51  E-value: 1.63e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 24429572 1431 KVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYN 1479
Cdd:cd05518   34 KDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYN 82
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 1435-1500 2.59e-05

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 45.02  E-value: 2.59e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1435 DYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL 1500
Cdd:cd05520   38 DYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLMQAKK 103
Bromo_ZMYND11 cd05492
Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear ...
 1557-1625 3.36e-05

Bromodomain; ZMYND11_like sub-family. ZMYND11 or BS69 is a ubiquitously expressed nuclear protein that has been shown to associate with chromatin. It interacts with chromatin remodeling factors and might play a role in chromatin remodeling and gene expression. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99924  Cd Length: 109  Bit Score: 44.68  E-value: 3.36e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24429572 1557 PDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITE 1625
Cdd:cd05492   37 PKRRRLIHTHLDVADIQEKINSEKYTSLEEFKADALLLLHNTAIFHGADSEQYDAARWLYRDTCHDLRE 105
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 1424-1479 7.42e-05

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 43.48  E-value: 7.42e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1424 FHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYN 1479
Cdd:cd05519   27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYN 82
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1409-1502 8.29e-05

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 44.25  E-value: 8.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1409 ESIINDMR------DLPNTHPFHTPVNAKV-VKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGP 1481
Cdd:cd05529   27 ERLISGLDklllslQLEIAEYFEYPVDLRAwYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEP 106

                         90       100
                 ....*....|....*....|.
gi 24429572 1482 KHSLTQISQSMLDLCDEKLKE 1502
Cdd:cd05529  107 NSEIAKKAKRLSDWLLRILSS 127
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 1711-1821 1.24e-04

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 46.71  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1711 LGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGtvQQPEASvlyedllisEGEDDEEDAGSDEEGDNPFSAIQ 1790
Cdd:COG4547  207 LAEELGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEG--AEAEDA---------EASGDDAEEGESEAAEAESDEMA 275

                         90       100       110
                 ....*....|....*....|....*....|.
gi 24429572 1791 LSESGSDSDVGYGGIRPKQPFMLQHASGEHK 1821
Cdd:COG4547  276 EEAEGEDSEEPGEPWRPNAPPPDDPADPDYK 306
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 1419-1483 1.41e-04

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 42.74  E-value: 1.41e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24429572 1419 PNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKH 1483
Cdd:cd05507   19 RYASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDH 83
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 1435-1481 2.03e-04

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 42.29  E-value: 2.03e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 24429572 1435 DYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGP 1481
Cdd:cd05515   38 DYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEP 84
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1423-1482 4.05e-04

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 41.61  E-value: 4.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1423 PFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPK 1482
Cdd:cd05525   28 PFINLPSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRK 87
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 1435-1481 8.20e-04

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 40.50  E-value: 8.20e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 24429572 1435 DYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGP 1481
Cdd:cd05517   38 DYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEP 84
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1420-1482 3.33e-03

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 38.84  E-value: 3.33e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24429572 1420 NTHP-FHTPVNAKVVKDYYKIITRPMDLQTLRENVRKclYPSREEFREHLELIVKNSATYNGPK 1482
Cdd:cd05521   23 EIHPiFNVLPLRKDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKG 84
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1414-1479 4.83e-03

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 38.38  E-value: 4.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24429572 1414 DMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYN 1479
Cdd:cd05522   18 DENGRLLTLHFEKLPDKAREPEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYN 83
Bromo_TBP7_like cd05491
Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is ...
 1485-1616 6.15e-03

Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is a yeast protein of unknown function that contains AAA-superfamily ATP-ase domains and a bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99923  Cd Length: 119  Bit Score: 38.59  E-value: 6.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24429572 1485 LTQISQSMLDLCDeKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHpvnkkfvpdyykmiv 1564
Cdd:cd05491    1 LKKFRQPIIDELQ-RKYLKFEKPPTEDAFVRPDNENNEERPYEIAKDKQGVDTILETASGKKFYN--------------- 64

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24429572 1565 npVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPEsqYTKTAQEIV 1616
Cdd:cd05491   65 --MDLDTIEERLWNGYYATPKDFLKDIKRIVRDAKTIGDRE--RLLKANEMF 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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