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Conserved domains on  [gi|24580529|ref|NP_722594|]
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S-adenosylmethionine synthetase, isoform A [Drosophila melanogaster]

Protein Classification

methionine adenosyltransferase( domain architecture ID 13030951)

methionine adenosyltransferase catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP

EC:  2.5.1.6
Gene Ontology:  GO:0005524|GO:0046872|GO:0004478

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
S-AdoMet_synt cd18079
S-adenosylmethionine synthetase; S-adenosylmethionine synthetase (EC 2.5.1.6), also known as ...
30-399 0e+00

S-adenosylmethionine synthetase; S-adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase, catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP in two steps, the formation of AdoMet and hydrolysis of the tripolyphosphate, which occurs prior to release of the product from the enzyme, which consists of three structural domains that have a similar alpha+beta fold.


:

Pssm-ID: 350837  Cd Length: 371  Bit Score: 665.26  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  30 LFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKG 109
Cdd:cd18079   1 LFTSESVTEGHPDKICDQISDAILDACLAQDPNSRVACETLVTTGLVIIAGEITTKAYVDIEKIVREVIKEIGYDDSDFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 110 FDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARP 189
Cdd:cd18079  81 FDAKTCGVLVSIHEQSPDIAQGVDEGLELEEIGAGDQGIMFGYATDETPELMPLPIVLAHKLARRLAEVRKNGTLPWLRP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 190 DSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGD 269
Cdd:cd18079 161 DGKTQVTVEYEDGK----PVRVDTIVVSTQHDEDVSLEELREDIIEKVIKPVIPEELLDEDTKYLINPTGRFVIGGPAGD 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 270 AGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTS 349
Cdd:cd18079 237 TGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYIAKNIVAAGLAKRCEVQLSYAIGVAEPVSIYVDTFGTG 316
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 24580529 350 HKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGR--AGFSWE 399
Cdd:cd18079 317 KISDEKIEEIIKKNFDLRPAGIIEDLDLRRPIYRKTAAYGHFGRedEDFPWE 368
 
Name Accession Description Interval E-value
S-AdoMet_synt cd18079
S-adenosylmethionine synthetase; S-adenosylmethionine synthetase (EC 2.5.1.6), also known as ...
30-399 0e+00

S-adenosylmethionine synthetase; S-adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase, catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP in two steps, the formation of AdoMet and hydrolysis of the tripolyphosphate, which occurs prior to release of the product from the enzyme, which consists of three structural domains that have a similar alpha+beta fold.


Pssm-ID: 350837  Cd Length: 371  Bit Score: 665.26  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  30 LFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKG 109
Cdd:cd18079   1 LFTSESVTEGHPDKICDQISDAILDACLAQDPNSRVACETLVTTGLVIIAGEITTKAYVDIEKIVREVIKEIGYDDSDFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 110 FDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARP 189
Cdd:cd18079  81 FDAKTCGVLVSIHEQSPDIAQGVDEGLELEEIGAGDQGIMFGYATDETPELMPLPIVLAHKLARRLAEVRKNGTLPWLRP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 190 DSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGD 269
Cdd:cd18079 161 DGKTQVTVEYEDGK----PVRVDTIVVSTQHDEDVSLEELREDIIEKVIKPVIPEELLDEDTKYLINPTGRFVIGGPAGD 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 270 AGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTS 349
Cdd:cd18079 237 TGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYIAKNIVAAGLAKRCEVQLSYAIGVAEPVSIYVDTFGTG 316
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 24580529 350 HKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGR--AGFSWE 399
Cdd:cd18079 317 KISDEKIEEIIKKNFDLRPAGIIEDLDLRRPIYRKTAAYGHFGRedEDFPWE 368
PTZ00104 PTZ00104
S-adenosylmethionine synthase; Provisional
28-408 0e+00

S-adenosylmethionine synthase; Provisional


Pssm-ID: 240268  Cd Length: 398  Bit Score: 648.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   28 TFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSS 107
Cdd:PTZ00104  10 HFLFTSESVSEGHPDKLCDQISDAVLDACLAQDPLSKVACETCAKTGMVMVFGEITTKAVVDYQKVVRDTVKEIGYDDTE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  108 KGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWA 187
Cdd:PTZ00104  90 KGLDYKTCNVLVAIEQQSPDIAQGVHVGKKEEDIGAGDQGIMFGYATDETEELMPLTHELATKLAKRLSELRKNGILPWL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  188 RPDSKTQVTCEYLFNQGSA-VPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGP 266
Cdd:PTZ00104 170 RPDAKTQVTVEYEYDTRGGlTPKRVHTILISTQHDEGVSNEEIREDLMEHVIKPVIPAKLLDEETKYHLNPSGRFVIGGP 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  267 MGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDY 346
Cdd:PTZ00104 250 HGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSLVAAGLCKRCLVQVSYAIGVAEPLSIHVNTY 329
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580529  347 GTSHK--SQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAG--FSWEEAKPLEIDN 408
Cdd:PTZ00104 330 GTGKKgyDDEDLLEIVQKNFDLRPGDIIKELDLRRPIFQKTASYGHFGRSDpeFTWEVPKDLEHEK 395
MetK COG0192
S-adenosylmethionine synthetase [Coenzyme transport and metabolism]; S-adenosylmethionine ...
29-399 0e+00

S-adenosylmethionine synthetase [Coenzyme transport and metabolism]; S-adenosylmethionine synthetase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 439962 [Multi-domain]  Cd Length: 384  Bit Score: 609.33  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  29 FLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSK 108
Cdd:COG0192   2 YLFTSESVTEGHPDKVCDQISDAILDAILAQDPNARVACETLVTTGLVVVAGEITTSAYVDIPEIVRETIKEIGYTSSEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 109 GFDFKTCNVLLALDQQSPEIAAGVHVNRAE-EEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWA 187
Cdd:COG0192  82 GFDADTCAVLTSIHEQSPDIAQGVDEALDElDEQGAGDQGIMFGYACNETPELMPLPISLAHRLARRLAEVRKSGELPYL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 188 RPDSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPM 267
Cdd:COG0192 162 RPDGKSQVTVEYEDGK----PVRIDTVVVSTQHDPDVSQEQLREDIIEEVIKPVLPAELLDDDTKYLINPTGRFVIGGPQ 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 268 GDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYG 347
Cdd:COG0192 238 GDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLADRCEVQLAYAIGVAEPVSIYVDTFG 317
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 24580529 348 TSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRA--GFSWE 399
Cdd:COG0192 318 TGKVSDEKIEEAVREVFDLRPAGIIERLDLRRPIYRKTAAYGHFGREdlDFPWE 371
metK TIGR01034
S-adenosylmethionine synthetase; Tandem isozymes of this S-adenosylmethionine synthetase in E. ...
30-405 0e+00

S-adenosylmethionine synthetase; Tandem isozymes of this S-adenosylmethionine synthetase in E. coli are designated MetK and MetX. [Central intermediary metabolism, Other]


Pssm-ID: 273406  Cd Length: 377  Bit Score: 594.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529    30 LFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKG 109
Cdd:TIGR01034   1 LFTSESVSEGHPDKIADQISDAVLDAILKQDPKSKVACETFVKTGLVLIGGEITTSAYVDIQEVARNTIKDIGYTDSDYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   110 FDFKTCNVLLALDQQSPEIAAGVHVNRAEEeIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARP 189
Cdd:TIGR01034  81 FDAKTCAVLDAIGNQSPDIAQGVDKANPEE-QGAGDQGIMFGYATNETPELMPLPITLAHKLLKRAAELRKSGTLPWLRP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   190 DSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGD 269
Cdd:TIGR01034 160 DGKSQVTIQYEDNK----PVRVDTVVLSTQHDPDISQKDLREAIIEEIIKPVLPAEFLDEKTKFFINPTGRFVIGGPMGD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   270 AGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTS 349
Cdd:TIGR01034 236 TGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYIAKNIVAAGLADRCEVQLSYAIGVAEPVSIMVETFGTS 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24580529   350 HKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405
Cdd:TIGR01034 316 KKSSEELLNVVKENFDLRPGGIIEKLDLLKPIYRKTAAYGHFGREEFPWEKPDKLE 371
S-AdoMet_synt_C pfam02773
S-adenosylmethionine synthetase, C-terminal domain; The three domains of S-adenosylmethionine ...
263-399 7.26e-88

S-adenosylmethionine synthetase, C-terminal domain; The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.


Pssm-ID: 460688 [Multi-domain]  Cd Length: 138  Bit Score: 262.32  E-value: 7.26e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   263 IGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSIT 342
Cdd:pfam02773   1 IGGPQGDTGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYIAKNIVAAGLAKRCEVQLSYAIGVAEPVSIY 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24580529   343 VFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGR-AGFSWE 399
Cdd:pfam02773  81 VDTFGTGKVSDEKILEIVRENFDLRPAGIIERLDLRRPIYRKTAAYGHFGRePDFPWE 138
 
Name Accession Description Interval E-value
S-AdoMet_synt cd18079
S-adenosylmethionine synthetase; S-adenosylmethionine synthetase (EC 2.5.1.6), also known as ...
30-399 0e+00

S-adenosylmethionine synthetase; S-adenosylmethionine synthetase (EC 2.5.1.6), also known as methionine adenosyltransferase, catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP in two steps, the formation of AdoMet and hydrolysis of the tripolyphosphate, which occurs prior to release of the product from the enzyme, which consists of three structural domains that have a similar alpha+beta fold.


Pssm-ID: 350837  Cd Length: 371  Bit Score: 665.26  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  30 LFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKG 109
Cdd:cd18079   1 LFTSESVTEGHPDKICDQISDAILDACLAQDPNSRVACETLVTTGLVIIAGEITTKAYVDIEKIVREVIKEIGYDDSDFG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 110 FDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARP 189
Cdd:cd18079  81 FDAKTCGVLVSIHEQSPDIAQGVDEGLELEEIGAGDQGIMFGYATDETPELMPLPIVLAHKLARRLAEVRKNGTLPWLRP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 190 DSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGD 269
Cdd:cd18079 161 DGKTQVTVEYEDGK----PVRVDTIVVSTQHDEDVSLEELREDIIEKVIKPVIPEELLDEDTKYLINPTGRFVIGGPAGD 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 270 AGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTS 349
Cdd:cd18079 237 TGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYIAKNIVAAGLAKRCEVQLSYAIGVAEPVSIYVDTFGTG 316
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|..
gi 24580529 350 HKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGR--AGFSWE 399
Cdd:cd18079 317 KISDEKIEEIIKKNFDLRPAGIIEDLDLRRPIYRKTAAYGHFGRedEDFPWE 368
PTZ00104 PTZ00104
S-adenosylmethionine synthase; Provisional
28-408 0e+00

S-adenosylmethionine synthase; Provisional


Pssm-ID: 240268  Cd Length: 398  Bit Score: 648.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   28 TFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSS 107
Cdd:PTZ00104  10 HFLFTSESVSEGHPDKLCDQISDAVLDACLAQDPLSKVACETCAKTGMVMVFGEITTKAVVDYQKVVRDTVKEIGYDDTE 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  108 KGFDFKTCNVLLALDQQSPEIAAGVHVNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWA 187
Cdd:PTZ00104  90 KGLDYKTCNVLVAIEQQSPDIAQGVHVGKKEEDIGAGDQGIMFGYATDETEELMPLTHELATKLAKRLSELRKNGILPWL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  188 RPDSKTQVTCEYLFNQGSA-VPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGP 266
Cdd:PTZ00104 170 RPDAKTQVTVEYEYDTRGGlTPKRVHTILISTQHDEGVSNEEIREDLMEHVIKPVIPAKLLDEETKYHLNPSGRFVIGGP 249
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  267 MGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDY 346
Cdd:PTZ00104 250 HGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDPSKVDRSAAYAARWIAKSLVAAGLCKRCLVQVSYAIGVAEPLSIHVNTY 329
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580529  347 GTSHK--SQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAG--FSWEEAKPLEIDN 408
Cdd:PTZ00104 330 GTGKKgyDDEDLLEIVQKNFDLRPGDIIKELDLRRPIFQKTASYGHFGRSDpeFTWEVPKDLEHEK 395
MetK COG0192
S-adenosylmethionine synthetase [Coenzyme transport and metabolism]; S-adenosylmethionine ...
29-399 0e+00

S-adenosylmethionine synthetase [Coenzyme transport and metabolism]; S-adenosylmethionine synthetase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 439962 [Multi-domain]  Cd Length: 384  Bit Score: 609.33  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  29 FLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSK 108
Cdd:COG0192   2 YLFTSESVTEGHPDKVCDQISDAILDAILAQDPNARVACETLVTTGLVVVAGEITTSAYVDIPEIVRETIKEIGYTSSEY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 109 GFDFKTCNVLLALDQQSPEIAAGVHVNRAE-EEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWA 187
Cdd:COG0192  82 GFDADTCAVLTSIHEQSPDIAQGVDEALDElDEQGAGDQGIMFGYACNETPELMPLPISLAHRLARRLAEVRKSGELPYL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 188 RPDSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPM 267
Cdd:COG0192 162 RPDGKSQVTVEYEDGK----PVRIDTVVVSTQHDPDVSQEQLREDIIEEVIKPVLPAELLDDDTKYLINPTGRFVIGGPQ 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529 268 GDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYG 347
Cdd:COG0192 238 GDAGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLADRCEVQLAYAIGVAEPVSIYVDTFG 317
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 24580529 348 TSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRA--GFSWE 399
Cdd:COG0192 318 TGKVSDEKIEEAVREVFDLRPAGIIERLDLRRPIYRKTAAYGHFGREdlDFPWE 371
metK TIGR01034
S-adenosylmethionine synthetase; Tandem isozymes of this S-adenosylmethionine synthetase in E. ...
30-405 0e+00

S-adenosylmethionine synthetase; Tandem isozymes of this S-adenosylmethionine synthetase in E. coli are designated MetK and MetX. [Central intermediary metabolism, Other]


Pssm-ID: 273406  Cd Length: 377  Bit Score: 594.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529    30 LFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSSKG 109
Cdd:TIGR01034   1 LFTSESVSEGHPDKIADQISDAVLDAILKQDPKSKVACETFVKTGLVLIGGEITTSAYVDIQEVARNTIKDIGYTDSDYG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   110 FDFKTCNVLLALDQQSPEIAAGVHVNRAEEeIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARP 189
Cdd:TIGR01034  81 FDAKTCAVLDAIGNQSPDIAQGVDKANPEE-QGAGDQGIMFGYATNETPELMPLPITLAHKLLKRAAELRKSGTLPWLRP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   190 DSKTQVTCEYLFNQgsavPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGGPMGD 269
Cdd:TIGR01034 160 DGKSQVTIQYEDNK----PVRVDTVVLSTQHDPDISQKDLREAIIEEIIKPVLPAEFLDEKTKFFINPTGRFVIGGPMGD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   270 AGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFDYGTS 349
Cdd:TIGR01034 236 TGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAARYIAKNIVAAGLADRCEVQLSYAIGVAEPVSIMVETFGTS 315
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 24580529   350 HKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGRAGFSWEEAKPLE 405
Cdd:TIGR01034 316 KKSSEELLNVVKENFDLRPGGIIEKLDLLKPIYRKTAAYGHFGREEFPWEKPDKLE 371
PLN02243 PLN02243
S-adenosylmethionine synthase
28-404 0e+00

S-adenosylmethionine synthase


Pssm-ID: 177886 [Multi-domain]  Cd Length: 386  Bit Score: 546.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   28 TFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSS 107
Cdd:PLN02243   3 TFLFTSESVNEGHPDKLCDQISDAVLDACLAQDPDSKVACETCTKTNMVMVFGEITTKAKVDYEKIVRDTCREIGFVSDD 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  108 KGFDFKTCNVLLALDQQSPEIAAGVH--VNRAEEEIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFW 185
Cdd:PLN02243  83 VGLDADKCKVLVNIEQQSPDIAQGVHghLTKKPEEIGAGDQGHMFGYATDETPELMPLTHVLATKLGARLTEVRKNGTCP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  186 WARPDSKTQVTCEYLFNQGSAVPKRVHTIVVSMQHSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLFVIGG 265
Cdd:PLN02243 163 WLRPDGKTQVTVEYKNEGGAMVPIRVHTVLISTQHDETVTNDEIAADLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGG 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529  266 PMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSITVFD 345
Cdd:PLN02243 243 PHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVAAGLARRCIVQVSYAIGVPEPLSVFVDT 322
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24580529  346 YGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQ---PIYQRTSTYGHFGRAG--FSWEEAKPL 404
Cdd:PLN02243 323 YGTGKIPDKEILKIVKENFDFRPGMIAINLDLKRggnGRFQKTAAYGHFGRDDpdFTWEVVKPL 386
S-AdoMet_synt_C pfam02773
S-adenosylmethionine synthetase, C-terminal domain; The three domains of S-adenosylmethionine ...
263-399 7.26e-88

S-adenosylmethionine synthetase, C-terminal domain; The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.


Pssm-ID: 460688 [Multi-domain]  Cd Length: 138  Bit Score: 262.32  E-value: 7.26e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   263 IGGPMGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFTKVDRSAAYAARWVAKSLVKAGLCKRCLVQVSYAIGLAEPLSIT 342
Cdd:pfam02773   1 IGGPQGDTGLTGRKIIVDTYGGYARHGGGAFSGKDPTKVDRSAAYAARYIAKNIVAAGLAKRCEVQLSYAIGVAEPVSIY 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 24580529   343 VFDYGTSHKSQKELLDIIRRNFDLRPGKIVKDLNLRQPIYQRTSTYGHFGR-AGFSWE 399
Cdd:pfam02773  81 VDTFGTGKVSDEKILEIVRENFDLRPAGIIERLDLRRPIYRKTAAYGHFGRePDFPWE 138
S-AdoMet_synt_N pfam00438
S-adenosylmethionine synthetase, N-terminal domain; The three domains of S-adenosylmethionine ...
28-125 2.01e-65

S-adenosylmethionine synthetase, N-terminal domain; The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.


Pssm-ID: 459810 [Multi-domain]  Cd Length: 98  Bit Score: 203.73  E-value: 2.01e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529    28 TFLFTSESVGEGHPDKMCDQISDAILDAHLKQDPNAKVACETVAKTGMILLCGEITSKAVVDYQKVVRETVQHIGYDDSS 107
Cdd:pfam00438   1 KYLFTSESVTEGHPDKVCDQISDAILDAFLAQDPNSRVACETLVTTGLVVVAGEITTKAYVDIEKIVRDTIKEIGYDDAE 80
                          90
                  ....*....|....*...
gi 24580529   108 KGFDFKTCNVLLALDQQS 125
Cdd:pfam00438  81 YGFDADTCAVLVAIHEQS 98
S-AdoMet_synt_M pfam02772
S-adenosylmethionine synthetase, central domain; The three domains of S-adenosylmethionine ...
140-261 8.91e-60

S-adenosylmethionine synthetase, central domain; The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.


Pssm-ID: 460687 [Multi-domain]  Cd Length: 118  Bit Score: 189.91  E-value: 8.91e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580529   140 EIGAGDQGIMFGYATDETEECMPLTVVLAHKLNEKIAELRRSDVFWWARPDSKTQVTCEYLFNqgsaVPKRVHTIVVSMQ 219
Cdd:pfam02772   1 EIGAGDQGIMFGYACDETPELMPLPISLAHRLARRLAEVRKDGTLPYLRPDGKTQVTVEYDDG----KPVRIDTIVVSTQ 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 24580529   220 HSEKISLETLRSEVMEKVVKVVIPAKYIDANTIVHINPCGLF 261
Cdd:pfam02772  77 HDPDVSLEQLREDIIEEVIKPVLPAELLDDDTKYHINPTGRF 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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