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Conserved domains on  [gi|24580811|ref|NP_722687|]
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uncharacterized protein Dmel_CG31922 [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 366524)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-U1 super family cl22907
U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) ...
 3-39 7.24e-11

U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.


The actual alignment was detected with superfamily member pfam06220:

Pssm-ID: 389966  Cd Length: 38  Bit Score: 53.59  E-value: 7.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24580811     3 GKSYYCDYCCCFLKND-LNVRKLHNGGIAHAIAKSNYL 39
Cdd:pfam06220   1 MPKYYCDYCDCYLTHDsPSVRKSHNGGRKHKDNVKDYY 38
 
Name Accession Description Interval E-value
zf-U1 pfam06220
U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) ...
 3-39 7.24e-11

U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.


Pssm-ID: 368798  Cd Length: 38  Bit Score: 53.59  E-value: 7.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24580811     3 GKSYYCDYCCCFLKND-LNVRKLHNGGIAHAIAKSNYL 39
Cdd:pfam06220   1 MPKYYCDYCDCYLTHDsPSVRKSHNGGRKHKDNVKDYY 38
COG5136 COG5136
U1 snRNP-specific protein C [RNA processing and modification];
6-44 1.20e-05

U1 snRNP-specific protein C [RNA processing and modification];


Pssm-ID: 227465 [Multi-domain]  Cd Length: 188  Bit Score: 42.76  E-value: 1.20e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24580811   6 YYCDYCCCFLKND-LNVRKLHNGGIAHA-IAKSNYLKRYED 44
Cdd:COG5136   4 YFCEYCNKMLTHDrLSVRKMHCGGAKHGlMRKDYYMEMAED 44
 
Name Accession Description Interval E-value
zf-U1 pfam06220
U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) ...
 3-39 7.24e-11

U1 zinc finger; This family consists of several U1 small nuclear ribonucleoprotein C (U1-C) proteins. The U1 small nuclear ribonucleoprotein (U1 snRNP) binds to the pre-mRNA 5' splice site (ss) at early stages of spliceosome assembly. Recruitment of U1 to a class of weak 5' ss is promoted by binding of the protein TIA-1 to uridine-rich sequences immediately downstream from the 5' ss. Binding of TIA-1 in the vicinity of a 5' ss helps to stabilize U1 snRNP recruitment, at least in part, via a direct interaction with U1-C, thus providing one molecular mechanism for the function of this splicing regulator. This domain is probably a zinc-binding. It is found in multiple copies in some members of the family.


Pssm-ID: 368798  Cd Length: 38  Bit Score: 53.59  E-value: 7.24e-11
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24580811     3 GKSYYCDYCCCFLKND-LNVRKLHNGGIAHAIAKSNYL 39
Cdd:pfam06220   1 MPKYYCDYCDCYLTHDsPSVRKSHNGGRKHKDNVKDYY 38
COG5136 COG5136
U1 snRNP-specific protein C [RNA processing and modification];
6-44 1.20e-05

U1 snRNP-specific protein C [RNA processing and modification];


Pssm-ID: 227465 [Multi-domain]  Cd Length: 188  Bit Score: 42.76  E-value: 1.20e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|.
gi 24580811   6 YYCDYCCCFLKND-LNVRKLHNGGIAHA-IAKSNYLKRYED 44
Cdd:COG5136   4 YFCEYCNKMLTHDrLSVRKMHCGGAKHGlMRKDYYMEMAED 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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