uncharacterized protein Dmel_CG30356 [Drosophila melanogaster]
Protein Classification
HMG-box domain-containing protein( domain architecture ID 228)
HMG (High Mobility Group)-box domain-containing protein binds DNA and may be a chromosomal protein or function as a transcription factor
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| HMG-box_SF super family | cl00082 | high mobility group (HMG)-box domain superfamily; The High Mobility Group (HMG)-box is found ... |
39-96 | 9.16e-05 | ||
high mobility group (HMG)-box domain superfamily; The High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenetically distinct groups of Class I proteins bind DNA in a sequence specific fashion and contain a single HMG box. One group (SOX-TCF) includes transcription factors, TCF-1, -3, -4, and also SRY and LEF-1, which bind four-way DNA junctions and duplex DNA targets. The second group (MATA) includes fungal mating type gene products MC, MATA1 and Ste11. Class II and III proteins (HMGB-UBF) bind DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal proteins, HMG1 and HMG2, which bind to bent or distorted DNA such as four-way DNA junctions, synthetic DNA cruciforms, kinked cisplatin-modified DNA, DNA bulges, cross-overs in supercoiled DNA, and can cause looping of linear DNA. Class III members include nucleolar and mitochondrial transcription factors, UBF and mtTF1, which bind four-way DNA junctions. The actual alignment was detected with superfamily member cd22014: Pssm-ID: 469606 [Multi-domain] Cd Length: 62 Bit Score: 38.50 E-value: 9.16e-05
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| Name | Accession | Description | Interval | E-value | ||
| HMG-box_CMB1-like | cd22014 | high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 ... |
39-96 | 9.16e-05 | ||
high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 and similar proteins; Cmb1 binds to cytosines in base mismatches and opposite chemically altered guanines. It contains only one HMG-box domain. Pssm-ID: 438830 [Multi-domain] Cd Length: 62 Bit Score: 38.50 E-value: 9.16e-05
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| Name | Accession | Description | Interval | E-value | ||
| HMG-box_CMB1-like | cd22014 | high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 ... |
39-96 | 9.16e-05 | ||
high mobility group (HMG)-box found in Schizosaccharomyces pombe mismatch-binding protein cmb1 and similar proteins; Cmb1 binds to cytosines in base mismatches and opposite chemically altered guanines. It contains only one HMG-box domain. Pssm-ID: 438830 [Multi-domain] Cd Length: 62 Bit Score: 38.50 E-value: 9.16e-05
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| HMG-box_SoxF_SOX17 | cd22047 | high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and ... |
70-100 | 2.39e-03 | ||
high mobility group (HMG)-box found in sex determining region Y (SRY)-box 17 (SOX17) and similar proteins; SOX-17 is a developmental transcription regulator involved in endoderm formation, angiogenesis, and carcinogenesis. It acts as a tumor suppressor and modulates WNT signaling. SOX-17 binds target promoter DNA and bends the DNA. It binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX-17 belongs to the group F of SRY-related high-mobility group (HMG) box (Sox) transcription factors. Pssm-ID: 438850 [Multi-domain] Cd Length: 81 Bit Score: 35.06 E-value: 2.39e-03
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| HMG-box_AtHMGB1-like | cd22005 | high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 ... |
40-93 | 2.63e-03 | ||
high mobility group (HMG)-box found in Arabidopsis thaliana high mobility group B protein 1 (HMGB1) and similar proteins; This subfamily contains a group of Arabidopsis thaliana HMGB family proteins, including HMGB1, 2, 3, 4, 5, 7, 12 and 14. They bind preferentially to double-stranded DNA. HMGB1 modulates general plant growth and stress tolerance and confers sensitivity to salt and genotoxic (methyl methanesulfonate, MMS) stresses. HMGB2 and HMGB5 confer sensitivity to salt and drought stresses. HMGB7 is required for karyogamy during female gametophyte development, when the two polar nuclei fuse to form the diploid central cell nucleus. Members of this subfamily contain only one HMG-box domain. Pssm-ID: 438821 [Multi-domain] Cd Length: 60 Bit Score: 34.21 E-value: 2.63e-03
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