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Conserved domains on  [gi|24653098|ref|NP_725188|]
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Sin3A, isoform C [Drosophila melanogaster]

Protein Classification

Sin3 family protein( domain architecture ID 1001704)

Sin3 family protein similar to Homo sapiens paired amphipathic helix proteins Sin3a and Sin3b, which act as transcriptional repressors

CATH:  1.20.1160.11
Gene Ontology:  GO:0003714

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sin3 super family cl35027
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
238-1715 5.56e-105

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5602:

Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 366.16  E-value: 5.56e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  238 KAQTPPSSVvANSIPVGGT------------TPPQGQSgnaTPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKS 305
Cdd:COG5602   86 DVEQILSSL-AGDNPDPSTdhgsasnqnmerSPPPRIP---YRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKS 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  306 HCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSmpsPPGAPTSTgtvhmltgnssmsgaghi 385
Cdd:COG5602  162 QAIDTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQPNGSRLHVT---TPQGPLSS------------------ 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  386 aikttnaatltpaagagaaaaaaavaqiqsagavnlmthggasltqttihalqqaTPPQSQSPGGGHVHvsvtNSTAANA 465
Cdd:COG5602  221 -------------------------------------------------------PPVQSSYYVAPCNH----DQRTSHP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  466 VVPGQPGISVSAHNvpqnysrdreratitptgqvagaaanvnasasivvggpptpnslselsphggagggpgagaaqhnl 545
Cdd:COG5602  242 TLPSDSQPEPSAPS------------------------------------------------------------------ 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  546 hhiqqahqsiLLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMkegslnqgkmlteQEVYT 625
Cdd:COG5602  256 ----------HMPSDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSI-------------QEVYA 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  626 QVAKLFGQDEDLLREFGQFLPDAtnhqsgqymsksasvhndhgkrptatlsggahitmssaspapsgsplhlgattlpqI 705
Cdd:COG5602  313 RVTKLFAEAPDLLEEFKEFLPDS--------------------------------------------------------S 336

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  706 DKSAHAAAignlsavntsvsiktynnnqqqqnhvigsglNATrndilfekdyhaglqqqahqrgagvgghhhlagtaaga 785
Cdd:COG5602  337 VSAEQSTA-------------------------------NAQ-------------------------------------- 347

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  786 nigrpgvgasvmvsydkehrnnhhvqkyvghAPNQNLthghnakksPSYGIPSVIGSMPHISDNSLDRSSPGIsyatppl 865
Cdd:COG5602  348 -------------------------------KPSKRL---------PPIGSFSLPTAAPEQNRPSLLWESPRS------- 380

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  866 psgphgQHNsGSATRRPGDDSLVGHYAsgapPAKRPKPYCRDVSFSEAsskctisdaaFFDKVRKALRSPEVYDNFLRCL 945
Cdd:COG5602  381 ------ISN-ISRYRADLLTSFSRNFV----PIRIHMPISHLSNESED----------FFERIKQYLKDKNLYHEFLKLL 439

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  946 TLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLG--PPSGQPagglidgmplaatqrqgggssnssHDRgtshqsaae 1023
Cdd:COG5602  440 NLYSQKIIDKNDLVERLFAFLGSNEELIRWFKAFINysEPEKEP------------------------LRE--------- 486

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1024 yvQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELD 1103
Cdd:COG5602  487 --TRKDLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHPTWASEDSGFIAHRKNQYEEALFKIEEERYEYD 564

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1104 LVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSG-EIITGMKKNPFVAVPIVLKRL 1182
Cdd:COG5602  565 RHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKVIKKVYDKEHApEILEALLKKPHVTIPIVLKRL 644

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1183 KVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPy 1262
Cdd:COG5602  645 KMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQAKIHVSIDDKKVFQFVFVLC- 723

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1263 kDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLF--FAPRQPLSDDERDdafpflvddntkMDVDSPLGRT 1340
Cdd:COG5602  724 -DTYIFVNILDLKDTLITNMSSYLESDKERLKANLKTIVSLFFllCIFRIIIIVYERL------------LNVKGLNIDG 790

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1341 ESSTRNAKSTPSESASPARSNASTSSVtpagiKKETDdskattgsfapassatassatpvddatpstssaaaaasaasss 1420
Cdd:COG5602  791 LKADRSSRSDESAQRYSKVKSGNLEQV-----SKQID------------------------------------------- 822

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1421 tvsgtegkpkddplsshkeegagstssgvatsprqaqdtaGAGVDVEIK-LEHPADFSNPKLLPPHAHGQREDESYTlFF 1499
Cdd:COG5602  823 ----------------------------------------EYAIEDEIKePTHPDGLKEHNISKGISENEKQVIALT-EF 861

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1500 ANNNWYLFLRLHAILCDRLhvmYERARLlaieEERCRVnrrestatalrlkpkpEIQVEDYYPTFLDMLKNVLDGNMDSN 1579
Cdd:COG5602  862 GNSLMYVFFRLRFDSYERL---YEIKKI----KEAVTI----------------GMMEPGHYENELWDSYRLIFGALTPC 918

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1580 TFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFatEQRRGCTGGFCRDahktfdrEMSYQRKAESI 1659
Cdd:COG5602  919 EFEKYLRPFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELF--EMNSAASSKRKQD-------QTKYRLEVESL 989

                       1450      1460      1470      1480      1490
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24653098 1660 LN-EENCFKVYIYKIDCRVTIELLDSEPEEVDKPAAlKAQKFSKYVERLANPALGGG 1715
Cdd:COG5602  990 LNpDEILFRFCWINKFKSFGIQIMKRADLTVDQSLD-TQRVWKYYVQSYAIQHLTEG 1045
 
Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
238-1715 5.56e-105

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 366.16  E-value: 5.56e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  238 KAQTPPSSVvANSIPVGGT------------TPPQGQSgnaTPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKS 305
Cdd:COG5602   86 DVEQILSSL-AGDNPDPSTdhgsasnqnmerSPPPRIP---YRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKS 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  306 HCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSmpsPPGAPTSTgtvhmltgnssmsgaghi 385
Cdd:COG5602  162 QAIDTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQPNGSRLHVT---TPQGPLSS------------------ 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  386 aikttnaatltpaagagaaaaaaavaqiqsagavnlmthggasltqttihalqqaTPPQSQSPGGGHVHvsvtNSTAANA 465
Cdd:COG5602  221 -------------------------------------------------------PPVQSSYYVAPCNH----DQRTSHP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  466 VVPGQPGISVSAHNvpqnysrdreratitptgqvagaaanvnasasivvggpptpnslselsphggagggpgagaaqhnl 545
Cdd:COG5602  242 TLPSDSQPEPSAPS------------------------------------------------------------------ 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  546 hhiqqahqsiLLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMkegslnqgkmlteQEVYT 625
Cdd:COG5602  256 ----------HMPSDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSI-------------QEVYA 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  626 QVAKLFGQDEDLLREFGQFLPDAtnhqsgqymsksasvhndhgkrptatlsggahitmssaspapsgsplhlgattlpqI 705
Cdd:COG5602  313 RVTKLFAEAPDLLEEFKEFLPDS--------------------------------------------------------S 336

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  706 DKSAHAAAignlsavntsvsiktynnnqqqqnhvigsglNATrndilfekdyhaglqqqahqrgagvgghhhlagtaaga 785
Cdd:COG5602  337 VSAEQSTA-------------------------------NAQ-------------------------------------- 347

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  786 nigrpgvgasvmvsydkehrnnhhvqkyvghAPNQNLthghnakksPSYGIPSVIGSMPHISDNSLDRSSPGIsyatppl 865
Cdd:COG5602  348 -------------------------------KPSKRL---------PPIGSFSLPTAAPEQNRPSLLWESPRS------- 380

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  866 psgphgQHNsGSATRRPGDDSLVGHYAsgapPAKRPKPYCRDVSFSEAsskctisdaaFFDKVRKALRSPEVYDNFLRCL 945
Cdd:COG5602  381 ------ISN-ISRYRADLLTSFSRNFV----PIRIHMPISHLSNESED----------FFERIKQYLKDKNLYHEFLKLL 439

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  946 TLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLG--PPSGQPagglidgmplaatqrqgggssnssHDRgtshqsaae 1023
Cdd:COG5602  440 NLYSQKIIDKNDLVERLFAFLGSNEELIRWFKAFINysEPEKEP------------------------LRE--------- 486

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1024 yvQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELD 1103
Cdd:COG5602  487 --TRKDLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHPTWASEDSGFIAHRKNQYEEALFKIEEERYEYD 564

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1104 LVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSG-EIITGMKKNPFVAVPIVLKRL 1182
Cdd:COG5602  565 RHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKVIKKVYDKEHApEILEALLKKPHVTIPIVLKRL 644

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1183 KVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPy 1262
Cdd:COG5602  645 KMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQAKIHVSIDDKKVFQFVFVLC- 723

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1263 kDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLF--FAPRQPLSDDERDdafpflvddntkMDVDSPLGRT 1340
Cdd:COG5602  724 -DTYIFVNILDLKDTLITNMSSYLESDKERLKANLKTIVSLFFllCIFRIIIIVYERL------------LNVKGLNIDG 790

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1341 ESSTRNAKSTPSESASPARSNASTSSVtpagiKKETDdskattgsfapassatassatpvddatpstssaaaaasaasss 1420
Cdd:COG5602  791 LKADRSSRSDESAQRYSKVKSGNLEQV-----SKQID------------------------------------------- 822

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1421 tvsgtegkpkddplsshkeegagstssgvatsprqaqdtaGAGVDVEIK-LEHPADFSNPKLLPPHAHGQREDESYTlFF 1499
Cdd:COG5602  823 ----------------------------------------EYAIEDEIKePTHPDGLKEHNISKGISENEKQVIALT-EF 861

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1500 ANNNWYLFLRLHAILCDRLhvmYERARLlaieEERCRVnrrestatalrlkpkpEIQVEDYYPTFLDMLKNVLDGNMDSN 1579
Cdd:COG5602  862 GNSLMYVFFRLRFDSYERL---YEIKKI----KEAVTI----------------GMMEPGHYENELWDSYRLIFGALTPC 918

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1580 TFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFatEQRRGCTGGFCRDahktfdrEMSYQRKAESI 1659
Cdd:COG5602  919 EFEKYLRPFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELF--EMNSAASSKRKQD-------QTKYRLEVESL 989

                       1450      1460      1470      1480      1490
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24653098 1660 LN-EENCFKVYIYKIDCRVTIELLDSEPEEVDKPAAlKAQKFSKYVERLANPALGGG 1715
Cdd:COG5602  990 LNpDEILFRFCWINKFKSFGIQIMKRADLTVDQSLD-TQRVWKYYVQSYAIQHLTEG 1045
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
 1498-1706 2.83e-60

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


Pssm-ID: 465294  Cd Length: 281  Bit Score: 209.00  E-value: 2.83e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098   1498 FFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVN---------RRESTATALRLKPkpeiqVEDYYPTFLDML 1568
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEEVAEEIKRRKANkpakdlgliSKELEDFGLDLSD-----PEDYYPQLLELC 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098   1569 KNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTggfcrdahkTFDR 1648
Cdd:pfam16879   76 ERLIDGEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEET---------TAQD 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653098   1649 EMSYQRKAESIL-NEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVER 1706
Cdd:pfam16879  147 EILYRKQAEKLLgKDENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSS 205
HDAC_interact smart00761
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ...
 1032-1133 4.21e-52

Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 214808 [Multi-domain]  Cd Length: 102  Bit Score: 178.27  E-value: 4.21e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098    1032 SCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSA 1111
Cdd:smart00761    1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWASEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80

                            90       100
                    ....*....|....*....|..
gi 24653098    1112 TIRVLENLQKKMSRMSTEELSK 1133
Cdd:smart00761   81 TIKLLEEILNKIEDMSDEERAN 102
 
Name Accession Description Interval E-value
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
238-1715 5.56e-105

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 366.16  E-value: 5.56e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  238 KAQTPPSSVvANSIPVGGT------------TPPQGQSgnaTPRLKVEDALSYLDQVKYQYADQPQIYNNFLDIMKEFKS 305
Cdd:COG5602   86 DVEQILSSL-AGDNPDPSTdhgsasnqnmerSPPPRIP---YRPLDVSDALSYLEKVKEQFSNRPEIYNNFLDIMKDFKS 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  306 HCIDTPGVIERVSTLFKGHTELIYGFNMFLPPGYKIEIHSDALGCSVPVVSmpsPPGAPTSTgtvhmltgnssmsgaghi 385
Cdd:COG5602  162 QAIDTPGVIERVSVLFRGYPHLIEGFNTFLPSGYKIEGSLPQPNGSRLHVT---TPQGPLSS------------------ 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  386 aikttnaatltpaagagaaaaaaavaqiqsagavnlmthggasltqttihalqqaTPPQSQSPGGGHVHvsvtNSTAANA 465
Cdd:COG5602  221 -------------------------------------------------------PPVQSSYYVAPCNH----DQRTSHP 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  466 VVPGQPGISVSAHNvpqnysrdreratitptgqvagaaanvnasasivvggpptpnslselsphggagggpgagaaqhnl 545
Cdd:COG5602  242 TLPSDSQPEPSAPS------------------------------------------------------------------ 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  546 hhiqqahqsiLLGETGQQNQPVEFNHAITYVNKIKNRFQNQPAKYKKFLEILHDYQREQKVMkegslnqgkmlteQEVYT 625
Cdd:COG5602  256 ----------HMPSDARGKHQVDFNQAIIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSI-------------QEVYA 312

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  626 QVAKLFGQDEDLLREFGQFLPDAtnhqsgqymsksasvhndhgkrptatlsggahitmssaspapsgsplhlgattlpqI 705
Cdd:COG5602  313 RVTKLFAEAPDLLEEFKEFLPDS--------------------------------------------------------S 336

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  706 DKSAHAAAignlsavntsvsiktynnnqqqqnhvigsglNATrndilfekdyhaglqqqahqrgagvgghhhlagtaaga 785
Cdd:COG5602  337 VSAEQSTA-------------------------------NAQ-------------------------------------- 347

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  786 nigrpgvgasvmvsydkehrnnhhvqkyvghAPNQNLthghnakksPSYGIPSVIGSMPHISDNSLDRSSPGIsyatppl 865
Cdd:COG5602  348 -------------------------------KPSKRL---------PPIGSFSLPTAAPEQNRPSLLWESPRS------- 380

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  866 psgphgQHNsGSATRRPGDDSLVGHYAsgapPAKRPKPYCRDVSFSEAsskctisdaaFFDKVRKALRSPEVYDNFLRCL 945
Cdd:COG5602  381 ------ISN-ISRYRADLLTSFSRNFV----PIRIHMPISHLSNESED----------FFERIKQYLKDKNLYHEFLKLL 439

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  946 TLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLG--PPSGQPagglidgmplaatqrqgggssnssHDRgtshqsaae 1023
Cdd:COG5602  440 NLYSQKIIDKNDLVERLFAFLGSNEELIRWFKAFINysEPEKEP------------------------LRE--------- 486

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1024 yvQDVDLSSCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELD 1103
Cdd:COG5602  487 --TRKDLEKFEKCGPSYRLLPKSEEEIKCSGRDDLAWEVLNDDWVSHPTWASEDSGFIAHRKNQYEEALFKIEEERYEYD 564

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1104 LVIEVNSATIRVLENLQKKMSRMSTEELSKFHLDDHLGGTSQTIHQRAIHRIYGDKSG-EIITGMKKNPFVAVPIVLKRL 1182
Cdd:COG5602  565 RHIEATQRTIKALEQIIDKIKDMEESEKANKTLPGGLGLPSKSIYKKVIKKVYDKEHApEILEALLKKPHVTIPIVLKRL 644

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1183 KVKEEEWREAQKTFNKQWREQNEKYYLKSLDHQAINFKPNDMKALRSKSLFNEIETLYDERHDQEDDAMEPFGPHLVLPy 1262
Cdd:COG5602  645 KMKDEEWRSCKREWNKIWREIEEKNYHKSLDHQGVSFKSRDKKILSTKNILEEIDDRSQAKIHVSIDDKKVFQFVFVLC- 723

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1263 kDKTILDDAANLLIHHVKRQTGIQKQEKQKIKQIIRQFVPDLF--FAPRQPLSDDERDdafpflvddntkMDVDSPLGRT 1340
Cdd:COG5602  724 -DTYIFVNILDLKDTLITNMSSYLESDKERLKANLKTIVSLFFllCIFRIIIIVYERL------------LNVKGLNIDG 790

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1341 ESSTRNAKSTPSESASPARSNASTSSVtpagiKKETDdskattgsfapassatassatpvddatpstssaaaaasaasss 1420
Cdd:COG5602  791 LKADRSSRSDESAQRYSKVKSGNLEQV-----SKQID------------------------------------------- 822

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1421 tvsgtegkpkddplsshkeegagstssgvatsprqaqdtaGAGVDVEIK-LEHPADFSNPKLLPPHAHGQREDESYTlFF 1499
Cdd:COG5602  823 ----------------------------------------EYAIEDEIKePTHPDGLKEHNISKGISENEKQVIALT-EF 861

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1500 ANNNWYLFLRLHAILCDRLhvmYERARLlaieEERCRVnrrestatalrlkpkpEIQVEDYYPTFLDMLKNVLDGNMDSN 1579
Cdd:COG5602  862 GNSLMYVFFRLRFDSYERL---YEIKKI----KEAVTI----------------GMMEPGHYENELWDSYRLIFGALTPC 918

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098 1580 TFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFatEQRRGCTGGFCRDahktfdrEMSYQRKAESI 1659
Cdd:COG5602  919 EFEKYLRPFYNNTCYKIYTIDRLRQSLKKQLHPITYDIKYIAKSELF--EMNSAASSKRKQD-------QTKYRLEVESL 989

                       1450      1460      1470      1480      1490
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 24653098 1660 LN-EENCFKVYIYKIDCRVTIELLDSEPEEVDKPAAlKAQKFSKYVERLANPALGGG 1715
Cdd:COG5602  990 LNpDEILFRFCWINKFKSFGIQIMKRADLTVDQSLD-TQRVWKYYVQSYAIQHLTEG 1045
Sin3a_C pfam16879
C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at ...
 1498-1706 2.83e-60

C-terminal domain of Sin3a protein; Sin3a_C is a family of eukaryotic species. It is found at the C-terminus of the co-repressor Sin3a, and downstream of family Sin3_corepress, pfam08295.


Pssm-ID: 465294  Cd Length: 281  Bit Score: 209.00  E-value: 2.83e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098   1498 FFANNNWYLFLRLHAILCDRLHVMYERARLLAIEEERCRVN---------RRESTATALRLKPkpeiqVEDYYPTFLDML 1568
Cdd:pfam16879    1 FFANTTIYVFFRLFQILYERLLKIKQAEEEVAEEIKRRKANkpakdlgliSKELEDFGLDLSD-----PEDYYPQLLELC 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098   1569 KNVLDGNMDSNTFEDTMREMFGIYAYISFTLDKVVSNAVRQLQYCVTERAALDCVELFATEQRRGCTggfcrdahkTFDR 1648
Cdd:pfam16879   76 ERLIDGEIDQSQFEDSLRQMYGNKAYKLYTIDKLIQALVKQLQTIVSDSKSQELLELFEKERSKEET---------TAQD 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24653098   1649 EMSYQRKAESIL-NEENCFKVYIYKIDCRVTIELLDSEPEEVDKPAALKAQKFSKYVER 1706
Cdd:pfam16879  147 EILYRKQAEKLLgKDENLFRIEWNPQSKTVTIQLLDKDDLTFDDDELTAEERWQYYVSS 205
HDAC_interact smart00761
Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It ...
 1032-1133 4.21e-52

Histone deacetylase (HDAC) interacting; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 214808 [Multi-domain]  Cd Length: 102  Bit Score: 178.27  E-value: 4.21e-52
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098    1032 SCKRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDSTFVTSRKTQFEETIYRTEDERFELDLVIEVNSA 1111
Cdd:smart00761    1 NCERCGPSYRLLPKSEKQPKCSGRDELCKEVLNDTWVSHPTWASEDSGFVAHRKNQYEEALFRCEDERFELDMVIESNSS 80

                            90       100
                    ....*....|....*....|..
gi 24653098    1112 TIRVLENLQKKMSRMSTEELSK 1133
Cdd:smart00761   81 TIKLLEEILNKIEDMSDEERAN 102
Sin3_corepress pfam08295
Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms ...
 1034-1129 2.58e-50

Sin3 family co-repressor; This domain is found on transcriptional regulators. It forms interactions with histone deacetylases.


Pssm-ID: 462418  Cd Length: 97  Bit Score: 173.18  E-value: 2.58e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098   1034 KRLGASYCALPQSTVPKKCSGRTALCREVLNDKWVSFPTWASEDS-TFVTSRKTQFEETIYRTEDERFELDLVIEVNSAT 1112
Cdd:pfam08295    1 KRCGPSYRLLPKSEPQLPCSGRDELCWEVLNDEWVSHPTWASEDSgSFVAHRKNQYEEALFRCEDERYEYDMHIESNLRT 80

                           90
                   ....*....|....*..
gi 24653098   1113 IRVLENLQKKMSRMSTE 1129
Cdd:pfam08295   81 IKLLEPIAEKINNMSPE 97
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 291-335 6.10e-17

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 75.92  E-value: 6.10e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 24653098    291 QIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFL 335
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 936-980 9.85e-13

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 63.98  E-value: 9.85e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 24653098    936 EVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFL 980
Cdd:pfam02671    1 EVYDEFLKILNDYKQEIIDIAEVIARVSELLKGHPDLLEGFNTFL 45
PAH pfam02671
Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The ...
 588-645 6.24e-12

Paired amphipathic helix repeat; This family contains the paired amphipathic helix repeat. The family contains the yeast SIN3 gene (also known as SDI1) that is a negative regulator of the yeast HO gene. This repeat may be distantly related to the helix-loop-helix motif, which mediate protein-protein interactions.


Pssm-ID: 460645 [Multi-domain]  Cd Length: 45  Bit Score: 61.67  E-value: 6.24e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 24653098    588 AKYKKFLEILHDYQREQKvmkegslnqgkmlTEQEVYTQVAKLFGQDEDLLREFGQFL 645
Cdd:pfam02671    1 EVYDEFLKILNDYKQEII-------------DIAEVIARVSELLKGHPDLLEGFNTFL 45
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
793-1026 2.95e-07

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 56.08  E-value: 2.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  793 GASVMVSYDKEHRNnhhvqkyVGHAPNQNLTHGHNAKKSPSYgipsvigSMPHISDNSLDRSSPG--ISYATPPLPSGPH 870
Cdd:COG5602    1 MDAMNVPVDPPHDN-------PGDKVMTGSLKQISPKYHPSM-------SRDHDVNTSLQNSEPWpdNGSARKPSYSPES 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  871 GQHNSG-----SATRRPGDDslvGHYASGAPPAKRPKPYCRDVSFS----EASS-------KCTISDA-AFFDKVRKALR 933
Cdd:COG5602   67 MSSYGGpmderSGTRRYYED---VEQILSSLAGDNPDPSTDHGSASnqnmERSPppripyrPLDVSDAlSYLEKVKEQFS 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  934 S-PEVYDNFLRCLTLFNQEIVSKTELLGLVSPFLMKFPDLLRWFTDFLgpPSG--------QPAG-GLIDGMPLAATQRQ 1003
Cdd:COG5602  144 NrPEIYNNFLDIMKDFKSQAIDTPGVIERVSVLFRGYPHLIEGFNTFL--PSGykiegslpQPNGsRLHVTTPQGPLSSP 221

                        250       260
                 ....*....|....*....|....*..
gi 24653098 1004 GGGSS----NSSHDRGTSHQSAAEYVQ 1026
Cdd:COG5602  222 PVQSSyyvaPCNHDQRTSHPTLPSDSQ 248
Sin3 COG5602
Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];
196-336 4.10e-07

Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics];


Pssm-ID: 227889 [Multi-domain]  Cd Length: 1163  Bit Score: 55.69  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653098  196 SSSSQTGTIRQRTISGTQTVATAVGNLATisqqqpVQQSPLGKAQTPPSSVVANSIPVGGTTPPQGQSGNatPRLKVEDA 275
Cdd:COG5602  201 LPQPNGSRLHVTTPQGPLSSPPVQSSYYV------APCNHDQRTSHPTLPSDSQPEPSAPSHMPSDARGK--HQVDFNQA 272

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24653098  276 LSYLDQVKYQYADQPQIYNNFLDIMKEFKSHCIDTPGVIERVSTLFKGHTELIYGFNMFLP 336
Cdd:COG5602  273 IIFVNKVKVRFQNNPEMYYDFLDSLRTYQMKQRSIQEVYARVTKLFAEAPDLLEEFKEFLP 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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