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Conserved domains on  [gi|28573845|ref|NP_725227|]
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tafazzin, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
113-320 2.98e-29

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


:

Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 110.82  E-value: 2.98e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 113 VVLMFLNKPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPlgivcntYKIRWsMAAHDIcFTNKLHSLFF 192
Cdd:cd07989   4 LLRLLGVRVRVEGLENL-------PPKGPVIIVANHQSYLDPLVLGAALP-------RPIRF-VAKKEL-FKIPFLGWLL 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 193 MFGKCIPVVRGIGV-YQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESpKIPIIlPMWHEGMDDLLP 271
Cdd:cd07989  68 RLLGAIPIDRGNGRsAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA-GVPIV-PVAISGTWGSLP 145
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 28573845 272 NvePYVIQRGKQVTLNVGQPLDLNDFILDlkkrqvpePTARKLITDKIQ 320
Cdd:cd07989 146 K--GKKLPRPGRVTVRIGEPIPPEGLELA--------EEDRKELREKVR 184
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
113-320 2.98e-29

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 110.82  E-value: 2.98e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 113 VVLMFLNKPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPlgivcntYKIRWsMAAHDIcFTNKLHSLFF 192
Cdd:cd07989   4 LLRLLGVRVRVEGLENL-------PPKGPVIIVANHQSYLDPLVLGAALP-------RPIRF-VAKKEL-FKIPFLGWLL 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 193 MFGKCIPVVRGIGV-YQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESpKIPIIlPMWHEGMDDLLP 271
Cdd:cd07989  68 RLLGAIPIDRGNGRsAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA-GVPIV-PVAISGTWGSLP 145
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 28573845 272 NvePYVIQRGKQVTLNVGQPLDLNDFILDlkkrqvpePTARKLITDKIQ 320
Cdd:cd07989 146 K--GKKLPRPGRVTVRIGEPIPPEGLELA--------EEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
142-266 4.76e-24

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 94.73  E-value: 4.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845    142 LVTVSNHYSCFDDPGLWGCLPlgivcnTYKIRWSMAAHDICFTNKLHSLFFMFGKCIPVVRGIG-VYQDAINLCIEKAAL 220
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLP------RKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKE 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 28573845    221 GHWIHVFPEGKVNMDKEELRLKWGVGRIIYESPkiPIILPMWHEGM 266
Cdd:smart00563  75 GEWLLIFPEGTRSRPGKLLPFKKGAARLALEAG--VPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
94-329 1.19e-19

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 85.83  E-value: 1.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845  94 KFWYVVSQFVVSAVGIFSKVVLMFLN-KPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPLGIVCntyki 172
Cdd:COG0204   3 SLFLLLRRFRYRLVRLWARLLLRLLGvRVRVEGLENL-------PADGPVLIVANHQSWLDILLLLAALPRPVRF----- 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 173 rwsMAAHDIcFTNKLHSLFFMFGKCIPVVRG-IGVYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYE 251
Cdd:COG0204  71 ---VAKKEL-FKIPLLGWLLRALGAIPVDRSkRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALE 146
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28573845 252 SpKIPIIlPMWHEGMDDLLPnvePYVIQRGKQVTLNVGQPLDLNDFildlkkrqvpEPTARKLITDKIQEAFRDLRAE 329
Cdd:COG0204 147 A-GVPIV-PVAIDGTERALP---KGFLPRPGKVTVRIGPPIDPSDL----------EGEDRRELAERLRAAIEALLAE 209
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
120-263 1.44e-18

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 80.40  E-value: 1.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845   120 KPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPlgivcNTYKIRWSMAAHDIcFTNKLHSLFFMFGKCIP 199
Cdd:pfam01553   1 RIEVHGLENL-------PRGGPAIVVANHQSYLDVLLLSLALY-----KRGRPLVFVAKKEL-FDIPLVGWLMRLLGCIF 67
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28573845   200 VVRG-IGVYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESpKIPIIlPMWH 263
Cdd:pfam01553  68 IDRKnRKDAAGTLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-GVPIV-PVAI 130
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
113-320 2.98e-29

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 110.82  E-value: 2.98e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 113 VVLMFLNKPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPlgivcntYKIRWsMAAHDIcFTNKLHSLFF 192
Cdd:cd07989   4 LLRLLGVRVRVEGLENL-------PPKGPVIIVANHQSYLDPLVLGAALP-------RPIRF-VAKKEL-FKIPFLGWLL 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 193 MFGKCIPVVRGIGV-YQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESpKIPIIlPMWHEGMDDLLP 271
Cdd:cd07989  68 RLLGAIPIDRGNGRsAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA-GVPIV-PVAISGTWGSLP 145
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 28573845 272 NvePYVIQRGKQVTLNVGQPLDLNDFILDlkkrqvpePTARKLITDKIQ 320
Cdd:cd07989 146 K--GKKLPRPGRVTVRIGEPIPPEGLELA--------EEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
142-266 4.76e-24

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 94.73  E-value: 4.76e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845    142 LVTVSNHYSCFDDPGLWGCLPlgivcnTYKIRWSMAAHDICFTNKLHSLFFMFGKCIPVVRGIG-VYQDAINLCIEKAAL 220
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLP------RKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKE 74
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 28573845    221 GHWIHVFPEGKVNMDKEELRLKWGVGRIIYESPkiPIILPMWHEGM 266
Cdd:smart00563  75 GEWLLIFPEGTRSRPGKLLPFKKGAARLALEAG--VPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
94-329 1.19e-19

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 85.83  E-value: 1.19e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845  94 KFWYVVSQFVVSAVGIFSKVVLMFLN-KPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPLGIVCntyki 172
Cdd:COG0204   3 SLFLLLRRFRYRLVRLWARLLLRLLGvRVRVEGLENL-------PADGPVLIVANHQSWLDILLLLAALPRPVRF----- 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 173 rwsMAAHDIcFTNKLHSLFFMFGKCIPVVRG-IGVYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYE 251
Cdd:COG0204  71 ---VAKKEL-FKIPLLGWLLRALGAIPVDRSkRRAALRALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALE 146
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28573845 252 SpKIPIIlPMWHEGMDDLLPnvePYVIQRGKQVTLNVGQPLDLNDFildlkkrqvpEPTARKLITDKIQEAFRDLRAE 329
Cdd:COG0204 147 A-GVPIV-PVAIDGTERALP---KGFLPRPGKVTVRIGPPIDPSDL----------EGEDRRELAERLRAAIEALLAE 209
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
120-263 1.44e-18

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 80.40  E-value: 1.44e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845   120 KPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPGLWGCLPlgivcNTYKIRWSMAAHDIcFTNKLHSLFFMFGKCIP 199
Cdd:pfam01553   1 RIEVHGLENL-------PRGGPAIVVANHQSYLDVLLLSLALY-----KRGRPLVFVAKKEL-FDIPLVGWLMRLLGCIF 67
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 28573845   200 VVRG-IGVYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYESpKIPIIlPMWH 263
Cdd:pfam01553  68 IDRKnRKDAAGTLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-GVPIV-PVAI 130
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
107-306 2.19e-09

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 56.50  E-value: 2.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 107 VGIFSKVVL-MFLNKPRVYNRERLiqlitkrPKGIPLVTVSNHYSCFDDPglwgcLPLGIVCNTyKIRwSMAAHDIcFTN 185
Cdd:cd07992   1 VRLLSRVILrIYFRRITVVGRENV-------PKDGPVIFLGNHPNALIDP-----LLLAATLRR-PVR-FLAKADL-FKN 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28573845 186 KLHS-LFFMFGkCIPVVR-------GIG--VYQDAINLCIEKAALGHWIHVFPEGKVNMDKEELRLKWGVGRIIYE---S 252
Cdd:cd07992  66 PLIGwLLESFG-AIPVYRpkdlargGIGkiSNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALEaleA 144
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 28573845 253 PKIPI-ILPMwheGMddllpNVEPYVIQRGKqVTLNVGQPLDLNDFILDLKKRQV 306
Cdd:cd07992 145 GQKDVkIVPV---GL-----NYEDKSRFRSR-VLVEFGKPISVSAFEEAEASRDV 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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