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Conserved domains on  [gi|24653810|ref|NP_725445|]
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scab, isoform A [Drosophila melanogaster]

Protein Classification

integrin alpha( domain architecture ID 12028124)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Integrin_alpha2 super family cl26747
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
509-829 2.91e-22

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


The actual alignment was detected with superfamily member pfam08441:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 101.24  E-value: 2.91e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    509 PVVKVHATVKSESREIKPEQEK----------VKITACyrLSTTSTDKLVQEQELAIRIAMD-----KQLKRVKFTQTQT 573
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRAC--FSYTGKPIPNPSLVLNYELELDrqkkkGLPPRVLFLDSQQ 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    574 NEISFKV--NANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCAT 651
Cdd:pfam08441   80 PSLTGTLvlLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDCGE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    652 D-VCTADLQLRSKDVS----PTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV-------PGNCKV----V 715
Cdd:pfam08441  160 DnVCVPDLQLSAKFDSresdEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrregsekQLSCTAkkenS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    716 DAVMVCDLnrGRPLAKGDTDSVTISFDVSQLSGQ--SLIIHAEVFSTGyEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQ 793
Cdd:pfam08441  240 TRQVVCDL--GNPMKRGTQVTFGLRFSVSGLELSteELSFDLQIRSTN-EQNSNSNPVSLKVPVVAEAQLSLSGVSKPDQ 316
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 24653810    794 IDLEHYSNSAEIVNN------------YEIKSNGPSVIEQLTVSFYIP 829
Cdd:pfam08441  317 VVGGSVKGESAMKPRseedigplvehtYEVINNGPSTVSGASLEISWP 364
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
409-459 1.17e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.55  E-value: 1.17e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 24653810     409 ARFGTALSRLGDINHDGYNDVAVGAPFAGN----GTVFIYLGSENGLRDQPSQRL 459
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
350-388 7.43e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.43e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24653810    350 FGYSVLAEDLNGDGKTDVIVSAPQhalEDSHDNGAIYVF 388
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPG---EGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
473-515 1.95e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 45.83  E-value: 1.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24653810     473 MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA 515
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSS 46
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
509-829 2.91e-22

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 101.24  E-value: 2.91e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    509 PVVKVHATVKSESREIKPEQEK----------VKITACyrLSTTSTDKLVQEQELAIRIAMD-----KQLKRVKFTQTQT 573
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRAC--FSYTGKPIPNPSLVLNYELELDrqkkkGLPPRVLFLDSQQ 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    574 NEISFKV--NANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCAT 651
Cdd:pfam08441   80 PSLTGTLvlLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDCGE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    652 D-VCTADLQLRSKDVS----PTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV-------PGNCKV----V 715
Cdd:pfam08441  160 DnVCVPDLQLSAKFDSresdEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrregsekQLSCTAkkenS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    716 DAVMVCDLnrGRPLAKGDTDSVTISFDVSQLSGQ--SLIIHAEVFSTGyEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQ 793
Cdd:pfam08441  240 TRQVVCDL--GNPMKRGTQVTFGLRFSVSGLELSteELSFDLQIRSTN-EQNSNSNPVSLKVPVVAEAQLSLSGVSKPDQ 316
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 24653810    794 IDLEHYSNSAEIVNN------------YEIKSNGPSVIEQLTVSFYIP 829
Cdd:pfam08441  317 VVGGSVKGESAMKPRseedigplvehtYEVINNGPSTVSGASLEISWP 364
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
409-459 1.17e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.55  E-value: 1.17e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 24653810     409 ARFGTALSRLGDINHDGYNDVAVGAPFAGN----GTVFIYLGSENGLRDQPSQRL 459
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
350-388 7.43e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.43e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24653810    350 FGYSVLAEDLNGDGKTDVIVSAPQhalEDSHDNGAIYVF 388
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPG---EGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
346-390 5.14e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.45  E-value: 5.14e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 24653810     346 FGEYFGYSV-LAEDLNGDGKTDVIVSAPQHalEDSHDNGAIYVFIN 390
Cdd:smart00191    1 PGSYFGYSVaGVGDVNGDGYPDLLVGAPRA--NDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
411-444 3.03e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.51  E-value: 3.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24653810    411 FGTALSrLGDINHDGYNDVAVGAPFA---GNGTVFIY 444
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
473-515 1.95e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 45.83  E-value: 1.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24653810     473 MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA 515
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSS 46
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
474-505 6.52e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.18  E-value: 6.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24653810    474 FGHGLSRGsDIDGNGFNDFAIGAP-----NAEAVYLY 505
Cdd:pfam01839    1 FGYSVAVG-DLNGDGYADLAVGAPgeggaGAGAVYVL 36
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
509-829 2.91e-22

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 101.24  E-value: 2.91e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    509 PVVKVHATVKSESREIKPEQEK----------VKITACyrLSTTSTDKLVQEQELAIRIAMD-----KQLKRVKFTQTQT 573
Cdd:pfam08441    2 PVVSVSASLQVEPNSINPEKKNctltgtpvscFTVRAC--FSYTGKPIPNPSLVLNYELELDrqkkkGLPPRVLFLDSQQ 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    574 NEISFKV--NANFGEQCRDFETQVRYSEKDIFTPIDLEMHYELTKKVPDSEEFCETCAIVDPTEPKVSTQNIIFSTGCAT 651
Cdd:pfam08441   80 PSLTGTLvlLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVDPRAPSDLPGLKPILDQNQPSTVQEQANFLKDCGE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    652 D-VCTADLQLRSKDVS----PTYILGSADTLRLNYEITNIGETAYLPQFNVTSTSRLAFAQV-------PGNCKV----V 715
Cdd:pfam08441  160 DnVCVPDLQLSAKFDSresdEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVrregsekQLSCTAkkenS 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24653810    716 DAVMVCDLnrGRPLAKGDTDSVTISFDVSQLSGQ--SLIIHAEVFSTGyEQNPTDNRQTNVIGLKEFTEIDASGGQTNSQ 793
Cdd:pfam08441  240 TRQVVCDL--GNPMKRGTQVTFGLRFSVSGLELSteELSFDLQIRSTN-EQNSNSNPVSLKVPVVAEAQLSLSGVSKPDQ 316
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 24653810    794 IDLEHYSNSAEIVNN------------YEIKSNGPSVIEQLTVSFYIP 829
Cdd:pfam08441  317 VVGGSVKGESAMKPRseedigplvehtYEVINNGPSTVSGASLEISWP 364
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
409-459 1.17e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.55  E-value: 1.17e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 24653810     409 ARFGTALSRLGDINHDGYNDVAVGAPFAGN----GTVFIYLGSENGLRDQPSQRL 459
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDagetGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
350-388 7.43e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.43e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 24653810    350 FGYSVLAEDLNGDGKTDVIVSAPQhalEDSHDNGAIYVF 388
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPG---EGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
346-390 5.14e-08

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 50.45  E-value: 5.14e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 24653810     346 FGEYFGYSV-LAEDLNGDGKTDVIVSAPQHalEDSHDNGAIYVFIN 390
Cdd:smart00191    1 PGSYFGYSVaGVGDVNGDGYPDLLVGAPRA--NDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
411-444 3.03e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 47.51  E-value: 3.03e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24653810    411 FGTALSrLGDINHDGYNDVAVGAPFA---GNGTVFIY 444
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEggaGAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
358-431 9.74e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 46.83  E-value: 9.74e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24653810    358 DLNGDGKTDVIVSapqhaledSHDNGAIYVFINKGFFNFERQILRSPVETMARFgtalsRLGDINHDGYNDVAV 431
Cdd:pfam13517    1 DLDGDGKLDLVVA--------NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSV-----AVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
473-515 1.95e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 45.83  E-value: 1.95e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 24653810     473 MFGHGLSRGSDIDGNGFNDFAIGAPNAEAVYLYRAYPVVKVHA 515
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSS 46
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
474-505 6.52e-03

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 35.18  E-value: 6.52e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 24653810    474 FGHGLSRGsDIDGNGFNDFAIGAP-----NAEAVYLY 505
Cdd:pfam01839    1 FGYSVAVG-DLNGDGYADLAVGAPgeggaGAGAVYVL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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