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Conserved domains on  [gi|24654044|ref|NP_725533|]
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spinster, isoform E [Drosophila melanogaster]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 117-368 1.90e-123

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 363.09  E-value: 1.90e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 117 VTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLL 196
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 197 GSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVT 276
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 277 PILGIVAVFLILLI-KDPVRGHSEGS--HNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKM 353
Cdd:cd17328 161 GVLGVLLAILLLLFvREPPRGAAEGGvmAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV 240

                       250
                ....*....|....*
gi 24654044 354 QPGNENivqDDMWWF 368
Cdd:cd17328 241 GDLSSA---DVGLIF 252
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 117-368 1.90e-123

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 363.09  E-value: 1.90e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 117 VTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLL 196
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 197 GSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVT 276
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 277 PILGIVAVFLILLI-KDPVRGHSEGS--HNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKM 353
Cdd:cd17328 161 GVLGVLLAILLLLFvREPPRGAAEGGvmAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV 240

                       250
                ....*....|....*
gi 24654044 354 QPGNENivqDDMWWF 368
Cdd:cd17328 241 GDLSSA---DVGLIF 252
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
107-290 9.15e-35

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 131.92  E-value: 9.15e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 107 SSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVG 186
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 187 VGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLA 266
Cdd:COG2271  82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161

                       170       180
                ....*....|....*....|....
gi 24654044 267 nDWRWALRVTPILGIVAVFLILLI 290
Cdd:COG2271 162 -GWRAAFLILGLPGLLLALLRFWL 184
MFS_1 pfam07690
Major Facilitator Superfamily;
120-347 1.86e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 116.75  E-value: 1.86e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   120 LCFVNLINYMDRFTIAGVL-TDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGS 198
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   199 FMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPI 278
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAI 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24654044   279 LGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFtCVAFVAGALAWWGPSFI 347
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL-LFGFAFFGLLTYLPLYQ 227
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 120-347 2.28e-16

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 80.07  E-value: 2.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   120 LCFVnlINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSF 199
Cdd:TIGR00893   1 LVTV--INYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   200 MKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGY-IVGSKTAHLanDWRWALRVTPI 278
Cdd:TIGR00893  79 AGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWILIHF--SWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   279 LGIVAVFLIL-LIKDP----------------VRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAW 341
Cdd:TIGR00893 157 LGIIWGVLWLkFIPDPpqkakwlteeekyivvGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLT 236


                  ....*.
gi 24654044   342 WGPSFI 347
Cdd:TIGR00893 237 WFPTYL 242
PRK11195 PRK11195
lysophospholipid transporter LplT; Provisional
 154-287 4.43e-08

lysophospholipid transporter LplT; Provisional


Pssm-ID: 236879 [Multi-domain]  Cd Length: 393  Bit Score: 54.46  E-value: 4.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  154 LLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLwsttTLLGSFMKQFGW--FIAFrALVGIGEASYSTIAPTIISDL 231
Cdd:PRK11195  42 LLQMFFVLAYIVLAPFVGAFADSFPKGRVMFIANGI----KLLGCLLMLFGIhpLLAY-GLVGIGAAAYSPAKYGILTEL 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  232 FVHDMRSK----MLALFYFAIPVGSGLGYIVGSKTAHLAndwrwalrvtpILGIVAVFLI 287
Cdd:PRK11195 117 LPGEKLVKangwMEGSTIAAILLGTVLGGALADPHAEAA-----------LAVCALIYLL 165
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 117-368 1.90e-123

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 363.09  E-value: 1.90e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 117 VTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLL 196
Cdd:cd17328   1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 197 GSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVT 276
Cdd:cd17328  81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 277 PILGIVAVFLILLI-KDPVRGHSEGS--HNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKM 353
Cdd:cd17328 161 GVLGVLLAILLLLFvREPPRGAAEGGvmAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV 240

                       250
                ....*....|....*
gi 24654044 354 QPGNENivqDDMWWF 368
Cdd:cd17328 241 GDLSSA---DVGLIF 252
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
107-290 9.15e-35

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 131.92  E-value: 9.15e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 107 SSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVG 186
Cdd:COG2271   2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 187 VGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLA 266
Cdd:COG2271  82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161

                       170       180
                ....*....|....*....|....
gi 24654044 267 nDWRWALRVTPILGIVAVFLILLI 290
Cdd:COG2271 162 -GWRAAFLILGLPGLLLALLRFWL 184
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
107-346 6.05e-33

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 126.63  E-value: 6.05e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 107 SSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVG 186
Cdd:COG2814   2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 187 VGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLA 266
Cdd:COG2814  82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 267 nDWRWALRVTPILGIVAVFLILLIKDPVRGHsegshnlEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSF 346
Cdd:COG2814 162 -GWRWVFLVNAVLALLALLLLLRLLPESRPA-------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY 233
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 120-351 9.30e-33

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 126.77  E-value: 9.30e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSF 199
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 200 MKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTA-HLANDWRWALRVTPI 278
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAAA 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 279 LGIVAVFLILL-IKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFV-AGALAWWGPSFIYLGM 351
Cdd:cd06174 161 LALLAAILLLLvVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAyYSFSTLLPLFLLDLGG 235
MFS_1 pfam07690
Major Facilitator Superfamily;
120-347 1.86e-29

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 116.75  E-value: 1.86e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   120 LCFVNLINYMDRFTIAGVL-TDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGS 198
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   199 FMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPI 278
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLILAI 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24654044   279 LGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFtCVAFVAGALAWWGPSFI 347
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALL-LFGFAFFGLLTYLPLYQ 227
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 110-351 2.97e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 101.43  E-value: 2.97e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 110 GRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGL 189
Cdd:COG0477   9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 190 WSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAnDW 269
Cdd:COG0477  89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL-GW 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 270 RWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYL 349
Cdd:COG0477 168 RWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLL 247


                ..
gi 24654044 350 GM 351
Cdd:COG0477 248 LA 249
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 114-347 6.51e-22

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 95.72  E-value: 6.51e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTT 193
Cdd:cd17319   2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 194 TLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWAL 273
Cdd:cd17319  82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG-WRWAF 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654044 274 RVTPILGIVAVFLILLIKdpvrghsegshnleattykqdikalvrnRSFMLSTAGFTCVAFVAGALAWWGPSFI 347
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL----------------------------RQVWGLALGYFGINYALYGLLTWLPTYL 206
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
111-347 7.27e-22

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 96.10  E-value: 7.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 111 RSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLW 190
Cdd:COG2223   1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 191 STTTLLGSFMKQFGWFIAFRALVGIGE-ASYSTIAPTiISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHlANDW 269
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGgGSFAVGIAL-VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA-AFGW 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24654044 270 RWALRVT-PILGIVAVFLILLIKDPVRGHSEGSHNLEAttykqDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFI 347
Cdd:COG2223 159 RNAFLILgILLLVVAVLAWLFLRDPPAGAAAAAKASLR-----DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYL 232
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 117-339 7.17e-21

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 93.02  E-value: 7.17e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 117 VTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLL 196
Cdd:cd17474   1 LYAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 197 GSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAhlANDWRWALRVT 276
Cdd:cd17474  81 CGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA--AISWRYPFFLL 158

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654044 277 PILGIVAVFLILLIKDPVRGHSEGShnleATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGAL 339
Cdd:cd17474 159 AALIPVAFLAILFLLPEPKEKAKSS----SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAF 217
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 132-347 6.76e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 90.30  E-value: 6.76e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 132 FTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRA 211
Cdd:cd17324  16 YVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 212 LVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAnDWRWALRVTPILGIVAVFLILLIK 291
Cdd:cd17324  96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLAIAVLALLAALLLWRLL 174

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654044 292 DPVRGHSEGSHNLEATtykqdIKALVRNRSFMLS-----------TAGFTCVAFVAGALAWWGPSFI 347
Cdd:cd17324 175 PSLPPKKPGSLGLLSS-----LLLLLRNPRLRLAylitfllfggfFALYTYLAPFLTDVPGFSSSAI 236
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 120-339 2.70e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 88.40  E-value: 2.70e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSF 199
Cdd:cd17325   1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 200 MKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAnDWRWALRVTPIL 279
Cdd:cd17325  81 ATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAAL 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 280 GIVAVFLILLIKDPVRGHSEGSHNLEATTyKQDIKALVRNRSFMLSTAGFTCVAFVAGAL 339
Cdd:cd17325 160 ALLALVLALLLLPEPRPPPNKRAVSAARL-RSGLRLLLRDRRLLALFLAIFVLAFAFGAL 218
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
133-346 9.42e-19

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 87.22  E-value: 9.42e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 133 TIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRAL 212
Cdd:COG0738  26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFL 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 213 VGIGEASYSTIAPTIISDLFvHDMRSKMLALFYFAIPVGSGLGYIVGSK--TAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:COG0738 106 LGLGLGLLDVAANPYVAALG-PETAASRLNLLHAFFSLGALLGPLLGGLliLLGLSLSWHLPYLILAVLLLLLALLFLRS 184

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 24654044 291 KDPVRGHSEGshnlEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSF 346
Cdd:COG0738 185 KLPEIEEEEE----EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLY 236
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
99-347 1.13e-18

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 86.85  E-value: 1.13e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  99 SAVVPSRLSSVGRSQWFTVT--VLCFVNLinymdRFTIAGV---LTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYL 173
Cdd:COG2807   2 STTSSSARRSRRAGRWLLLLaiVLVALNL-----RPAITSVgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRL 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 174 GDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFvHDMRSKMLALFYFAIPVGSG 253
Cdd:COG2807  77 ARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 254 LGYIVgskTAHLAN--DWRWALRVTPILGIVA-VFLILLIKDPVRGHSEGSHNleattykQDIKALVRNRSFMLSTAGFT 330
Cdd:COG2807 156 LAAGL---TVPLAAalGWRGALAVWALLALLAlLLWLPLLRRRPAAAAAAPAA-------ASLRSLWRSPLAWLLTLFFG 225

                       250
                ....*....|....*..
gi 24654044 331 CVAFVAGALAWWGPSFI 347
Cdd:COG2807 226 LQSLLYYAVVAWLPPIL 242
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 119-307 1.73e-16

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 80.31  E-value: 1.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 119 VLCFVNLINYMDRFTIAGVLTDVRNDFDIGND-SAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLG 197
Cdd:cd17473   3 TLLLASTLTVMAGAAIAPALPAIAQHFVPNSElLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 198 SFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGsktAHLAN-DWRWALRVT 276
Cdd:cd17473  83 LFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLG---GALAEiGWRAPFLVY 159

                       170       180       190
                ....*....|....*....|....*....|.
gi 24654044 277 PILGIVAVFLILLIKDPVRGHSEGSHNLEAT 307
Cdd:cd17473 160 LLALPVLILVLLFLPEPARKSKSAASPGAAT 190
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 120-347 2.28e-16

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 80.07  E-value: 2.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   120 LCFVnlINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSF 199
Cdd:TIGR00893   1 LVTV--INYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   200 MKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGY-IVGSKTAHLanDWRWALRVTPI 278
Cdd:TIGR00893  79 AGAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWILIHF--SWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   279 LGIVAVFLIL-LIKDP----------------VRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAW 341
Cdd:TIGR00893 157 LGIIWGVLWLkFIPDPpqkakwlteeekyivvGGLLAEQQGKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLT 236


                  ....*.
gi 24654044   342 WGPSFI 347
Cdd:TIGR00893 237 WFPTYL 242
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 117-290 2.52e-16

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 79.57  E-value: 2.52e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 117 VTVLCFVNLINYMDRFTIAGVLTDVRNDFD--IGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTT 194
Cdd:cd17316   1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 195 LLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAND---WRW 271
Cdd:cd17316  81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgWRI 160

                       170
                ....*....|....*....
gi 24654044 272 ALrvtpILGIVAVFLILLI 290
Cdd:cd17316 161 LF----LIGALPALLALLL 175
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 117-290 2.47e-15

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 76.85  E-value: 2.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 117 VTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLL 196
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 197 GSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHlANDWRWALRVT 276
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQ-SLGWRWIFWFL 159

                       170
                ....*....|....
gi 24654044 277 PILGIVAVFLILLI 290
Cdd:cd17323 160 AIISGFCLILIFLF 173
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 132-287 2.59e-14

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 73.75  E-value: 2.59e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 132 FTIAGV-LTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFR 210
Cdd:cd17321  12 VTIVNVaLPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAAR 91

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654044 211 ALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPILGIVAVFLI 287
Cdd:cd17321  92 ALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINVPIGLVALLLA 167
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 153-291 3.19e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 70.30  E-value: 3.19e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 153 GLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLF 232
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 24654044 233 VHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHlANDWRWALRVTPILGIVAVFLILLIK 291
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 137-290 3.42e-13

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 70.30  E-value: 3.42e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 137 VLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIG 216
Cdd:cd17504  18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIG 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 217 EASYsTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSK-TAHLanDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17504  98 GAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWiVQHL--GWRWIFWTAAPVAVLLAALVPLI 169
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 156-290 6.09e-13

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 69.15  E-value: 6.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 156 QTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHD 235
Cdd:cd17317  31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPK 110

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 236 MRSkmLALFYFAIPVgsGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17317 111 YRS--FVGILFGLFW--ALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWL 161
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 114-290 1.25e-12

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 68.81  E-value: 1.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFTVTVLCFVNLINYMDRFTI-----AGVLTD---VRNDFDIGNdsagllqTVFVISYMVCAPIFGYLGDRYSRPWIMAV 185
Cdd:cd17327   4 LFILPLLCILYFLQYLDKSNIsnaavMGMKEDlklVGNQYNWGN-------TVFYVGYIIFELPGNLLLQRFPPSKWLSV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 186 GVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHL 265
Cdd:cd17327  77 FIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKI 156

                       170       180       190
                ....*....|....*....|....*....|
gi 24654044 266 AN-----DWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17327 157 LGvgglaGWRWLFIIEGLITIIIGLVIFFW 186
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 125-293 1.60e-12

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 68.17  E-value: 1.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   125 LINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFG 204
Cdd:TIGR00881   5 AAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLW 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   205 WFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILG-IVA 283
Cdd:TIGR00881  85 VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIAiIVS 164

                         170
                  ....*....|
gi 24654044   284 VFLILLIKDP 293
Cdd:TIGR00881 165 LICFLLLRDS 174
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 124-290 3.53e-12

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 67.14  E-value: 3.53e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 124 NLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRpWIMAVGVGLWSTT-TLLGSFMKQ 202
Cdd:cd17442  10 GVAEAMEIMLLAVVSPEIRCEWHLEDWQVALVTTMVFFGYMVFSILLGLLADRYGR-WKILLLSFVWGAYfSLLTSFAPS 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 203 FGWFIAFRALVGIGEASYSTiAPTIISDLFVHDMRSKMLALFYFAIPVGS----GLGYIVGSKTAhlandWRWALRVTPI 278
Cdd:cd17442  89 YIWFVFLRCMVGCGVSGHSQ-GLIIKTEFLPTKYRGYMLPLSQIFWLAGSlliiGLASVVIPTLG-----WRWLIRFASI 162

                       170
                ....*....|..
gi 24654044 279 LGIVAVFLILLI 290
Cdd:cd17442 163 PGIILIVVFKFI 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 120-340 4.93e-12

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 66.85  E-value: 4.93e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSF 199
Cdd:cd17489   1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 200 MKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHlANDWRWALRVTPIL 279
Cdd:cd17489  81 ATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLFIVAAVL 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654044 280 GIVAVFLILLIKDPVRGHSEGShnleatTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALA 340
Cdd:cd17489 160 ALLALLLVFLVKDPPPVAAEEA------EAGTRAFRRLVEKKVLPPALILFLASIAYGAIS 214
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 152-339 5.37e-12

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 66.48  E-value: 5.37e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 152 AGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDL 231
Cdd:cd17329  37 VGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 232 FVHDMRSKMLALFYFAIPVGSGLGYIVGSktaHLAN-DWRWALRVTPILGIVAvFLILLIKdpVRGHSEGSHNLEATTYK 310
Cdd:cd17329 117 TTPENRTRAFSLLYWAINLGVAIGPLLGG---LLLLySFRLLFLAAAVLFLLA-ALVLLFL--LPETRPKRRAAEKTEIL 190

                       170       180
                ....*....|....*....|....*....
gi 24654044 311 QDIKALVRNRSFMLSTAGFTCVAFVAGAL 339
Cdd:cd17329 191 RGYKIVLRDRAFLLFLLASFLISLIYFQL 219
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 118-294 8.96e-12

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 66.04  E-value: 8.96e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 118 TVLCFV-NLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLL 196
Cdd:cd17380   1 VILLFLaTCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 197 GSFMKQ--FGWFIAFRALVGIGEA-SYSTIApTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWAL 273
Cdd:cd17380  81 TPLLAYssLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVF 158

                       170       180
                ....*....|....*....|.
gi 24654044 274 RVTPILGIVAVFLILLIKDPV 294
Cdd:cd17380 159 YFFGLLGLLWALVWLIYLPPV 179
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
97-254 2.89e-11

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 64.22  E-value: 2.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  97 PPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLtdVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDR 176
Cdd:COG2814 192 ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR 269

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 177 YSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGL 254
Cdd:COG2814 270 FGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 120-290 3.50e-11

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 63.74  E-value: 3.50e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTDVRNDFDiGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWstttLLGSF 199
Cdd:cd17502   1 LMLALFLAALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIF----ELGSL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 200 MKQF----GWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVG-SKTAHLanDWRWALR 274
Cdd:cd17502  76 LCGLapnmTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGgAFTDHL--SWRWCFY 153

                       170
                ....*....|....*.
gi 24654044 275 VTPILGIVAVFLILLI 290
Cdd:cd17502 154 INLPIGGLALALLRTI 169
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 134-318 7.45e-11

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 62.96  E-value: 7.45e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 134 IAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALV 213
Cdd:cd17478  15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 214 GIGEASYSTIAPTIISDLFvhdMRSKMLALFYFAipVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIK-- 291
Cdd:cd17478  95 GIGSAAFHPEGARLASQAA---GGRRGLAMSIFS--VGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLrl 169

                       170       180       190
                ....*....|....*....|....*....|
gi 24654044 292 ---DPVRGHSEGSHNLEATTYKQDIKALVR 318
Cdd:cd17478 170 rplKKPEAKKAAAKSSARSTLKGVWRALLL 199
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 146-301 1.18e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 63.03  E-value: 1.18e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 146 DIGNDSA-GLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGeASYSTIA 224
Cdd:cd06179  27 DLGPSSNsTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIG-AGTQGLG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 225 PTIISDLFVHDMRSKMLALFYFAIPVGSGLG-YIVGSKTAHLANDWRWALRVTPILGIVAVFLILLI---KDPVRGHSEG 300
Cdd:cd06179 106 AAVASELVPNKYRGLVQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFyhpPPRPQLHGSS 185


                .
gi 24654044 301 S 301
Cdd:cd06179 186 T 186
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 134-290 1.92e-10

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 61.81  E-value: 1.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 134 IAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSR-PWIMAVGVgLWSTTTLLGSFMKQFGWFIAFRAL 212
Cdd:cd17359  20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRrKTLLISAV-LFFISALGSAFSPNFTIFIIARII 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 213 VGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAND-------WRWALRVTPILGIVAVF 285
Cdd:cd17359  99 GGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPAILFLL 178


                ....*
gi 24654044 286 LILLI 290
Cdd:cd17359 179 GMLFI 183
Sugar_tr pfam00083
Sugar (and other) transporter;
150-290 6.72e-10

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 60.36  E-value: 6.72e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   150 DSAGLLQTVFVISYMVCAPI----FGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQ---FGWFIAFRALVGIGEASYST 222
Cdd:pfam00083  42 AALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGkwsVYQLIVGRVLVGIGVGGASV 121

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24654044   223 IAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWalRVTPILGIV-AVFLILLI 290
Cdd:pfam00083 122 LAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGW--RIPLGLQLVpALLLIIGL 188
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 113-292 1.09e-09

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 59.59  E-value: 1.09e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 113 QWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWST 192
Cdd:cd17312   1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 193 TTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAhLANDWRWA 272
Cdd:cd17312  81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLA-SYYGWRAA 159

                       170       180
                ....*....|....*....|.
gi 24654044 273 LRVTPILGIV-AVFLILLIKD 292
Cdd:cd17312 160 FLVPGIVGLVvAIILFFFLRD 180
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 114-347 1.21e-09

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 59.91  E-value: 1.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   114 WFtVTVLCFVNLINYMdRFT-IAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRP-WI------MAV 185
Cdd:pfam03137   1 FF-LVFLSLLGLAQAL-VSGyFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPrWIgvgallMGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   186 GVGLWSTTTLLGSFMKQFgwfiafraLVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHL 265
Cdd:pfam03137  79 GSLLFALPHFLSFFLGQL--------LLGIGGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   266 ANDW-RWALRVTP--------------ILGIVAVFLILLI----------KDPVRGHSEGSHNLEATTYKQD-------- 312
Cdd:pfam03137 151 YVDIgKVSITLTPkdprwvgawwlgflIAGLLLLLTAIPFfffpkslpgaAKRRAKKKKEPHSQDIADLKKTkslkklgp 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 24654044   313 --------IKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFI 347
Cdd:pfam03137 231 slkdfpkaLKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYI 273
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 120-288 1.61e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 58.98  E-value: 1.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTDV-RNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRY-SRPWIMAVGVGLWSTTTLLG 197
Cdd:cd06174 208 LLLAIFLVNLAYYSFSTLLPLFlLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLLIGLLLMALGLALL 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 198 SFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTP 277
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367

                       170
                ....*....|.
gi 24654044 278 ILGIVAVFLIL 288
Cdd:cd06174 368 VLLLLAAILLL 378
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
119-289 2.50e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 58.76  E-value: 2.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 119 VLCFVNLINYMDRFTIAGVLT-DVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLG 197
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 198 SFMK--QFGWFIAFRALVGIGEASYSTIAPTIISDLFVHD-------MRSKMLALFYFAIPVGSGL------------GY 256
Cdd:COG2211 312 FFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAIKLGQALagalaglllalfGY 391

                       170       180       190
                ....*....|....*....|....*....|....
gi 24654044 257 IVGSKTAHLANDW-RWALRVTPILGIVAVFLILL 289
Cdd:COG2211 392 VAGAAQSPSALTGiRLLFFLLPAVLLLLAALLLL 425
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 94-260 4.44e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 57.55  E-value: 4.44e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  94 PGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLtdvrnDFDIGNDSAGLLQTVFVISYMVCAPIFGYL 173
Cdd:cd17370 183 PPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQ-----ELGLSAALIPLLYALFNLVYALAAYPAGRL 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 174 GDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFaipvGSG 253
Cdd:cd17370 258 SDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT----VVG 333


                ....*..
gi 24654044 254 LGYIVGS 260
Cdd:cd17370 334 IGWLLAS 340
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 152-306 5.36e-09

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 57.72  E-value: 5.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   152 AGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDL 231
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEF 208

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654044   232 fvhdMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEA 306
Cdd:TIGR00898 209 ----LPKKQRAIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEA 279
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 138-351 5.99e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.20  E-value: 5.99e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 138 LTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGE 217
Cdd:cd17320  22 LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGA 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 218 ASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAnDWRwALRVTPILGIVAVFLILLIKDPVRGH 297
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFF-GWR-AIFVFLALLGLLLLLLVLLFLPETLP 179

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 298 SEGSHNLEATTYKqDIKALVRNRSFMLSTagFTCVAFVAGALAWWGPS-FIYLGM 351
Cdd:cd17320 180 EEKRKPLLSSLLR-AYKRVLKNRRFLGYA--LALGLSFAGLFAYLAAApFIYIEQ 231
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 114-260 1.73e-08

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 56.09  E-value: 1.73e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFtVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTT 193
Cdd:cd17336   3 VF-VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLG 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 194 TLLGSfMKQFgwFIAFRALVGIGEASYSTIAPTIISDlFVHDMRSKM-LALFYFAIPVGSGLGYIVGS 260
Cdd:cd17336  82 CFLLA-LPHF--LFVGQFLLGIGSSPLYTLGITYIDD-NVSKKNSPLyIGILYAMRVLGPALGFLLGS 145
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
114-295 2.06e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.65  E-value: 2.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFTVTVLCFVNLINYMDRFTIAGVLTD-VRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRP--WIMAVGVGLW 190
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLA 258

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 191 STTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWR 270
Cdd:COG2271 259 ALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQ 337

                       170       180
                ....*....|....*....|....*
gi 24654044 271 WALRVTPILGIVAVFLILLIKDPVR 295
Cdd:COG2271 338 AAFLLLAALALLAALLALLLLRETR 362
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 137-281 2.15e-08

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 55.72  E-value: 2.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 137 VLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWStttlLGSFM---KQFGWFIAFRALV 213
Cdd:cd17403  26 SITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMG----IGSLVfalPHFTVFILAQLLH 101

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 214 GIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRwalRVTPILGI 281
Cdd:cd17403 102 GAGATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDID---QVDSELGL 166
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
112-300 2.42e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 55.27  E-value: 2.42e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 112 SQWFTVTVLCFVNLINYMdrftiAGVLTDVrndFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRP-WIMAVGVGLW 190
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWL-----PPYLVDQ---FGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRrVLLIVFALMA 282

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 191 STTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWR 270
Cdd:COG2223 283 LGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYT 362

                       170       180       190
                ....*....|....*....|....*....|
gi 24654044 271 WALRVTPILGIVAVFLILLIKDPVRGHSEG 300
Cdd:COG2223 363 AAFLVFAVLALVALVLTLLLYRRPRRAAAA 392
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 115-293 3.75e-08

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 54.58  E-value: 3.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 115 FTVTVLCFVNLINYMDRFTIAGVLTDvrnDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTT 194
Cdd:cd17476   1 ATISGAQLLNQAGLGSVIVILPIIGD---SFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWS 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 195 LLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLF-VHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWAL 273
Cdd:cd17476  78 LIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYpPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAW-WPWIF 156

                       170       180
                ....*....|....*....|
gi 24654044 274 RVTPILGIVAVFLILLIKDP 293
Cdd:cd17476 157 WFLAILAAIVAVAAIFWTSP 176
PRK11195 PRK11195
lysophospholipid transporter LplT; Provisional
 154-287 4.43e-08

lysophospholipid transporter LplT; Provisional


Pssm-ID: 236879 [Multi-domain]  Cd Length: 393  Bit Score: 54.46  E-value: 4.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  154 LLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLwsttTLLGSFMKQFGW--FIAFrALVGIGEASYSTIAPTIISDL 231
Cdd:PRK11195  42 LLQMFFVLAYIVLAPFVGAFADSFPKGRVMFIANGI----KLLGCLLMLFGIhpLLAY-GLVGIGAAAYSPAKYGILTEL 116

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  232 FVHDMRSK----MLALFYFAIPVGSGLGYIVGSKTAHLAndwrwalrvtpILGIVAVFLI 287
Cdd:PRK11195 117 LPGEKLVKangwMEGSTIAAILLGTVLGGALADPHAEAA-----------LAVCALIYLL 165
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 133-290 5.85e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 54.12  E-value: 5.85e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 133 TIAGV-LTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRA 211
Cdd:cd17503  13 TIVNVaLPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 212 LVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGS-KTAHLanDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17503  93 LQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGwLTDNL--SWRWIFYINLPIGILALLLAPLL 170
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 142-334 9.35e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 53.40  E-value: 9.35e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 142 RNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGeasYS 221
Cdd:cd17475  23 QEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAG---YG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 222 TIAPT---IISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPILGIV-AVFLILLIKDPVRGH 297
Cdd:cd17475 100 SVQPGggrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILaAVLFWLFYREPPAAS 178

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 24654044 298 SEGShnlEATTYKQDIKALVRNRSFML-STAGFTCVAF 334
Cdd:cd17475 179 AATE---SASTLLRSLKEVLRNRDVWLiAIAGALLVAP 213
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 129-346 1.34e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 53.07  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 129 MDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIA 208
Cdd:cd17371  13 FDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 209 FRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDwRWALRVTPILGIVAVFLIL 288
Cdd:cd17371  93 LRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPP-EIAWRVLFLLGALPALLVL 171

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 289 LI----KDPVRgHSEGSHNLEATTYKQDIKALVRN---RSFMLSTAGFTCVAFVAGALAWWGPSF 346
Cdd:cd17371 172 FIrrfvKEPPQ-WQAARAARRHFADRPSLRELFSPpllRTTLLASLLATGALGGYYGITTWLPSY 235
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
151-351 1.51e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 52.98  E-value: 1.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 151 SAGLLQTVFVISY---MVCAPIFGYLGDRYS------RPWIMAVGVGL------------WSTTTLLGSFmkqFGWFIAF 209
Cdd:COG2211  44 SAALVGLILLVARlwdAITDPLIGALSDRTRtrwgrrRPWILIGAIPLalsfvllftapdLSPTGKLIYA---LVTYLLL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 210 RALVGIGEASYSTIAPTIISDlfvHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHL-----ANDWRWALRVTPILGIVAV 284
Cdd:COG2211 121 GLAYTLVNIPYSALGAELTPD---YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaALGYRLTALIFAVLGLLAF 197

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 285 FL-ILLIKDPVRGHSEgshnleATTYKQDIKALVRNRSFMLstagftcvaFVAGALAWWGPSFIYLGM 351
Cdd:COG2211 198 LLtFFGTKERPVPEEE------KVSLKESLKALLKNRPFLL---------LLLAYLLFFLALALVAAL 250
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 105-261 1.98e-07

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 52.74  E-value: 1.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   105 RLSSVGRSQWFTVtVLCF-VNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIM 183
Cdd:TIGR00895   7 RKQPLSRYQWRAI-ILSFlIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVL 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044   184 AVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSK 261
Cdd:TIGR00895  86 LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGW 163
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 121-292 2.19e-07

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 52.19  E-value: 2.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 121 CFVNLINYMDRFTIAGVLTDVRNDFDIGNDS--AGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGS 198
Cdd:cd17315   3 ALGGLLFGYDLGVINGALLYIAKDLGFGLSTslQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 199 FMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAH-LANDWRWALRVTP 277
Cdd:cd17315  83 LAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLsPPGWWRLMFALAA 162

                       170
                ....*....|....*
gi 24654044 278 ILGIVAVFLILLIKD 292
Cdd:cd17315 163 VPALLQLLLMFFLPE 177
MFS_1 pfam07690
Major Facilitator Superfamily;
94-255 3.15e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.65  E-value: 3.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044    94 PGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYmdrFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYL 173
Cdd:pfam07690 182 PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF---FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   174 GDRYSRPWIMAVGVG---LWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPV 250
Cdd:pfam07690 259 SDRLGRRRRLLLALLlliLAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338


                  ....*
gi 24654044   251 GSGLG 255
Cdd:pfam07690 339 GGALG 343
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 110-242 5.53e-07

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 51.90  E-value: 5.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   110 GRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGL 189
Cdd:TIGR01299 162 GRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV 241

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24654044   190 WSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLA 242
Cdd:TIGR01299 242 NGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLS 294
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 129-282 5.88e-07

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 51.00  E-value: 5.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 129 MDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIA 208
Cdd:cd17372  13 MEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLII 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 209 FRALVGIGEASYSTIApTIISDLFVHDMRSKMLALFYFAIPVGS----GLGYIVGSKTAhlandWRWALRVTPILGIV 282
Cdd:cd17372  93 LRCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTifeaSLAWLVMPRLG-----WRWLLAFSSVPSSL 164
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 134-295 7.34e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 50.73  E-value: 7.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 134 IAGVLTDVRNDFDIGNDSAGLLQTVF---VISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFR 210
Cdd:cd17360  16 ISGALLYIKDDLGEVVLSTGWQELIVsstVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGR 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 211 ALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17360  96 VLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFL 175


                ....*
gi 24654044 291 KDPVR 295
Cdd:cd17360 176 PESPR 180
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 134-282 1.24e-06

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 50.04  E-value: 1.24e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 134 IAGVLTDVRNDFDIGNDSAGL--LQTVFVISYMVCAPIFGYL-----GDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWF 206
Cdd:cd17362  16 TSGALLSITSPALSGTDWYNLssLQSGLVVSGSLLGALLGSLvagalIDRLGRRKELILAALLYLVGSLVTGLAPSYPVL 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24654044 207 IAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIV 282
Cdd:cd17362  96 LVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALL 171
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 119-290 1.32e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.89  E-value: 1.32e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 119 VLCFvnLINYMDRF--TIAG-VLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTL 195
Cdd:cd17365   2 ALCF--LIIVLDGFdlAVMGfVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 196 LGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWAL-- 273
Cdd:cd17365  80 LTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVFll 158

                       170
                ....*....|....*...
gi 24654044 274 -RVTPILGIVAVFLILLI 290
Cdd:cd17365 159 gGVPPLILLPLLRGTLLL 176
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 153-335 4.41e-06

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 48.37  E-value: 4.41e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 153 GLLQTVFVISymvcapiFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGeaSYSTIAPTIISDLF 232
Cdd:cd17472  42 GLTQAIFQIP-------FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSG--AISSVVMALLADLT 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 233 VHDMRSKMLALFYFAIPVGSGLGYIVGSK-TAHLANDWRWALrvTPILGIVAVFLILL-IKDPVRghsegsHNLEATTYK 310
Cdd:cd17472 113 REENRTKAMALIGASIGIAFAISMVLGPLlAAHLGVSGLFLI--TAILSLVSLLILLFfVPDPPK------IVQISEKEK 184

                       170       180
                ....*....|....*....|....*
gi 24654044 311 QDIKALVRNRSFMLSTAGFTCVAFV 335
Cdd:cd17472 185 KKLKKLLKNKRLLRLDFSIFILHFV 209
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 152-339 4.65e-06

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 48.38  E-value: 4.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 152 AGLLQTVFVISYMVCAPIFGYLGDRYSRPWIM-------AVGVGLWSTTTLLGSFMKQFGWFIAFraLVGIGEASYSTIA 224
Cdd:cd06173  36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLiladllrALLAAVLALLALLGSLSLWLLLVLAF--LLGIASAFFGPAR 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 225 PTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNL 304
Cdd:cd06173 114 QALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG-PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSL 192

                       170       180       190
                ....*....|....*....|....*....|....*
gi 24654044 305 EATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGAL 339
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGAL 227
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 146-290 6.21e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 6.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 146 DIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAP 225
Cdd:cd17489 223 ERGISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQ 302

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 226 TIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLandwrWALRVTPILGIVAVFLILLI 290
Cdd:cd17489 303 ALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL-----FGYRAMFLLAAVVVLLALVL 362
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 156-287 6.25e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 47.67  E-value: 6.25e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 156 QTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHD 235
Cdd:cd17374  41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPR 120

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 24654044 236 MRSKM--LALFYFAIpvgsglGYIVGSKTAHLANDWRWALRVTPILGIVAVFLI 287
Cdd:cd17374 121 HRALAitLTSCFFSI------GQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYS 168
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 115-259 7.13e-06

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 47.55  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 115 FTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDR--YSRPWIMAVGVGLWST 192
Cdd:cd17352 183 PTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGL 262

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654044 193 TTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAipvgSGLGYIVG 259
Cdd:cd17352 263 SLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLF----QGLAALVG 325
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 153-259 7.80e-06

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 47.65  E-value: 7.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 153 GLLQTVFVISYMVCAPIFGYLGDRYSR-PWIMAVGVGLwSTTTLLGSFMKQFGWFIAFRALVGIGEASYStIAPTIISDL 231
Cdd:cd17389  67 GLIGSLFSLLQFLSSPITGAASDVYGRkPVLLLTMIGL-AISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADV 144

                        90       100
                ....*....|....*....|....*...
gi 24654044 232 FVHDMRSKMLALfyfaIPVGSGLGYIVG 259
Cdd:cd17389 145 TSPKKRSKGMAL----IGVAFSLGFIIG 168
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 120-346 1.03e-05

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 47.32  E-value: 1.03e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSF 199
Cdd:cd17333   1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 200 MKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFaipvgSGLGYIVGSKTAHLA----NDWRWALRV 275
Cdd:cd17333  81 TPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHGF-----FGLGALIGPLIATSLltseLSWSWAYLI 155

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654044 276 TPILGIVAVFLILLIKDPVRGHSeGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSF 346
Cdd:cd17333 156 IGLIYLLLAILILLTLFPELPSA-RNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSY 225
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 152-295 1.04e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.19  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 152 AGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGeASYSTIAPTIISDL 231
Cdd:cd17330  36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSVAQAYIADI 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654044 232 FVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDwRWALRVTPILGIVAVFLILLIKDPVR 295
Cdd:cd17330 115 TDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY-ALPFLVAAALALLNLVLVLFFLPPLR 177
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 113-347 1.41e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 46.88  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 113 QWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWST 192
Cdd:cd17355   1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 193 TTLLGSFMKQFGWFIAFRALVGIGEAS--YSTIAPTIISDLFVHDmRSKMLALFYFAIPVGSGLG-YIVGSKTAHLanDW 269
Cdd:cd17355  81 GLVLLALATSLWQLYLLWGLLGGGGAGtlAAVAFATVAAWWFERR-RGLALGILTAGGGLGSLVFlPLGAALIEAF--GW 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 270 RWALRVTPILGIVAVFLILLI--KDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFI 347
Cdd:cd17355 158 RTALLVLALLALLVLVPVLLLlrRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL 237
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 114-290 1.79e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.45  E-value: 1.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFTVTVLCFVNLINYMdrfTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTT 193
Cdd:cd06173 211 RLLLLALALFALLGGA---LTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 194 TLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWAL 273
Cdd:cd06173 288 LLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVF 366

                       170
                ....*....|....*..
gi 24654044 274 RVTPILGIVAVFLILLI 290
Cdd:cd06173 367 LLAGALLLLAALLLLLL 383
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 134-336 2.09e-05

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 46.61  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  134 IAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALV 213
Cdd:PRK03893  39 ITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVI 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  214 GIGEA-SYSTIAPTIISDLFVHdMRSKMLALFYFAIPVGSGLGYIVGSktaHLANDWRWalRVTPILGIVAVFLILLIKD 292
Cdd:PRK03893 119 GMGMAgEYGSSATYVIESWPKH-LRNKASGFLISGFSIGAVVAAQVYS---LVVPVWGW--RALFFIGILPIIFALWLRK 192

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 24654044  293 PVRGHSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVA 336
Cdd:PRK03893 193 NLPEAEDWKEKHAGKAPVRTMVDILYRGEHRIINILLTLAAAAA 236
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
 119-347 2.33e-05

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 46.37  E-value: 2.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 119 VLCFVNLINYMDRFTIAG----VLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSttt 194
Cdd:cd17462   4 VLFFLCAASFLQGMTVNGfintVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMG--- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 195 lLGSFM---KQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVG----------SK 261
Cdd:cd17462  81 -LGSLVfalPHFTVFMLGQFLHGIGATPLYTLGVTYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGgfflniyteiGR 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 262 TAHLAND---WRWALRVTPILGIVAVFLILLikdPVRGhsegshnleattYKQDIKALVRNRSFM-LSTAGFTCVAFVAG 337
Cdd:cd17462 160 QTELTPEnplWVGAWWIGFLGAGAAALLIAL---PILG------------YPRQLPGLLKNPTFIfLCLAGATEATLIAG 224

                       250
                ....*....|
gi 24654044 338 aLAWWGPSFI 347
Cdd:cd17462 225 -MSTFGPKFL 233
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 144-289 2.45e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 46.01  E-value: 2.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 144 DFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTI 223
Cdd:cd17477  25 REGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVV 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24654044 224 APTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILL 289
Cdd:cd17477 105 SESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRR 170
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 154-290 3.32e-05

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 45.53  E-value: 3.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 154 LLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFV 233
Cdd:cd17376  39 LTTSLFFVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGQISNYVVAFVLGTEILG 118

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24654044 234 HDMRSKMLALFYFaipVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17376 119 KSVRILFSTLGVC---IFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFI 172
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 114-290 3.81e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.29  E-value: 3.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFTVTVLCFVNLINYmdrFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLW--S 191
Cdd:cd17316 180 LLLILLWFFISFGYY---GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgiL 256

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 192 TTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYfaipvgsGLGYIVGSKTAHLANdwrW 271
Cdd:cd17316 257 ALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSY-------NLGRLGGGGAPPLIA---L 326

                       170
                ....*....|....*....
gi 24654044 272 ALRVTPILGIVAVFLILLI 290
Cdd:cd17316 327 LLASTGGTGVPALILALLA 345
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 144-290 4.86e-05

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 44.95  E-value: 4.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 144 DFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWS-TTTLLGSFMKQFGWFIAFRALVGIGEASYST 222
Cdd:cd17355 239 DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRAlGLALLLLLPFPPLALLLFAALFGLGWGATVP 318

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 223 IAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17355 319 LTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 165-349 5.34e-05

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 44.99  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   165 VCAPIFGYLGDRYS------RPWIMAVGVGLWST-----TTLLGSFMKQFGWF----IAFRALVGIGEASYSTIAPTIIS 229
Cdd:pfam13347  48 FTDPIVGHIIDRTRtrwgrrRPWLLLSAIILAVSfillfTPPELGRAPLFIWLlatyILLRIAYTFFEIPYWSLGPELTR 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044   230 DlfvHDMRSKMLALFYFAIPVGSGLGYIVG-------SKTAHLANDWRWALRVTPILGIVAVFLILLI--KDPVRGHSEG 300
Cdd:pfam13347 128 D---YDERTSLTSYRSFFSVGGGLLAAALAfplvlilGGTGLERKGYRIFALIGAVLMLLGVIITAAGtkERVSMRSKED 204

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 24654044   301 SHNLEATTYKQDIKALVRNRSFMlstAGFTCVAFVAGALAWWGPSFIYL 349
Cdd:pfam13347 205 TGQKEAGSLLDMLKEVFRNRAFL---ILLASFLLAALAMGVLNGLLLYY 250
PRK10091 PRK10091
MFS transport protein AraJ; Provisional
 129-288 5.80e-05

MFS transport protein AraJ; Provisional


Pssm-ID: 182234 [Multi-domain]  Cd Length: 382  Bit Score: 44.70  E-value: 5.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  129 MDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIA 208
Cdd:PRK10091  17 MAEFGIMGVLTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  209 FR--------ALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVgsktahlanDWRWALRVTPILG 280
Cdd:PRK10091  97 GRlvsgfphgAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEF---------SWRYTFLLIAVFN 167


                 ....*...
gi 24654044  281 IVAVFLIL 288
Cdd:PRK10091 168 IAVLASIY 175
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 94-290 7.98e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.48  E-value: 7.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  94 PGIPPSAVVPSRLSSVGRSQWFTVTVL--CFVNLInymdRFTIAGVLTDV-RNDFDIGNDSAGLLQTVFVISYMVCAPIF 170
Cdd:cd17474 179 KAKSSSATKLRDLKKALRGRGLLTFLVsaFLYFFL----YFAFLTYLPFLlELLYGISPIIIGLLFAGWSVLLALGSLFV 254

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 171 GY-LGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIP 249
Cdd:cd17474 255 GRlLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRF 334

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 24654044 250 VGSGLGYIVGSktaHLANdwRWALRVTPILGIVAVFLILLI 290
Cdd:cd17474 335 LGQAVGPLLFG---LLLE--IFGLSAPFLVGAAIALAAAVL 370
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 134-260 8.44e-05

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 44.27  E-value: 8.44e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 134 IAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLwsttTLLGSF---MKQFgwFIAFR 210
Cdd:cd17404  22 LNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVL----IALGSFlfsLPHF--FILAQ 95

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 24654044 211 ALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGS 260
Cdd:cd17404  96 ILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145
MFS_NIMT_like cd17409
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ...
 132-288 1.93e-04

2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340967 [Multi-domain]  Cd Length: 374  Bit Score: 43.02  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 132 FT-IAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRY-------SRPWIMAVGVGLWSTTTLLGSFMKQf 203
Cdd:cd17409  15 FTgVAPLLDTIRESFGLSTAQAGLLTTLPLLAFALFSPLAAKLARRYglerslfAALLLIAAGIALRSTGSVWALYLGT- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 204 gwfiafrALVGIGEASYSTIAPTIISDLFVHDMrSKMLALFYFAIPVGSGLGYIVGSKTAH-LANDWRWALRVTPILGIV 282
Cdd:cd17409  94 -------AIIGAGIAIGNVLLPSLLKRDFPARV-ATLTGAYALTMGVGAALGSALVVPLAQvLAFGWQLALGAFLVFPLV 165


                ....*.
gi 24654044 283 AVFLIL 288
Cdd:cd17409 166 AALIWL 171
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 153-290 2.73e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 42.62  E-value: 2.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 153 GLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLgSFMKQFGW--FIAFRALVGIGEASYSTIAPTIISD 230
Cdd:cd17356  48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAII-QVAAIGKWyqLIVGRIIAGLGVGFASVLVPVYQSE 126

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 231 LFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWalRVTpiLGIVAVFLILLI 290
Cdd:cd17356 127 VAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLDGSAQW--RIP--LGLQIVWGLLLL 182
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 132-216 2.85e-04

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 42.86  E-value: 2.85e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 132 FTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRA 211
Cdd:cd17363  16 FVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRL 95


                ....*
gi 24654044 212 LVGIG 216
Cdd:cd17363  96 LSGIG 100
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 94-229 3.30e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  94 PGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDS-AGLLQTVFVISYMVCAPIFGY 172
Cdd:cd17473 176 PARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAAlIGLALAIASLAGAIGALLFGR 255

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 24654044 173 LGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGeasYSTIAPTIIS 229
Cdd:cd17473 256 LKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLG---FGLLLPTLNS 309
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 115-289 3.83e-04

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 42.24  E-value: 3.83e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 115 FTVTVLCFVnlINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTT 194
Cdd:cd17341   1 LHLSWLSFF--LGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPL 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 195 L-LGSFMKQFGWFIAFRALVGIGEASYStIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAND----- 268
Cdd:cd17341  79 LaLALAVSSYWGLLVLGFLLGFAGANFA-SGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFdggfv 157

                       170       180
                ....*....|....*....|..
gi 24654044 269 -WRWALRVTPILGIVAVFLILL 289
Cdd:cd17341 158 gWRNAFFVPGILLAIAAVLVLL 179
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 119-242 4.71e-04

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 42.22  E-value: 4.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 119 VLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGS 198
Cdd:cd17438   3 VLGLALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSS 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24654044 199 FMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLA 242
Cdd:cd17438  83 FVQGYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLS 126
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 132-242 4.98e-04

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 41.94  E-value: 4.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 132 FTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRA 211
Cdd:cd17439  16 FVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRL 95

                        90       100       110
                ....*....|....*....|....*....|.
gi 24654044 212 LVGIGEASYSTIAPTIISDLFVHDMRSKMLA 242
Cdd:cd17439  96 LSGVGIGGSIPIVFSYFSEFLAQEKRGEHLS 126
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 176-290 6.58e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.44  E-value: 6.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 176 RYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLG 255
Cdd:cd17329 262 RFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG 341

                        90       100       110
                ....*....|....*....|....*....|....*
gi 24654044 256 YIVGSKTAHLANDWrWALRVTPILGIVAVFLILLI 290
Cdd:cd17329 342 PLVGGLLLDLLGPG-LPWLILAALGLIAAALLLGL 375
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 149-197 8.44e-04

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 41.05  E-value: 8.44e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 149 NDSAGLLQTVFVI---SYMVCAPIFGYLGDRYSRPWIMAVgVGLWSTTT---LLG 197
Cdd:cd17385 232 KLSPGQVGLMFLIlagSYAISAPLWGWLSDKKKIPKWLMV-IGSIITGVgflLLG 285
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
141-336 9.92e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 41.08  E-value: 9.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  141 VRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASY 220
Cdd:PRK15402  39 VVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFI 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  221 STIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLAnDWRWALRVTPILGIVAvFLILLIKDPVRGHSEG 300
Cdd:PRK15402 119 GAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVL-PWRGMFVLFAALAALS-FFGLWRAMPETAGRVG 196

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 24654044  301 sHNLEATTYKQDIKALVRNRSFM-----LSTAGFTCVAFVA 336
Cdd:PRK15402 197 -EKLSLKELGRDYKLVLKNRRFVagalaLGLVSLPLLAWIA 236
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 151-290 1.02e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.06  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 151 SAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAV-----GVGLWstttLLGSFMKQFGWFIAFRALVGIGEASYSTIAP 225
Cdd:cd17353 250 IAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIafliqGVAMF----LLPFIGSVAVLFVLGVALIGFCYGGGFALFP 325

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24654044 226 TIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSkTAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17353 326 ALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALLL 389
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 133-290 1.14e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 41.02  E-value: 1.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 133 TIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRAL 212
Cdd:cd17358  24 ALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFL 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 213 VGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSktaHLanDWRWalrvTPILGIV--AVFLILLI 290
Cdd:cd17358 104 AGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGS---FL--PWRT----LALIGAIppVVFLILLF 174
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 144-283 1.24e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 40.48  E-value: 1.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 144 DFDIGNDSAGLLQ---TVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASY 220
Cdd:cd17447  26 EWDLVCDRKGLNQataTFFFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGF 105

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24654044 221 STIapTIISDLFVHDMRSKMLALFYfaIPVGSGLGYIVGSKTAHLANDWRW-ALRVTP--ILGIVA 283
Cdd:cd17447 106 SII--SMVLCVEWVDIEHRTVAGVL--ISLFWTVGNMLLALVAYLIRDWRWlILAVTLpcAPGIIT 167
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 150-258 1.33e-03

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 40.53  E-value: 1.33e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 150 DSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFG--WFIAFRALVGIGE--------AS 219
Cdd:cd17381  65 ETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGagYLIAVRALEGLGEgvtfpamhAM 144

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 24654044 220 YSTIAPTIisdlfvhdMRSKMLALFYfaipVGSGLGYIV 258
Cdd:cd17381 145 WASWAPPL--------ERSRLLTISY----AGAQLGTVV 171
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 133-286 1.38e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 40.64  E-value: 1.38e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 133 TIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLwsttTLLGSFMKQFG---WFIAF 209
Cdd:cd17339  17 SVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLL----LAAGILLRSLGgiaLLFLG 92

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24654044 210 RALVGIGEASYSTIAPTIISDLFVHDMRSkMLALFYFAIPVGSGLG-YIVGSKTAHLANDWRWALRVTPILGIVAVFL 286
Cdd:cd17339  93 TALAGAGIAVGNVLLPSLIKRDFPRRVGL-MTGLYTTSMNLGAALAsGLSVPLAQALGGGWRGALAIWALPALLALLI 169
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 149-290 1.39e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 40.47  E-value: 1.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 149 NDSAGLLQTVFVISYMVCA---PIFGYLGDRYS-RPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIA 224
Cdd:cd17314  34 GYSSSQIATAASLSNLGMLltqPILGFIADSFGpRPLMALAGIMVLAGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSA 113

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24654044 225 PTIISDLFVHdmrSKMLALfyfAIPV-GSGLGYIVGSKTAHLANDWRWALRVTPILGIVAVFLILLI 290
Cdd:cd17314 114 VLVTTQYFPD---TKGLAL---GLPTtGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVV 174
emrD PRK11652
multidrug transporter EmrD;
151-288 1.40e-03

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 40.66  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044  151 SAGLLQTV---FVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTI 227
Cdd:PRK11652  41 REGAVQAVmaaYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGVMARTL 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24654044  228 ISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPILGIVAVFLIL 288
Cdd:PRK11652 121 PRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFG-WRACYLFLLLLGAGVTFSMA 180
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 120-248 1.69e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 40.30  E-value: 1.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 120 LCFVNLINYMDRFTIAGVLTD------------VRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGV 187
Cdd:cd17313 239 LLLVIFFWWIAFFPFELFFTDymgeevyhgtsaASSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGL 318

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654044 188 GLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISDLFVHDMRS--KMLALFYFAI 248
Cdd:cd17313 319 VLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGqgTDTGLLNLAI 381
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 143-294 2.78e-03

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 39.52  E-value: 2.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 143 NDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGW--FIAFRALVGIGEASY 220
Cdd:cd17318  49 PEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYgaLIVLRILQGLAQGVT 128

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654044 221 STIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANdWRWALRVTPILGIVAVFLILLIKDPV 294
Cdd:cd17318 129 FPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLG-WPSIFYIFGGLGLLWCLLWFFLVLPV 201
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 132-242 3.48e-03

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 39.51  E-value: 3.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 132 FTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRA 211
Cdd:cd17440  16 FVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRL 95

                        90       100       110
                ....*....|....*....|....*....|.
gi 24654044 212 LVGIGEASYSTIAPTIISDLFVHDMRSKMLA 242
Cdd:cd17440  96 LSGFGIGGAVPTVFSYFAEVLAREKRGEHLS 126
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 147-260 4.01e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 147 IGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALV--GIGEASYsTIA 224
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLwgGAAGPLY-TLA 298

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 24654044 225 PTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGS 260
Cdd:cd17477 299 LALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAG 334
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 130-260 4.89e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 38.80  E-value: 4.89e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 130 DRFTIAGVLTDVRNDF--DIGNDSAGLLQTVFVISYMVCAP---IFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFM---- 200
Cdd:cd17364  14 DLFSISLVTKILGRLYygGKGSLPSGVSGLVNAAALVGTIIgqlFFGFLGDRFGRKRVYGVELIIMIIGTILSALSpgst 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24654044 201 --KQFGWFIAFRALVGIGEASYSTIAPTIISDlFVHDMRSKMLALFYFAIpvgSGLGYIVGS 260
Cdd:cd17364  94 plGVMGWLIFFRFLLGIGIGGDYPLSATIMSE-YANKKRRGALIAAVFAM---QGFGILAGA 151
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 151-322 6.79e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 38.35  E-value: 6.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 151 SAGLLQTVFVISY---MVCAPIFGYLGDRY------SRPWI-------MAVGVGLWstTTLLGSFMKQFGWFIAFRALVG 214
Cdd:cd17332  33 SAAAAGTIFLVARiidAINDPLMGYLIDRTrsrwgrFRPWLlwgaiplALLFVLLF--TTPDGSGTGKLIYALITYILLD 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 215 IGEA----SYSTIAPTIISDlfvHDMRSKMLAL-FYFAIPVGSGLGYIVGSKTAHLAND-----WRWALRVTPILGIVAV 284
Cdd:cd17332 111 LLYTlvniPYTALIPELTDD---PEERTSLTSWrMFFATIGGLLVTVLPPPLVAYFGGGnasrgYFLTALIIGIIGIILL 187

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24654044 285 FL-ILLIKDPVRGHSEGSHNLeatTYKQDIKALVRNRSF 322
Cdd:cd17332 188 LIcFFGTRERVVPPEEEKSKL---PLLKSLKALLKNRPF 223
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 114-324 7.20e-03

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 38.40  E-value: 7.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 114 WFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYS-RP------WIMAVG 186
Cdd:cd17399   3 WFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGlRTaiilgaWLNFIG 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 187 VGLWSTTTLlgSFMKQFGWFIAFRALVGIGEASYSTI--APTIISDL-FVHDMRSKMLALFYFAIPVGSGLGYIVGSKTA 263
Cdd:cd17399  83 AVIRVISSL--PFVDPSFRFPVLMTGQTLAAFAQPFIlfLPTKLAALwFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24654044 264 HLANDWRWALRVTPILGIVAVFLILLI---KDPVRGHSEGSHNlEATTYKQDIKALVRNRSFML 324
Cdd:cd17399 161 KSSEDIFLLLSIYTIPALIAVVLATFGvrsSVPPTPPSASAAH-ESEPFFVGLKQLFKNKQYLI 223
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 154-347 8.00e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 38.44  E-value: 8.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 154 LLQTVFVISYM---VCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGEASYSTIAPTIISD 230
Cdd:cd17322  38 LLSTINVVNNIvsaVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTLILAD 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 231 LfvHDMRSKMLALFYFAIPvgsglgYIV----GSKTAHLAN---DWRWALRV----TPILGIVAVFLILLIKDPVRGHSE 299
Cdd:cd17322 118 F--SSLKNRGFASAIPSLP------YIIttwiGGNIAQAALpnsNWRWGYGMwaiiLPLSSLPLVLCLLYMQRKARKDGE 189

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24654044 300 --GSHNLEATTYKQDIKALVRNRSFMLS-------TAGFTCVaFVAGALA------WWGPSFI 347
Cdd:cd17322 190 ikELKNQETEEQTGGLSQNLVKLFWKLDifgvillTAGLGLI-LVPLTLAggakskWKNSSII 251
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 131-368 9.46e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 38.05  E-value: 9.46e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 131 RFTIAGVLTDVRNDFDIGNDSAGLLQTVFVISYMVCAPIFGYLgdRYSRPWIMAVGVGLWSTTTLLG--SFMKQFGWFIA 208
Cdd:cd06180  15 RFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFL--RRRGRARRLIRGGLLLTVLLLAamALTSGFAALLA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 209 FRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYfaipVGSGLGYIVGSKTA----HLANDWR--WAlrvtpILGIV 282
Cdd:cd06180  93 LRFLAGAASAFVFVFGSNLVLHHATAAGRGHLIGLLF----AGVGLGIALSGLLVpaglGGGLSWRagWL-----ALALL 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 283 AvFLILLIKDPVRGHSEGSHnleaTTYKQDIKALVRNRSFMLSTAGFTCVAFVAGALAwwgpSFIYLGMKMQPGNEniVQ 362
Cdd:cd06180 164 S-AVLLLLSFLLLRRGPSAP----TEASAAESAPGLNRPLWRLALAYGLFGFGYIITA----TFLPLIARETGAGS--LL 232


                ....*.
gi 24654044 363 DDMWWF 368
Cdd:cd06180 233 AGLLWS 238
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 154-271 9.82e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 37.78  E-value: 9.82e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24654044 154 LLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFRALVGIGeasYSTIAPTIISdLFV 233
Cdd:cd17446  37 LAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMA---LSGIVLNSVS-LNV 112

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 24654044 234 HDMRSKMLALfyfaipVGSGLGY------IVGSKTAHLANDWRW 271
Cdd:cd17446 113 EWMPTRVRAV------VGTLLGYcytlgqLILAGVAYAIRDWRW 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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