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Conserved domains on  [gi|24641355|ref|NP_727546|]
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valette, isoform C [Drosophila melanogaster]

Protein Classification

COMM domain-containing protein( domain architecture ID 4715)

COMM (copper metabolism gene MURR1) domain-containing protein is involved in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd super family cl06336
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 24-187 2.97e-60

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


The actual alignment was detected with superfamily member cd04758:

Pssm-ID: 471425 [Multi-domain]  Cd Length: 186  Bit Score: 186.43  E-value: 2.97e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355  24 RVDSSTEENPTSNTEPEYTLEELERLvgvpRQDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDaiLRL 103
Cdd:cd04758  25 QKLHLKAERSFSEEEEEKLQEAFKLL----SQDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAF--VNA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355 104 WVRETTPIMNNLASKRYESNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTAVG----EDINIEMTQPELMELYNQFES 179
Cdd:cd04758  99 WEAEGEDVLEKLRSRILAPNQLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEdgnlEKINLEFNHEELLEFYNQLES 178


                ....*...
gi 24641355 180 IQGELDAM 187
Cdd:cd04758 179 IQEQLDSL 186
 
Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 24-187 2.97e-60

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 186.43  E-value: 2.97e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355  24 RVDSSTEENPTSNTEPEYTLEELERLvgvpRQDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDaiLRL 103
Cdd:cd04758  25 QKLHLKAERSFSEEEEEKLQEAFKLL----SQDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAF--VNA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355 104 WVRETTPIMNNLASKRYESNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTAVG----EDINIEMTQPELMELYNQFES 179
Cdd:cd04758  99 WEAEGEDVLEKLRSRILAPNQLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEdgnlEKINLEFNHEELLEFYNQLES 178


                ....*...
gi 24641355 180 IQGELDAM 187
Cdd:cd04758 179 IQEQLDSL 186
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 122-180 1.50e-10

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 54.86  E-value: 1.50e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24641355   122 SNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTA----VGEDINIEMTQPELMELYNQFESI 180
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSdgdgSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd10 cd04758
COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of ...
 24-187 2.97e-60

COMM_Domain containing protein 10. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240106 [Multi-domain]  Cd Length: 186  Bit Score: 186.43  E-value: 2.97e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355  24 RVDSSTEENPTSNTEPEYTLEELERLvgvpRQDFLLLIKTFSYILRRISTFIIKPSLLQRELREKLQLEDEAKIDaiLRL 103
Cdd:cd04758  25 QKLHLKAERSFSEEEEEKLQEAFKLL----SQDLKLLLETISFILEQAAYHNLKPSNLQQQLRNILLLEDKASAF--VNA 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355 104 WVRETTPIMNNLASKRYESNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTAVG----EDINIEMTQPELMELYNQFES 179
Cdd:cd04758  99 WEAEGEDVLEKLRSRILAPNQLEDVSWRLNLQMSSSTQAKLKSPLAVLELGVTSEdgnlEKINLEFNHEELLEFYNQLES 178


                ....*...
gi 24641355 180 IQGELDAM 187
Cdd:cd04758 179 IQEQLDSL 186
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 122-180 1.50e-10

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 54.86  E-value: 1.50e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24641355   122 SNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTA----VGEDINIEMTQPELMELYNQFESI 180
Cdd:pfam07258   2 LPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSdgdgSSEEVTFELSKEQLQDLLNELEEA 64
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 103-184 1.75e-09

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 52.70  E-value: 1.75e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641355 103 LWVRETTPIMNNLASKRYESNVIEDVAWKLNMEISSHCQQREKTPLAVLQMKTAVG-----EDINIEMTQPELMELYNQF 177
Cdd:cd04748   1 LLTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGdnnssEKICFEMTKEELQNFLNKL 80


                ....*..
gi 24641355 178 ESIQGEL 184
Cdd:cd04748  81 KKIKAQL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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