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Conserved domains on  [gi|24641720|ref|NP_727682|]
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histone deacetylase 4, isoform B [Drosophila melanogaster]

Protein Classification

histone deacetylase( domain architecture ID 10184833)

class IIa histone deacetylase is Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HDAC_classIIa cd11681
Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that ...
 749-1123 0e+00

Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones. This subclass includes animal HDAC4, HDAC5, HDAC7, and HDCA9. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. HDAC7 is involved in regulation of myocyte migration and differentiation. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis.


:

Pssm-ID: 212544 [Multi-domain]  Cd Length: 377  Bit Score: 760.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  749 VTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcqLS 828
Cdd:cd11681    1 FTTGLAYDPLMLKHQCICGNNSSHPEHGGRLQSIWSRLQETGLVNRCERLRGRKATLEELQLVHSEVHTLLYGTNP--LS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  829 RPKLENTLSA-----SFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLA 903
Cdd:cd11681   79 RLKLDPTKLAglpqkSFVRLPCGGIGVDSDTVWNELHTSNAARMAVGCVIDLAFKVATGELKNGFAVVRPPGHHAEPSQA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  904 MGFCFFNSIAIAAKLLRQRMPeVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGF 983
Cdd:cd11681  159 MGFCFFNSVAIAAKQLQQKLK-LRKILIVDWDVHHGNGTQQIFYEDPNVLYISLHRYDDGNFFPGTGAPTEVGSGAGEGF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  984 NVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKV 1063
Cdd:cd11681  238 NVNIAWSGGLDPPMGDAEYLAAFRTVVMPIAREFSPDIVLVSAGFDAAEGHPPPLGGYKVSPACFGYMTRQLMNLAGGKV 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1064 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd11681  318 VLALEGGYDLTAICDASEACVRALLGDELDPLSEEELERRPNPNAVTSLEKVIAIQSPYW 377
 
Name Accession Description Interval E-value
HDAC_classIIa cd11681
Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that ...
 749-1123 0e+00

Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones. This subclass includes animal HDAC4, HDAC5, HDAC7, and HDCA9. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. HDAC7 is involved in regulation of myocyte migration and differentiation. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis.


Pssm-ID: 212544 [Multi-domain]  Cd Length: 377  Bit Score: 760.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  749 VTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcqLS 828
Cdd:cd11681    1 FTTGLAYDPLMLKHQCICGNNSSHPEHGGRLQSIWSRLQETGLVNRCERLRGRKATLEELQLVHSEVHTLLYGTNP--LS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  829 RPKLENTLSA-----SFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLA 903
Cdd:cd11681   79 RLKLDPTKLAglpqkSFVRLPCGGIGVDSDTVWNELHTSNAARMAVGCVIDLAFKVATGELKNGFAVVRPPGHHAEPSQA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  904 MGFCFFNSIAIAAKLLRQRMPeVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGF 983
Cdd:cd11681  159 MGFCFFNSVAIAAKQLQQKLK-LRKILIVDWDVHHGNGTQQIFYEDPNVLYISLHRYDDGNFFPGTGAPTEVGSGAGEGF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  984 NVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKV 1063
Cdd:cd11681  238 NVNIAWSGGLDPPMGDAEYLAAFRTVVMPIAREFSPDIVLVSAGFDAAEGHPPPLGGYKVSPACFGYMTRQLMNLAGGKV 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1064 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd11681  318 VLALEGGYDLTAICDASEACVRALLGDELDPLSEEELERRPNPNAVTSLEKVIAIQSPYW 377
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 772-1087 2.24e-117

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 365.79  E-value: 2.24e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720    772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLfgsnqcqlsrpkLENTLSASFVRLSCGGLGVD 851
Cdd:pfam00850    1 HPENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEF------------LEEAAPEGGALLLLSYLSGD 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720    852 LDTtWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMpEVRRILI 931
Cdd:pfam00850   69 DDT-PVSPGSYEAALLAAGGTLAAADAVLSGEARNAFALVRPPGHHAERDRASGFCIFNNVAIAAKYLREKY-GLKRVAI 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720    932 VDWDVHHGNGTQQAFYQSPDILYLSIHRHdDGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVM 1011
Cdd:pfam00850  147 VDFDVHHGNGTQEIFYDDPSVLTLSIHQY-PGGFYPGTGFADETGEGKGKGYTLNV----PLPPGTGDAEYLAAFEEILL 221

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24641720   1012 PIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLA---NGKVVLALEGGYDLAAICDSAQECVRAL 1087
Cdd:pfam00850  222 PALEEFQPDLILVSAGFDAHAGD--PLGGLNLTTEGFAEITRILLELAdplCIRVVSVLEGGYNLDALARSATAVLAAL 298
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 751-1089 4.43e-103

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 327.83  E-value: 4.43e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  751 TGLAYDPLMLKHSCicGDNaqHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH-AMLFgsnqcqlsr 829
Cdd:COG0123    1 TALIYHPDYLLHDL--GPG--HPEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYvDALR--------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  830 pklENTLSASFVRLscgglgvDLDTTWNEHhTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFF 909
Cdd:COG0123   68 ---AASLDGGYGQL-------DPDTPVSPG-TWEAALLAAGGALAAADAVLEGEARNAFALVRPPGHHAERDRAMGFCLF 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  910 NSIAIAAKLLRQRmpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddgNFFPGTGGPTECGSGAGLGFNVNIsw 989
Cdd:COG0123  137 NNAAIAARYLLAK--GLERVAIVDFDVHHGNGTQDIFYDDPDVLTISIHQD---PLYPGTGAADETGEGAGEGSNLNV-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  990 sgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLA---NGKVVLA 1066
Cdd:COG0123  210 --PLPPGTGDAEYLAALEEALLPALEAFKPDLIVVSAGFDAHADD--PLGRLNLTTEGYAWRTRRVLELAdhcGGPVVSV 285

                        330       340
                 ....*....|....*....|...
gi 24641720 1067 LEGGYDLAAICDSAQECVRALLG 1089
Cdd:COG0123  286 LEGGYNLDALARSVAAHLETLLG 308
PTZ00063 PTZ00063
histone deacetylase; Provisional
 772-1033 2.01e-20

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 95.65  E-value: 2.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS---NQC-----QLSRPKL-ENTLSASFVR 842
Cdd:PTZ00063   23 HPMKPQRIRMAHALILSYDLYKHMEIYRPHKSVEPELVLFHDEEYVDFLSSispENYrdftyQLKRFNVgEATDCPVFDG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   843 L-----SCGGLGVDLDTTWNEHHTATAARMAAGCvidlalktakgdlrngfavvrppgHHAEANLAMGFCFFNSIAIAA- 916
Cdd:PTZ00063  103 LfefqqSCAGASIDGAYKLNNHQADICVNWSGGL------------------------HHAKRSEASGFCYINDIVLGIl 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   917 KLLRQRMpevrRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPP 996
Cdd:PTZ00063  159 ELLKYHA----RVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKF--GDFFPGTGDVTDIGVAQGKYYSVNV----PLNDG 228

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 24641720   997 LGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATG 1033
Cdd:PTZ00063  229 IDDDSFVDLFKPVISKCVEVYRPGAIVLQCGADSLTG 265
 
Name Accession Description Interval E-value
HDAC_classIIa cd11681
Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that ...
 749-1123 0e+00

Histone deacetylases, class IIa; Class IIa histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) to yield deacetylated histones. This subclass includes animal HDAC4, HDAC5, HDAC7, and HDCA9. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. HDAC7 is involved in regulation of myocyte migration and differentiation. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis.


Pssm-ID: 212544 [Multi-domain]  Cd Length: 377  Bit Score: 760.34  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  749 VTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcqLS 828
Cdd:cd11681    1 FTTGLAYDPLMLKHQCICGNNSSHPEHGGRLQSIWSRLQETGLVNRCERLRGRKATLEELQLVHSEVHTLLYGTNP--LS 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  829 RPKLENTLSA-----SFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLA 903
Cdd:cd11681   79 RLKLDPTKLAglpqkSFVRLPCGGIGVDSDTVWNELHTSNAARMAVGCVIDLAFKVATGELKNGFAVVRPPGHHAEPSQA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  904 MGFCFFNSIAIAAKLLRQRMPeVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGF 983
Cdd:cd11681  159 MGFCFFNSVAIAAKQLQQKLK-LRKILIVDWDVHHGNGTQQIFYEDPNVLYISLHRYDDGNFFPGTGAPTEVGSGAGEGF 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  984 NVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKV 1063
Cdd:cd11681  238 NVNIAWSGGLDPPMGDAEYLAAFRTVVMPIAREFSPDIVLVSAGFDAAEGHPPPLGGYKVSPACFGYMTRQLMNLAGGKV 317

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1064 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd11681  318 VLALEGGYDLTAICDASEACVRALLGDELDPLSEEELERRPNPNAVTSLEKVIAIQSPYW 377
HDAC4 cd10006
Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes ...
 748-1151 0e+00

Histone deacetylase 4; Histone deacetylase 4 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC4 participates in regulation of chondrocyte hypertrophy and skeletogenesis. However, biological substrates for HDAC4 have not been identified; only low lysine deacetylation activity has been demonstrated and active site mutant has enhanced activity toward acetylated lysines. HDAC4 does not bind DNA directly, but through transcription factors MEF2C (myocyte enhancer factor-2C) and MEF2D. Other known interaction partners of the protein are 14-3-3 proteins, SMRT and N-CoR co-repressors, BCL6, HP1, SUMO-1 ubiquitin-like protein, and ANKRA2. It appears to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.


Pssm-ID: 212530 [Multi-domain]  Cd Length: 409  Bit Score: 604.72  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  748 KVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcqL 827
Cdd:cd10006    3 RFTTGLVYDTLMLKHQCTCGNSNSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNP--L 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  828 SRPKLEN-----TLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANL 902
Cdd:cd10006   81 NRQKLDSkkllgSLASVFVRLPCGGVGVDSDTIWNEVHSSGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEEST 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  903 AMGFCFFNSIAIAAKLLRQRMpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLG 982
Cdd:cd10006  161 PMGFCYFNSVAIAAKLLQQRL-NVSKILIVDWDVHHGNGTQQAFYSDPNVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  983 FNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGK 1062
Cdd:cd10006  240 FNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSAKCFGYLTKQLMGLAGGR 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1063 VVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLK 1142
Cdd:cd10006  320 IVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGYSLIEAQT 399


                 ....*....
gi 24641720 1143 VEHDESETI 1151
Cdd:cd10006  400 CENEEAETV 408
HDAC5 cd10007
Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes ...
 747-1161 0e+00

Histone deacetylase 5; Histone deacetylase 5 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC5 is involved in integration of chronic drug (cocaine) addiction and depression with changes in chromatin structure and gene expression; cocaine regulates HDAC5 function to antagonize the rewarding impact of cocaine, possibly by blocking drug-stimulated gene expression that supports drug-induced behavioral change. It is also involved in regulation of angiogenesis and cell cycle as well as immune system development. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212531 [Multi-domain]  Cd Length: 420  Bit Score: 602.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  747 HKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS---N 823
Cdd:cd10007    1 HLFTTGLVYDTFMLKHQCTCGNTNVHPEHAGRIQSVWSRLQETGLLGKCERVRGRKATLDEIQTVHSEHHTLLYGTsplN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  824 QCQLSRPKLENTLSAS-FVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANL 902
Cdd:cd10007   81 RQKLDSKKLLGPLSQKmYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLIELAFKVAAGELKNGFAVIRPPGHHAEEST 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  903 AMGFCFFNSIAIAAKLLRQRMpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLG 982
Cdd:cd10007  161 AMGFCFFNSVAIAAKLLQQKL-NVGKILIVDWDIHHGNGTQQAFYNDPNVLYISLHRYDDGNFFPGSGAPDEVGAGPGVG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  983 FNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGK 1062
Cdd:cd10007  240 FNVNIAWTGGVDPPIGDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAVEGHQSPLGGYSVTAKCFGHLTKQLMTLAGGR 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1063 VVLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLK 1142
Cdd:cd10007  320 VVLALEGGHDLTAICDASEACVSALLGMELTPLDNTVLQQKPNDNAVATLERVIEIQSKHWSCLKRFAATLGFSLLEAQR 399

                        410
                 ....*....|....*....
gi 24641720 1143 VEHDESETINAMAGLSMQS 1161
Cdd:cd10007  400 GELEEAETVSAMASLSVDT 418
HDAC7 cd10008
Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes ...
 750-1123 0e+00

Histone deacetylase 7; Histone deacetylase 7 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, having N-terminal regulatory domain with two or three conserved serine residues; phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC7 is involved in regulation of myocyte migration and differentiation. Known interaction partners of class IIa HDAC7 are myocyte enhancer factors - MEF2A, -2C, and -2D, 14-3-3 proteins, SMRT and N-CoR co-repressors, HDAC3, ETA (endothelin receptor). This enzyme is also involved in the development of the immune system as well as brain and heart development. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.


Pssm-ID: 212532 [Multi-domain]  Cd Length: 378  Bit Score: 575.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  750 TTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcqLSR 829
Cdd:cd10008    2 TTGLVYDSVMLKHQCSCGDNSNHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNP--LSR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  830 PKLENTLSAS------FVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLA 903
Cdd:cd10008   80 LKLDNGKLAGllaqrmFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  904 MGFCFFNSIAIAAKLLRQRmPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGF 983
Cdd:cd10008  160 MGFCFFNSVAIACRQLQQQ-GKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGF 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  984 NVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKV 1063
Cdd:cd10008  239 NVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAV 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1064 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd10008  319 VLALEGGHDLTAICDASEACVAALLGNEVDPLSEESWKQKPNLNAIRSLEAVIRVHSKYW 378
HDAC9 cd10009
Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes ...
 750-1123 2.27e-170

Histone deacetylase 9; Histone deacetylase 9 is a class IIa Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Class IIa histone deacetylases are signal-dependent co-repressors, they have N-terminal regulatory domain with two or three conserved serine residues, phosphorylation of these residues is important for ability to shuttle between the nucleus and cytoplasm and act as transcriptional co-repressors. HDAC9 is involved in regulation of gene expression and dendritic growth in developing cortical neurons. It also plays a role in hematopoiesis. Its deregulated expression may be associated with some human cancers. HDAC5 and HDAC9 have been found to be significantly up-regulated in high-risk medulloblastoma compared with low-risk and may potentially be novel drug targets.


Pssm-ID: 212533 [Multi-domain]  Cd Length: 379  Bit Score: 508.02  E-value: 2.27e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  750 TTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcqLSR 829
Cdd:cd10009    2 ATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETGLLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNP--LDG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  830 PKLE------NTLSASFVRLSCGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLA 903
Cdd:cd10009   80 QKLDprillgDDSQKFFSSLPCGGLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  904 MGFCFFNSIAIAAKLLRQRMpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPTECGSGAGLGF 983
Cdd:cd10009  160 MGFCFFNSVAITAKYLRDQL-NISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFPGSGAPNEVGTGLGEGY 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  984 NVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKV 1063
Cdd:cd10009  239 NINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAGFDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRV 318

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1064 VLALEGGYDLAAICDSAQECVRALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd10009  319 VLALEGGHDLTAICDASEACVNALLGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYW 378
HDAC6-dom2 cd10003
Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that ...
 755-1127 6.29e-132

Histone deacetylase 6, domain 2; Histone deacetylase 6 is a class IIb Zn-dependent enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212527 [Multi-domain]  Cd Length: 350  Bit Score: 406.34  E-value: 6.29e-132
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  755 YDPLMLKHSCICgdNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAmlfgsnqcqlsrPKLEN 834
Cdd:cd10003    1 YDQRMMNHHNLW--DPGHPECPQRISRIYERHNDLGLLERCLRLPSRLATEDELLLCHSEEHL------------DEMKS 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  835 TLSASFVRLscGGLGVDLDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAI 914
Cdd:cd10003   67 LEKMKPREL--NRLGKEYDSIYIHPDSYQCALLAAGCVLQVVEAVLTGESRNGVAIVRPPGHHAEQDTACGFCFFNNVAI 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  915 AAKLLRQRMpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT--GGPTECGSGAGLGFNVNISWSGa 992
Cdd:cd10003  145 AARYAQKKY-GLKRILIVDWDVHHGNGTQHMFESDPSVLYISLHRYDNGSFFPNSpeGNYDVVGKGKGEGFNVNIPWNK- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  993 lnPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYD 1072
Cdd:cd10003  223 --GGMGDAEYIAAFQQVVLPIAYEFNPELVLVSAGFDAARGD--PLGGCKVTPEGYAHMTHMLMSLAGGRVIVILEGGYN 298

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 24641720 1073 LAAICDSAQECVRALLGDPAAPIakaELERPPCQNAINTLQKTIAIQQTHWPCVR 1127
Cdd:cd10003  299 LTSISESMSMCTKTLLGDPPPVL---DLPRPPCSSALKSINNVLQVHQKYWKSLR 350
HDAC_Clr3 cd11600
Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone ...
 771-1091 3.42e-129

Class II Histone deacetylase Clr3 and similar proteins; Clr3 is a class II Histone deacetylase Zn-dependent enzyme that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Clr3 is the homolog of the class-II HDAC HdaI in S. cerevisiae, and is essential for silencing in heterochromatin regions, such as centromeric regions, ribosomal DNA, the mating-type region and telomeric loci. Clr3 has also been implicated in the regulation of stress-related genes; the histone acetyltransferase, Gcn5, in S. cerevisiae, preferentially acetylates global histone H3K14 while Clr3 preferentially deacetylates H3K14ac, and therefore, interplay between Gcn5 and Clr3 is crucial for the regulation of many stress-response genes.


Pssm-ID: 212542 [Multi-domain]  Cd Length: 313  Bit Score: 397.49  E-value: 3.42e-129
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  771 QHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHaMLFGSNQCQLSRPKLENtLSASFVRLScggLGV 850
Cdd:cd11600    2 PHPEDPSRISRIFEKLKEAGLINRMLRIPIREATKEEILLVHSEEH-WDRVEATEKMSDEQLKD-RTEIFERDS---LYV 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  851 DldttwneHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMPE-VRRI 929
Cdd:cd11600   77 N-------NDTAFCARLSCGGAIEACRAVAEGRVKNAFAVVRPPGHHAEPDESMGFCFFNNVAVAAKWLQTEYPDkIKKI 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  930 LIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT--GGPTECGSGAGLGFNVNISWSgalNPPLGDAEYIAAFR 1007
Cdd:cd11600  150 LILDWDIHHGNGTQRAFYDDPNVLYISLHRFENGGFYPGTpyGDYESVGEGAGLGFNVNIPWP---QGGMGDADYIYAFQ 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1008 TVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRAL 1087
Cdd:cd11600  227 RIVMPIAYEFDPDLVIISAGFDAADGD--ELGQCHVTPAGYAHMTHMLMSLAGGKLVVALEGGYNLDAISDSALAVAKVL 304


                 ....
gi 24641720 1088 LGDP 1091
Cdd:cd11600  305 LGEA 308
HDAC_classII cd09992
Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are ...
 772-1088 1.08e-127

Histone deacetylases and histone-like deacetylases, classII; Class II histone deacetylases are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. This group includes animal HDAC4,5,6,7,8,9,10, fungal HOS3 and HDA1, plant HDA5 and HDA15 as well as other eukaryotes, archaeal and bacterial histone-like deacetylases. Eukaryotic deacetylases mostly use histones (H2, H3, H4) as substrates for deacetylation; however, non-histone substrates are known (for example, tubulin). Substrates for prokaryotic histone-like deacetylases are not known. Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Interaction partners of class II deacetylases include 14-3-3 proteins, MEF2 family of transcriptional factors, CtBP, calmodulin (CaM), SMRT, N-CoR, BCL6, HP1alpha and SUMO. Histone deacetylases play a role in the regulation of cell cycle, cell differentiation and survival. Class II mammalian HDACs are differentially inhibited by structurally diverse compounds with known antitumor activities, thus presenting them as potential drug targets for human diseases resulting from aberrant acetylation.


Pssm-ID: 212518 [Multi-domain]  Cd Length: 291  Bit Score: 392.63  E-value: 1.08e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGsnqcqlsrpklentlsasfvRLSCGGLGVD 851
Cdd:cd09992    1 HPERPERLLAILEALEEEGLLDRLVFVEPRPATEEELLRVHTPEYIERVE--------------------ETCEAGGGYL 60

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  852 LDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRmPEVRRILI 931
Cdd:cd09992   61 DPDTYVSPGSYEAALLAAGAALAAVDAVLSGEAENAFALVRPPGHHAEPDRAMGFCLFNNVAIAARYAQKR-YGLKRVLI 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  932 VDWDVHHGNGTQQAFYQSPDILYLSIHRHDdgnFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVM 1011
Cdd:cd09992  140 VDWDVHHGNGTQDIFYDDPSVLYFSIHQYP---FYPGTGAAEETGGGAGEGFTINV----PLPPGSGDAEYLAAFEEVLL 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1012 PIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLA----NGKVVLALEGGYDLAAICDSAQECVRAL 1087
Cdd:cd09992  213 PIAREFQPDLVLVSAGFDAHRGD--PLGGMNLTPEGYARLTRLLKELAdehcGGRLVFVLEGGYNLEALAESVLAVLEAL 290


                 .
gi 24641720 1088 L 1088
Cdd:cd09992  291 L 291
Hist_deacetyl pfam00850
Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. ...
 772-1087 2.24e-117

Histone deacetylase domain; Histones can be reversibly acetylated on several lysine residues. Regulation of transcription is caused in part by this mechanism. Histone deacetylases catalyze the removal of the acetyl group. Histone deacetylases are related to other proteins.


Pssm-ID: 425906 [Multi-domain]  Cd Length: 298  Bit Score: 365.79  E-value: 2.24e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720    772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLfgsnqcqlsrpkLENTLSASFVRLSCGGLGVD 851
Cdd:pfam00850    1 HPENPERLKAILEALREAGLLPDLEIIAPRPATEEELLLVHSPEYLEF------------LEEAAPEGGALLLLSYLSGD 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720    852 LDTtWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMpEVRRILI 931
Cdd:pfam00850   69 DDT-PVSPGSYEAALLAAGGTLAAADAVLSGEARNAFALVRPPGHHAERDRASGFCIFNNVAIAAKYLREKY-GLKRVAI 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720    932 VDWDVHHGNGTQQAFYQSPDILYLSIHRHdDGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVM 1011
Cdd:pfam00850  147 VDFDVHHGNGTQEIFYDDPSVLTLSIHQY-PGGFYPGTGFADETGEGKGKGYTLNV----PLPPGTGDAEYLAAFEEILL 221

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24641720   1012 PIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLA---NGKVVLALEGGYDLAAICDSAQECVRAL 1087
Cdd:pfam00850  222 PALEEFQPDLILVSAGFDAHAGD--PLGGLNLTTEGFAEITRILLELAdplCIRVVSVLEGGYNLDALARSATAVLAAL 298
AcuC COG0123
Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites ...
 751-1089 4.43e-103

Acetoin utilization deacetylase AcuC or a related deacetylase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 439893 [Multi-domain]  Cd Length: 308  Bit Score: 327.83  E-value: 4.43e-103
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  751 TGLAYDPLMLKHSCicGDNaqHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH-AMLFgsnqcqlsr 829
Cdd:COG0123    1 TALIYHPDYLLHDL--GPG--HPEPPERLRAILDALEASGLLDDLELVEPPPATEEDLLRVHTPDYvDALR--------- 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  830 pklENTLSASFVRLscgglgvDLDTTWNEHhTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFF 909
Cdd:COG0123   68 ---AASLDGGYGQL-------DPDTPVSPG-TWEAALLAAGGALAAADAVLEGEARNAFALVRPPGHHAERDRAMGFCLF 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  910 NSIAIAAKLLRQRmpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddgNFFPGTGGPTECGSGAGLGFNVNIsw 989
Cdd:COG0123  137 NNAAIAARYLLAK--GLERVAIVDFDVHHGNGTQDIFYDDPDVLTISIHQD---PLYPGTGAADETGEGAGEGSNLNV-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  990 sgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLA---NGKVVLA 1066
Cdd:COG0123  210 --PLPPGTGDAEYLAALEEALLPALEAFKPDLIVVSAGFDAHADD--PLGRLNLTTEGYAWRTRRVLELAdhcGGPVVSV 285

                        330       340
                 ....*....|....*....|...
gi 24641720 1067 LEGGYDLAAICDSAQECVRALLG 1089
Cdd:COG0123  286 LEGGYNLDALARSVAAHLETLLG 308
HDAC10_HDAC6-dom1 cd10002
Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are ...
 766-1123 8.32e-102

Histone deacetylase 6, domain 1 and histone deacetylase 10; Histone deacetylases 6 and 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD) while interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212526 [Multi-domain]  Cd Length: 336  Bit Score: 325.42  E-value: 8.32e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  766 CGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH----AMLFGSNQCQLsrpkleNTLSASFv 841
Cdd:cd10002    1 CNWDSNHIECPERLEAILERLTQDGLLERCVKIPAREAEEDEILLVHSQEYidlvKSTETMEKEEL------ESLCSGY- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  842 rlscgglgvdlDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQ 921
Cdd:cd10002   74 -----------DSVYLCPSTYEAARLAAGSTIELVKAVMAGKIQNGFALIRPPGHHAMRNEANGYCIFNNVAIAAKYAIE 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  922 RMpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGTGGPT--ECGSGAGLGFNVNISWSGALnppLGD 999
Cdd:cd10002  143 KL-GLKRILIVDWDVHHGQGTQQGFYEDPRVLYFSIHRYEHGRFWPHLFESDydYIGVGHGYGFNVNVPLNQTG---LGD 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1000 AEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGhpAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDS 1079
Cdd:cd10002  219 ADYLAIFHHILLPLALEFQPELVLVSAGFDASIG--DPEGEMAVTPAGYAHLTRLLMGLAGGKLLLVLEGGYLLESLAES 296

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....
gi 24641720 1080 AQECVRALLGDPAAPIAKAElerpPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd10002  297 VSMTLRGLLGDPLPPLAPPI----PIRSVLETILNAIAHLSPRW 336
HDAC6-dom1 cd11682
Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes ...
 766-1123 2.33e-82

Histone deacetylase 6, domain 1; Histone deacetylases 6 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC6 is the only histone deacetylase with internal duplication of two catalytic domains which appear to function independently of each other, and also has a C-terminal ubiquitin-binding domain. It is located in the cytoplasm and associates with microtubule motor complex, functioning as the tubulin deacetylase and regulating microtubule-dependent cell motility. Known interaction partners of HDAC6 are alpha tubulin (substrate) and ubiquitin-like modifier FAT10 (also known as Ubiquitin D or UBD).


Pssm-ID: 212545 [Multi-domain]  Cd Length: 337  Bit Score: 272.50  E-value: 2.33e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  766 CGDNAQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQcQLSRPKLEnTLSASFvrlsc 845
Cdd:cd11682    1 CLWDESFPECPERLHAIREKLIQEGLLERCVSVQAREASEEELLLVHSPEYVALMKSTQ-YMTEEELR-TLADTY----- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  846 gglgvdlDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMpE 925
Cdd:cd11682   74 -------DSVYLHPNSYSCACLAVGSVLQLVDKVLGGEIRNGLAIVRPPGHHAQHDKMDGYCMFNNVAIAARYAQQKH-G 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  926 VRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFP--GTGGPTECGSGAGLGFNVNISWSGAlnpPLGDAEYI 1003
Cdd:cd11682  146 VQRVLIVDWDVHHGQGTQFIFEQDPSVLYFSIHRYEQGRFWPhlKESDSSAVGFGRGEGYNINVPWNQV---GMRDADYI 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1004 AAFRTVVMPIARSFNPDIVLVSSGFDAATGHPAplGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQEC 1083
Cdd:cd11682  223 AAFLHVLLPVALEFQPQLVLVAAGFDAVIGDPK--GEMAATPACFAHLTHLLMGLAGGKLILSLEGGYNLRSLAEGVCAS 300

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|
gi 24641720 1084 VRALLGDPAAPIakaELERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd11682  301 LKALLGDPCPML---ESPGAPCRSALASVSCTISALEPFW 337
HDAC cd09301
Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family ...
 778-1087 2.02e-81

Histone deacetylase (HDAC) classes I, II, IV and related proteins; The HDAC/HDAC-like family includes Zn-dependent histone deacetylase classes I, II and IV (class III HDACs, also called sirtuins, are NAD-dependent and structurally unrelated, and therefore not part of this family). Histone deacetylases catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98), as opposed to the acetylation reaction by some histone acetyltransferases (EC 2.3.1.48). Deacetylases of this family are involved in signal transduction through histone and other protein modification, and can repress/activate transcription of a number of different genes. They usually act via the formation of large multiprotein complexes. They are involved in various cellular processes, including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212512 [Multi-domain]  Cd Length: 279  Bit Score: 267.76  E-value: 2.02e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  778 RLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKlentlsasfvrlscGGLGVDLDTTWN 857
Cdd:cd09301    1 RIRDLIEALKELGLRPKIELIECREATEELLLKVHTEEYLNELKANFAVATITE--------------SKPVIFGPNFPV 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  858 EHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRmpEVRRILIVDWDVH 937
Cdd:cd09301   67 QRHYFRGARLSTGGVVEAAELVAKGELERAFAVVGAGGHHAGKSRAWGFCYFNDVVLAIKFLRER--GISRILIIDTDAH 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  938 HGNGTQQAFYQSPDILYLSIHRHDDGNFfpgtggptecGSGAGLGFNVNISWSGAlnppLGDAEYIAAFRTVVMPIARSF 1017
Cdd:cd09301  145 HGDGTREAFYDDDRVLHMSFHNYDIYPF----------GRGKGKGYKINVPLEDG----LGDEEYLDAVERVISKVLEEF 210

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24641720 1018 NPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLANGK-VVLALEGGYDLAAICDSAQECVRAL 1087
Cdd:cd09301  211 EPEVVVLQFGHDTHEGD--RLGGFNLSEKGFVKLAEIVKEFARGGpILMVLGGGYNPEAAARIWTAIIKEL 279
HDAC_classII_1 cd09996
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial ...
 751-1074 3.87e-81

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes bacterial as well as eukaryotic Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Included in this family is a bacterial HDAC-like amidohydrolase (Bordetella/Alcaligenes species FB18817, denoted as FB188 HDAH) shown to be most similar in sequence and function to class II HDAC6 domain 3 or b (HDAC6b). FB188 HDAH is able to remove the acetyl moiety from acetylated histones, and can be inhibited by common HDAC inhibitors such as SAHA (suberoylanilide hydroxamic acid) as well as class II-specific but not class I specific inhibitors.


Pssm-ID: 212521 [Multi-domain]  Cd Length: 359  Bit Score: 269.82  E-value: 3.87e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  751 TGLAYDPLMLKH----------SCICGDNA-QHPEHSGRLQsvwaRLNE----TDLVKRCDRLRARKATQEELQTVHTEA 815
Cdd:cd09996    1 TGFVWDERYLWHdtgtgalflpVGGLLVQPgRHPENPETKR----RIKNllevSGLSDHLVLITPRPATDEELLRVHTPE 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  816 HamlfgsnqcqLSRPKlenTLSASfvrlscGGLGVDLDTTWNeHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPG 895
Cdd:cd09996   77 Y----------IDRVK---AASAA------GGGEAGGGTPFG-PGSYEIALLAAGGAIAAVDAVLDGEVDNAYALVRPPG 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  896 HHAEANLAMGFCFFNSIAIAAKLLRQRMpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRhdDGNFFPGTGGPTEC 975
Cdd:cd09996  137 HHAEPDQGMGFCLFNNVAIAARHALAVG-GVKRVAVVDWDVHHGNGTQAIFYDDPDVLTISLHQ--DRCFPPDSGAVEER 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  976 GSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTREL 1055
Cdd:cd09996  214 GEGAGEGYNLNI----PLPPGSGDGAYLHAFERIVLPALRAFRPELIIVASGFDASAFD--PLGRMMLTSDGFRALTRKL 287

                        330       340
                 ....*....|....*....|...
gi 24641720 1056 LQLAN----GKVVLALEGGYDLA 1074
Cdd:cd09996  288 RDLADelcgGRLVMVHEGGYSEA 310
HDAC10 cd11683
Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that ...
 778-1123 1.41e-77

Histone deacetylase 10; Histone deacetylases 10 are class IIb Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDACs usually act via association with DNA binding proteins to target specific chromatin regions. HDAC10 has an N-terminal deacetylase domain and a C-terminal pseudo-repeat that shares significant similarity with its catalytic domain. It is located in the nucleus and cytoplasm, and is involved in regulation of melanogenesis. It transcriptionally down-regulates thioredoxin-interacting protein (TXNIP), leading to altered reactive oxygen species (ROS) signaling in human gastric cancer cells. Known interaction partners of HDAC10 are Pax3, KAP1, hsc70 and HDAC3 proteins.


Pssm-ID: 212546 [Multi-domain]  Cd Length: 337  Bit Score: 259.41  E-value: 1.41e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  778 RLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLEntLSASFvrlscgglgvdlDTTWN 857
Cdd:cd11683   13 RLTASYERLRQYGLVQRCLRLPAREASEEEILLVHSPEYLSLVRETQVMNKEELMA--ISGKY------------DAVYF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  858 EHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRMpEVRRILIVDWDVH 937
Cdd:cd11683   79 HPNTFHCARLAAGATLQLVDAVLTGEVQNGMALVRPPGHHSQRNAANGFCVFNNVAIAAEYAKKKY-GLHRILIVDWDVH 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  938 HGNGTQQAFYQSPDILYLSIHRHDDGNFFPG--TGGPTECGSGAGLGFNVNISWSGAlnpPLGDAEYIAAFRTVVMPIAR 1015
Cdd:cd11683  158 HGQGIQYIFEEDPSVLYFSWHRYEHQRFWPFlrESDYDAVGRGKGLGFNINLPWNKV---GMGNADYLAAFFHVLLPLAF 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1016 SFNPDIVLVSSGFDAATGHPAplGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVRALLGDPAAPI 1095
Cdd:cd11683  235 EFDPELVLVSAGFDSAIGDPE--GQMCATPECFAHLTHLLMVLAGGKLCAVLEGGYHLESLAESVCMTVQTLLGDPLPRL 312

                        330       340
                 ....*....|....*....|....*...
gi 24641720 1096 AKaelERPPCQNAINTLQKTIAIQQTHW 1123
Cdd:cd11683  313 SG---EMTPCQSALESIQNVRAAQAPYW 337
HDAC_classII_2 cd11599
Histone deacetylases and histone-like deacetylases, classII; This subfamily includes ...
 772-1088 2.76e-76

Histone deacetylases and histone-like deacetylases, classII; This subfamily includes eukaryotic as well as bacterial Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. In D. discoideum, where four homologs (HdaA, HdaB, HdaC, HdaD) have been identified, HDAC activity is important for regulating the timing of gene expression during development. Also, inhibition of HDAC activity by trichostatin A is shown to cause hyperacetylation of the histone and a delay in cell aggregation and differentiation.


Pssm-ID: 212541 [Multi-domain]  Cd Length: 288  Bit Score: 253.59  E-value: 2.76e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAmlfgsnqcqlsrpklentlsaSFVRLSCGGLG-V 850
Cdd:cd11599    1 HPESPERLEAILDALIASGLDRLLRQLEAPPATREQLLRVHDAAYV---------------------DRLEAAAPEEGlV 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  851 DLDT-TWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAKLLRQRmPEVRRI 929
Cdd:cd11599   60 QLDPdTAMSPGSLEAALRAAGAVVAAVDAVMAGEARNAFCAVRPPGHHAERDKAMGFCLFNNVAIAAAHALAH-HGLERV 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  930 LIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddgNFFPGTGGPTECGSGaglgfnvNIswsgaLNPPL----GDAEYIAA 1005
Cdd:cd11599  139 AIVDFDVHHGNGTEDIFRDDPRVLFCSSHQH---PLYPGTGAPDETGHG-------NI-----VNVPLpagtGGAEFREA 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1006 FRTVVMPIARSFNPDIVLVSSGFDAatgHPA-PLGGYHVSPACFGFMTRELLQLAN----GKVVLALEGGYDLAAICDSA 1080
Cdd:cd11599  204 VEDRWLPALDAFKPDLILISAGFDA---HRDdPLAQLNLTEEDYAWITEQLMDVADrycdGRIVSVLEGGYDLSALARSV 280


                 ....*...
gi 24641720 1081 QECVRALL 1088
Cdd:cd11599  281 AAHVRALM 288
HDAC_classII_APAH cd10001
Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine ...
 755-1089 4.96e-70

Histone deacetylase class IIa; This subfamily includes bacterial acetylpolyamine amidohydrolase (APAH) as well as other Class II histone deacetylase (HDAC) and related proteins. Deacetylases of class II are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues of histones (EC 3.5.1.98) and possibly other proteins to yield deacetylated histones/other proteins. Mycoplana ramosa APAH exhibits broad substrate specificity and catalyzes the deacetylation of polyamines such as putrescine, spermidine, and spermine by cleavage of a non-peptide amide bond.


Pssm-ID: 212525 [Multi-domain]  Cd Length: 298  Bit Score: 236.67  E-value: 4.96e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  755 YDPLMLKHS----CICGDNAQHPEHSGRLQSVWARLNETDLVkrcDRLRARKATQEELQTVHTEAHamlfgsnqcqlsrp 830
Cdd:cd10001    4 YSEDHLLHHpkteLSRGKLVPHPENPERAEAILDALKRAGLG---EVLPPRDFGLEPILAVHDPDY-------------- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  831 kLEntlsasFVRlscgglGVDLDTTWNEHhTATAARMAAGCVIDLALKTAKGDlRNGFAVVRPPGHHAEANLAMGFCFFN 910
Cdd:cd10001   67 -VD------FLE------TADTDTPISEG-TWEAALAAADTALTAADLVLEGE-RAAYALCRPPGHHAGRDRAGGFCYFN 131

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  911 SIAIAAKLLRQRMPevrRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRhDDGNFFPGTGG-PTECGSGAGLGFNVNIsw 989
Cdd:cd10001  132 NAAIAAQYLRDRAG---RVAILDVDVHHGNGTQEIFYERPDVLYVSIHG-DPRTFYPFFLGfADETGEGEGEGYNLNL-- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  990 sgalnpPL----GDAEYIAAFRTVVMPIARsFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLaNGKVVL 1065
Cdd:cd10001  206 ------PLppgtGDDDYLAALDEALAAIAA-FGPDALVVSLGFDTHEGD--PLSDFKLTTEDYARIGRRIAAL-GLPTVF 275

                        330       340
                 ....*....|....*....|....
gi 24641720 1066 ALEGGYDLAAIcdsaQECVRALLG 1089
Cdd:cd10001  276 VQEGGYNVDAL----GRNAVAFLA 295
HDAC_AcuC_like cd09994
Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin ...
 753-1073 2.79e-48

Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; AcuC (Acetoin utilization protein) is a class I deacetylase found only in bacteria and is involved in post-translational control of the acetyl-coenzyme A synthetase (AcsA). Deacetylase AcuC works in coordination with deacetylase SrtN (class III), possibly to maintain AcsA in active (deacetylated) form and let the cell grow under low concentration of acetate. B. subtilis AcuC is a member of operon acuABC; this operon is repressed by the presence of glucose and does not show induction by acetoin; acetoin is a bacterial fermentation product that can be converted to acetate via the butanediol cycle in absence of other carbon sources. Inactivation of AcuC leads to slower growth and lower cell yield under low-acetate conditions in Bacillus subtilis. In general, Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212520 [Multi-domain]  Cd Length: 313  Bit Score: 174.67  E-value: 2.79e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  753 LAYDPLMLKHSCicGDNaqHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEA---HAMLFGSNQCQLSR 829
Cdd:cd09994    2 FIYSEEYLRYSF--GPN--HPFNPPRLSLTKDLLRALGLLPPVDLVPPRPATEEELLLFHTPDyieAVKEASRGQEPEGR 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  830 PKLentlsasfvrlscgGLGvDLDTTWNEH-HTAtaARMAAGCVIDLALKTAKGDLRNGFAvvrPPG--HHAEANLAMGF 906
Cdd:cd09994   78 GRL--------------GLG-TEDNPVFPGmHEA--AALVVGGTLLAARLVLEGEARRAFN---PAGglHHAMRGRASGF 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  907 CFFNSIAIAAKLLRQRmpEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRhDDGNFFPGTGGPTECGSGAGLGFNVN 986
Cdd:cd09994  138 CVYNDAAVAIERLRDK--GGLRVAYVDIDAHHGDGVQAAFYDDPRVLTISLHE-SGRYLFPGTGFVDEIGEGEGYGYAVN 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  987 IswsgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLA----NGK 1062
Cdd:cd09994  215 I----PLPPGTGDDEFLRAFEAVVPPLLRAFRPDVIVSQHGADAHAGD--PLTHLNLSNRAYRAAVRRIRELAdeycGGR 288

                        330
                 ....*....|.
gi 24641720 1063 VVLALEGGYDL 1073
Cdd:cd09994  289 WLALGGGGYNP 299
HDAC_classIV cd09993
Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone ...
 782-1078 7.22e-33

Histone deacetylase class IV also known as histone deacetylase 11; Class IV histone deacetylases (HDAC11; EC 3.5.1.98) are predicted Zn-dependent enzymes. This class includes animal HDAC11, plant HDA2 and related bacterial deacetylases. Enzymes in this subfamily participate in regulation of a number of different processes through protein modification (deacetylation). They catalyze hydrolysis of N(6)-acetyl-lysine of histones (or other proteins) to yield a deacetylated proteins. Histone deacetylases often act as members of large multi-protein complexes such as mSin3A or SMRT/N-CoR. Human HDAC11 does not associate with them but can interact with HDAC6 in vivo. It has been suggested that HDAC11 and HDAC6 may use non-histone proteins as their substrates and play a role other than to directly modulate chromatin structure. In normal tissues, expression of HDAC11 is limited to kidney, heart, brain, skeletal muscle and testis, suggesting that its function might be tissue-specific. In mammals, HDAC11 proteins are known to be involved in progression of various tumors. HDAC11 plays an essential role in regulating OX40 ligand (OX40L) expression in Hodgkin lymphoma (HL); selective inhibition of HDAC11 expression significantly up-regulates OX40L and induces apoptosis in HL cell lines. Thus, inhibition of HDAC11 could be a therapeutic drug option for antitumor immune response in HL patients.


Pssm-ID: 212519 [Multi-domain]  Cd Length: 275  Bit Score: 128.77  E-value: 7.22e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  782 VWARLNETDLVKRCDRLRARKATQEELQTVHTEA--HAMLFGSNQCQLSR-------PKLENTlsasfVRLSCGGlgvdl 852
Cdd:cd09993   11 LREALLEEGLVLPEDIVEPEPATREDLLRVHDPEylESLKSGELSREEIRrigfpwsPELVER-----TRLAVGG----- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  853 dttwnehhTATAARMA--AGCVIDLAlktakGdlrnGFavvrppgHHAEANLAMGFCFFNSIAIAAKLLRQRmPEVRRIL 930
Cdd:cd09993   81 --------TILAARLAleHGLAINLA-----G----GT-------HHAFPDRGEGFCVFNDIAIAARVLLAE-GLVRRVL 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  931 IVDWDVHHGNGTQQAFYQSPDILYLSIHrhdDGNFFPGTGGPtecgsgaglgfnvnISWSGALNPPLGDAEYIAAFRTVV 1010
Cdd:cd09993  136 IVDLDVHQGNGTAAIFADDPSVFTFSMH---GEKNYPFRKEP--------------SDLDVPLPDGTGDDEYLAALEEAL 198

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24641720 1011 MPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPAcfGFMTRELLQLANGK-----VVLALEGGY--DLAAICD 1078
Cdd:cd09993  199 PRLLAEFRPDLVFYNAGVDVLAGD--RLGRLSLSLE--GLRERDRLVLRFARargipVAMVLGGGYsrDIARLVA 269
HDAC_classI cd09991
Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes ...
 791-1071 9.69e-33

Class I histone deacetylases; Class I histone deacetylases (HDACs) are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. This group includes animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3, HOS1 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212517 [Multi-domain]  Cd Length: 306  Bit Score: 129.62  E-value: 9.69e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  791 LVKRCDRLRARKATQEELQTVHTEAHaMLFgsnqcqLSRPKLEN--TLSASFVRLscgGLGVD---LDTTWnehhtaTAA 865
Cdd:cd09991   34 LYKKMEIYRPRPATAEELTKFHSDDY-IDF------LRSVSPDNmkEFKKQLERF---NVGEDcpvFDGLY------EYC 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  866 RMAAGCVIDLALKTAKGDlrnGFAVVRPPG--HHAEANLAMGFCFFNSIAIAAKLLRQRMPevrRILIVDWDVHHGNGTQ 943
Cdd:cd09991   98 QLYAGGSIAAAVKLNRGQ---ADIAINWAGglHHAKKSEASGFCYVNDIVLAILELLKYHQ---RVLYIDIDIHHGDGVE 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  944 QAFYQSPDILYLSIHRHddGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVL 1023
Cdd:cd09991  172 EAFYTTDRVMTVSFHKF--GEYFFPGTGLRDIGAGKGKYYAVNV----PLKDGIDDESYLQIFEPVLSKVMEVFQPSAVV 245

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 24641720 1024 VSSGFDAATGHpaPLGGYHVSP----ACFGFMTRellqlANGKVVLALEGGY 1071
Cdd:cd09991  246 LQCGADSLAGD--RLGCFNLSIkghaKCVKFVKS-----FNIPLLVLGGGGY 290
HDAC8 cd10000
Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that ...
 791-1077 7.17e-31

Histone deacetylase 8 (HDAC8); HDAC8 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. HDAC8 is found in human cytoskeleton-bound protein fraction and insoluble cell pellets. It plays a crucial role in intramembraneous bone formation; germline deletion of HDAC8 is detrimental to skull bone formation. HDAC8 is possibly associated with the smooth muscle actin cytockeleton and may regulate the contractive capacity of smooth muscle cells. HDAC8 is also involved in the metabolic control of the estrogen receptor related receptor (ERR)-alpha/peroxisome proliferator activated receptor (PPAR) gamma coactivator 1 alpha (PGC1-alpha) transcriptional complex as well as in the development of neuroblastoma and T-cell lymphoma. HDAC8-selective small-molecule inhibitors could be a therapeutic drug option for these diseases.


Pssm-ID: 212524 [Multi-domain]  Cd Length: 364  Bit Score: 125.53  E-value: 7.17e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  791 LVKRCDRLRARKATQEELQTVHTEAHaMLFGSNQCQLSRPKLENTLSASFvrlscgGLGvdLDTTWNEHhTATAARMAAG 870
Cdd:cd10000   35 LLKQLRVVKPRVATEEELASFHSDEY-IQFLKKASNEGDNDEEPSEQQEF------GLG--YDCPIFEG-IYDYAAAVAG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  871 CVIDLALKTAKGDLRngFAVVRPPG-HHAEANLAMGFCFFNSIAIAAKLLRQRMpevRRILIVDWDVHHGNGTQQAFYQS 949
Cdd:cd10000  105 ATLTAAQLLIDGKCK--VAINWFGGwHHAQRDEASGFCYVNDIVLGILKLREKF---DRVLYVDLDLHHGDGVEDAFSFT 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  950 PDILYLSIHRHDDGnFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFD 1029
Cdd:cd10000  180 SKVMTVSLHKYSPG-FFPGTGDVSDVGLGKGKYYTVNV----PLRDGIQDEQYLQIFTAVVPEIVAAFRPEAVVLQCGAD 254

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 24641720 1030 AATGHpaPLGGYHVSPACFGFMTRELLQLANGKVVLAlEGGYDLA--AIC 1077
Cdd:cd10000  255 TLAGD--PMGAFNLTPVGIGKCLKYVLGWKLPTLILG-GGGYNLAntARC 301
HDAC_Hos1 cd11680
Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is ...
 773-1077 8.95e-29

Class I histone deacetylases Hos1 and related proteins; Saccharomyces cerevisiae Hos1 is responsible for Smc3 deacetylation. Smc3 is an important player during the establishment of sister chromatid cohesion. Hos1 belongs to the class I histone deacetylases (HDACs). HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98). Enzymes belonging to this group participate in regulation of a number of processes through protein (mostly different histones) modification (deacetylation). Class I histone deacetylases in general act via the formation of large multiprotein complexes. Other class I HDACs are animal HDAC1, HDAC2, HDAC3, HDAC8, fungal RPD3 and HOS2, plant HDA9, protist, archaeal and bacterial (AcuC) deacetylases. Members of this class are involved in cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and in posttranslational control of the acetyl coenzyme A synthetase.


Pssm-ID: 212543 [Multi-domain]  Cd Length: 294  Bit Score: 117.75  E-value: 8.95e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  773 PEHSGRLQSVWARLNETDLVKRCDR-LRARKATQEELQTVHTEahamlfgsnqcqlsrpklentlsaSFVRLSCGGLGVD 851
Cdd:cd11680   16 PSNKGRSSLVHSLIRAYGLLQHFDEiIEPERATRKDLTKYHDK------------------------DYVDFLLKKYGLE 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  852 LDTTW----NEHhtataARMAAGCVIDLAlKTAKGDLRNGFAVVRPPG-HHAEANLAMGFCFFNSIAIAAKLLRQRmpEV 926
Cdd:cd11680   72 DDCPVfpflSMY-----VQLVAGSSLALA-KHLITQVERDIAINWYGGrHHAQKSRASGFCYVNDIVLAILRLRRA--RF 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  927 RRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGnFFPGTGGPTECGSgaglGFNVNIswsgALNPPLGDAEYIAAF 1006
Cdd:cd11680  144 RRVFYLDLDLHHGDGVESAFFFSKNVLTCSIHRYDPG-FFPGTGSLKNSSD----KGMLNI----PLKRGLSDKTLLRII 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24641720 1007 RTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVSPACFGFMTRELLQLANGKVVLAL-EGGYD--LAAIC 1077
Cdd:cd11680  215 DSIVRPLIEKFEPEVIVIQCGCDGLSGD--PHKEWNLTIRGYGSVIELLLKEFKDKPTLLLgGGGYNhtEAARA 286
HDAC_Hos2 cd11598
Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I ...
 772-1050 4.61e-28

Class I histone deacetylases including ScHos2 and SpPhd1; This subfamily includes Class I histone deacetylase (HDAC) Hos2 from Saccharomyces cerevisiae as well as a histone deacetylase Phd1 from Schizosaccharomyces pombe. Hos2 binds to the coding regions of genes during gene activation, specifically it deacetylates the lysines in H3 and H4 histone tails. It is preferentially associated with genes of high activity genome-wide and is shown to be necessary for efficient transcription. Thus, Hos2 is directly required for gene activation in contrast to other class I histone deacetylases. Protein encoded by phd1 is inhibited by trichostatin A (TSA), a specific inhibitor of histone deacetylase, and is involved in the meiotic cell cycle in S. pombe. Class 1 HDACs are Zn-dependent enzymes that catalyze hydrolysis of N(6)-acetyl-lysine residues in histone amino termini to yield a deacetylated histone (EC 3.5.1.98).


Pssm-ID: 212540 [Multi-domain]  Cd Length: 311  Bit Score: 116.02  E-value: 4.61e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAH----AMLFGSNQCQLSRPKLENTlsasfvrlscgG 847
Cdd:cd11598   18 HPMKPFRLTLTKHLVMGYGLHKAMDTYEARAATREELRQFHDADYldflSKVSPENANQLRFDKAEPF-----------N 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  848 LGVDLDTTwneHHTATAARMAAGCVIDLALKTAKGdlRNGFAVVRPPG-HHAEANLAMGFCFFNSIAIAAKLLRQRMPev 926
Cdd:cd11598   87 IGDDCPVF---DGMYDYCQLYAGASLDAARKLCSG--QSDIAINWSGGlHHAKKSEASGFCYVNDIVLAILNLLRYFP-- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  927 rRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHdDGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAF 1006
Cdd:cd11598  160 -RVLYIDIDVHHGDGVEEAFYRTDRVMTLSFHKY-NGEFFPGTGDLDDNGGTPGKHFALNV----PLEDGIDDEQYNLLF 233

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 24641720 1007 RTVVMPIARSFNPDIVLVSSGFDAATGHpaPLGGYHVS----PACFGF 1050
Cdd:cd11598  234 KSIIGPTIEKFQPSAIVLQCGADSLGGD--RLGQFNLNikahGACVKF 279
Arginase_HDAC cd09987
Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily ...
 860-1087 2.28e-21

Arginase-like and histone-like hydrolases; Arginase-like/histone-like hydrolase superfamily includes metal-dependent enzymes that belong to Arginase-like amidino hydrolase family and histone/histone-like deacetylase class I, II, IV family, respectively. These enzymes catalyze hydrolysis of amide bond. Arginases are known to be involved in control of cellular levels of arginine and ornithine, in histidine and arginine degradation and in clavulanic acid biosynthesis. Deacetylases play a role in signal transduction through histone and/or other protein modification and can repress/activate transcription of a number of different genes. They participate in different cellular processes including cell cycle regulation, DNA damage response, embryonic development, cytokine signaling important for immune response and post-translational control of the acetyl coenzyme A synthetase. Mammalian histone deacetyases are known to be involved in progression of different tumors. Specific inhibitors of mammalian histone deacetylases are an emerging class of promising novel anticancer drugs.


Pssm-ID: 212513  Cd Length: 217  Bit Score: 93.98  E-value: 2.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  860 HTATAARMAAGCVIDLAlktakGDLRNGFAVVrppGHHAEANlamgfcffnSIAIAAKLLRQRmpevrrILIVDWDVHHG 939
Cdd:cd09987    6 RKAEAHELLAGVVVAVL-----KDGKVPVVLG---GDHSIAN---------GAIRAVAELHPD------LGVIDVDAHHD 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  940 NGTQQAFY--------------QSPDILYLSIHRHDDGNFFPGtggptecGSGAGLGFNVNISWSGalnppLGDAEYIAA 1005
Cdd:cd09987   63 VRTPEAFGkgnhhtprhllcepLISDVHIVSIGIRGVSNGEAG-------GAYARKLGVVYFSMTE-----VDKLGLGDV 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1006 FRTVVMPIarSFNPDIVLVSSGFDAATGHPAPLGGyhvSPACFGFMTRELLQL------ANGKVVLALEGGYDLA----A 1075
Cdd:cd09987  131 FEEIVSYL--GDKGDNVYLSVDVDGLDPSFAPGTG---TPGPGGLSYREGLYIteriakTNLVVGLDIVEVNPLLdetgR 205

                        250
                 ....*....|..
gi 24641720 1076 ICDSAQECVRAL 1087
Cdd:cd09987  206 TARLAAALTLEL 217
HDAC1 cd10010
Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme ...
 772-1033 4.69e-21

Histone deacetylase 1 (HDAC1); Histone deacetylase 1 (HDAC1) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC1 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. In particular, HDAC1 appears to play a major role in pre-implantation embryogenesis in establishing a repressive chromatin state. Its interaction with retinoblastoma tumor-suppressor protein is essential in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 (MTA2), it deacetylates p53, thereby modulating its effect on cell growth and apoptosis. It participates in DNA-damage response, along with HDAC2; together, they promote DNA non-homologous end-joining. HDAC1 is also involved in tumorogenesis; its overexpression modulates cancer progression. Specific inhibitors of HDAC1 are currently used in cancer therapy.


Pssm-ID: 212534 [Multi-domain]  Cd Length: 371  Bit Score: 96.67  E-value: 4.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSnqcqlSRPKLENTLSASFVRLSCGGLGVD 851
Cdd:cd10010   25 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRS-----IRPDNMSEYSKQMQRFNVGEDCPV 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  852 LDTTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFavvrppgHHAEANLAMGFCFFNSIAIAA-KLLRQRmpevRRIL 930
Cdd:cd10010  100 FDGLFEFCQLSAGGSVASAVKLNKQQTDIAVNWAGGL-------HHAKKSEASGFCYVNDIVLAIlELLKYH----QRVL 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  931 IVDWDVHHGNGTQQAFYQSPDILYLSIHRHddGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVV 1010
Cdd:cd10010  169 YIDIDIHHGDGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNY----PLRDGIDDESYEAIFKPVM 242

                        250       260
                 ....*....|....*....|...
gi 24641720 1011 MPIARSFNPDIVLVSSGFDAATG 1033
Cdd:cd10010  243 SKVMEMFQPSAVVLQCGADSLSG 265
RPD3-like cd10004
reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I ...
 770-1033 1.37e-20

reduced potassium dependency-3 (RPD3)-like; Proteins of the Rpd3-like family are class I Zn-dependent Histone deacetylases that catalyze hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). RPD3 is the yeast homolog of class I HDACs. The main function of RPD3-like group members is regulation of a number of different processes through protein (mostly different histones) modification (deacetylation). This group includes fungal RPD3 and acts via the formation of large multiprotein complexes. Members of this group are involved in cell cycle regulation, DNA damage response, embryonic development and cytokine signaling important for immune response. Histone deacetylation by yeast RPD3 represses genes regulated by the Ash1 and Ume6 DNA-binding proteins. In mammals, they are known to be involved in progression of various tumors. Specific inhibitors of mammalian histone deacetylases could be a therapeutic drug option.


Pssm-ID: 212528 [Multi-domain]  Cd Length: 375  Bit Score: 95.26  E-value: 1.37e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  770 AQHPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFG----SNQCQLSRPKLENTLSA------- 838
Cdd:cd10004   19 PGHPMKPHRIRMAHSLVMNYGLYKKMEIYRAKPATKNEMTQFHTDEYIDFLSrvtpDNMEKFQKEQVKYNVGDdcpvfdg 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  839 --SFVRLSCGGlgvdldttwnehHTATAARMAAG-CviDLALKTAKGDlrngfavvrppgHHAEANLAMGFCFFNSIAIA 915
Cdd:cd10004   99 lfEFCSISAGG------------SMEGAARLNRGkC--DIAVNWAGGL------------HHAKKSEASGFCYVNDIVLG 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  916 A-KLLRQRmpevRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddGNFFPGTGGPTECGSGAGLGFNVNIswsgALN 994
Cdd:cd10004  153 IlELLRYH----QRVLYIDIDVHHGDGVEEAFYTTDRVMTCSFHKY--GEYFPGTGELRDIGIGTGKNYAVNV----PLR 222

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 24641720  995 PPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATG 1033
Cdd:cd10004  223 DGIDDESYKSIFEPVIKHVMEWYQPEAVVLQCGGDSLSG 261
PTZ00063 PTZ00063
histone deacetylase; Provisional
 772-1033 2.01e-20

histone deacetylase; Provisional


Pssm-ID: 240251  Cd Length: 436  Bit Score: 95.65  E-value: 2.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGS---NQC-----QLSRPKL-ENTLSASFVR 842
Cdd:PTZ00063   23 HPMKPQRIRMAHALILSYDLYKHMEIYRPHKSVEPELVLFHDEEYVDFLSSispENYrdftyQLKRFNVgEATDCPVFDG 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   843 L-----SCGGLGVDLDTTWNEHHTATAARMAAGCvidlalktakgdlrngfavvrppgHHAEANLAMGFCFFNSIAIAA- 916
Cdd:PTZ00063  103 LfefqqSCAGASIDGAYKLNNHQADICVNWSGGL------------------------HHAKRSEASGFCYINDIVLGIl 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   917 KLLRQRMpevrRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddGNFFPGTGGPTECGSGAGLGFNVNIswsgALNPP 996
Cdd:PTZ00063  159 ELLKYHA----RVMYIDIDVHHGDGVEEAFYVTHRVMTVSFHKF--GDFFPGTGDVTDIGVAQGKYYSVNV----PLNDG 228

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 24641720   997 LGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATG 1033
Cdd:PTZ00063  229 IDDDSFVDLFKPVISKCVEVYRPGAIVLQCGADSLTG 265
HDAC_Hos3 cd09998
Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from ...
 873-1080 8.24e-19

Class II histone deacetylases Hos3 and related proteins; Fungal histone deacetylase Hos3 from Saccharomyces cerevisiae is a Zn-dependent enzyme belonging to HDAC class II. It catalyzes hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. Histone deacetylases usually act via association with DNA binding proteins to target specific chromatin regions. Hos3 deacetylase is homodimer, in vitro it shows specificity to H4, H3 and H2A.


Pssm-ID: 212522 [Multi-domain]  Cd Length: 353  Bit Score: 89.43  E-value: 8.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  873 IDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNSIAIAAK--LLRQrmpEVRRILIVDWDVHHGNGTQ------- 943
Cdd:cd09998   97 VDSVFKPESPGTKRAFVAIRPPGHHCSESTPSGFCWVNNVHVGAAhaYLTH---GITRVVILDIDLHHGNGTQdiawrin 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  944 -----------------QAFYQSPDILYLSIHrhdDGNFFPGTGGPTECGSGAglgfNVNIS-------WSGALNPPLGD 999
Cdd:cd09998  174 aeankqalesssyddfkPAGAPGLRIFYSSLH---DINSFPCEDGDPAKVKDA----SVSIDgahgqwiWNVHLQPWTTE 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720 1000 AEYIAAFR---TVVMPIARSF-------NPD--IVLVSSGFDAATGHPAPLG--GYHVSPACFGFMTRELLQLA----NG 1061
Cdd:cd09998  247 EDFWELYYpkyRILFEKAAEFlrlttaaTPFktLVFISAGFDASEHEYESMQrhGVNVPTSFYYRFARDAVRFAdahaHG 326

                        250
                 ....*....|....*....
gi 24641720 1062 KVVLALEGGYDLAAICDSA 1080
Cdd:cd09998  327 RLISVLEGGYSDRALCSGV 345
HDAC3 cd10005
Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that ...
 896-1030 9.18e-18

Histone deacetylase 3 (HDAC3); HDAC3 is a Zn-dependent class I histone deacetylase that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. In order to target specific chromatin regions, HDAC3 can interact with DNA-binding proteins (transcriptional factors) either directly or after forming complexes with a number of other proteins, as observed for the SMPT/N-CoR complex which recruits human HDAC3 to specific chromatin loci and activates deacetylation. Human HDAC3 is also involved in deacetylation of non-histone substrates such as RelA, SPY and p53 factors. This protein can also down-regulate p53 function and subsequently modulate cell growth and apoptosis. This gene is therefore regarded as a potential tumor suppressor gene. HDAC3 plays a role in various physiological processes, including subcellular protein localization, cell cycle progression, cell differentiation, apoptosis and survival. HDAC3 has been found to be overexpressed in some tumors including leukemia, lung carcinoma, colon cancer and maxillary carcinoma. Thus, inhibitors precisely targeting HDAC3 (in some cases together with retinoic acid or hyperthermia) could be a therapeutic drug option.


Pssm-ID: 212529  Cd Length: 381  Bit Score: 86.68  E-value: 9.18e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  896 HHAEANLAMGFCFFNSIAIAAKLLRQRMPevrRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHddGN-FFPGTGGPTE 974
Cdd:cd10005  132 HHAKKFEASGFCYVNDIVIAILELLKYHP---RVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKY--GNyFFPGTGDMYE 206

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 24641720  975 CGSGAGLGFNVNIswsgALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDA 1030
Cdd:cd10005  207 VGAESGRYYSVNV----PLKDGIDDQSYLQLFKPVIQQVIDFYQPTCIVLQCGADS 258
HDAC2 cd10011
Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme ...
 772-1033 3.94e-17

Histone deacetylase 2 (HDAC2); Histone deacetylase 2 (HDAC2) is a Zn-dependent class I enzyme that catalyzes hydrolysis of N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (EC 3.5.1.98). Histone acetylation/deacetylation process is important for mediation of transcriptional regulation of many genes. HDAC2 is involved in regulation through association with DNA binding proteins to target specific chromatin regions. It forms transcriptional repressor complexes by associating with several proteins, including the mammalian zinc-finger transcription factor YY1, thus playing an important role in transcriptional regulation, cell cycle progression and developmental events. Additionally, a few non-histone HDAC2 substrates have been found. HDAC2 plays a role in embryonic development and cytokine signaling important for immune response, and is over-expressed in several solid tumors including oral, prostate, ovarian, endometrial and gastric cancer. It participates in DNA-damage response, along with HDAC1; together, they can promote DNA non-homologous end-joining. HDAC2 is considered an important cancer prognostic marker. Inhibitors specifically targeting HDAC2 could be a therapeutic drug option.


Pssm-ID: 212535 [Multi-domain]  Cd Length: 366  Bit Score: 84.73  E-value: 3.94e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  772 HPEHSGRLQSVWARLNETDLVKRCDRLRARKATQEELQTVHTEAHAMLFGSnqcqlSRPKLENTLSASFVRLSCGGLGVD 851
Cdd:cd10011   21 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRS-----IRPDNMSEYSKQMQRFNVGEDCPV 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  852 LDTTWNEHHTATAARMAAGCVI-----DLALKTAKGDlrngfavvrppgHHAEANLAMGFCFFNSIAIAA-KLLRQRmpe 925
Cdd:cd10011   96 FDGLFEFCQLSTGGSVAGAVKLnrqqtDMAVNWAGGL------------HHAKKSEASGFCYVNDIVLAIlELLKYH--- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720  926 vRRILIVDWDVHHGNGTQQAFYQSPDILYLSihRHDDGNFFPGTGGPTECGSGAGLGFNVNISWSGALNpplgDAEYIAA 1005
Cdd:cd10011  161 -QRVLYIDIDIHHGDGVEEAFYTTDRVMTVS--FHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----DESYGQI 233

                        250       260
                 ....*....|....*....|....*...
gi 24641720 1006 FRTVVMPIARSFNPDIVLVSSGFDAATG 1033
Cdd:cd10011  234 FKPIISKVMEMYQPSAVVLQCGADSLSG 261
PTZ00346 PTZ00346
histone deacetylase; Provisional
 806-1033 1.83e-16

histone deacetylase; Provisional


Pssm-ID: 240374 [Multi-domain]  Cd Length: 429  Bit Score: 83.54  E-value: 1.83e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   806 EELQTVHTEAHAMLFGSNQCqlsRPKLENT-LSASFVRLSCGGLgvdldTTWNEHHTATAARMAAGCVIdlaLKTAKGDL 884
Cdd:PTZ00346   77 EELMAYHTDTYLANLGLHSC---RSWLWNAeTSKVFFSGDCPPV-----EGLMEHSIATASGTLMGAVL---LNSGQVDV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641720   885 rngfAVVRPPG-HHAEANLAMGFCFFNSIAIAA-KLLRQRmpevRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDD 962
Cdd:PTZ00346  146 ----AVHWGGGmHHSKCGECSGFCYVNDIVLGIlELLKCH----DRVLYVDIDMHHGDGVDEAFCTSDRVFTLSLHKFGE 217

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24641720   963 gNFFPGTGGPTECGSGAGLGFNVNIS-WSGalnppLGDAEYIAAFRTVVMPIARSFNPDIVLVSSGFDAATG 1033
Cdd:PTZ00346  218 -SFFPGTGHPRDVGYGRGRYYSMNLAvWDG-----ITDFYYLGLFEHALHSIVRRYSPDAIVLQCGADSLAG 283
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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