F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 665393162 239 FERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTR 281
Cdd:cd22149    1 FERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 665393162 239 FERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTR 281
Cdd:cd22149    1 FERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 309 QTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLtLLSHCRQLKKISLE-NIELDDDICAEIAKN------------- 374
Cdd:cd09293   11 LGQITQSNISQLLRILHSGLEWLELYMCPISDPPLD-QLSNCNKLKKLILPgSKLIDDEGLIALAQScpnlqvldlrace 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 375 --------------EALEAVNL---TMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHISPNLIRLNIAGC 437
Cdd:cd09293   90 nitdsgivalatncPKLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGCDVTDKGVWELASGCSKSLERLSLNNC 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 665393162 438 RRvLFDSHVATL--QKRCPQLLELDLSDCNSLTPtvITAIMKFKM 480
Cdd:cd09293  170 RN-LTDQSIPAIlaSNYFPNLSVLEFRGCPLITD--FSRIILFKL 211

Leucine-rich repeat (LRR) protein [Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 326 TRLQYLDLSmasitrssLLTLLSHCRQLKKISLENIELDDdICAEIAKNEALEAVNLTmASGLTSNSVRLmmESLTSLSS 405
Cdd:COG4886   96 TNLTELDLS--------GNEELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLS-NNQLTDLPEPL--GNLTNLKS 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 406 LNISWTDLS--ADAVTALvthisPNLIRLNiagcrrvLFDSHVATLQK---RCPQLLELDLSDcNSLTpTVITAIMKFKM 480
Cdd:COG4886  164 LDLSNNQLTdlPEELGNL-----TNLKELD-------LSNNQITDLPEplgNLTNLEELDLSG-NQLT-DLPEPLANLTN 229

                        170       180       190
                 ....*....|....*....|....*....|...
gi 665393162 481 LEYLSVSRCYLipaTKFIELKSMPSLTYLDIFG 513
Cdd:COG4886  230 LETLDLSNNQL---TDLPELGNLTNLEELDLSN 259

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 665393162 239 FERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTR 281
Cdd:cd22149    1 FERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESLWRR 43

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 665393162 240 ERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRL 282
Cdd:cd22091    2 EELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPELWKRL 44

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 309 QTSIQEPAFAPYTEVFRTRLQYLDLSMASITRSSLLtLLSHCRQLKKISLE-NIELDDDICAEIAKN------------- 374
Cdd:cd09293   11 LGQITQSNISQLLRILHSGLEWLELYMCPISDPPLD-QLSNCNKLKKLILPgSKLIDDEGLIALAQScpnlqvldlrace 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 375 --------------EALEAVNL---TMASGLTSNSVRLMMESLTSLSSLNISWTDLSADAVTALVTHISPNLIRLNIAGC 437
Cdd:cd09293   90 nitdsgivalatncPKLQTINLgrhRNGHLITDVSLSALGKNCTFLQTVGFAGCDVTDKGVWELASGCSKSLERLSLNNC 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 665393162 438 RRvLFDSHVATL--QKRCPQLLELDLSDCNSLTPtvITAIMKFKM 480
Cdd:cd09293  170 RN-LTDQSIPAIlaSNYFPNLSVLEFRGCPLITD--FSRIILFKL 211

F-box domain found in F-box/LRR-repeat protein 7 (FBXL7) and similar proteins; FBXL7, also called F-box and leucine-rich repeat protein 7, or F-box protein FBL6/FBL7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of Aurora kinase A (AURKA) during mitosis, causing mitotic arrest. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 665393162 239 FERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRL 282
Cdd:cd22120    1 FDRLPDDVILQIFSHLPTNQLCRCARVCRRWYNLAWDPRLWTTI 44

F-box domain found in F-box/LRR-repeat protein 1 (FBXL1) and similar proteins; FBXL1, also called S-phase kinase-associated protein 2, cyclin-A/CDK2-associated protein p45, F-box protein Skp2, or p45skp2, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. It specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 665393162 239 FERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLW 279
Cdd:cd22114    1 WDSLPDELLLGIFSCLCLPDLLKVSQVCKRWYRLASDESLW 41

A Receptor for Ubiquitination Targets;

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 665393162   242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLW 279
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFW 38

Leucine-rich repeat (LRR) protein [Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 326 TRLQYLDLSmasitrssLLTLLSHCRQLKKISLENIELDDdICAEIAKNEALEAVNLTmASGLTSNSVRLmmESLTSLSS 405
Cdd:COG4886   96 TNLTELDLS--------GNEELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLS-NNQLTDLPEPL--GNLTNLKS 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393162 406 LNISWTDLS--ADAVTALvthisPNLIRLNiagcrrvLFDSHVATLQK---RCPQLLELDLSDcNSLTpTVITAIMKFKM 480
Cdd:COG4886  164 LDLSNNQLTdlPEELGNL-----TNLKELD-------LSNNQITDLPEplgNLTNLEELDLSG-NQLT-DLPEPLANLTN 229

                        170       180       190
                 ....*....|....*....|....*....|...
gi 665393162 481 LEYLSVSRCYLipaTKFIELKSMPSLTYLDIFG 513
Cdd:COG4886  230 LETLDLSNNQL---TDLPELGNLTNLEELDLSN 259

F-box domain found in F-box only protein 41 (FBXO41) and similar proteins; FBXO41, also called FBX41, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a novel central nervous system (CNS)-specific F-box protein that localizes to the centrosome and the cytoplasm of neurons and promotes neuronal migration. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 665393162 239 FERL-SDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRL 282
Cdd:cd22109    2 LESLrRRDALFCVFSYLDTKSLLRCAEVCREWRDVSRHPALWQRV 46

F-box domain found in the JmjC domain-containing histone demethylation protein (JHDM) family; The JHDM family includes F-box/LRR-repeat proteins FBXL10, FBXL11 and FBXL19. FBXL10 is also called lysine-specific demethylase 2B (KDM2B), CXXC-type zinc finger protein 2 (CXXC2), F-box and leucine-rich repeat protein 10 (FBL10), JmjC domain-containing histone demethylation protein 1B (JHDM1B), Jumonji domain-containing EMSY-interactor methyltransferase motif protein, protein JEMMA, protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, or NDY1. It is a histone demethylase that catalyzes the demethylation of H3K4me3 and H3K36me2, thereby playing a central role in the histone code. It preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. FBXL10 may also serve as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. FBXL11, also called KDM2A, CXXC8, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, JmjC domain-containing histone demethylation protein 1A (JHDM1A), or [Histone-H3]-lysine-36 demethylase 1A, is a histone H3 lysine 36 (H3K36) demethylase that regulates epithelial mesenchymal transition (EMT) and the metastasis of ovarian cancer. It plays an essential role in embryonic development and homeostasis by regulating cell proliferation and survival. FBXL11 may also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. It associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. It is required to sustain centromeric integrity and genomic stability, particularly during mitosis. FBXL19, also called F-box and leucine-rich repeat protein 19, is the substrate-recognition component of an SCF-type E3 ubiquitin ligase complex. It acts as a CpG island-binding protein in mouse embryonic stem (ES) cells and has been shown to associate with the CDK-Mediator complex. It promotes H2Bub1 at the promoters of CpG island-containing genes by interacting with RNF20. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 665393162 242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTR 281
Cdd:cd22122    4 LPREVWLPVFQYLSPKDLCVCMRVCKTWNRWCCDPSLWKR 43

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665393162 239 FERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRLDL 284
Cdd:cd22117    1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLLWKELNL 46

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 665393162 238 YFERLSDEILLDIFKWLPKKTLLRMATVCRRFNR-CSRDeTLWTRL 282
Cdd:cd20090    1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRlISRD-AVWRRI 45

F-box domain found in F-box only protein 9 (FBXO9) and similar proteins; FBXO9, also called FBX9, cross-immune reaction antigen 1, renal carcinoma antigen NY-REN-57, or VCIA1, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. FBXO9 acts as an E3 ubiquitin ligase that regulates the stability and activity of peroxisome proliferator-activated receptor gamma (PPARgamma) through ubiquitination. It is also required for adipocyte differentiation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 665393162 241 RLSDEILLDIFKWLPK----KTLLRMATVCRRFNRCSRDETLW 279
Cdd:cd22089    5 ALPSEILLYILRWVVSdldlRSLEQLSLVCRKFYLLARDPSIW 47

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 665393162 242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTR 281
Cdd:cd22102    4 LPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTDTIWQR 43

F-box domain found in Arabidopsis thaliana F-box/WD-40 repeat-containing protein 1 (AtFBW1) and similar proteins; AtFBW1, also called WD-40-associated F-box protein 1, is an F-box protein that contains four WD-40 repeats, which are separated from each other by a spacer region. Like other F-box proteins, AtFBW1 may be a component of SCF (Skp1 Cdc53 F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. This subfamily also contains many F-box only proteins that do not have any WD repeat. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 665393162 242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRD 275
Cdd:cd22157    3 LPDDLVEEILSRLPAKSLLRFRCVCKQWNSLISS 36

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 665393162 242 LSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRL 282
Cdd:cd22098    5 LPPEILDRIISFLPVKDIVSLGQTCRYFHEVCNSEAVWRRL 45

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 22 (AtSKIP22) and similar proteins; AtSKIP22, also called F-box protein SKIP22, is a component of SCF (SKP1/ASK-cullin-F-box protein) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 665393162 238 YFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTR 281
Cdd:cd22165    1 CLMRLPTELKLKILELLPGVDLARMACVCSELRFLASNDDLWKQ 44