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Conserved domains on  [gi|24645899|ref|NP_731558|]
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uncharacterized protein Dmel_CG31441, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 7-81 5.57e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 55.16  E-value: 5.57e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24645899     7 ICRTCGKNVTNLQGratkLFN--KSNYHFISILENITDMYLEFDTTLPHLICQCCKVQLDRILTFRNKCLEVHKSFM 81
Cdd:pfam07776   1 VCRLCLDESDELIP----IFDpsDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQ 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-290 1.87e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|..
gi 24645899   269 HERTHTNERPFQCQHCDKAFTS 290
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
174-337 8.42e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 8.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645899 174 SIISKGVSARVPKRTKRNSKSWF-CDQCGGVFKSSTYLKLHLQrhSGHKPFACDI--CQAKYYTDNEMRRHRILHTDARP 250
Cdd:COG5048 274 SPNESDSSSEKGFSLPIKSKQCNiSFSRSSPLTRHLRSVNHSG--ESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645899 251 YACRF--CSKTYRGCSSKVVHERTH-----TNERPFQCQH--CDKAFTSTSTRQKHEMLHTNQRKYHCEicdqWFLRSSH 321
Cdd:COG5048 352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCK----NPPCSKS 427

                       170
                ....*....|....*.
gi 24645899 322 LTLHQSTKLHQRRAES 337
Cdd:COG5048 428 FNRHYNLIPHKKIHTN 443
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 7-81 5.57e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 55.16  E-value: 5.57e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24645899     7 ICRTCGKNVTNLQGratkLFN--KSNYHFISILENITDMYLEFDTTLPHLICQCCKVQLDRILTFRNKCLEVHKSFM 81
Cdd:pfam07776   1 VCRLCLDESDELIP----IFDpsDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQ 73
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 7-82 2.62e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 44.43  E-value: 2.62e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24645899      7 ICRTCGKNVTNLQGratkLFNKSNYHFIS-ILENITDMYLEFDTTLPHLICQCCKVQLDRILTFRNKCLEVHKSFMA 82
Cdd:smart00868   1 VCRLCLSESENLVS----IFDESSEASLAeKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-290 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|..
gi 24645899   269 HERTHTNERPFQCQHCDKAFTS 290
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-337 8.42e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 8.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645899 174 SIISKGVSARVPKRTKRNSKSWF-CDQCGGVFKSSTYLKLHLQrhSGHKPFACDI--CQAKYYTDNEMRRHRILHTDARP 250
Cdd:COG5048 274 SPNESDSSSEKGFSLPIKSKQCNiSFSRSSPLTRHLRSVNHSG--ESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645899 251 YACRF--CSKTYRGCSSKVVHERTH-----TNERPFQCQH--CDKAFTSTSTRQKHEMLHTNQRKYHCEicdqWFLRSSH 321
Cdd:COG5048 352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCK----NPPCSKS 427

                       170
                ....*....|....*.
gi 24645899 322 LTLHQSTKLHQRRAES 337
Cdd:COG5048 428 FNRHYNLIPHKKIHTN 443
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 7-81 5.57e-10

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 55.16  E-value: 5.57e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24645899     7 ICRTCGKNVTNLQGratkLFN--KSNYHFISILENITDMYLEFDTTLPHLICQCCKVQLDRILTFRNKCLEVHKSFM 81
Cdd:pfam07776   1 VCRLCLDESDELIP----IFDpsDSEKTLAEILEDCTGIELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQ 73
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 7-82 2.62e-06

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 44.43  E-value: 2.62e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24645899      7 ICRTCGKNVTNLQGratkLFNKSNYHFIS-ILENITDMYLEFDTTLPHLICQCCKVQLDRILTFRNKCLEVHKSFMA 82
Cdd:smart00868   1 VCRLCLSESENLVS----IFDESSEASLAeKIEECTGIEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
zf-H2C2_2 pfam13465
Zinc-finger double domain;
269-290 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|..
gi 24645899   269 HERTHTNERPFQCQHCDKAFTS 290
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
174-337 8.42e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 8.42e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645899 174 SIISKGVSARVPKRTKRNSKSWF-CDQCGGVFKSSTYLKLHLQrhSGHKPFACDI--CQAKYYTDNEMRRHRILHTDARP 250
Cdd:COG5048 274 SPNESDSSSEKGFSLPIKSKQCNiSFSRSSPLTRHLRSVNHSG--ESLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24645899 251 YACRF--CSKTYRGCSSKVVHERTH-----TNERPFQCQH--CDKAFTSTSTRQKHEMLHTNQRKYHCEicdqWFLRSSH 321
Cdd:COG5048 352 AKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCK----NPPCSKS 427

                       170
                ....*....|....*.
gi 24645899 322 LTLHQSTKLHQRRAES 337
Cdd:COG5048 428 FNRHYNLIPHKKIHTN 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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