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Conserved domains on  [gi|24646855|ref|NP_731919|]
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uncharacterized protein Dmel_CG31313, isoform A [Drosophila melanogaster]

Protein Classification

cystatin family protein( domain architecture ID 430)

cystatin family protein may function as a cysteine protease inhibitor, such as Glycine max cystatin that inhibits papain and cathepsin B

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
PubMed:  1855589|9007972|3555466|14587292
SCOP:  4001013

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 25-115 8.28e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member smart00043:

Pssm-ID: 447698  Cd Length: 107  Bit Score: 54.74  E-value: 8.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855     25 PGAPKPLDGDDlSKAKELLDTTLAKLATGDGPNY--QVVNVISASSQLVAGSLYKFEVKLSNGAETKE------------ 90
Cdd:smart00043   3 LGGPSDVPPND-PEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLsvdlencpfldq 81

                           90       100
                   ....*....|....*....|....*....
gi 24646855     91 ----CNVKIWDRPWlheQGEATNVKVQCK 115
Cdd:smart00043  82 gekfCTAKVWEKPW---ENKIKLVEFKCT 107
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 25-115 8.28e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 54.74  E-value: 8.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855     25 PGAPKPLDGDDlSKAKELLDTTLAKLATGDGPNY--QVVNVISASSQLVAGSLYKFEVKLSNGAETKE------------ 90
Cdd:smart00043   3 LGGPSDVPPND-PEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLsvdlencpfldq 81

                           90       100
                   ....*....|....*....|....*....
gi 24646855     91 ----CNVKIWDRPWlheQGEATNVKVQCK 115
Cdd:smart00043  82 gekfCTAKVWEKPW---ENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-114 1.46e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.32  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855  26 GAPKPLDGDDlSKAKELLDTTLAKLATG-DGPNYQVVNVISASSQLVAGSLYKFEVKLSNG------------------- 85
Cdd:cd00042   1 GGPSDIPAND-PEVQELADFAVAEYNKKsNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTnckkssvpldcpdckllee 79

                        90       100
                ....*....|....*....|....*....
gi 24646855  86 AETKECNVKIWDRPWLHEQgeaTNVKVQC 114
Cdd:cd00042  80 GKKKFCTAKVWEKPWENFK---ELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 26-100 4.20e-08

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 47.33  E-value: 4.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855    26 GAPKPLDGDDlSKAKELLDTTLAKLATG-DGPNYQVVNVISASSQLVAGSLYKFEVKLSNG-----------------AE 87
Cdd:pfam00031   1 GGLSPIPDNS-PELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETdcskskklledcplldeKW 79

                          90
                  ....*....|...
gi 24646855    88 TKECNVKIWDRPW 100
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
 
Name Accession Description Interval E-value
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 25-115 8.28e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 54.74  E-value: 8.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855     25 PGAPKPLDGDDlSKAKELLDTTLAKLATGDGPNY--QVVNVISASSQLVAGSLYKFEVKLSNGAETKE------------ 90
Cdd:smart00043   3 LGGPSDVPPND-PEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVGETNCKKLsvdlencpfldq 81

                           90       100
                   ....*....|....*....|....*....
gi 24646855     91 ----CNVKIWDRPWlheQGEATNVKVQCK 115
Cdd:smart00043  82 gekfCTAKVWEKPW---ENKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-114 1.46e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 51.32  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855  26 GAPKPLDGDDlSKAKELLDTTLAKLATG-DGPNYQVVNVISASSQLVAGSLYKFEVKLSNG------------------- 85
Cdd:cd00042   1 GGPSDIPAND-PEVQELADFAVAEYNKKsNDKYLEFFKVLSAKSQVVAGTNYYITVEAGDTnckkssvpldcpdckllee 79

                        90       100
                ....*....|....*....|....*....
gi 24646855  86 AETKECNVKIWDRPWLHEQgeaTNVKVQC 114
Cdd:cd00042  80 GKKKFCTAKVWEKPWENFK---ELLSFKC 105
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 26-100 4.20e-08

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 47.33  E-value: 4.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24646855    26 GAPKPLDGDDlSKAKELLDTTLAKLATG-DGPNYQVVNVISASSQLVAGSLYKFEVKLSNG-----------------AE 87
Cdd:pfam00031   1 GGLSPIPDNS-PELQEALDFALAEYNAKtDNYYFELVEVKRAKSQVVAGTNYFIKVEVGETdcskskklledcplldeKW 79

                          90
                  ....*....|...
gi 24646855    88 TKECNVKIWDRPW 100
Cdd:pfam00031  80 LGLCSAQVYKVPW 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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