View
Concise Results
Standard Results
Full Results
Histidine kinase/HSP90-like ATPase domain-containing protein [Caenorhabditis elegans]
Protein Classification
Hsp90 family chaperone protein ( domain architecture ID 11480452 )
Hsp90 (heat shock protein 90) family chaperone protein, such as molecular chaperone HtpG (high-temperature protein G) that facilitates the folding and conformational changes of a wide array of proteins
List of domain hits
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
40-662
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 622.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 40 SEPQRH EFQAE TRN L MDIVAK SLYS HS E V F V RELISNASDA LE K R R YAE L KGD - VA EG PSE -- IRI TTN K DK RT I T FE D T 116
Cdd:PRK05218 1 MAMETG EFQAE VKQ L LHLMIH SLYS NK E I F L RELISNASDA ID K L R FEA L TDP a LY EG DGD lk IRI SFD K EA RT L T IS D N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 117 GIGM N RE DLVKF LGTIAKSG S K D F I E NN K ENAE --- AV IGQFGVGFYSAFMVAD S V V V T TR KV G S s D A DGLQ W TWN G DNS 193
Cdd:PRK05218 81 GIGM T RE EVIEN LGTIAKSG T K E F L E KL K GDQK kds QL IGQFGVGFYSAFMVAD K V T V I TR SA G P - A A EAVR W ESD G EGE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 194 Y E I A E TSGLQT GT K I EIR LK v G D SATYAE E D RI KEV I N KYS Y F VSA PI LVNG --- E RV N NLN A I WT MQAR E VNK E MHET F 270
Cdd:PRK05218 160 Y T I E E IEKEER GT E I TLH LK - E D EDEFLD E W RI RSI I K KYS D F IPV PI KLEK eee E TI N SAS A L WT RSKS E ITD E EYKE F 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 271 F K Q L vktqgk QEMYTR P QYT IH FQTDT P VSLRSVI YIP QT qf NQLTFMAQQTMC GL S LY AR RV L I KP DA Q EL I P N YLRFV 350
Cdd:PRK05218 239 Y K H L ------ AHDFDD P LFW IH NNVEG P FEYTGLL YIP KK -- APFDLFNRDRKG GL K LY VK RV F I MD DA E EL L P E YLRFV 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 351 I GV V DSED I PLN L SRE M LQ NNP V LR K L RK I IT D K I L GS L QSEM K K D PV KY SE F F K NYSLYF KEG VVT eq D QGVK E DV AKL 430
Cdd:PRK05218 311 K GV I DSED L PLN V SRE I LQ EDR V VK K I RK A IT K K V L DE L EKLA K N D RE KY EK F W K EFGPVL KEG LYE -- D FANR E KL AKL 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 431 L L F E S S sk KA G ELT SL GD YV K RM Q EGQK E IYY MYANN R QL A ES SP YY E VI K SQNK EVL F L Y DP A DE VVFLG L GQ F GM K QL 510
Cdd:PRK05218 389 L R F A S T -- HE G KYV SL AE YV E RM K EGQK K IYY ITGDS R EA A KN SP HL E LF K KKGI EVL L L T DP I DE FWISY L EE F DG K PF 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 511 VP V EK w AQEEAE K T g TDDK K DT K DFRDN E K K E LL DWM KE T LG s VR V SEISGN HR PSEH P VMVTVLDMGAARHFLRTGEIK 590
Cdd:PRK05218 467 KS V AR - GDLDLG K E - DEEE K EE K EEAEE E F K P LL ERL KE A LG - DK V KDVRLS HR LTDS P ACLVADEGDMSTQMEKLLKAA 543
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115535205 591 DM E h LVYF KP HVHV N LT HPLVK AMYK mr KT D KETAAI LAE QI YD N AL ITA G L - IK D TSRM V G RLN K LL TS L AG 662
Cdd:PRK05218 544 GQ E - VPES KP ILEI N PN HPLVK KLAD -- EA D EAKFKD LAE LL YD Q AL LAE G G s LE D PAAF V K RLN E LL LK L LA 613
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
40-662
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 622.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 40 SEPQRH EFQAE TRN L MDIVAK SLYS HS E V F V RELISNASDA LE K R R YAE L KGD - VA EG PSE -- IRI TTN K DK RT I T FE D T 116
Cdd:PRK05218 1 MAMETG EFQAE VKQ L LHLMIH SLYS NK E I F L RELISNASDA ID K L R FEA L TDP a LY EG DGD lk IRI SFD K EA RT L T IS D N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 117 GIGM N RE DLVKF LGTIAKSG S K D F I E NN K ENAE --- AV IGQFGVGFYSAFMVAD S V V V T TR KV G S s D A DGLQ W TWN G DNS 193
Cdd:PRK05218 81 GIGM T RE EVIEN LGTIAKSG T K E F L E KL K GDQK kds QL IGQFGVGFYSAFMVAD K V T V I TR SA G P - A A EAVR W ESD G EGE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 194 Y E I A E TSGLQT GT K I EIR LK v G D SATYAE E D RI KEV I N KYS Y F VSA PI LVNG --- E RV N NLN A I WT MQAR E VNK E MHET F 270
Cdd:PRK05218 160 Y T I E E IEKEER GT E I TLH LK - E D EDEFLD E W RI RSI I K KYS D F IPV PI KLEK eee E TI N SAS A L WT RSKS E ITD E EYKE F 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 271 F K Q L vktqgk QEMYTR P QYT IH FQTDT P VSLRSVI YIP QT qf NQLTFMAQQTMC GL S LY AR RV L I KP DA Q EL I P N YLRFV 350
Cdd:PRK05218 239 Y K H L ------ AHDFDD P LFW IH NNVEG P FEYTGLL YIP KK -- APFDLFNRDRKG GL K LY VK RV F I MD DA E EL L P E YLRFV 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 351 I GV V DSED I PLN L SRE M LQ NNP V LR K L RK I IT D K I L GS L QSEM K K D PV KY SE F F K NYSLYF KEG VVT eq D QGVK E DV AKL 430
Cdd:PRK05218 311 K GV I DSED L PLN V SRE I LQ EDR V VK K I RK A IT K K V L DE L EKLA K N D RE KY EK F W K EFGPVL KEG LYE -- D FANR E KL AKL 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 431 L L F E S S sk KA G ELT SL GD YV K RM Q EGQK E IYY MYANN R QL A ES SP YY E VI K SQNK EVL F L Y DP A DE VVFLG L GQ F GM K QL 510
Cdd:PRK05218 389 L R F A S T -- HE G KYV SL AE YV E RM K EGQK K IYY ITGDS R EA A KN SP HL E LF K KKGI EVL L L T DP I DE FWISY L EE F DG K PF 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 511 VP V EK w AQEEAE K T g TDDK K DT K DFRDN E K K E LL DWM KE T LG s VR V SEISGN HR PSEH P VMVTVLDMGAARHFLRTGEIK 590
Cdd:PRK05218 467 KS V AR - GDLDLG K E - DEEE K EE K EEAEE E F K P LL ERL KE A LG - DK V KDVRLS HR LTDS P ACLVADEGDMSTQMEKLLKAA 543
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115535205 591 DM E h LVYF KP HVHV N LT HPLVK AMYK mr KT D KETAAI LAE QI YD N AL ITA G L - IK D TSRM V G RLN K LL TS L AG 662
Cdd:PRK05218 544 GQ E - VPES KP ILEI N PN HPLVK KLAD -- EA D EAKFKD LAE LL YD Q AL LAE G G s LE D PAAF V K RLN E LL LK L LA 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
41-662
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 615.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 41 EPQRH EFQAE TRN L M D IVAK SLYS HS E V F V RELISNASDA LE K R R YAE L KGD --- VAE G PSE IRI TTN K DKR T I T FE D T G 117
Cdd:COG0326 2 AKETG EFQAE VKQ L L D LMIH SLYS NK E I F L RELISNASDA ID K L R FLA L TDP elk EED G DLK IRI EVD K EAK T L T IS D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 118 IGM N RE DLVKF LGTIAKSG SKD F I E NN K ENAEA --- V IGQFGVGFYSAFMVAD S V V V T TR KV G S s DA DGLQ W TWN GD NS Y 194
Cdd:COG0326 82 IGM T RE EVIEN LGTIAKSG TRE F L E KL K GDQKK dsd L IGQFGVGFYSAFMVAD K V E V V TR SA G E - DA EAVR W ESD GD GE Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 195 E I A E TSGLQT GT K I EIR LK v G D SATYA EE D R IK E V I N KYS Y F VSA PI LVN G -------- E RV N NLN A I WT MQAR E VNK E M 266
Cdd:COG0326 161 T I E E AEKAER GT E I TLH LK - E D AEEFL EE W R LR E I I K KYS D F IPV PI KME G eeeeteed E TI N SAT A L WT RSKS E ITD E E 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 267 HET F F K Q L VK tqgkqe MYTR P QYT IH FQTDT P VSLRSVI YIP QTQFNQ L TFMAQQ tm C G LS LY AR RV L I KP DA QE L I P N Y 346
Cdd:COG0326 240 YKE F Y K H L FH ------ DFED P LFW IH LNVEG P FEYTGLL YIP KKAPFD L YDRDRK -- G G IK LY VK RV F I MD DA ED L L P E Y 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 347 LRFV I GVVDS E D I PLN L SRE M LQ NNPV L R K L RK I IT D K I L GS L QSEM K K D PV KY SE F F K NYS L YF KEG VVTEQDQ gv K E D 426
Cdd:COG0326 312 LRFV R GVVDS P D L PLN V SRE I LQ EDRQ L K K I RK A IT K K V L DE L EKLA K N D RE KY EK F W K EFG L VL KEG ALEDFKN -- R E K 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 427 V A K LL L FES S sk K A G ELTS L GD YV K RM Q EGQK E IYY MYANN R QL AE S SP YY E VI K SQNK EVL F L Y DP A DE VVFLG L GQ F G 506
Cdd:COG0326 390 I A D LL R FES T -- K E G GYVT L AE YV E RM K EGQK K IYY ITGES R EA AE Q SP HL E IF K AKGI EVL L L T DP I DE FLISH L EE F D 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 507 M K QLVP V ekw AQEEAEKTGTDD KK DTKD f RDN E K K E LL DWM KE T LG S v R V SEISGNH R PSEH P VMVTVLDMGAA R HF --- 583
Cdd:COG0326 468 G K KFKS V --- DSGDLDLDKLEE KK ESEE - EEE E F K P LL ERF KE A LG D - K V KDVRVSA R LTDS P ACLVADEGDMS R RM ekm 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 584 L RTGEIKDM E H lvyf KP HVHV N LT HPLVK AM yk MRKT D K E TAAI LAE QI YD N AL ITA G - L IK D TSRM V G RLNKLL TSLA G 662
Cdd:COG0326 543 L KAMGQDMP E A ---- KP ILEI N PN HPLVK KL -- AAEE D E E LFKD LAE LL YD Q AL LAE G g L LE D PAAF V K RLNKLL EKAL G 616
HSP90
pfam00183 Hsp90 protein;
220-657
1.55e-90
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 291.00
E-value: 1.55e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 220 Y A EE DR IKE VIN KYS Y F VSA PI - L VNG -------------------------------------------------- E RV 248
Cdd:pfam00183 2 Y L EE KK IKE LVK KYS E F INF PI y L WVE keeevevpdeeeeeeeeeeeeedddpkveeedeeeekkktkkvketvwew E LL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 249 N NLNA IWT MQAR EV NK E MHET F F K Q L V K T qgkqem YTR P QYTI HF QTDTP V SLR S VIY IP QTQFNQ L t F MAQQTMCGLS L 328
Cdd:pfam00183 82 N KTKP IWT RNPK EV TE E EYAE F Y K S L S K D ------ WED P LAVK HF SVEGE V EFK S LLF IP KRAPFD L - F ENKKKKNNIK L 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 329 Y A RRV L I KP D AQE LIP N YL R FV I GVVDS E D I PLN L SRE M LQ N N PV L RKLR K IITD K I L GSLQ s E MKKDPVK Y SE F F K NYS 408
Cdd:pfam00183 155 Y V RRV F I TD D FED LIP E YL N FV K GVVDS D D L PLN V SRE T LQ Q N KI L KVIK K KLVR K A L DMFK - E IAEEKED Y KK F W K EFG 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 409 LYF K E G VV te Q D QGVKEDV AKLL L F E s SSK KAG ELTSL G DYV K RM Q EGQK E IYY MYANNRQLA E S SP YY E VI K SQNK EVL 488
Cdd:pfam00183 234 KNL K L G II -- E D SSNRNKL AKLL R F Y - SSK SGD ELTSL D DYV S RM K EGQK H IYY ITGESKEEV E N SP FL E RL K KKGY EVL 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 489 F L Y DP A DE VVFLG L GQ F GM K Q LV P V E K waq E EA E KTGTDDK K DTKDFRDN E KKE L LD W M K ET LG S ---- V R VS E isgnh R 564
Cdd:pfam00183 311 Y L T DP I DE YAVQQ L KE F DG K K LV N V A K --- E GL E LEEDEEE K KKDEELKK E FEP L TK W L K DV LG D kvek V V VS N ----- R 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 565 PSEH P VMVTVLDM G AARHFL R ---- TGEI KD -- M EHLVYF K PHVHV N LT HP LV K AMY K MRKT DK -- E TA AI LA EQI Y DN A 636
Cdd:pfam00183 383 LVDS P CVLVTSQY G WSANME R imka QALR KD ss M SSYMSS K KTLEI N PR HP II K ELL K RVEA DK dd K TA KD LA LLL Y ET A 462
490 500
....*....|....*....|..
gi 115535205 637 L ITA G - LIK D TSRMVG R LNKL L 657
Cdd:pfam00183 463 L LRS G f SLE D PASFAS R IYRM L 484
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
52-237
1.18e-89
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 277.09
E-value: 1.18e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 52 RN L M D IVAK SLYS HS E V F V RELISNASDAL E K R RY AE L KGDV --- AEGPS EIRI TTN K DK RT I T FE DTGIGM NR E D L VKF 128
Cdd:cd16927 1 NQ L L D LIIH SLYS NK E I F L RELISNASDAL D K L RY LS L TDPS lld DDPEL EIRI SPD K EN RT L T IS DTGIGM TK E E L INN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 129 LGTIA K SG S K D F I E NNK E N A EAV -- IGQFGVGFYSAFMVAD S V V VTT RKV G ss D AD G LQ W TWN G DN SY E I A E TS G - L QT G 205
Cdd:cd16927 81 LGTIA R SG T K A F L E ALQ E G A KDS dl IGQFGVGFYSAFMVAD K V T VTT KSA G -- D DE G YR W ESD G GG SY T I E E AE G e L GR G 158
170 180 190
....*....|....*....|....*....|..
gi 115535205 206 TKI EIR LK V g D SATYA EE D RIKE VIN KYS Y F V 237
Cdd:cd16927 159 TKI TLH LK E - D AKEFL EE A RIKE LVK KYS D F I 189
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
70-214
5.72e-07
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 48.41
E-value: 5.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 70 VRE L IS NA sdalek RR Y AELK G DV aegps EIRITTNK D KRT IT F ED T G I G MNR EDL vkflgtiaksg S K D F IENNK - ENA 148
Cdd:smart00387 10 LSN L LD NA ------ IK Y TPEG G RI ----- TVTLERDG D HVE IT V ED N G P G IPP EDL ----------- E K I F EPFFR t DKR 67
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115535205 149 EAV IG QF G V G FYSAFMVADSVVV ttrkvgssdadglqwtwngdnsy EI AET S GLQT GT KIE I R L KV 214
Cdd:smart00387 68 SRK IG GT G L G LSIVKKLVELHGG ----------------------- EI SVE S EPGG GT TFT I T L PL 110
Name
Accession
Description
Interval
E-value
PRK05218
PRK05218 heat shock protein 90; Provisional
40-662
0e+00
heat shock protein 90; Provisional
Pssm-ID: 235366 [Multi-domain]
Cd Length: 613
Bit Score: 622.52
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 40 SEPQRH EFQAE TRN L MDIVAK SLYS HS E V F V RELISNASDA LE K R R YAE L KGD - VA EG PSE -- IRI TTN K DK RT I T FE D T 116
Cdd:PRK05218 1 MAMETG EFQAE VKQ L LHLMIH SLYS NK E I F L RELISNASDA ID K L R FEA L TDP a LY EG DGD lk IRI SFD K EA RT L T IS D N 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 117 GIGM N RE DLVKF LGTIAKSG S K D F I E NN K ENAE --- AV IGQFGVGFYSAFMVAD S V V V T TR KV G S s D A DGLQ W TWN G DNS 193
Cdd:PRK05218 81 GIGM T RE EVIEN LGTIAKSG T K E F L E KL K GDQK kds QL IGQFGVGFYSAFMVAD K V T V I TR SA G P - A A EAVR W ESD G EGE 159
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 194 Y E I A E TSGLQT GT K I EIR LK v G D SATYAE E D RI KEV I N KYS Y F VSA PI LVNG --- E RV N NLN A I WT MQAR E VNK E MHET F 270
Cdd:PRK05218 160 Y T I E E IEKEER GT E I TLH LK - E D EDEFLD E W RI RSI I K KYS D F IPV PI KLEK eee E TI N SAS A L WT RSKS E ITD E EYKE F 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 271 F K Q L vktqgk QEMYTR P QYT IH FQTDT P VSLRSVI YIP QT qf NQLTFMAQQTMC GL S LY AR RV L I KP DA Q EL I P N YLRFV 350
Cdd:PRK05218 239 Y K H L ------ AHDFDD P LFW IH NNVEG P FEYTGLL YIP KK -- APFDLFNRDRKG GL K LY VK RV F I MD DA E EL L P E YLRFV 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 351 I GV V DSED I PLN L SRE M LQ NNP V LR K L RK I IT D K I L GS L QSEM K K D PV KY SE F F K NYSLYF KEG VVT eq D QGVK E DV AKL 430
Cdd:PRK05218 311 K GV I DSED L PLN V SRE I LQ EDR V VK K I RK A IT K K V L DE L EKLA K N D RE KY EK F W K EFGPVL KEG LYE -- D FANR E KL AKL 388
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 431 L L F E S S sk KA G ELT SL GD YV K RM Q EGQK E IYY MYANN R QL A ES SP YY E VI K SQNK EVL F L Y DP A DE VVFLG L GQ F GM K QL 510
Cdd:PRK05218 389 L R F A S T -- HE G KYV SL AE YV E RM K EGQK K IYY ITGDS R EA A KN SP HL E LF K KKGI EVL L L T DP I DE FWISY L EE F DG K PF 466
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 511 VP V EK w AQEEAE K T g TDDK K DT K DFRDN E K K E LL DWM KE T LG s VR V SEISGN HR PSEH P VMVTVLDMGAARHFLRTGEIK 590
Cdd:PRK05218 467 KS V AR - GDLDLG K E - DEEE K EE K EEAEE E F K P LL ERL KE A LG - DK V KDVRLS HR LTDS P ACLVADEGDMSTQMEKLLKAA 543
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 115535205 591 DM E h LVYF KP HVHV N LT HPLVK AMYK mr KT D KETAAI LAE QI YD N AL ITA G L - IK D TSRM V G RLN K LL TS L AG 662
Cdd:PRK05218 544 GQ E - VPES KP ILEI N PN HPLVK KLAD -- EA D EAKFKD LAE LL YD Q AL LAE G G s LE D PAAF V K RLN E LL LK L LA 613
HtpG
COG0326 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, ...
41-662
0e+00
Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440095 [Multi-domain]
Cd Length: 616
Bit Score: 615.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 41 EPQRH EFQAE TRN L M D IVAK SLYS HS E V F V RELISNASDA LE K R R YAE L KGD --- VAE G PSE IRI TTN K DKR T I T FE D T G 117
Cdd:COG0326 2 AKETG EFQAE VKQ L L D LMIH SLYS NK E I F L RELISNASDA ID K L R FLA L TDP elk EED G DLK IRI EVD K EAK T L T IS D N G 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 118 IGM N RE DLVKF LGTIAKSG SKD F I E NN K ENAEA --- V IGQFGVGFYSAFMVAD S V V V T TR KV G S s DA DGLQ W TWN GD NS Y 194
Cdd:COG0326 82 IGM T RE EVIEN LGTIAKSG TRE F L E KL K GDQKK dsd L IGQFGVGFYSAFMVAD K V E V V TR SA G E - DA EAVR W ESD GD GE Y 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 195 E I A E TSGLQT GT K I EIR LK v G D SATYA EE D R IK E V I N KYS Y F VSA PI LVN G -------- E RV N NLN A I WT MQAR E VNK E M 266
Cdd:COG0326 161 T I E E AEKAER GT E I TLH LK - E D AEEFL EE W R LR E I I K KYS D F IPV PI KME G eeeeteed E TI N SAT A L WT RSKS E ITD E E 239
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 267 HET F F K Q L VK tqgkqe MYTR P QYT IH FQTDT P VSLRSVI YIP QTQFNQ L TFMAQQ tm C G LS LY AR RV L I KP DA QE L I P N Y 346
Cdd:COG0326 240 YKE F Y K H L FH ------ DFED P LFW IH LNVEG P FEYTGLL YIP KKAPFD L YDRDRK -- G G IK LY VK RV F I MD DA ED L L P E Y 311
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 347 LRFV I GVVDS E D I PLN L SRE M LQ NNPV L R K L RK I IT D K I L GS L QSEM K K D PV KY SE F F K NYS L YF KEG VVTEQDQ gv K E D 426
Cdd:COG0326 312 LRFV R GVVDS P D L PLN V SRE I LQ EDRQ L K K I RK A IT K K V L DE L EKLA K N D RE KY EK F W K EFG L VL KEG ALEDFKN -- R E K 389
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 427 V A K LL L FES S sk K A G ELTS L GD YV K RM Q EGQK E IYY MYANN R QL AE S SP YY E VI K SQNK EVL F L Y DP A DE VVFLG L GQ F G 506
Cdd:COG0326 390 I A D LL R FES T -- K E G GYVT L AE YV E RM K EGQK K IYY ITGES R EA AE Q SP HL E IF K AKGI EVL L L T DP I DE FLISH L EE F D 467
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 507 M K QLVP V ekw AQEEAEKTGTDD KK DTKD f RDN E K K E LL DWM KE T LG S v R V SEISGNH R PSEH P VMVTVLDMGAA R HF --- 583
Cdd:COG0326 468 G K KFKS V --- DSGDLDLDKLEE KK ESEE - EEE E F K P LL ERF KE A LG D - K V KDVRVSA R LTDS P ACLVADEGDMS R RM ekm 542
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 584 L RTGEIKDM E H lvyf KP HVHV N LT HPLVK AM yk MRKT D K E TAAI LAE QI YD N AL ITA G - L IK D TSRM V G RLNKLL TSLA G 662
Cdd:COG0326 543 L KAMGQDMP E A ---- KP ILEI N PN HPLVK KL -- AAEE D E E LFKD LAE LL YD Q AL LAE G g L LE D PAAF V K RLNKLL EKAL G 616
PTZ00272
PTZ00272 heat shock protein 83 kDa (Hsp83); Provisional
47-657
3.75e-106
heat shock protein 83 kDa (Hsp83); Provisional
Pssm-ID: 240341
Cd Length: 701
Bit Score: 337.42
E-value: 3.75e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 47 FQAE TRN LM DIVAKSL YS HS E V F V RELISNASDA LE K R RY AE L KGDVAE G P S --- E IR ITTN K DKR T I T F ED T GIGM NRE 123
Cdd:PTZ00272 7 FQAE INQ LM SLIINTF YS NK E I F L RELISNASDA CD K I RY QS L TDPSVL G E S prl C IR VVPD K ENK T L T V ED N GIGM TKA 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 124 DLV KF LGTIA K SG S K D F I E NNKENAE - AV IGQFGVGFYSA FM VAD S V V VT TR kvg SSDADGLQ W TWNGDNSYE I AE T -- S 200
Cdd:PTZ00272 87 DLV NN LGTIA R SG T K A F M E ALEAGGD m SM IGQFGVGFYSA YL VAD R V T VT SK --- NNSDESYV W ESSAGGTFT I TS T pe S 163
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 201 GLQT GT K I EIR LK v G D SAT Y A E ED R I KE V I N K Y S Y F VSAP I LVNG E RV -------------------------------- 248
Cdd:PTZ00272 164 DMKR GT R I TLH LK - E D QME Y L E PR R L KE L I K K H S E F IGYD I ELMV E KT tekevtdedeedtkkadedgeepkveevkegd 242
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 249 -------------------- N NLNAI WT MQARE V N KE MHET F F K QLVKT qgkqem YTR P QY T I HF QTDTPVSL RS VIYI P 308
Cdd:PTZ00272 243 egkkkktkkvkevtkeyevq N KHKPL WT RDPKD V T KE EYAA F Y K AISND ------ WED P AA T K HF SVEGQLEF RS IMFV P 316
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 309 Q - TQ F NQ lt F MAQQTMCGLS LY A RRV L I KPDAQE L I P NY L R FV I GVVDSED I PLN L SRE M LQ N N PV L RKL RK I I TD K I L g 387
Cdd:PTZ00272 317 K r AP F DM -- F EPNKKRNNIK LY V RRV F I MDNCED L C P DW L G FV K GVVDSED L PLN I SRE N LQ Q N KI L KVI RK N I VK K C L - 393
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 388 SLQS E MKKDPVK Y SE F FKNYSLYF K E G V vt EQ D QGVKEDVAK LL L F E s S SKKAG E L T S L G DYV K RM QE GQK E IYY MYANN 467
Cdd:PTZ00272 394 EMFD E VAENKED Y KQ F YEQFGKNI K L G I -- HE D TANRKKLME LL R F Y - S TESGE E M T T L K DYV T RM KA GQK S IYY ITGDS 470
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 468 RQLA E S SP YY E VIKSQNK EVLF LYD P A DE V V FLGLGQ F GM K QLVPVE K waqeea E KTGTDDKKDT K DF R DN EK --- KE L L 544
Cdd:PTZ00272 471 KKKL E T SP FI E QARRRGL EVLF MTE P I DE Y V MQQVKD F ED K KFACLT K ------ E GVHFEESEEE K QQ R EE EK aac EK L C 544
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 545 DW MKE T LG S v R V SEISGNH R P S EH P VMVTVLDM G AAR H F --- L R TGEIK D -- M EHLVYF K PHVHV N LT HP LV K AMYKMRK 619
Cdd:PTZ00272 545 KT MKE V LG D - K V EKVIVSE R L S TS P CILVTSEF G WSA H M eqi M R NQALR D ss M AQYMMS K KTMEL N PR HP II K ELRRRVG 623
650 660 670 680
....*....|....*....|....*....|....*....|.
gi 115535205 620 T D KETA A I -- L AEQIY D NA L I T A G L - IK D TSRMVG R L N KLL 657
Cdd:PTZ00272 624 A D ENDK A V kd L VFLLF D TS L L T S G F q LE D PTGYAE R I N RMI 664
HSP90
pfam00183 Hsp90 protein;
220-657
1.55e-90
Hsp90 protein;
Pssm-ID: 459703
Cd Length: 516
Bit Score: 291.00
E-value: 1.55e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 220 Y A EE DR IKE VIN KYS Y F VSA PI - L VNG -------------------------------------------------- E RV 248
Cdd:pfam00183 2 Y L EE KK IKE LVK KYS E F INF PI y L WVE keeevevpdeeeeeeeeeeeeedddpkveeedeeeekkktkkvketvwew E LL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 249 N NLNA IWT MQAR EV NK E MHET F F K Q L V K T qgkqem YTR P QYTI HF QTDTP V SLR S VIY IP QTQFNQ L t F MAQQTMCGLS L 328
Cdd:pfam00183 82 N KTKP IWT RNPK EV TE E EYAE F Y K S L S K D ------ WED P LAVK HF SVEGE V EFK S LLF IP KRAPFD L - F ENKKKKNNIK L 154
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 329 Y A RRV L I KP D AQE LIP N YL R FV I GVVDS E D I PLN L SRE M LQ N N PV L RKLR K IITD K I L GSLQ s E MKKDPVK Y SE F F K NYS 408
Cdd:pfam00183 155 Y V RRV F I TD D FED LIP E YL N FV K GVVDS D D L PLN V SRE T LQ Q N KI L KVIK K KLVR K A L DMFK - E IAEEKED Y KK F W K EFG 233
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 409 LYF K E G VV te Q D QGVKEDV AKLL L F E s SSK KAG ELTSL G DYV K RM Q EGQK E IYY MYANNRQLA E S SP YY E VI K SQNK EVL 488
Cdd:pfam00183 234 KNL K L G II -- E D SSNRNKL AKLL R F Y - SSK SGD ELTSL D DYV S RM K EGQK H IYY ITGESKEEV E N SP FL E RL K KKGY EVL 310
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 489 F L Y DP A DE VVFLG L GQ F GM K Q LV P V E K waq E EA E KTGTDDK K DTKDFRDN E KKE L LD W M K ET LG S ---- V R VS E isgnh R 564
Cdd:pfam00183 311 Y L T DP I DE YAVQQ L KE F DG K K LV N V A K --- E GL E LEEDEEE K KKDEELKK E FEP L TK W L K DV LG D kvek V V VS N ----- R 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 565 PSEH P VMVTVLDM G AARHFL R ---- TGEI KD -- M EHLVYF K PHVHV N LT HP LV K AMY K MRKT DK -- E TA AI LA EQI Y DN A 636
Cdd:pfam00183 383 LVDS P CVLVTSQY G WSANME R imka QALR KD ss M SSYMSS K KTLEI N PR HP II K ELL K RVEA DK dd K TA KD LA LLL Y ET A 462
490 500
....*....|....*....|..
gi 115535205 637 L ITA G - LIK D TSRMVG R LNKL L 657
Cdd:pfam00183 463 L LRS G f SLE D PASFAS R IYRM L 484
HATPase_Hsp90-like
cd16927 Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including ...
52-237
1.18e-89
Histidine kinase-like ATPase domain of human cytosolic Hsp90 and its homologs including Escherichia coli HtpG, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of 90 kilodalton heat-shock protein (Hsp90) eukaryotic homologs including cytosolic Hsp90, mitochondrial TRAP1 (tumor necrosis factor receptor-associated protein 1), GRP94 (94 kDa glucose-regulated protein) of the endoplasmic reticulum (ER), and chloroplast Hsp90C. It also includes the bacterial homologs of Hsp90, known as HtpG (High temperature protein G). Hsp90 family of chaperones assist other proteins to fold correctly, stabilizes them against heat stress, and aids in protein degradation.
Pssm-ID: 340404 [Multi-domain]
Cd Length: 189
Bit Score: 277.09
E-value: 1.18e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 52 RN L M D IVAK SLYS HS E V F V RELISNASDAL E K R RY AE L KGDV --- AEGPS EIRI TTN K DK RT I T FE DTGIGM NR E D L VKF 128
Cdd:cd16927 1 NQ L L D LIIH SLYS NK E I F L RELISNASDAL D K L RY LS L TDPS lld DDPEL EIRI SPD K EN RT L T IS DTGIGM TK E E L INN 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 129 LGTIA K SG S K D F I E NNK E N A EAV -- IGQFGVGFYSAFMVAD S V V VTT RKV G ss D AD G LQ W TWN G DN SY E I A E TS G - L QT G 205
Cdd:cd16927 81 LGTIA R SG T K A F L E ALQ E G A KDS dl IGQFGVGFYSAFMVAD K V T VTT KSA G -- D DE G YR W ESD G GG SY T I E E AE G e L GR G 158
170 180 190
....*....|....*....|....*....|..
gi 115535205 206 TKI EIR LK V g D SATYA EE D RIKE VIN KYS Y F V 237
Cdd:cd16927 159 TKI TLH LK E - D AKEFL EE A RIKE LVK KYS D F I 189
PTZ00130
PTZ00130 heat shock protein 90; Provisional
43-635
2.82e-82
heat shock protein 90; Provisional
Pssm-ID: 185466 [Multi-domain]
Cd Length: 814
Bit Score: 276.92
E-value: 2.82e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 43 QR H EF Q A E TRN LMDI VAK SLY SHS EVF V RELISNA S DALEK R R YAE L KGDVAE G PS --- EIRI TT NK D K RTITFE DTGIG 119
Cdd:PTZ00130 66 EQ H QY Q T E VTR LMDI IVN SLY TQK EVF L RELISNA A DALEK I R FLS L SDESVL G EE kkl EIRI SA NK E K NILSIT DTGIG 145
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 120 M NR EDL VKF LGTIAKSG SKD F I E N - N K ENAE - AV IGQFGVGFYSAF M VAD S V V V T T R kvg SSDADGLQ W TWNG D NSYE I A 197
Cdd:PTZ00130 146 M TK EDL INN LGTIAKSG TSN F L E A i S K SGGD m SL IGQFGVGFYSAF L VAD K V I V Y T K --- NNNDEQYI W ESTA D AKFT I Y 222
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 198 ET --- S G L QT GT K I EIR LK v G D SATYAEEDRIKEV I N KYS Y F VSA PI LVNG E R V -------------------------- 248
Cdd:PTZ00130 223 KD prg S T L KR GT R I SLH LK - E D ATNLMNDKKLVDL I S KYS Q F IQY PI YLLH E N V yteevladiakemendpnydsvkvee 301
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 249 --------------------- N NLNA IW TMQAR E VNK E MHET FF KQ L vkt Q G KQE myt R P Q Y T IHF QTDTPVSLRSV IYI 307
Cdd:PTZ00130 302 tddpnkktrtvekkvkkwklm N EQKP IW LRPPK E LTD E DYKK FF SV L --- S G FND --- E P L Y H IHF FAEGEIEFKCL IYI 375
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 308 P QT -- QF N QLT F MA Q QT mcg LS LY A RRVL IKPDAQ E LI P N Y LR FV I GVVDS E D I PLN L SRE M LQ N N PV L RKLR K I I TD KI 385
Cdd:PTZ00130 376 P SR ap SI N DHL F TK Q NS --- IK LY V RRVL VADEFV E FL P R Y MS FV K GVVDS D D L PLN V SRE Q LQ Q N KI L KAVS K R I VR KI 452
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 386 L GS -------------- L QS E MK K --------------- D P VK Y SEFF K N Y SL Y F K E G VV te Q D QGVKEDVA KLLLF ESS 436
Cdd:PTZ00130 453 L DT frtlykegkknket L RA E LA K etdeekkkeiqkkin E P ST Y KLIY K E Y RK Y L K T G CY -- E D DINRNKIV KLLLF KTM 530
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 437 SKKAG el T SL GD Y VKR M QEG QK E IYY MYANNRQLAESS P YYEVI K SQ N KE V L FL YDPA DE VVFLGLGQFGM K QLVPVE K w 516
Cdd:PTZ00130 531 LHPKS -- I SL DT Y IEN M KPD QK F IYY ASGDSYEYLSKI P QLQIF K KK N ID V V FL TESV DE SCVQRVQEYDG K KFKSIQ K - 607
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 517 aq E E AEKTG T D D K K DTKDFRDNEK K E L L D WMKE TL GS v RVSEISGNH R PSEH P VM V TVLDM G AARHFLRTGE I K ---- D M 592
Cdd:PTZ00130 608 -- G E ITFEL T E D E K KKEEKVKKMY K A L I D VISD TL RN - QIFKVEISR R LVDA P CA V VSTEW G LSGQMEKLMK I N vnns D Q 684
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 115535205 593 EHLVYFKPHVHV N LT HP L -------------------- V K AM Y KMR K T ---- D K E TA A I LA EQI YD N 635
Cdd:PTZ00130 685 IKAMSGQKILEI N PD HP I midllkrsvsnpkdsqltes I K II Y QSA K L asgf D L E DT A D LA QIV YD H 751
PRK14083
PRK14083 HSP90 family protein; Provisional
44-471
3.05e-44
HSP90 family protein; Provisional
Pssm-ID: 237603 [Multi-domain]
Cd Length: 601
Bit Score: 167.81
E-value: 3.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 44 R H E FQ AET R NLM D IVAKS LYS HSE V F VREL IS NA S DA LEK RR YAE lkgdv AEG P SE IRI - T T NKDKR T ITF ED T GIG MNR 122
Cdd:PRK14083 2 S H R FQ VDL R GVI D LLSRH LYS SPR V Y VREL LQ NA V DA ITA RR ALD ----- PTA P GR IRI e L T DAGGG T LIV ED N GIG LTE 76
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 123 E DLVK FL G TI AK S GSK D fi EN NKENAEAVI GQFG V G FY S A F M VAD SV VV TT R KVG ss D ADGLQ W TWNG D NS Y EI -- A ET S 200
Cdd:PRK14083 77 E EVHE FL A TI GR S SKR D -- EN LGFARNDFL GQFG I G LL S C F L VAD EI VV VS R SAK -- D GPAVE W RGKA D GT Y SV rk L ET E 152
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 201 GLQT GT KIEI R LK v G D SATYA E EDRIK E VIN KY SYFVSA PI L V N GE -- R VN NLNAI WT MQ arevn KEMH ET FFKQ L VK t Q 278
Cdd:PRK14083 153 RAEP GT TVYL R PR - P D AEEWL E RETVE E LAK KY GSLLPV PI R V E GE kg G VN ETPPP WT RD ----- YPDP ET RREA L LA - Y 225
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 279 G KQEMYTR P QYT I HFQTDT p VS L RS V I Y I - P QTQ fn QLTFMAQQT mcgls L Y AR R V L IKPD A QE L I P NYLR FV IG VV DSE 357
Cdd:PRK14083 226 G EELLGFT P LDV I PLDVPS - GG L EG V A Y V l P YAV -- SPAARRKHR ----- V Y LK R M L LSEE A EN L L P DWAF FV RC VV NTD 297
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 358 DIPLNL SRE M L QNNPV L RKL R KIITDK I LGS L QSEMKK DP VKYSEFFKNYS L YF K E gv VTEQ D QGVKEDVAKL L L FE SSS 437
Cdd:PRK14083 298 ELRPTA SRE A L YEDDA L AAV R EELGEA I RKW L IGLATT DP ERLRRLLAVHH L GV K A -- LASH D DELLRLILPW L P FE TTD 375
410 420 430
....*....|....*....|....*....|....*.
gi 115535205 438 kka G EL T s L GDYVK R MQ egqk E I Y Y MYANN -- RQLA 471
Cdd:PRK14083 376 --- G RM T - L AEIRR R HG ---- V I R Y TSSVD ef RQLA 403
HATPase_c
smart00387 Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
70-214
5.72e-07
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain]
Cd Length: 111
Bit Score: 48.41
E-value: 5.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 70 VRE L IS NA sdalek RR Y AELK G DV aegps EIRITTNK D KRT IT F ED T G I G MNR EDL vkflgtiaksg S K D F IENNK - ENA 148
Cdd:smart00387 10 LSN L LD NA ------ IK Y TPEG G RI ----- TVTLERDG D HVE IT V ED N G P G IPP EDL ----------- E K I F EPFFR t DKR 67
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 115535205 149 EAV IG QF G V G FYSAFMVADSVVV ttrkvgssdadglqwtwngdnsy EI AET S GLQT GT KIE I R L KV 214
Cdd:smart00387 68 SRK IG GT G L G LSIVKKLVELHGG ----------------------- EI SVE S EPGG GT TFT I T L PL 110
HATPase_MORC-like
cd16931 Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
64-178
7.18e-06
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.
Pssm-ID: 340408 [Multi-domain]
Cd Length: 118
Bit Score: 45.48
E-value: 7.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 64 S HS EV F -- V R EL IS NA S DA le KRRYAELKG D V aegpseir I TTNKDKRTIT F E D T G I GM NR E DLVKFL g TIAK S g S K DFI 141
Cdd:cd16931 8 T HS WP F ga V A EL VD NA R DA -- DATRLDIFI D D -------- I NLLRGGFMLS F L D D G N GM TP E EAHHMI - SFGF S - D K RSD 75
90 100 110
....*....|....*....|....*....|....*...
gi 115535205 142 ENNK enaeav IG QF G V GF Y S AF M - VADS V V V T T R K VG S 178
Cdd:cd16931 76 DHDH ------ IG RY G N GF K S GS M r LGRD V I V F T K K DE S 107
HATPase_c_3
pfam13589 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
66-189
1.12e-05
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 433332 [Multi-domain]
Cd Length: 135
Bit Score: 45.40
E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 66 S E VFVR ELI S N AS DA lekrryaelkgd V A E gps E I R I TT NK DKRT --- I TF ED T G I GM NR E D L VKF L -- G T I AK SGSKD f 140
Cdd:pfam13589 1 L E GALA ELI D N SI DA ------------ D A T --- N I K I EV NK NRGG gte I VI ED D G H GM SP E E L INA L rl A T S AK EAKRG - 64
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 115535205 141 iennkena EAVI G QF G V G FYS A - FMVADSVV VT TR K V G S S DA dg L QWTWN 189
Cdd:pfam13589 65 -------- STDL G RY G I G LKL A s LSLGAKLT VT SK K E G K S ST -- L TLDRD 104
HATPase_TopVIB-like
cd16933 Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ...
46-220
3.89e-05
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain]
Cd Length: 203
Bit Score: 45.03
E-value: 3.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 46 EF QAETRNLM -- D IVAK SLY S hsev F VREL IS N AS DA L E K rr YAE L kgdvaegp SE I RITTN --- KD KRTITF ED T G I G M 120
Cdd:cd16933 2 EF FRKNKEML gf D NPIR SLY T ---- T VREL VE N SL DA T E E -- AGI L -------- PD I KVEIE eig KD HYKVIV ED N G P G I 67
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 121 NR E DLV K FL G TIA k S GSK DFIENNK enaeavi GQ F G V G FYS A FMVADS ----- V VVTTRKVG S SD A DGLQWTWNG D - N SY 194
Cdd:cd16933 68 PE E QIP K VF G KVL - Y GSK YHNKQSR ------- GQ Q G L G ISA A VLYSQM ttgkp V EIISSTKD S NY A YVVKLMIDT D k N EP 139
170 180 190
....*....|....*....|....*....|.
gi 115535205 195 EI A E ----- TSGLQT GT KI E IR L K v G DSATY 220
Cdd:cd16933 140 EI L E keeve NRYKWH GT RV E LE L E - G NWVAA 169
HATPase_c
pfam02518 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ...
70-214
5.37e-04
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain]
Cd Length: 109
Bit Score: 40.04
E-value: 5.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115535205 70 VRE L IS NA sdalekrryae LK GDVAE G PSEIRITT n KDKR T I T F ED T GIG MNR EDL VKFLG tiaksgsk D F IENN K ENA e 149
Cdd:pfam02518 10 LSN L LD NA ----------- LK HAAKA G EITVTLSE - GGEL T L T V ED N GIG IPP EDL PRIFE -------- P F STAD K RGG - 68
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 115535205 150 avi G QF G V G FYSAFMVADS vvvttrkvgssdadglqwt WN G D nsye I AET S GLQT GT KIEIR L KV 214
Cdd:pfam02518 69 --- G GT G L G LSIVRKLVEL ------------------- LG G T ---- I TVE S EPGG GT TVTLT L PL 107
COG4191
COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ...
73-125
3.57e-03
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain]
Cd Length: 361
Bit Score: 40.17
E-value: 3.57e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 115535205 73 L IS NA S DA L E KRR yaelkgdvaeg PSE I R I T T NKDKR -- T I TFE D T G I G MNR E D L 125
Cdd:COG4191 264 L LI NA I DA M E EGE ----------- GGR I T I S T RREGD yv V I SVR D N G P G IPP E V L 307
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
