NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|27734909|ref|NP_775817|]
View 

kelch domain-containing protein 8B [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 19803719)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-340 5.02e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 158.01  E-value: 5.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLMDEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 137 ---PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRA 213
Cdd:COG3055  81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 214 FAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPrslRMRDKRADFVVGSLGGHIVAIGGLGNq 292
Cdd:COG3055 161 HLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLA---PLPTARAGHAAAVLGGKILVFGGESG- 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 27734909 293 pcPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
Cdd:COG3055 218 --FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-86 1.42e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 1.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   3 AGGGRAF-----AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:COG3055 174 VIGGRNGsgfsnTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250


                ....*....
gi 27734909  78 GKQVLVVGG 86
Cdd:COG3055 251 DGKVYVIGG 259
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-340 5.02e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 158.01  E-value: 5.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLMDEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 137 ---PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRA 213
Cdd:COG3055  81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 214 FAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPrslRMRDKRADFVVGSLGGHIVAIGGLGNq 292
Cdd:COG3055 161 HLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLA---PLPTARAGHAAAVLGGKILVFGGESG- 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 27734909 293 pcPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
Cdd:COG3055 218 --FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
PHA03098 PHA03098
kelch-like protein; Provisional
 7-210 2.62e-19

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 89.06  E-value: 2.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909    7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGlPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:PHA03098 319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI-SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   87 VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRV--YEPRRDCWLSLPSMPTP 164
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVesYNPVTNKWTELSSLNFP 477

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 27734909  165 CYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 210
Cdd:PHA03098 478 RINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-86 1.42e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 1.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   3 AGGGRAF-----AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:COG3055 174 VIGGRNGsgfsnTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250


                ....*....
gi 27734909  78 GKQVLVVGG 86
Cdd:COG3055 251 DGKVYVIGG 259
Kelch smart00612
Kelch domain;
176-222 4.84e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 4.84e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 27734909    176 KIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEG 222
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 164-209 2.03e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 2.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 27734909   164 PCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLP 209
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
20-69 5.87e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 5.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 27734909    20 CRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTAR 69
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
32-79 8.48e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 8.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 27734909     32 HLLVLGGCGRaGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGK 79
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
58-340 5.02e-46

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 158.01  E-value: 5.02e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  58 TWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLMDEGRWERRATLPQAA-MGVATVERDGMVYALGGMG 136
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG-GSASNSFEVYDPATNTWSELAPLPGPPrHHAAAVAQDGKLYVFGGFT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 137 ---PDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRA 213
Cdd:COG3055  81 ganPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRD 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 214 FAGCAMA-EGSVFSLGGLQQPGPHNfysrphfvntvemfdlehgSWTKLPrslRMRDKRADFVVGSLGGHIVAIGGLGNq 292
Cdd:COG3055 161 HLAAAVLpDGKILVIGGRNGSGFSN-------------------TWTTLA---PLPTARAGHAAAVLGGKILVFGGESG- 217

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 27734909 293 pcPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGGVAQG 340
Cdd:COG3055 218 --FSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKP 263
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
11-252 8.06e-37

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 134.13  E-value: 8.06e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  11 WQVFPPMPTCRVYGTVA-HQDGHLLVLGGCGRA---GLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:COG3055  50 WSELAPLPGPPRHHAAAvAQDGKLYVFGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  87 VDEvQSPVAAVEAFLMDEGRWERRATLPQAAMGV-ATVERDGMVYALGGMGPDTAPQAqvrvyeprrdcWLSLPSMPTPC 165
Cdd:COG3055 130 WDD-GGNVAWVEVYDPATGTWTQLAPLPTPRDHLaAAVLPDGKILVIGGRNGSGFSNT-----------WTTLAPLPTAR 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 166 YGASTFLHGNKIYVLGGRQGKLpvTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQPGphnfySRPHFV 245
Cdd:COG3055 198 AGHAAAVLGGKILVFGGESGFS--DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPG-----VRTPLV 270


                ....*..
gi 27734909 246 NTVEMFD 252
Cdd:COG3055 271 TSAEVYD 277
PHA03098 PHA03098
kelch-like protein; Provisional
 7-210 2.62e-19

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 89.06  E-value: 2.62e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909    7 RAFAWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAGlPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGG 86
Cdd:PHA03098 319 KTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSI-SLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG 397

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   87 VDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDTAPQAQVRV--YEPRRDCWLSLPSMPTP 164
Cdd:PHA03098 398 ISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYNIVesYNPVTNKWTELSSLNFP 477

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 27734909  165 CYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPS 210
Cdd:PHA03098 478 RINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPK 523
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
155-344 9.29e-18

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 82.13  E-value: 9.29e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 155 WLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLP-SRRAFAGCAMAEGSVFSLGGlqqp 233
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGG---- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909 234 gphnfysrphfvntvemFDLEHGSWTklprslrmrdkradfvvgslgghivaigglgnqpcPLGSVESFSLARRRWEALP 313
Cdd:COG3055  79 -----------------FTGANPSST-----------------------------------PLNDVYVYDPATNTWTKLA 106

                       170       180       190
                ....*....|....*....|....*....|.
gi 27734909 314 AMPTARCSCSSLQAGPRLFVIGGVAQGPSQA 344
Cdd:COG3055 107 PMPTPRGGATALLLDGKIYVVGGWDDGGNVA 137
PHA03098 PHA03098
kelch-like protein; Provisional
 23-259 3.59e-16

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 79.43  E-value: 3.59e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   23 YGTVAHQDgHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEvQSPVAAVEAFLM 102
Cdd:PHA03098 288 FGSVVLNN-VIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYN-SISLNTVESWKP 365

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  103 DEGRWERRATL--PQAAMGVATVerDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVL 180
Cdd:PHA03098 366 GESKWREEPPLifPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVI 443

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  181 GGR---QGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGlqqpgphnfYSRPHFVNTVEMFDLEHGS 257
Cdd:PHA03098 444 GGIsyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG---------DKYEYYINEIEVYDDKTNT 514


                 ..
gi 27734909  258 WT 259
Cdd:PHA03098 515 WT 516
PLN02153 PLN02153
epithiospecifier protein
 114-336 5.50e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.94  E-value: 5.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  114 PQAAMGVATVerDGMVYALGG-MGPDTAPQAQVRVYEPRRDCWLSLPSMPTP----CYGASTFLHGNKIYVLGGRQGKLP 188
Cdd:PLN02153  22 PRCSHGIAVV--GDKLYSFGGeLKPNEHIDKDLYVFDFNTHTWSIAPANGDVprisCLGVRMVAVGTKLYIFGGRDEKRE 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  189 VTAFEAFDLEARTWTRHPSL-----PSRRAFAGCAMAEGSVFSLGGLQQPGPHNfysRPHFVNTVEMFDLEHGSWTKLPR 263
Cdd:PLN02153 100 FSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGLMK---TPERFRTIEAYNIADGKWVQLPD 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  264 SLRMRDKR--ADFVVgsLGGHIVAIGGLGNQPCPLG-------SVESFSLARRRW---EALPAMPTARCSCSSLQAGPRL 331
Cdd:PLN02153 177 PGENFEKRggAGFAV--VQGKIWVVYGFATSILPGGksdyesnAVQFFDPASGKWtevETTGAKPSARSVFAHAVVGKYI 254


                 ....*
gi 27734909  332 FVIGG 336
Cdd:PLN02153 255 IIFGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 129-336 7.35e-14

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 72.49  E-value: 7.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  129 VYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSL 208
Cdd:PHA03098 297 IYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPL 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  209 PSRRAFAGCAMAEGSVFSLGGLQQPGphnfysrpHFVNTVEMFDLEHGSWTKLprsLRMRDKRADFVVGSLGGHIVAIGG 288
Cdd:PHA03098 377 IFPRYNPCVVNVNNLIYVIGGISKND--------ELLKTVECFSLNTNKWSKG---SPLPISHYGGCAIYHDGKIYVIGG 445

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 27734909  289 LG--NQPCPLGSVESFSLARRRWEALPAMPTARCSCSSLQAGPRLFVIGG 336
Cdd:PHA03098 446 ISyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGG 495
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-86 1.42e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 67.10  E-value: 1.42e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   3 AGGGRAF-----AWQVFPPMPTCRVYGTVAHQDGHLLVLGGCGRAglpLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:COG3055 174 VIGGRNGsgfsnTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATNTWTALGELPTPRHGHAAVLT 250


                ....*....
gi 27734909  78 GKQVLVVGG 86
Cdd:COG3055 251 DGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 73-288 5.60e-12

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 66.71  E-value: 5.60e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   73 AAVVLGKQVLVVGGVDEVQSPVAAVEAFLMDEGRWERRATLPQAAMGVATVERDGMVYALGGMGPDtAPQAQVRVYEPRR 152
Cdd:PHA03098 289 GSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS-ISLNTVESWKPGE 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  153 DCWLSLPSMPTPCYGASTFLHGNKIYVLGG-RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLq 231
Cdd:PHA03098 368 SKWREEPPLIFPRYNPCVVNVNNLIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGI- 446

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 27734909  232 qpgphNFYSRPHFVNTVEMFDLEHGSWTKLPrslRMRDKRADFVVGSLGGHIVAIGG 288
Cdd:PHA03098 447 -----SYIDNIKVYNIVESYNPVTNKWTELS---SLNFPRINASLCIFNNKIYVVGG 495
PHA03098 PHA03098
kelch-like protein; Provisional
 155-337 5.60e-11

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 63.63  E-value: 5.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  155 WLSLPSMPTPCYGASTFLHgNKIYVLGGRQGK-LPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEGSVFSLGGLQQP 233
Cdd:PHA03098 276 INTIIDIHYVYCFGSVVLN-NVIYFIGGMNKNnLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNS 354

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  234 GPhnfysrphfVNTVEMFDLEHGSWTKLPRslrMRDKRADFVVGSLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALP 313
Cdd:PHA03098 355 IS---------LNTVESWKPGESKWREEPP---LIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGS 422

                        170       180
                 ....*....|....*....|....
gi 27734909  314 AMPTARCSCSSLQAGPRLFVIGGV 337
Cdd:PHA03098 423 PLPISHYGGCAIYHDGKIYVIGGI 446
Kelch smart00612
Kelch domain;
176-222 4.84e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 46.01  E-value: 4.84e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 27734909    176 KIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCAMAEG 222
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 164-209 2.03e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 44.14  E-value: 2.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 27734909   164 PCYGASTFLHGNKIYVLGGRQGKLPVTAFEAFDLEARTWTRHPSLP 209
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_6 pfam13964
Kelch motif;
278-319 7.68e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 7.68e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 27734909   278 SLGGHIVAIGGLGNQPCPLGSVESFSLARRRWEALPAMPTAR 319
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PRK14131 PRK14131
N-acetylneuraminate epimerase;
106-182 1.01e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.93  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  106 RWERRATLP-QAAMGVATVERDGMVYALGGMGP---DTAPQAQ--VRVYEPRRDCWLSLPSM-PTPCYGASTF-LHGNKI 177
Cdd:PRK14131  63 GWTKIAAFPgGPREQAVAAFIDGKLYVFGGIGKtnsEGSPQVFddVYKYDPKTNSWQKLDTRsPVGLAGHVAVsLHNGKA 142


                 ....*
gi 27734909  178 YVLGG 182
Cdd:PRK14131 143 YITGG 147
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 271-316 2.38e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 27734909   271 RADFVVGSLGGHIVAIGGLGNQpCPLGSVESFSLARRRWEALPAMP 316
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGN-QSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
129-174 2.43e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.00  E-value: 2.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 27734909    129 VYALGGMGPDTApQAQVRVYEPRRDCWLSLPSMPTP-CYGASTFLHG 174
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNKWTPLPSMPTPrSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
164-212 2.92e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 2.92e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 27734909   164 PCYGASTFLHGNKIYVLGGR-QGKLPVTAFEAFDLEARTWTRHPSLPSRR 212
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PLN02193 PLN02193
nitrile-specifier protein
 114-353 3.81e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 45.33  E-value: 3.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  114 PQAAMGVATVerDGMVYALGG-MGPDTAPQAQVRVYEPRRDCWLSLPS---MPT-PCYGASTFLHGNKIYVLGGRQGKLP 188
Cdd:PLN02193 165 LRCSHGIAQV--GNKIYSFGGeFTPNQPIDKHLYVFDLETRTWSISPAtgdVPHlSCLGVRMVSIGSTLYVFGGRDASRQ 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  189 VTAFEAFDLEARTW---TRHPSLPSRRAFAGCAMAEGSVFSLGGLqqpgphnfySRPHFVNTVEMFDLEHGSWTKLPRSL 265
Cdd:PLN02193 243 YNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGV---------SATARLKTLDSYNIVDKKWFHCSTPG 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  266 RMRDKRADFVVGSLGGHIVAIGGLGNqpCPLGSVESFSLARRRW---EALPAMPTARCSCSSLQAGPRLFVIGG-VAQGP 341
Cdd:PLN02193 314 DSFSIRGGAGLEVVQGKVWVVYGFNG--CEVDDVHYYDPVQDKWtqvETFGVRPSERSVFASAAVGKHIVIFGGeIAMDP 391

                        250
                 ....*....|..
gi 27734909  342 SQAVEALCLRDG 353
Cdd:PLN02193 392 LAHVGPGQLTDG 403
Kelch_6 pfam13964
Kelch motif;
20-69 5.87e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 5.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 27734909    20 CRVYGTVAHQDGHLLVLGGCGRAGLPLDTAETLDMASHTWLALAPLPTAR 69
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PHA02790 PHA02790
Kelch-like protein; Provisional
 49-258 8.15e-05

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 44.26  E-value: 8.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909   49 AETLDMASHTWLALAPLPTARAGAAAVVLGKQVLVVGGVDEVQSpvaaVEAFLMDEGRWERRATLPQAAMGVATVERDGM 128
Cdd:PHA02790 289 AIAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTS----VERWFHGDAAWVNMPSLLKPRCNPAVASINNV 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  129 VYALGGMG-PDTAPQAQVrvyePRRDCWLSLPSMPTPCYGASTFLHGNKIYVLGGRQgklpvtafEAFDLEARTWT--RH 205
Cdd:PHA02790 365 IYVIGGHSeTDTTTEYLL----PNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRNA--------EFYCESSNTWTliDD 432

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 27734909  206 PSLPsrRAFAGCAMAEGSVFSLGGlqqpgphnFYsRPHFVNTVEMFDLEHGSW 258
Cdd:PHA02790 433 PIYP--RDNPELIIVDNKLLLIGG--------FY-RGSYIDTIEVYNNRTYSW 474
Kelch smart00612
Kelch domain;
32-79 8.48e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 8.48e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 27734909     32 HLLVLGGCGRaGLPLDTAETLDMASHTWLALAPLPTARAGAAAVVLGK 79
Cdd:smart00612   1 KIYVVGGFDG-GQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
282-324 1.41e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.08  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 27734909    282 HIVAIGGL-GNQPcpLGSVESFSLARRRWEALPAMPTARCSCSS 324
Cdd:smart00612   1 KIYVVGGFdGGQR--LKSVEVYDPETNKWTPLPSMPTPRSGHGV 42
Kelch_3 pfam13415
Galactose oxidase, central domain;
174-218 3.80e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.65  E-value: 3.80e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 27734909   174 GNKIYVLGG--RQGKLPVTAFEAFDLEARTWTRHPSLPSRRAFAGCA 218
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
Kelch_6 pfam13964
Kelch motif;
114-164 4.78e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 4.78e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 27734909   114 PQAAMGVATVerDGMVYALGGMGPDTAPQAQVRVYEPRRDCWLSLPSMPTP 164
Cdd:pfam13964   1 PRTFHSVVSV--GGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTP 49
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 211-262 8.39e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 8.39e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 27734909   211 RRAFAGCAMAEGSVFSLGGlqqpgphnfYSRPHFVNTVEMFDLEHGSWTKLP 262
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG---------FDGNQSLNSVEVYDPETNTWSKLP 43
Kelch_4 pfam13418
Galactose oxidase, central domain;
165-210 1.67e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 1.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 27734909   165 CYGASTFLHGNKIYVLGGRQGKLPVTAF-EAFDLEARTWTRHPSLPS 210
Cdd:pfam13418   3 AYHTSTSIPDDTIYLFGGEGEDGTLLSDlWVFDLSTNEWTRLGSLPS 49
Kelch smart00612
Kelch domain;
239-281 1.85e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 1.85e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 27734909    239 YSRPHFVNTVEMFDLEHGSWTKLPrslRMRDKRADFVVGSLGG 281
Cdd:smart00612   8 FDGGQRLKSVEVYDPETNKWTPLP---SMPTPRSGHGVAVING 47
Kelch_3 pfam13415
Galactose oxidase, central domain;
30-77 3.93e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 3.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 27734909    30 DGHLLVLGGCGRAG-LPLDTAETLDMASHTWLALAPLPTARAGAAAVVL 77
Cdd:pfam13415   1 GDKLYIFGGLGFDGqTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
158-288 4.49e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.46  E-value: 4.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27734909  158 LPSMPTPCYGASTFLHGNKIYVLGGRQGklpvTAFEAFDLEA--RTWTRHPSLPS-RRAFAGCAMAEGSVFSLGGLqqpG 234
Cdd:PRK14131  22 LPDLPVPFKNGTGAIDNNTVYVGLGSAG----TSWYKLDLNApsKGWTKIAAFPGgPREQAVAAFIDGKLYVFGGI---G 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27734909  235 PHNFYSRPHFVNTVEMFDLEHGSWTKL----PRSLrmrdkradfvVGSL-----GGHIVAIGG 288
Cdd:PRK14131  95 KTNSEGSPQVFDDVYKYDPKTNSWQKLdtrsPVGL----------AGHVavslhNGKAYITGG 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH