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Conserved domains on  [gi|295444820|ref|NP_776289|]
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complement C1s-1 subcomponent precursor [Mus musculus]

Protein Classification

CUB domain-containing protein( domain architecture ID 11505041)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to CUB domain-containing protein 2 (CDCP2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 443-681 2.76e-69

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


:

Pssm-ID: 214473  Cd Length: 229  Bit Score: 226.02  E-value: 2.76e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   443 KIFGGQPAKIENFPWQVFF----NHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADLENAQRLYTKRVIIHP 518
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLqyggGRHFCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVIKVSKVIIHP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   519 GWkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPgtSSEYNLSPGDMGLISGWGRTEKRLHVIN--LRGAKVPVT 596
Cdd:smart00020  81 NY------NPST-YDNDIALLKLKEPVTLSDNVRPICLP--SSNYNVPAGTTCTVSGWGRTSEGAGSLPdtLQEVNVPIV 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   597 SLETCKQvkeenptARPEDYVITDNMICAG--EKGVDSCKGDSGGAFAFQVpnvkaPKFYVAGLVSWGKKCG---AYGVY 671
Cdd:smart00020 152 SNATCRR-------AYSGGGAITDNMLCAGglEGGKDACQGDSGGPLVCND-----GRWVLVGIVSWGSGCArpgKPGVY 219

                          250
                   ....*....|
gi 295444820   672 TKVKNYVDWI 681
Cdd:smart00020 220 TRVSSYLDWI 229
CUB pfam00431
CUB domain;
181-293 1.13e-27

CUB domain;


:

Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 107.38  E-value: 1.13e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  181 CSGdVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTmqREDFDVEPADSegnCP-DSLTF----AAKNQQFGP 255
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLT--FQDFELEDHDE---CGyDYVEIrdgpSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 295444820  256 YCGDGfpGPLTIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:pfam00431  75 FCGSG--IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 24-135 9.06e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 105.19  E-value: 9.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  24 TMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEE----GRLCGQRTskspns 99
Cdd:cd00041    8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSspllGRFCGSTL------ 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 295444820 100 piIEEFQFPYNKLQVVFTSDFSIeeQFTGFAAYYTA 135
Cdd:cd00041   82 --PPPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 149-177 1.76e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 1.76e-07
                          10        20
                  ....*....|....*....|....*....
gi 295444820  149 CSHFCNNFIGGYFCSCPPEYFLHDDMRNC 177
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295444820 300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVEghvsstSYYSTCQSDGQWSNSGLKCQ 361
Cdd:cd00033    1 CPPpPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 365-428 1.72e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 1.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 295444820 365 CGIPDPIANGKVEEPENS-VFGTVIHYTCeEPYYYMEHEEggEYRCAANGRWVNdqlgiELPRCI 428
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSC-NEGYTLVGSS--TITCTENGGWSP-----PPPTCE 57
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 443-681 2.76e-69

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 226.02  E-value: 2.76e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   443 KIFGGQPAKIENFPWQVFF----NHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADLENAQRLYTKRVIIHP 518
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLqyggGRHFCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVIKVSKVIIHP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   519 GWkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPgtSSEYNLSPGDMGLISGWGRTEKRLHVIN--LRGAKVPVT 596
Cdd:smart00020  81 NY------NPST-YDNDIALLKLKEPVTLSDNVRPICLP--SSNYNVPAGTTCTVSGWGRTSEGAGSLPdtLQEVNVPIV 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   597 SLETCKQvkeenptARPEDYVITDNMICAG--EKGVDSCKGDSGGAFAFQVpnvkaPKFYVAGLVSWGKKCG---AYGVY 671
Cdd:smart00020 152 SNATCRR-------AYSGGGAITDNMLCAGglEGGKDACQGDSGGPLVCND-----GRWVLVGIVSWGSGCArpgKPGVY 219

                          250
                   ....*....|
gi 295444820   672 TKVKNYVDWI 681
Cdd:smart00020 220 TRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 444-684 3.01e-69

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 226.00  E-value: 3.01e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 444 IFGGQPAKIENFPWQVF----FNHPTAGGALINEYWVLTAAHVVEKNSDPSM--YAGITALRLADlENAQRLYTKRVIIH 517
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSlqytGGRHFCGGSLISPRWVLTAAHCVYSSAPSNYtvRLGSHDLSSNE-GGGQVIKVKKVIVH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 518 PGWkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPgtSSEYNLSPGDMGLISGWGRTEKRL-HVINLRGAKVPVT 596
Cdd:cd00190   80 PNY------NPST-YDNDIALLKLKRPVTLSDNVRPICLP--SSGYNLPAGTTCTVSGWGRTSEGGpLPDVLQEVNVPIV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 597 SLETCKQvkeenptARPEDYVITDNMICAG--EKGVDSCKGDSGGAFAFQVPNVkapkFYVAGLVSWGKKCGA---YGVY 671
Cdd:cd00190  151 SNAECKR-------AYSYGGTITDNMLCAGglEGGKDACQGDSGGPLVCNDNGR----GVLVGIVSWGSGCARpnyPGVY 219

                        250
                 ....*....|...
gi 295444820 672 TKVKNYVDWILKT 684
Cdd:cd00190  220 TRVSSYLDWIQKT 232
Trypsin pfam00089
Trypsin;
444-681 6.98e-62

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 205.75  E-value: 6.98e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  444 IFGGQPAKIENFPWQVFF----NHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADlENAQRLYTKRVIIHPG 519
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLqlssGKHFCGGSLISENWVLTAAHCVSGASDVKVVLGAHNIVLRE-GGEQKFDVEKIIVHPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  520 WkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPGTSSeyNLSPGDMGLISGWGRTEKRLHVINLRGAKVPVTSLE 599
Cdd:pfam00089  80 Y------NPDT-LDNDIALLKLESPVTLGDTVRPICLPDASS--DLPVGTTCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  600 TCKQVKeenptarpeDYVITDNMICAGEKGVDSCKGDSGGAFafqVPNVKapkfYVAGLVSWGKKCGA---YGVYTKVKN 676
Cdd:pfam00089 151 TCRSAY---------GGTVTDTMICAGAGGKDACQGDSGGPL---VCSDG----ELIGIVSWGYGCASgnyPGVYTPVSS 214


                  ....*
gi 295444820  677 YVDWI 681
Cdd:pfam00089 215 YLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 433-689 3.99e-51

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 178.30  E-value: 3.99e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 433 VPTEPFQVQQKIFGGQPAKIENFPWQVFFNHPTA------GGALINEYWVLTAAHVVEKNSDPSM--YAGITALRLADle 504
Cdd:COG5640   20 AAAPAADAAPAIVGGTPATVGEYPWMVALQSSNGpsgqfcGGTLIAPRWVLTAAHCVDGDGPSDLrvVIGSTDLSTSG-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 505 nAQRLYTKRVIIHPGWkedddlNPRTnFDNDIALVQLKDPVkmgPKFSPICLPGTSSEynLSPGDMGLISGWGRTEKRLH 584
Cdd:COG5640   98 -GTVVKVARIVVHPDY------DPAT-PGNDIALLKLATPV---PGVAPAPLATSADA--AAPGTPATVAGWGRTSEGPG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 585 VIN--LRGAKVPVTSLETCKQVKEenptarpedyVITDNMICAG--EKGVDSCKGDSGGAFAFQVPNVkapkFYVAGLVS 660
Cdd:COG5640  165 SQSgtLRKADVPVVSDATCAAYGG----------FDGGTMLCAGypEGGKDACQGDSGGPLVVKDGGG----WVLVGVVS 230

                        250       260       270
                 ....*....|....*....|....*....|..
gi 295444820 661 WGK-KCGA--YGVYTKVKNYVDWILKTMQENS 689
Cdd:COG5640  231 WGGgPCAAgyPGVYTRVSAYRDWIKSTAGGLG 262
CUB pfam00431
CUB domain;
181-293 1.13e-27

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 107.38  E-value: 1.13e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  181 CSGdVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTmqREDFDVEPADSegnCP-DSLTF----AAKNQQFGP 255
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLT--FQDFELEDHDE---CGyDYVEIrdgpSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 295444820  256 YCGDGfpGPLTIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:pfam00431  75 FCGSG--IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 24-135 9.06e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 105.19  E-value: 9.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  24 TMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEE----GRLCGQRTskspns 99
Cdd:cd00041    8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSspllGRFCGSTL------ 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 295444820 100 piIEEFQFPYNKLQVVFTSDFSIeeQFTGFAAYYTA 135
Cdd:cd00041   82 --PPPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 181-293 2.80e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.95  E-value: 2.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 181 CSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMqrEDFDVEpadSEGNCP-DSLTF----AAKNQQFGP 255
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF--EDFDLE---SSPNCSyDYLEIydgpSTSSPLLGR 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 295444820 256 YCGDGFPGPltIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:cd00041   76 FCGSTLPPP--IISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 27-133 4.63e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 99.77  E-value: 4.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820    27 GEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISG----GIEEGRLCGqrtSKSPNSPII 102
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCG---SEAPPPVIS 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 295444820   103 EEfqfpYNKLQVVFTSDFSIeeQFTGFAAYY 133
Cdd:smart00042  78 SS----SNSLTLTFVSDSSV--QKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 191-293 1.74e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 95.15  E-value: 1.74e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   191 GEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMqrEDFDVEPADsegNCP-DSLTF----AAKNQQFGPYCGDGFPgPL 265
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF--TDFDLESSD---NCEyDYVEIydgpSASSPLLGRFCGSEAP-PP 74

                           90       100
                   ....*....|....*....|....*...
gi 295444820   266 TIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:smart00042  75 VISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
24-133 1.29e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 81.57  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   24 TMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEE----GRLCGqrtskspnS 99
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASspllGRFCG--------S 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 295444820  100 PIIEEFQFPYNKLQVVFTSDFSIeeQFTGFAAYY 133
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASV--QKRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 149-177 1.76e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 1.76e-07
                          10        20
                  ....*....|....*....|....*....
gi 295444820  149 CSHFCNNFIGGYFCSCPPEYFLHDDMRNC 177
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295444820 300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVEghvsstSYYSTCQSDGQWSNSGLKCQ 361
Cdd:cd00033    1 CPPpPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 365-428 1.72e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 1.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 295444820 365 CGIPDPIANGKVEEPENS-VFGTVIHYTCeEPYYYMEHEEggEYRCAANGRWVNdqlgiELPRCI 428
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSC-NEGYTLVGSS--TITCTENGGWSP-----PPPTCE 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
137-177 2.28e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 295444820   137 DVNECTdfTDVPCSH--FCNNFIGGYFCSCPPEYFlhdDMRNC 177
Cdd:smart00179   1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 365-427 7.02e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 7.02e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295444820   365 CGIPDPIANGKVEEPENS-VFGTVIHYTCEEPYYYMeheEGGEYRCAANGRWVNdqlgiELPRC 427
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLI---GSSTITCLENGTWSP-----PPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 137-177 8.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 8.89e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 295444820 137 DVNECTDFTdvPCSH--FCNNFIGGYFCSCPPEYFLhddmRNC 177
Cdd:cd00054    1 DIDECASGN--PCQNggTCVNTVGSYRCSCPPGYTG----RNC 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-360 3.07e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 3.07e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295444820   300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVEghvsstSYYSTCQSDGQWSNSGLKC 360
Cdd:smart00032   1 CPPpPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
300-360 1.65e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 37.09  E-value: 1.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295444820  300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVeghvssTSYYSTCQSDGQWSNSGLKC 360
Cdd:pfam00084   1 CPPpPDIPNGKVSATKNEYNYGASVSYECDPGYRLV------GSPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 443-681 2.76e-69

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 226.02  E-value: 2.76e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   443 KIFGGQPAKIENFPWQVFF----NHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADLENAQRLYTKRVIIHP 518
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLqyggGRHFCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVIKVSKVIIHP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   519 GWkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPgtSSEYNLSPGDMGLISGWGRTEKRLHVIN--LRGAKVPVT 596
Cdd:smart00020  81 NY------NPST-YDNDIALLKLKEPVTLSDNVRPICLP--SSNYNVPAGTTCTVSGWGRTSEGAGSLPdtLQEVNVPIV 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   597 SLETCKQvkeenptARPEDYVITDNMICAG--EKGVDSCKGDSGGAFAFQVpnvkaPKFYVAGLVSWGKKCG---AYGVY 671
Cdd:smart00020 152 SNATCRR-------AYSGGGAITDNMLCAGglEGGKDACQGDSGGPLVCND-----GRWVLVGIVSWGSGCArpgKPGVY 219

                          250
                   ....*....|
gi 295444820   672 TKVKNYVDWI 681
Cdd:smart00020 220 TRVSSYLDWI 229
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 444-684 3.01e-69

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 226.00  E-value: 3.01e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 444 IFGGQPAKIENFPWQVF----FNHPTAGGALINEYWVLTAAHVVEKNSDPSM--YAGITALRLADlENAQRLYTKRVIIH 517
Cdd:cd00190    1 IVGGSEAKIGSFPWQVSlqytGGRHFCGGSLISPRWVLTAAHCVYSSAPSNYtvRLGSHDLSSNE-GGGQVIKVKKVIVH 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 518 PGWkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPgtSSEYNLSPGDMGLISGWGRTEKRL-HVINLRGAKVPVT 596
Cdd:cd00190   80 PNY------NPST-YDNDIALLKLKRPVTLSDNVRPICLP--SSGYNLPAGTTCTVSGWGRTSEGGpLPDVLQEVNVPIV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 597 SLETCKQvkeenptARPEDYVITDNMICAG--EKGVDSCKGDSGGAFAFQVPNVkapkFYVAGLVSWGKKCGA---YGVY 671
Cdd:cd00190  151 SNAECKR-------AYSYGGTITDNMLCAGglEGGKDACQGDSGGPLVCNDNGR----GVLVGIVSWGSGCARpnyPGVY 219

                        250
                 ....*....|...
gi 295444820 672 TKVKNYVDWILKT 684
Cdd:cd00190  220 TRVSSYLDWIQKT 232
Trypsin pfam00089
Trypsin;
444-681 6.98e-62

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 205.75  E-value: 6.98e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  444 IFGGQPAKIENFPWQVFF----NHPTAGGALINEYWVLTAAHVVEKNSDPSMYAGITALRLADlENAQRLYTKRVIIHPG 519
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLqlssGKHFCGGSLISENWVLTAAHCVSGASDVKVVLGAHNIVLRE-GGEQKFDVEKIIVHPN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  520 WkedddlNPRTnFDNDIALVQLKDPVKMGPKFSPICLPGTSSeyNLSPGDMGLISGWGRTEKRLHVINLRGAKVPVTSLE 599
Cdd:pfam00089  80 Y------NPDT-LDNDIALLKLESPVTLGDTVRPICLPDASS--DLPVGTTCTVSGWGNTKTLGPSDTLQEVTVPVVSRE 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  600 TCKQVKeenptarpeDYVITDNMICAGEKGVDSCKGDSGGAFafqVPNVKapkfYVAGLVSWGKKCGA---YGVYTKVKN 676
Cdd:pfam00089 151 TCRSAY---------GGTVTDTMICAGAGGKDACQGDSGGPL---VCSDG----ELIGIVSWGYGCASgnyPGVYTPVSS 214


                  ....*
gi 295444820  677 YVDWI 681
Cdd:pfam00089 215 YLDWI 219
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 433-689 3.99e-51

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 178.30  E-value: 3.99e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 433 VPTEPFQVQQKIFGGQPAKIENFPWQVFFNHPTA------GGALINEYWVLTAAHVVEKNSDPSM--YAGITALRLADle 504
Cdd:COG5640   20 AAAPAADAAPAIVGGTPATVGEYPWMVALQSSNGpsgqfcGGTLIAPRWVLTAAHCVDGDGPSDLrvVIGSTDLSTSG-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 505 nAQRLYTKRVIIHPGWkedddlNPRTnFDNDIALVQLKDPVkmgPKFSPICLPGTSSEynLSPGDMGLISGWGRTEKRLH 584
Cdd:COG5640   98 -GTVVKVARIVVHPDY------DPAT-PGNDIALLKLATPV---PGVAPAPLATSADA--AAPGTPATVAGWGRTSEGPG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 585 VIN--LRGAKVPVTSLETCKQVKEenptarpedyVITDNMICAG--EKGVDSCKGDSGGAFAFQVPNVkapkFYVAGLVS 660
Cdd:COG5640  165 SQSgtLRKADVPVVSDATCAAYGG----------FDGGTMLCAGypEGGKDACQGDSGGPLVVKDGGG----WVLVGVVS 230

                        250       260       270
                 ....*....|....*....|....*....|..
gi 295444820 661 WGK-KCGA--YGVYTKVKNYVDWILKTMQENS 689
Cdd:COG5640  231 WGGgPCAAgyPGVYTRVSAYRDWIKSTAGGLG 262
CUB pfam00431
CUB domain;
181-293 1.13e-27

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 107.38  E-value: 1.13e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  181 CSGdVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTmqREDFDVEPADSegnCP-DSLTF----AAKNQQFGP 255
Cdd:pfam00431   1 CGG-VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLT--FQDFELEDHDE---CGyDYVEIrdgpSASSPLLGR 74

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 295444820  256 YCGDGfpGPLTIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:pfam00431  75 FCGSG--IPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 24-135 9.06e-27

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 105.19  E-value: 9.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820  24 TMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEE----GRLCGQRTskspns 99
Cdd:cd00041    8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSspllGRFCGSTL------ 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 295444820 100 piIEEFQFPYNKLQVVFTSDFSIeeQFTGFAAYYTA 135
Cdd:cd00041   82 --PPPIISSGNSLTVRFRSDSSV--TGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 181-293 2.80e-25

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.95  E-value: 2.80e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 181 CSGDVFTALIGEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMqrEDFDVEpadSEGNCP-DSLTF----AAKNQQFGP 255
Cdd:cd00041    1 CGGTLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTF--EDFDLE---SSPNCSyDYLEIydgpSTSSPLLGR 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 295444820 256 YCGDGFPGPltIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:cd00041   76 FCGSTLPPP--IISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 27-133 4.63e-25

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 99.77  E-value: 4.63e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820    27 GEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISG----GIEEGRLCGqrtSKSPNSPII 102
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGpsasSPLLGRFCG---SEAPPPVIS 77

                           90       100       110
                   ....*....|....*....|....*....|.
gi 295444820   103 EEfqfpYNKLQVVFTSDFSIeeQFTGFAAYY 133
Cdd:smart00042  78 SS----SNSLTLTFVSDSSV--QKRGFSARY 102
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 191-293 1.74e-23

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 95.15  E-value: 1.74e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   191 GEISSPNYPNPYPENSRCEYQIQLQEGFQVVVTMqrEDFDVEPADsegNCP-DSLTF----AAKNQQFGPYCGDGFPgPL 265
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQF--TDFDLESSD---NCEyDYVEIydgpSASSPLLGRFCGSEAP-PP 74

                           90       100
                   ....*....|....*....|....*...
gi 295444820   266 TIRTQSNTLGIVFQTDLMGQKKGWKLRY 293
Cdd:smart00042  75 VISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
24-133 1.29e-18

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 81.57  E-value: 1.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820   24 TMHGEILSPNYPQAYPNDVVKSWDIEVPEGFGIHLYFTHVDIEPSESCAYDSVQIISGGIEE----GRLCGqrtskspnS 99
Cdd:pfam00431   7 DSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASspllGRFCG--------S 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 295444820  100 PIIEEFQFPYNKLQVVFTSDFSIeeQFTGFAAYY 133
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASV--QKRGFKATY 110
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 149-177 1.76e-07

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 47.62  E-value: 1.76e-07
                          10        20
                  ....*....|....*....|....*....
gi 295444820  149 CSHFCNNFIGGYFCSCPPEYFLHDDMRNC 177
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
eMpr COG3591
V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, ...
 468-687 1.51e-06

V8-like Glu-specific endopeptidase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442810 [Multi-domain]  Cd Length: 194  Bit Score: 49.29  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 468 GALINEYWVLTAAHVVEknsDPSMYAGITALR-LADLENAQRLYTK--RVIIHPGWKEDddlnprTNFDNDIALVQLKDP 544
Cdd:COG3591   16 GTLIGPNLVLTAGHCVY---DGAGGGWATNIVfVPGYNGGPYGTATatRFRVPPGWVAS------GDAGYDYALLRLDEP 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444820 545 VkmGPKFSPIclpGTSSEYNLSPGDMGLISGWGRTekRLHVINLRgakvpvtslETCKqvkeenPTARPEDYVITDnmiC 624
Cdd:COG3591   87 L--GDTTGWL---GLAFNDAPLAGEPVTIIGYPGD--RPKDLSLD---------CSGR------VTGVQGNRLSYD---C 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295444820 625 agekgvDSCKGDSGGAfafqVPNVKAPKFYVAGLVSWG-KKCGAYGVYTkVKNYVDWILKTMQE 687
Cdd:COG3591  142 ------DTTGGSSGSP----VLDDSDGGGRVVGVHSAGgADRANTGVRL-TSAIVAALRAWASA 194
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 300-361 1.21e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 1.21e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 295444820 300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVEghvsstSYYSTCQSDGQWSNSGLKCQ 361
Cdd:cd00033    1 CPPpPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVG------SSTITCTENGGWSPPPPTCE 57
EGF_CA pfam07645
Calcium-binding EGF domain;
137-166 1.58e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.22  E-value: 1.58e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 295444820  137 DVNECTDFTDV-PCSHFCNNFIGGYFCSCPP 166
Cdd:pfam07645   1 DVDECATGTHNcPANTVCVNTIGSFECRCPD 31
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 365-428 1.72e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.84  E-value: 1.72e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 295444820 365 CGIPDPIANGKVEEPENS-VFGTVIHYTCeEPYYYMEHEEggEYRCAANGRWVNdqlgiELPRCI 428
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSC-NEGYTLVGSS--TITCTENGGWSP-----PPPTCE 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
137-177 2.28e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 2.28e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 295444820   137 DVNECTdfTDVPCSH--FCNNFIGGYFCSCPPEYFlhdDMRNC 177
Cdd:smart00179   1 DIDECA--SGNPCQNggTCVNTVGSYRCECPPGYT---DGRNC 38
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 365-427 7.02e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 40.97  E-value: 7.02e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 295444820   365 CGIPDPIANGKVEEPENS-VFGTVIHYTCEEPYYYMeheEGGEYRCAANGRWVNdqlgiELPRC 427
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTySYGDTVTYSCDPGYTLI---GSSTITCLENGTWSP-----PPPTC 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 137-177 8.89e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 8.89e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 295444820 137 DVNECTDFTdvPCSH--FCNNFIGGYFCSCPPEYFLhddmRNC 177
Cdd:cd00054    1 DIDECASGN--PCQNggTCVNTVGSYRCSCPPGYTG----RNC 37
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 300-360 3.07e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.05  E-value: 3.07e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295444820   300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVEghvsstSYYSTCQSDGQWSNSGLKC 360
Cdd:smart00032   1 CPPpPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIG------SSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
300-360 1.65e-03

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 37.09  E-value: 1.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 295444820  300 CPK-ESTANSNWEPDKAKYVFKDVVKITCVDGFEVVeghvssTSYYSTCQSDGQWSNSGLKC 360
Cdd:pfam00084   1 CPPpPDIPNGKVSATKNEYNYGASVSYECDPGYRLV------GSPTITCQEDGTWSPPFPEC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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