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Conserved domains on  [gi|386768044|ref|NP_788360|]
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cGAS-like receptor 1 [Drosophila melanogaster]

Protein Classification

Mab-21 family protein( domain architecture ID 10505530)

Mab-21 family protein, similar to Caenorhabditis elegans Mab-21 (Protein male abnormal 21) which acts in a cell autonomous fashion to specify the properties of the sensory ray and non-autonomously in the choice of hypodermal versus neuroblast cell fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mab-21 pfam03281
Mab-21 protein nucleotidyltransferase domain; This family contains Mab-21 and Mab-21 like ...
 60-246 5.15e-35

Mab-21 protein nucleotidyltransferase domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


:

Pssm-ID: 460873  Cd Length: 191  Bit Score: 127.16  E-value: 5.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044   60 YGDKLKVSIPDEFDLLIHLVFPENDKIIVkadASKPGNVILDMTKVMEIigsqEHNKPVFDRLQK---IVNNKKQLLEDK 136
Cdd:pfam03281   1 YYENLKVLSPDEFDVMLPLRGPMNDLIIV---MGVPGYVVLKLTRWRYY----LHNPVGRPESLSqwlEFTAEGYLSAAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044  137 LNSFLESIMTQTLNKmgnqieVAGRISHLQYKKC--GPAHTIFVKGS-CKYSVDFVPAIRLSAA---------------- 197
Cdd:pfam03281  74 VLSRFQSLVEKALNT------VNDSIYGLVYKREkgGPAVTLAIETSeDQYSVDLVPAIECPGIwpksarwprclkrwps 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 386768044  198 QVVLAPEQRihfgetLYWDAIPKPMKPAKTDNT-SFTSSFYEAERRLLYG 246
Cdd:pfam03281 148 QKVLRKIKS------EGFHLVAKSSPWPSSDENySWRLSFSQAEKVLLKG 191
Mab-21_C pfam20266
Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In ...
 250-342 1.36e-25

Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


:

Pssm-ID: 466416  Cd Length: 102  Bit Score: 99.23  E-value: 1.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044  250 LKPAIRLMKQNRNV------KNKANLKSYHIKTLFLWQVIQQ-DPSYWSNSP-KDIFIEMLGKLADSLaltpKKGKLPFF 321
Cdd:pfam20266   2 RKKCLRILKKLKEPgkrdvkTELSKICSYHLKTLFLWECEKHpDDSDWDKENlSDRFLGLLEELHKCL----RNGKLPHF 77

                          90       100
                  ....*....|....*....|.
gi 386768044  322 WDPKLDMFAQLTDSQRTDLYN 342
Cdd:pfam20266  78 FIPKLNLFQSLSRKELDDLAK 98
 
Name Accession Description Interval E-value
Mab-21 pfam03281
Mab-21 protein nucleotidyltransferase domain; This family contains Mab-21 and Mab-21 like ...
 60-246 5.15e-35

Mab-21 protein nucleotidyltransferase domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


Pssm-ID: 460873  Cd Length: 191  Bit Score: 127.16  E-value: 5.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044   60 YGDKLKVSIPDEFDLLIHLVFPENDKIIVkadASKPGNVILDMTKVMEIigsqEHNKPVFDRLQK---IVNNKKQLLEDK 136
Cdd:pfam03281   1 YYENLKVLSPDEFDVMLPLRGPMNDLIIV---MGVPGYVVLKLTRWRYY----LHNPVGRPESLSqwlEFTAEGYLSAAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044  137 LNSFLESIMTQTLNKmgnqieVAGRISHLQYKKC--GPAHTIFVKGS-CKYSVDFVPAIRLSAA---------------- 197
Cdd:pfam03281  74 VLSRFQSLVEKALNT------VNDSIYGLVYKREkgGPAVTLAIETSeDQYSVDLVPAIECPGIwpksarwprclkrwps 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 386768044  198 QVVLAPEQRihfgetLYWDAIPKPMKPAKTDNT-SFTSSFYEAERRLLYG 246
Cdd:pfam03281 148 QKVLRKIKS------EGFHLVAKSSPWPSSDENySWRLSFSQAEKVLLKG 191
Mab-21_C pfam20266
Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In ...
 250-342 1.36e-25

Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


Pssm-ID: 466416  Cd Length: 102  Bit Score: 99.23  E-value: 1.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044  250 LKPAIRLMKQNRNV------KNKANLKSYHIKTLFLWQVIQQ-DPSYWSNSP-KDIFIEMLGKLADSLaltpKKGKLPFF 321
Cdd:pfam20266   2 RKKCLRILKKLKEPgkrdvkTELSKICSYHLKTLFLWECEKHpDDSDWDKENlSDRFLGLLEELHKCL----RNGKLPHF 77

                          90       100
                  ....*....|....*....|.
gi 386768044  322 WDPKLDMFAQLTDSQRTDLYN 342
Cdd:pfam20266  78 FIPKLNLFQSLSRKELDDLAK 98
 
Name Accession Description Interval E-value
Mab-21 pfam03281
Mab-21 protein nucleotidyltransferase domain; This family contains Mab-21 and Mab-21 like ...
 60-246 5.15e-35

Mab-21 protein nucleotidyltransferase domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


Pssm-ID: 460873  Cd Length: 191  Bit Score: 127.16  E-value: 5.15e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044   60 YGDKLKVSIPDEFDLLIHLVFPENDKIIVkadASKPGNVILDMTKVMEIigsqEHNKPVFDRLQK---IVNNKKQLLEDK 136
Cdd:pfam03281   1 YYENLKVLSPDEFDVMLPLRGPMNDLIIV---MGVPGYVVLKLTRWRYY----LHNPVGRPESLSqwlEFTAEGYLSAAK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044  137 LNSFLESIMTQTLNKmgnqieVAGRISHLQYKKC--GPAHTIFVKGS-CKYSVDFVPAIRLSAA---------------- 197
Cdd:pfam03281  74 VLSRFQSLVEKALNT------VNDSIYGLVYKREkgGPAVTLAIETSeDQYSVDLVPAIECPGIwpksarwprclkrwps 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 386768044  198 QVVLAPEQRihfgetLYWDAIPKPMKPAKTDNT-SFTSSFYEAERRLLYG 246
Cdd:pfam03281 148 QKVLRKIKS------EGFHLVAKSSPWPSSDENySWRLSFSQAEKVLLKG 191
Mab-21_C pfam20266
Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In ...
 250-342 1.36e-25

Mab-21 protein HhH/H2TH-like domain; This family contains Mab-21 and Mab-21 like proteins. In C. elegans these proteins are required for several aspects of embryonic development.


Pssm-ID: 466416  Cd Length: 102  Bit Score: 99.23  E-value: 1.36e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386768044  250 LKPAIRLMKQNRNV------KNKANLKSYHIKTLFLWQVIQQ-DPSYWSNSP-KDIFIEMLGKLADSLaltpKKGKLPFF 321
Cdd:pfam20266   2 RKKCLRILKKLKEPgkrdvkTELSKICSYHLKTLFLWECEKHpDDSDWDKENlSDRFLGLLEELHKCL----RNGKLPHF 77

                          90       100
                  ....*....|....*....|.
gi 386768044  322 WDPKLDMFAQLTDSQRTDLYN 342
Cdd:pfam20266  78 FIPKLNLFQSLSRKELDDLAK 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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