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Conserved domains on  [gi|29244168|ref|NP_808380|]
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zinc finger protein 874 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-59 2.98e-26

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 100.36  E-value: 2.98e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 29244168      5 LSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFLGLAVAKPYLVTFLEQ 59
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-351 5.15e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168  59 QNQGSSGVKSQTSATIPPGTTGNEFNNHNEAIDHSSLSMQcqRIHTGEEPYYFEDCGKALSSQATLSVL-----QGHFIG 133
Cdd:COG5048 152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN--VSTSIPSSSENSPLSSSYSIPSSSSDQnlensSSSLPL 229
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 134 DKPYKCRECHKTLSSRSSLLIHQKYHTDEKTYKCEKCGKGFFRSSDLQHHQKIHTG-EKPYKCEECDKAFLHHSYLRKHQ 212
Cdd:COG5048 230 TTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHL 309
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 213 --AIHTGE--KPYKCEE--CGNSFYYPAMLKQHQRIHSGEKLDKC--EECGKVFSSAFFLNQHKGID--SGEKRYKCQEC 282
Cdd:COG5048 310 rsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqyKDLKNDKKSET 389
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29244168 283 GKSFCY-----RSYLREHYRMH--SGEYPYKCEECGKGFSRSSKLQEHQTIHTGVKPYKCEECGKcFSSFTSLKRH 351
Cdd:COG5048 390 LSNSCIrnfkrDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-435 7.13e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 275 KRYKCQECGKSFCYRSYLREHYRM--HSGEY--PYKCEE--CGKGFSRSSKLQEHQTIHTGVKPYKC--EECGKCFSSFT 346
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 347 SLKRHQIIH-----SEDTPHECV--ECGKRFSSSSRLQEHQKIHIEEKP--YKCEECDKAFLYHSFLRRHRAVHTREKPY 417
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
                       170
                ....*....|....*...
gi 29244168 418 TCEKCGKcFSSFTSLKRH 435
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-59 2.98e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 100.36  E-value: 2.98e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 29244168      5 LSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFLGLAVAKPYLVTFLEQ 59
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
4-45 3.14e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 3.14e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29244168     4 MLSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
5-44 2.05e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 64.11  E-value: 2.05e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 29244168   5 LSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFL 44
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-351 5.15e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168  59 QNQGSSGVKSQTSATIPPGTTGNEFNNHNEAIDHSSLSMQcqRIHTGEEPYYFEDCGKALSSQATLSVL-----QGHFIG 133
Cdd:COG5048 152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN--VSTSIPSSSENSPLSSSYSIPSSSSDQnlensSSSLPL 229
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 134 DKPYKCRECHKTLSSRSSLLIHQKYHTDEKTYKCEKCGKGFFRSSDLQHHQKIHTG-EKPYKCEECDKAFLHHSYLRKHQ 212
Cdd:COG5048 230 TTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHL 309
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 213 --AIHTGE--KPYKCEE--CGNSFYYPAMLKQHQRIHSGEKLDKC--EECGKVFSSAFFLNQHKGID--SGEKRYKCQEC 282
Cdd:COG5048 310 rsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqyKDLKNDKKSET 389
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29244168 283 GKSFCY-----RSYLREHYRMH--SGEYPYKCEECGKGFSRSSKLQEHQTIHTGVKPYKCEECGKcFSSFTSLKRH 351
Cdd:COG5048 390 LSNSCIrnfkrDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-435 7.13e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 275 KRYKCQECGKSFCYRSYLREHYRM--HSGEY--PYKCEE--CGKGFSRSSKLQEHQTIHTGVKPYKC--EECGKCFSSFT 346
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 347 SLKRHQIIH-----SEDTPHECV--ECGKRFSSSSRLQEHQKIHIEEKP--YKCEECDKAFLYHSFLRRHRAVHTREKPY 417
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
                       170
                ....*....|....*...
gi 29244168 418 TCEKCGKcFSSFTSLKRH 435
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-232 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*.
gi 29244168   207 YLRKHQAIHTGEKPYKCEECGNSFYY 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-400 3.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 29244168   375 RLQEHQKIHIEEKPYKCEECDKAFLY 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-59 2.98e-26

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 100.36  E-value: 2.98e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 29244168      5 LSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFLGLAVAKPYLVTFLEQ 59
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
4-45 3.14e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 77.90  E-value: 3.14e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 29244168     4 MLSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
5-44 2.05e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 64.11  E-value: 2.05e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 29244168   5 LSFWDVAIDFSPEEKECLEPAQWDLYRDVMLENFSHLDFL 44
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
59-351 5.15e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168  59 QNQGSSGVKSQTSATIPPGTTGNEFNNHNEAIDHSSLSMQcqRIHTGEEPYYFEDCGKALSSQATLSVL-----QGHFIG 133
Cdd:COG5048 152 PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN--VSTSIPSSSENSPLSSSYSIPSSSSDQnlensSSSLPL 229
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 134 DKPYKCRECHKTLSSRSSLLIHQKYHTDEKTYKCEKCGKGFFRSSDLQHHQKIHTG-EKPYKCEECDKAFLHHSYLRKHQ 212
Cdd:COG5048 230 TTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHL 309
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 213 --AIHTGE--KPYKCEE--CGNSFYYPAMLKQHQRIHSGEKLDKC--EECGKVFSSAFFLNQHKGID--SGEKRYKCQEC 282
Cdd:COG5048 310 rsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqyKDLKNDKKSET 389
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 29244168 283 GKSFCY-----RSYLREHYRMH--SGEYPYKCEECGKGFSRSSKLQEHQTIHTGVKPYKCEECGKcFSSFTSLKRH 351
Cdd:COG5048 390 LSNSCIrnfkrDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
275-435 7.13e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 275 KRYKCQECGKSFCYRSYLREHYRM--HSGEY--PYKCEE--CGKGFSRSSKLQEHQTIHTGVKPYKC--EECGKCFSSFT 346
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGESlkPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 347 SLKRHQIIH-----SEDTPHECV--ECGKRFSSSSRLQEHQKIHIEEKP--YKCEECDKAFLYHSFLRRHRAVHTREKPY 417
Cdd:COG5048 368 NNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447
                       170
                ....*....|....*...
gi 29244168 418 TCEKCGKcFSSFTSLKRH 435
Cdd:COG5048 448 LCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-445 1.02e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 191 KPYKCEECDKAFLHHSYLRKHQAIHTGEKPYKC--EECGNSFYYPAMLKQHQRIHSGEKLDkcEECGKVFSSAFFLNQHK 268
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 269 GIDSGEKR---YKCQECGKSFCYRSYLREHYRMHSGEYPYKCEECGKGF----SRSSKLQEHQTIHTGVKPYKCEECGKC 341
Cdd:COG5048 110 LSSSSSNSndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpQSNSLHPPLPANSLSKDPSSNLSLLIS 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 342 ------------------FSSFTSLKRHQIIHSEDTPHECVECGKRFSSSSRLQEHQKIHIEEKPYKCEECDKAFLYHSF 403
Cdd:COG5048 190 snvstsipsssensplssSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTAS 269
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 29244168 404 LRRHRAVHT-------REKPYTCEKCGKCFSSFTSLKRHQIHSIDISHE 445
Cdd:COG5048 270 SQSSSPNESdsssekgFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGES 318
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
384-441 2.41e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.41e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244168 384 IEEKPYKCE--ECDKAFLYHSFLRRHR-------------------AVHTREKPYTCEKCGKCFSSFTSLKRHQIHSID 441
Cdd:COG5189 345 KDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSHD 423
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
329-408 4.77e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 4.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 329 GVKPYKCE--ECGKCFSSFTSLKRHQIiHSEdtphecveCGKRFSSSSRLQEHQKIHIEEKPYKCEECDKAFLYHSFLRR 406
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416

                ..
gi 29244168 407 HR 408
Cdd:COG5189 417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
207-232 1.47e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|....*.
gi 29244168   207 YLRKHQAIHTGEKPYKCEECGNSFYY 232
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
132-211 1.62e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 132 IGDKPYKCR--ECHKTLSSRSSLLIHQKY-HTDEKTYKcekcgkgffrSSDLQHHQKIHTGEKPYKCEECDKAFLHHSYL 208
Cdd:COG5189 345 KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGL 414

                ...
gi 29244168 209 RKH 211
Cdd:COG5189 415 KYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
158-244 2.47e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244168 158 YHTDEKTYKCE--KCGKGFFRSSDLQHHqKIHTGEKPYKCEECDKAflhhsylrKHQAIHTGEKPYKCEECGNSFYYPAM 235
Cdd:COG5189 343 KVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNG 413

                ....*....
gi 29244168 236 LKQHqRIHS 244
Cdd:COG5189 414 LKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
179-204 2.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.58e-03
                          10        20
                  ....*....|....*....|....*.
gi 29244168   179 DLQHHQKIHTGEKPYKCEECDKAFLH 204
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-344 3.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*
gi 29244168   320 LQEHQTIHTGVKPYKCEECGKCFSS 344
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-400 3.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.57e-03
                          10        20
                  ....*....|....*....|....*.
gi 29244168   375 RLQEHQKIHIEEKPYKCEECDKAFLY 400
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
291-316 6.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 29244168   291 YLREHYRMHSGEYPYKCEECGKGFSR 316
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-428 9.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 9.53e-03
                          10        20
                  ....*....|....*....|....*
gi 29244168   404 LRRHRAVHTREKPYTCEKCGKCFSS 428
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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