|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
1-449 |
0e+00 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 971.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 1 MTSSLSLHSSFVPSFADLSDRGLISKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVD---------------AMN 65
Cdd:PLN02509 1 MTSSLSLHSSFVPSFADLSDRGLVSKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVDvstsavvdgvadclnEMN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 66 IKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 145
Cdd:PLN02509 81 IKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 146 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIS 225
Cdd:PLN02509 161 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 226 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 305
Cdd:PLN02509 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 306 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYF 385
Cdd:PLN02509 321 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYF 400
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694565 386 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKTFPL 449
Cdd:PLN02509 401 SIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFRTGPL 464
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
72-449 |
0e+00 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 705.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 72 VSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH 151
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 152 LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQ 231
Cdd:TIGR01329 81 LLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 232 GALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIK 311
Cdd:TIGR01329 161 NALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 312 TMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSF 391
Cdd:TIGR01329 241 TLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQAKGAGSVLSFETGSVALSKRLVEATKLFSITVSF 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 30694565 392 GSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKTFPL 449
Cdd:TIGR01329 321 GSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAFVTAPA 378
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
73-445 |
0e+00 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 578.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 73 STLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVT 150
Cdd:pfam01053 1 DTLAVHAGQRPDPqTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAItAAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 151 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA 230
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 231 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGI 310
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 311 KTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVAL-SKHLVETTKYFSIAV 389
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQMKGFGGMLSFELKGGLEaAKKFLDNLKLFSLAV 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 30694565 390 SFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:pfam01053 321 SLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSVGIEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
87-445 |
0e+00 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 518.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 87 DAMSTPLYQTATFKQPSAIE--------NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGE 157
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEaadlfalrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVlLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 158 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLV 237
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 238 DNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRI 317
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 318 EKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKS 396
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQMSGYGGVFSFeLKGGLEAAKKFLNALKLFSLAVSLGGVES 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 30694565 397 LISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:cd00614 321 LVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQALK 369
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
73-445 |
0e+00 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 514.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 73 STLLVNLDNKFDP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGM 143
Cdd:COG0626 4 ATRAVHAGRDPDPqTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 144 AALSAV-THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIR 222
Cdd:COG0626 84 AAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVDIA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 223 KISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFD 302
Cdd:COG0626 164 AIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFD 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 303 CWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVET 381
Cdd:COG0626 244 AWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQMSGFGGMLSFeLKGGREAARRFLDA 323
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694565 382 TKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:COG0626 324 LKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRLSVGLEDVDDLIADLEQALA 387
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
88-445 |
7.14e-148 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 426.06 E-value: 7.14e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 167
Cdd:PRK07671 20 AVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMMLFSSGDHVILTDDVYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 168 GSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 247
Cdd:PRK07671 100 GTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTPYWQ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 248 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 327
Cdd:PRK07671 180 SPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAI 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 328 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 407
Cdd:PRK07671 260 AEFLNNHPAVNKVYYPGLPSHPNHELAKEQANGFGGMISFDVGSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHA 339
|
330 340 350
....*....|....*....|....*....|....*...
gi 30694565 408 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK07671 340 SIPADRRKELGITDGLIRISVGIEDGEDLIEDLAQALA 377
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
68-445 |
1.76e-146 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 423.03 E-value: 1.76e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 68 EEASVSTLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 146
Cdd:PRK08064 3 MSYSIDTLLLHNQYKHDKqTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 147 SAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISE 226
Cdd:PRK08064 83 STAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 227 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLC 306
Cdd:PRK08064 163 LAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLV 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 307 LRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFS 386
Cdd:PRK08064 243 LRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQATSAGAVLSFTLQSEEAVRQFVSHVKLPV 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 30694565 387 IAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK08064 323 FAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGLLRLSVGLENVDDLIADFEQALS 381
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
73-444 |
4.88e-142 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 411.35 E-value: 4.88e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 73 STLLVNLDNKFDPFD-AMSTPLYQTATFKQ--PSAIENGpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SA 148
Cdd:PRK07811 14 ATRAIHAGYEPDPATgAVNPPIYASSTFAQdgVGGLRGG-YEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATdCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 149 VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMA 228
Cdd:PRK07811 93 LRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 229 HAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLR 308
Cdd:PRK07811 173 HDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLR 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 309 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSI 387
Cdd:PRK07811 253 GLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQMRGFGGMVSVrLAGGEEAARDFCARTKVFTL 332
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 388 AVSFGSVKSLISMPCFMSHASI---PAEVrearglTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK07811 333 AESLGGVESLIEHPSAMTHASTagsQLEV------PDDLVRLSVGIEDVADLLADLEQAL 386
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
88-444 |
2.19e-126 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 371.54 E-value: 2.19e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 167
Cdd:PRK06176 20 AVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLFQSGDHVLLGDDVYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 168 GSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 247
Cdd:PRK06176 100 GTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 248 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 327
Cdd:PRK06176 180 NPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 328 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 407
Cdd:PRK06176 260 AEFLEKHPKVEKVYYPGLPTHPNHELAKKQMRGFSGMLSFTLKNDSEAVAFVESLKLFILGESLGGVESLVGIPAFMTHA 339
|
330 340 350
....*....|....*....|....*....|....*..
gi 30694565 408 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK06176 340 CIPKEQREAAGIRDGLVRLSVGIEHEQDLLEDLEQAF 376
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
71-445 |
2.73e-120 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 355.16 E-value: 2.73e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 71 SVSTLLVNLDNKFDPFD-AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV 149
Cdd:PRK08247 4 TIETKLAQIGNRSDERTgTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 150 THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAH 229
Cdd:PRK08247 84 MSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 230 AQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRG 309
Cdd:PRK08247 164 KHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 310 IKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAglpdhpghhlhfsqakGAGSVFSFITGSVALSKHLVETTKYFSIAV 389
Cdd:PRK08247 244 MKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP----------------GRGGMLSFRLQDEEWVNPFLKSLKLITFAE 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 30694565 390 SFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK08247 308 SLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSVGIENVEDLIADLKQAFK 363
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
86-444 |
2.78e-118 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 350.64 E-value: 2.78e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 86 FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDD 164
Cdd:TIGR02080 19 YGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVtTALLGPDDLLVAPHD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 165 VYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSP 244
Cdd:TIGR02080 99 CYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 245 VLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 324
Cdd:TIGR02080 179 ALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 325 RKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCF 403
Cdd:TIGR02080 259 QAIVEYLQTQPLVKKIYYPGLPDHPGHEIAARQQKGFGAMLSFeLKGGEQTVRRFLGGLSLFTLAESLGGVESLIAHPAT 338
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 30694565 404 MSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:TIGR02080 339 MTHAAMGPEARAEAGISDTLLRLSVGLEDADDLIADLEQGL 379
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
84-443 |
3.43e-110 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 330.31 E-value: 3.43e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 84 DPFDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIK 154
Cdd:TIGR01328 17 DQFGALTPPIYQTSTFVFDSCEQGGNrfagqesgYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAAtLLTILK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 155 NGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGAL 234
Cdd:TIGR01328 97 AGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQGVK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 235 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK-EVYFLQNSEGSGLAPFDCWLCLRGIKTM 313
Cdd:TIGR01328 177 VIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGSVISPFDAWLILRGLKTL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 314 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 392
Cdd:TIGR01328 257 NIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRMGGGMITFeLKGGFAGAKKLLNNLKLIRLAVSLG 336
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 30694565 393 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIA 443
Cdd:TIGR01328 337 DAETLIQHPASMTHAVVPKEEREAAGITDGMIRLSVGLEDADDLIADLKQA 387
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
86-446 |
3.81e-110 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 330.64 E-value: 3.81e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 86 FDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLIKNG 156
Cdd:PRK06234 24 FGSLATPIYQTSTFIFDSAEQGGRrfageesgYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAIsSSLWSALKAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 157 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA--QGAL 234
Cdd:PRK06234 104 DHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKAISNIAHEnnKECL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 235 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEVYF--LQNSEGSGLAPFDCWLCLRGIKT 312
Cdd:PRK06234 184 VFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAG-FVVGKEEFINQVKLfgIKDMTGSVIGPFEAFLIIRGMKT 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 313 MALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSF 391
Cdd:PRK06234 263 LQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQMSLPGAMISFeLKGGVEEGKVVMNNVKLATLAVSL 342
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 30694565 392 GSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 446
Cdd:PRK06234 343 GDAETLIQHPASMTHSPYTAEERKEAGISDGLVRLSVGLEDVDDIIADLKQALDL 397
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
84-445 |
1.00e-109 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 330.45 E-value: 1.00e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 84 DP-FDAMSTPLYQTATFKQPSA---------IENGpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 152
Cdd:COG2873 20 DPtTGARAVPIYQTTSYVFDDAehaadlfalKEPG-NIYTRIMNPTTDVLEKRIAALEGGVAALATASGQAAITlAILNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 153 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG 232
Cdd:COG2873 99 AEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIAHEHG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 233 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL--------------------------AVKGEKLAKE 286
Cdd:COG2873 179 VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwaangkfpeltepdpsyhgLVYTEAFGNA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 287 VY------FLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLhfsqA-- 358
Cdd:COG2873 259 AFitkarvQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYHEL----Aqk 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 359 ---KGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVD 434
Cdd:COG2873 335 ylpKGAGGVLTFgLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLIRLSVGIEDID 414
|
410
....*....|.
gi 30694565 435 DLISDLDIAFK 445
Cdd:COG2873 415 DIIADLDQALA 425
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
94-444 |
2.42e-109 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 328.62 E-value: 2.42e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 94 YQTATFKQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRL 172
Cdd:PRK08249 46 YDVALGKKPGHI------YSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYtFLKPGDRVVSIKDTYGGTNKI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 173 LSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLEL 252
Cdd:PRK08249 120 FTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLAL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 253 GADIVMHSATKFIAGHSDVMAGVlAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLS 332
Cdd:PRK08249 200 GADLVIHSATKFLSGHADALGGV-VCGSKELMEQVYHYREINGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQ 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 333 SHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPA 411
Cdd:PRK08249 279 THPKVEAVYYPGLETHPNHEIAKAQMRGFGGILSFvLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTL 358
|
330 340 350
....*....|....*....|....*....|...
gi 30694565 412 EVREARGLTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK08249 359 EERAALGIPEGLVRISVGIEDTEDLIADLEQAF 391
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
68-441 |
1.14e-107 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 323.88 E-value: 1.14e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 68 EEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCF 139
Cdd:PRK08133 3 DSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAArfageepgNIYSRFTNPTVTMFQERLAALEGAEACVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 140 TSGMAA-LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQI 218
Cdd:PRK08133 83 ASGMAAiLAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 219 SDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEkLAKEVYFLQNSEGSGL 298
Cdd:PRK08133 163 ADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKE-LMEEVFGFLRTAGPTL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 299 APFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKH 377
Cdd:PRK08133 242 SPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQQKGGGAIVSFeVKGGREAAWR 321
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694565 378 LVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLD 441
Cdd:PRK08133 322 VIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIRVAVGLEDVADIKADLA 385
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
74-443 |
3.47e-106 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 319.87 E-value: 3.47e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 74 TLLVNLDNKFDPFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 145
Cdd:TIGR01325 2 TLAVRGGMLRSGFEETAEALYLTSGYVYDSAAvaakrfagELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 146 -LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKI 224
Cdd:TIGR01325 82 iFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 225 SEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCW 304
Cdd:TIGR01325 162 AELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAW 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 305 LCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKY 384
Cdd:TIGR01325 242 VLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHELAKRQMSGGGTVVTFDLDCRQAAFKVLDAMRL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 30694565 385 FSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIA 443
Cdd:TIGR01325 322 VDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSVGLEDVDDLIADIDRA 380
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
84-445 |
3.68e-103 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 312.38 E-value: 3.68e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 84 DPFDAMSTPLYQTATFKQPsaIENGPYD------YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNG 156
Cdd:PRK08574 15 DPYGSLQPPIYLTALFRQE--GEAYPSDrgfdlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLfFSLLKAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 157 EEIVAGDDVYGGSDRLLSQVVpRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 236
Cdd:PRK08574 93 DRVVLPMEAYGTTLRLLKSLE-KFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 237 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 316
Cdd:PRK08574 172 VDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVR 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 317 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLH---FSQAKgAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 392
Cdd:PRK08574 252 FERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGVAkrlFGKDL-YGGVVSFrVKGGRDAVLKFLRSLKLIKPSPSLG 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 30694565 393 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK08574 331 GVESLATYPVKSAASPIPEEDRKALGITEDLVRLSVGLEDVEDLIEDLDQALG 383
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
88-443 |
1.24e-101 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 307.52 E-value: 1.24e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 167
Cdd:PRK07269 24 ALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFSVFPVGSKVVAVRDLYG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 168 GSDRLLSQVVPRSGVVVKRVNTTKldEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 247
Cdd:PRK07269 104 GSFRWFNQQEKEGRFHFTYANTEE--ELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 248 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 327
Cdd:PRK07269 182 RPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 328 AMYLSSHPRVKKVYYAGLpdhpghhlhfsqakgaGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHA 407
Cdd:PRK07269 262 VAFLKKSPAVKEVLYTGK----------------GGMISFKVADETRIPHILNSLKVFTFAESLGGVESLITYPTTQTHA 325
|
330 340 350
....*....|....*....|....*....|....*.
gi 30694565 408 SIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIA 443
Cdd:PRK07269 326 DIPAEVRHSYGLTDDLLRLSIGIEDARDLIADLKQA 361
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
92-445 |
8.15e-101 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 306.44 E-value: 8.15e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 92 PLYQTAT-----FKQPSAiengpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDV 165
Cdd:PRK08045 26 PIHLSSTynftgFNEPRA-----HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVtTVFLKPGDLLVAPHDC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 166 YGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPV 245
Cdd:PRK08045 101 YGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 246 LSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENAR 325
Cdd:PRK08045 181 LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 326 KIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFM 404
Cdd:PRK08045 261 AIVKYLQTQPLVKKLYHPSLPENQGHEIAARQQKGFGAMLSFeLDGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATM 340
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 30694565 405 SHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK08045 341 THAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFR 381
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
88-440 |
1.52e-100 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 306.15 E-value: 1.52e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVY 166
Cdd:PRK08776 30 AVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNaLLQPGDTLVVPHDAY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 167 GGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVL 246
Cdd:PRK08776 110 GGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPAL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 247 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 326
Cdd:PRK08776 190 QKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADA 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 327 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 405
Cdd:PRK08776 270 IAALLDGHAAVNQVYYPGLASHPGHALAARQQKGFGAMLSFeLEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMT 349
|
330 340 350
....*....|....*....|....*....|....*
gi 30694565 406 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDL 440
Cdd:PRK08776 350 HAAMTAEARAAAGISDGLLRLSVGIESAEDLLIDL 384
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
83-445 |
6.71e-99 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 302.11 E-value: 6.71e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 83 FDPFD---AMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT- 150
Cdd:PRK07503 19 YDPLDhggALVPPVYLTATFAFPTAEygaecfagEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLw 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 151 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA 230
Cdd:PRK07503 99 TLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 231 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEV--YFLQNSEGSGLAPFDCWLCLR 308
Cdd:PRK07503 179 AGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAG-LVVGGKALADRIrlEGLKDMTGAVMSPFDAFLLMR 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 309 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSI 387
Cdd:PRK07503 258 GLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQMALPGGMIAFeLKGGIAAGRRFMNALQLFAR 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 30694565 388 AVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK07503 338 AVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLSVGLEDVADILADLAQALD 395
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
86-444 |
1.54e-96 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 295.27 E-value: 1.54e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 86 FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNGEEIVAGDD 164
Cdd:PRK08861 21 YHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwVSALLGPDDLIVAPHD 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 165 VYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSP 244
Cdd:PRK08861 101 CYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 245 VLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 324
Cdd:PRK08861 181 VLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESA 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 325 RKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCF 403
Cdd:PRK08861 261 QQILAYLQTQSLVGTIYHPSLPEHPGHEIAKKQQSGFGSMLSFeFAGSFEQLKVFVKALALFSLAESLGGVESLICHPAS 340
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 30694565 404 MSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK08861 341 MTHRAMGEEALAEAGVSQQLLRLSVGLEDAQDLIADLDQAF 381
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
86-445 |
1.74e-96 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 295.21 E-value: 1.74e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 86 FDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNG 156
Cdd:PRK06767 21 KGSLTPPLFQTSTFTFETAQQGEAsfagvdpsYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAISATlIGFLKAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 157 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 236
Cdd:PRK06767 101 DHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 237 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 316
Cdd:PRK06767 181 VDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVR 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 317 IEKQQENARKIAMYLSSHPRVKKVYYaglpdhPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVK 395
Cdd:PRK06767 261 MDRHCDNAEKIVSFLKNHDAVEGVWY------PEGELASRQMKRGGGVISFsIKGGKEETQAFINDLHFITIAVSLGDTE 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 30694565 396 SLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK06767 335 TLIQHPATMTHAAIPAELRQEMGIYDNLIRLSVGLESWEDIVSDLEQALK 384
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
88-445 |
3.83e-94 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 290.03 E-value: 3.83e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEE 158
Cdd:TIGR01326 19 SRAVPIYQTTSYVFDSTehaaalfgLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQAAITyAILNLAGAGDN 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 159 IVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVD 238
Cdd:TIGR01326 99 IVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIEAIAEVAHRHGIPLIVD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 239 NSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLaVKGEKL--AKEVY--FLQNSE-------------------- 294
Cdd:TIGR01326 179 NTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVI-VDGGKFdwNNGRFplFTTPDPsyhglvftetlgnpafilka 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 295 --------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL---HFSqaKGAGS 363
Cdd:TIGR01326 258 rvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPHHALakkYLP--KGFGA 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 364 VFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDI 442
Cdd:TIGR01326 336 VLSFeIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRLSVGIENIDDIIADLEQ 415
|
...
gi 30694565 443 AFK 445
Cdd:TIGR01326 416 ALE 418
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
83-443 |
1.68e-87 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 271.48 E-value: 1.68e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 83 FDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDkADRAFCFTSGMAALSAVTH-LIKNGEEIVA 161
Cdd:PRK07582 16 AVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELE-GAEALVFPSGMAAITAVLRaLLRPGDTVVV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 162 GDDVYGGSDRLLSQVVPRSGVVVKRVNTtklDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 241
Cdd:PRK07582 95 PADGYYQVRALAREYLAPLGVTVREAPT---AGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 242 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQ 321
Cdd:PRK07582 172 ATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQC 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 322 ENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVkslismp 401
Cdd:PRK07582 252 ANALAVAELLAGHPAVRGVRYPGLPGDPAHEVAARQMRRFGGLVSFELADAAAAERFVAASRLVVAATSFGGV------- 324
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 30694565 402 cfmsHASipAEVREARG--LTEDLVRISAGIEDVDDLISDLDIA 443
Cdd:PRK07582 325 ----HTS--ADRRARWGdaVPEGFVRLSCGIEDTDDLVADLERA 362
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
88-446 |
2.83e-86 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 268.62 E-value: 2.83e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATFKQPsaiENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT-HLIKNGEEIVAGDDVY 166
Cdd:PRK06460 18 AITTPIYQTTAYHYP---EGEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTAlALLKPGNSVLVHRDMF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 167 GGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVL 246
Cdd:PRK06460 95 GRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 247 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEkLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 326
Cdd:PRK06460 175 QKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQ 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 327 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMS 405
Cdd:PRK06460 254 IAEFLEGHPKVVKVYYPGLKSHVDYEIARRVLKGFGGVLSFeVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMS 333
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 30694565 406 HASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 446
Cdd:PRK06460 334 HRTLSLEERKIVGITDSLLRLSVGIEDVNDLIEDLDRALST 374
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
84-446 |
1.76e-85 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 268.53 E-value: 1.76e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 84 DP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLI 153
Cdd:PRK08134 21 DPaTGARAVPIHLTTSFVFRDSdhaaalfnLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHlAIATLM 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 154 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGA 233
Cdd:PRK08134 101 GAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAHEAGV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 234 LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG----EKLAK-----EVY-------FLQNSE--- 294
Cdd:PRK08134 181 PLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGrfdwEASGKfpeltEPYagfhgmvFAEESTvaa 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 295 -------------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLhfsqAK-- 359
Cdd:PRK08134 261 fllrarreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHAL----AKrl 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 360 ---GAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDD 435
Cdd:PRK08134 337 lprGAGSVFSFdLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRLSIGLEDADD 416
|
410
....*....|.
gi 30694565 436 LISDLDIAFKT 446
Cdd:PRK08134 417 LIDDLKRALKA 427
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
85-445 |
2.96e-85 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 266.98 E-value: 2.96e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 85 PFDAMSTPLYQTATFKQPSAIE-----NGPYD---YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLIKN 155
Cdd:PRK07810 29 GFEETAEALYLTSGYVYESAAAaeaafTGELDrfvYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVfTALGALLGA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 156 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 235
Cdd:PRK07810 109 GDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKV 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 236 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMAL 315
Cdd:PRK07810 189 VLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLAL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 316 RIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKH----LVETTKYFSIAVS 390
Cdd:PRK07810 269 RVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQMSGGGTVVTFeLDAPEDAAKKrafeVLDKLRVIDISNN 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 30694565 391 FGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK07810 349 LGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLDRALG 403
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
88-444 |
3.10e-84 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 265.08 E-value: 3.10e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 152
Cdd:PRK07812 31 ARALPIYQTTSYtfddtdhaaalfglAEPGNI------YTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETfAILNL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 153 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQ 231
Cdd:PRK07812 105 AGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 232 GALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL------------------------AVKGEKLAKEV 287
Cdd:PRK07812 185 GVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfttpdpsyhGVVFAELGPPA 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 288 YFLQ------NSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQA-KG 360
Cdd:PRK07812 265 YALKarvqllRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWYERAKRLApKG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 361 AGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISD 439
Cdd:PRK07812 345 TGAVLSFeLAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQLATGVTPGLVRLAVGIEGIDDILAD 424
|
....*
gi 30694565 440 LDIAF 444
Cdd:PRK07812 425 LEAGF 429
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
73-444 |
1.86e-82 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 260.42 E-value: 1.86e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 73 STLLVNLDNKFDPFD-AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAF 137
Cdd:PRK05994 9 ATLAVHAGAQPDPTTgARATPIYQTTSFvfndadhaaslfglQAFGNI------YTRITNPTNAVLEERVAALEGGTAAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 138 CFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQ 216
Cdd:PRK05994 83 AVASGHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 217 QISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE--------------- 281
Cdd:PRK05994 163 TVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTfdwsksgkypmlsep 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 282 ------------------KLAKEVYFLQNSeGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYA 343
Cdd:PRK05994 243 rpeyhglvlhetfgnfafAIAARVLGLRDL-GPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 344 GLPDHPGHHLHFSQA-KGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTE 421
Cdd:PRK05994 322 GLPDDPYHALAQKYSpKGAGAVFTFgLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGP 401
|
410 420
....*....|....*....|...
gi 30694565 422 DLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK05994 402 DVVRLSIGIEDVDDIIADLEQAL 424
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
84-444 |
4.59e-81 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 255.60 E-value: 4.59e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 84 DP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLI 153
Cdd:PRK06434 21 DPrFGNVTTPIFETSTFVYPNSekeaymdsTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAItSAILSLI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 154 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAaaIGPQT-KLVWLESPTNPRQQISDIRKISEMAHaqG 232
Cdd:PRK06434 101 KKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNPTLKVPDIKNVSSFCH--E 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 233 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKT 312
Cdd:PRK06434 177 NDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKT 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 313 MALRIEKQQENARKIAMYLSSHPRVKKVYYaglpdhPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFG 392
Cdd:PRK06434 257 LGLRMEKHNKNGMELARFLRDSKKISNVYY------PDTEIGKKVLRGFGGMLSFELRSMEDVHKFIRNLEIPMVAASLG 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 30694565 393 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK06434 331 GVESLITLPVETSHSSLSPEERERLGISDNLVRFSIGIEDIDDLIKDIENAL 382
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
85-446 |
1.66e-79 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 251.98 E-value: 1.66e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 85 PFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKN 155
Cdd:PRK07504 24 QFGETSEALFLTQGFVYDTAEaaearfkgEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTaAILCQVKA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 156 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 235
Cdd:PRK07504 104 GDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 236 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEV--YFLQNseGSGLAPFDCWLCLRGIKTM 313
Cdd:PRK07504 184 VVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLqdYFRHT--GPSLSPFNAWTLLKGLETL 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 314 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFG 392
Cdd:PRK07504 262 PVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHPQADIIAKQMTGGSTLVAFeLKGGKEAAFRFLNALKIVRISNNLG 341
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 30694565 393 SVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 446
Cdd:PRK07504 342 DAKSLITHPATTTHKNLSPEARAELGISEGFLRLSAGLEDTDDLIEDLAAALKK 395
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
73-444 |
5.52e-79 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 251.51 E-value: 5.52e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 73 STLLVNLDnkFDPF---DAMSTPLYQTATF------------------KQPSAIENGPYDYTRSGNPTRDALESLLAKLD 131
Cdd:PRK07049 19 ETQMLNYG--YDPElseGAVKPPVFLTSTFvfrsaedgrdffdyvsgrKEPPAGEGAGLVYSRFNHPNSEIVEDRLAVYE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 132 KADRAFCFTSGMAALSAVT-HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVV-------VKRVNTTKLDEVAAAIGPqT 203
Cdd:PRK07049 97 GAESAALFSSGMSAIATTLlAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGavgfadgLSEAAIGAAAEAAAAKGR-V 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 204 KLVWLESPTNPRQQISDIRKISEMAHAQGA------LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvlA 277
Cdd:PRK07049 176 SLILIETPANPTNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG--A 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 278 VKGEK-LAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGL--PDHPGHHLH 354
Cdd:PRK07049 254 VLGRKaLIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFldPDSAYGAVY 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 355 FSQAKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDV 433
Cdd:PRK07049 334 KRQCTGAGSTFSFdIKGGQAAAFRFLNALQIFKLAVSLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHP 413
|
410
....*....|.
gi 30694565 434 DDLISDLDIAF 444
Cdd:PRK07049 414 DDLIADLAQAL 424
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
76-445 |
1.72e-76 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 243.84 E-value: 1.72e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 76 LVNLDNKFDPFDAMSTPLYQTATFKQPS--------AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS 147
Cdd:PRK05968 13 LITAHDEGNAFDAVVPPIFQTSLFTFDSydemedvyAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAIS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 148 A-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIgPQTKLVWLESPTNPRQQISDIRKISE 226
Cdd:PRK05968 93 StVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 227 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK---EVY-FLqnseGSGLAPFD 302
Cdd:PRK05968 172 LAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARinaEAYpYL----GAKLSPFE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 303 CWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHfsqakGAGSVFSFITGSVALSKHLVETT 382
Cdd:PRK05968 248 AWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHPPAGLS-----GTSGLFSFIFREGIDVRAFADAL 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30694565 383 KYFSIAVSFGSVKSLIsmpcfmshasIPAEVR----------EARGLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK05968 323 KLFRLGVSWGGHESLV----------VPAEVVlqqkaqpnsaARFGVSPRSVRLHVGLEGTEALWADLEQALA 385
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
64-445 |
3.80e-76 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 244.37 E-value: 3.80e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 64 MNIKEEASVSTLLVNLDNKFDPFD-AMSTPLYQTAT--FKQPS------AIENGPYDYTRSGNPTRDALESLLAKLDKAD 134
Cdd:PRK08248 1 MSEERTFRLETLAIHAGQEIDPTTgSRAVPIYQTTSygFRDSEhaanlfSLKEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 135 RAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTN 213
Cdd:PRK08248 81 GALAVSSGQAAITySILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 214 PRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG------------- 280
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGkfdwkgsgkfpgl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 281 -------------EKLAKEVYFLQ------NSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVY 341
Cdd:PRK08248 241 tepdpsyhglvytDAVGEAAYITKarvqllRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVS 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 342 YAGLPDHPGHHLHFSQ-AKGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGL 419
Cdd:PRK08248 321 YPGLPSHPSYELAKKYlPKGQGAILTFgIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGV 400
|
410 420
....*....|....*....|....*.
gi 30694565 420 TEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK08248 401 TPGLVRLSVGTEAIDDILDDLRQAIR 426
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
88-444 |
1.76e-72 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 234.41 E-value: 1.76e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 152
Cdd:PRK06084 20 AVAVPIYQTTSYafddtqhgadlfdlKVPGNI------YTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITyAIQTI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 153 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG 232
Cdd:PRK06084 94 AEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAHRHG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 233 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE---KLAKEVYFLQN----------------- 292
Cdd:PRK06084 174 VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKfpwAEHKERFALLNtpdpsyhgvtyteafgp 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 293 -------------SEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAK 359
Cdd:PRK06084 254 aafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHELARRYMG 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 360 GA-GSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLI 437
Cdd:PRK06084 334 GKpASILSFgIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRLSIGIEHIDDII 413
|
....*..
gi 30694565 438 SDLDIAF 444
Cdd:PRK06084 414 ADLAQAL 420
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
108-446 |
4.92e-71 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 229.96 E-value: 4.92e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 108 GPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDVYGGSDRLLsQVVPRSGVVVKR 186
Cdd:PRK05939 37 PGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVfLTLLRAGDHLVSSQFLFGNTNSLF-GTLRGLGVEVTM 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 187 VNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIA 266
Cdd:PRK05939 116 VDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 267 GHSDVMAGVLAVKGE------KLAKEVYFLQNSEGSGLAPF------DCWLCLR---------GIKTMALRIEKQQENAR 325
Cdd:PRK05939 196 GHGNALGGAVTDTGLfdwsayPNIFPAYRKGDPQQWGLTQIrkkglrDMGATLSseaahriaiGAETLALRVDRSCSNAL 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 326 KIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVALSKHLVETTKYFSIAVSFGSVKSLIsmpcfms 405
Cdd:PRK05939 276 ALAQFLEAHPKVARVYYPGLASHPQHARATELFRHYGGLLSFELADGIDCFDFLNRLKLVIKATHLGDTRTLV------- 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 30694565 406 hasIP----------AEVREARGLTEDLVRISAGIEDVDDLISDLDIAFKT 446
Cdd:PRK05939 349 ---IPvaptiyyemgAERRASMGIADSLIRVSVGIEDEADLIADFEQALDA 396
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
88-444 |
1.77e-66 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 219.36 E-value: 1.77e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 88 AMSTPLYQTATF--------KQPSAIEN-GPYdYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGE 157
Cdd:PRK05613 31 ARNLPIYQTTSYvfdsaehaKQRFALEDlGPI-YSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETaAILNLAGAGD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 158 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 236
Cdd:PRK05613 110 HIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAVAEVAHRNQVPLI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 237 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG------EKLAKEV--YF------------------- 289
Cdd:PRK05613 190 VDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGkfdwtvERDGKPVfpYFvtpdpayhglkyadlgapa 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 290 --------LQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQA-KG 360
Cdd:PRK05613 270 fglkaragLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSPWYATKEKLGlKY 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 361 AGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISD 439
Cdd:PRK05613 350 TGSVLSFdIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGLARAGITQATVRLSVGIEDIDDIIAD 429
|
....*
gi 30694565 440 LDIAF 444
Cdd:PRK05613 430 LEGGF 434
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
62-444 |
8.13e-60 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 200.42 E-value: 8.13e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 62 DAMNIKEEASVSTLLVNLDNkfDPFDA---MSTPLYQTATFKQPSA----IENGPYDYTRSGNPTRDALESLLAKLDKAD 134
Cdd:PRK05967 3 KKQLKTEKAGINTRLAHDGN--DPGDYhgfVNPPVVHASTVLFPDAetmaTRGQKYTYGTRGTPTTDALCKAIDALEGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 135 RAFCFTSGMAALSA-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTN 213
Cdd:PRK05967 81 GTILVPSGLAAVTVpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 214 PRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKgEKLAKEVYFLQNS 293
Cdd:PRK05967 161 NTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN-EKCWPQLLEAHGT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 294 EGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITGSVA 373
Cdd:PRK05967 240 LGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKRDFSGASGIFSFVLAAGP 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30694565 374 LSKH-----LVETTKYFSIAVSFGSVKSLismpcfMSHASIpAEVREARGLTED-LVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK05967 320 EKGKakahaFLDALEIFGLGYSWGGYESL------ALHVKL-GDRTVAKAPYAGpVIRLQIGLEDVPDLKADLERGF 389
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
86-443 |
2.29e-59 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 199.18 E-value: 2.29e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 86 FDAMSTPLYQTATFKQPSAIE--------NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNG 156
Cdd:PRK07050 25 FRSFVTPVARASTVVFPDLATmraldwrqDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFgLVKAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 157 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 236
Cdd:PRK07050 105 DDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 237 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 316
Cdd:PRK07050 185 IDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 317 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFITG---SVALSKHLVETTKYFSIAVSFGS 393
Cdd:PRK07050 265 LAAHDRSALEVAEWLKARPEIATVLHPALPDCPGHAFWMRDFTGAGGLFSVVFDerySPAQVDAFVEALELFAIGWSWGG 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 30694565 394 VKSLismpcfmshaSIPAEVREARGLTED----LVRISAGIEDVDDLISDLDIA 443
Cdd:PRK07050 345 ACSL----------AMPYDVASMRTAKWPhrgtLVRLYIGLEDEADLIADLEQA 388
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
90-447 |
3.74e-55 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 188.02 E-value: 3.74e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 90 STPLYQTATFKQPSAIE--NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVY 166
Cdd:PRK09028 31 STVVFDTVAEMRHAAKNraNGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISnALLSFLKAGDHLLMVDSCY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 167 GGSDRLLSQVVPRSGVvvkrvNTTKLDE-----VAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 241
Cdd:PRK09028 111 EPTRDLCDKILKGFGI-----ETTYYDPmigegIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 242 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVlAVKGEKlakevYFLQNSEGSGL-----APFDCWLCLRGIKTMALR 316
Cdd:PRK09028 186 ASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT-ATANEK-----HWDQLREHSYLmgqctSPDDVYLAMRGLRTLGVR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 317 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFI--TGSVALSKHLVETTKYFSIAVSFGSV 394
Cdd:PRK09028 260 LAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFKRDFSGSNGLFSFVlkQGDPKAVTALVEGMQHFKMGFSWGGF 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 30694565 395 KSLIsmpcfMSHASIPAeVREAR--GLTEDLVRISAGIEDVDDLISDLDIAFKTF 447
Cdd:PRK09028 340 ESLI-----LGVFGINK-LRTATnwDFSKPLIRLHIGLEDVDDLIADLEAGFERY 388
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
56-430 |
4.56e-54 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 186.12 E-value: 4.56e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 56 VMEKSVDAMNIKEEASVSTLLVNLDNKFDPFDA--MSTPLYQTATFKQPSAI------ENGP----YDYTRSGNPTRDAL 123
Cdd:PLN02242 2 MSEKEKKSPAESKEEDPAAALASARHEFGEHGGvnMSIEASATFTVMEPDTMrrmfsgELGPdrdfYIYSRHFNPTVLNL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 124 ESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDVYGGSDRLLSQVVPR-SGVVVKRVNTTKLDEVAAAIGP 201
Cdd:PLN02242 82 GRQMAALEGTEAAYCTASGMSAISSVlLQLCSSGGHVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVP 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 202 -QTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSiMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvlAVKG 280
Cdd:PLN02242 162 gKTKVLYFESISNPTLTVADIPELARIAHEKGVTVVVDNT-FAPMVLSPARLGADVVVHSISKFISGGADIIAG--AVCG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 281 -EKLAKEVYFLQNSEGSGLAP-------FDcwLCLRgIKTMALRIekqQENARKIAMYLSshpRVK----KVYYAGLPDH 348
Cdd:PLN02242 239 pAELVNSMMDLHHGALMLLGPtmnpkvaFE--LSER-LPHLSLRM---KEHCRRAMEYAK---RMKelglKVIYPGLEDH 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 349 PGHHLHFSQAK---GAGSVFSFITGSVA----LSKHLVETTKYFSIAVSFGSVKSLisMPCFMSHAS--IPAEVREARGL 419
Cdd:PLN02242 310 PQHALLKSMANkgyGFGGLLCLDMDTEEranrLMRYLQNSTQFGFMAVSLGYYETL--MSCSGSSTSseLDPEEKAAAGI 387
|
410
....*....|.
gi 30694565 420 TEDLVRISAGI 430
Cdd:PLN02242 388 SPGLVRMSVGY 398
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
92-444 |
2.03e-49 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 174.09 E-value: 2.03e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 92 PLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAG 162
Cdd:PRK06702 27 PLYQSTTYKYDTSddlaalfnLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMlAVLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 163 DDVYGGSDRLLSQVVPRSGVVVKRVNTT-KLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 241
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 242 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLA---------------VKGEKLAKEVYFLQN-------------- 292
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSYHGVSYVQNfgaaayivkarvql 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 293 --SEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ-AKGAGSVFSF-I 368
Cdd:PRK06702 267 lrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSLAQKYlKKGASGVLTFgI 346
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30694565 369 TGSVALSKHLVETTKYFSIAVSFGSVKSLISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 444
Cdd:PRK06702 347 KGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIRLSVGIEDVSDIIADLEAAL 422
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
107-445 |
1.03e-44 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 160.64 E-value: 1.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 107 NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVvvk 185
Cdd:PRK08114 51 NGELFYGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVAnAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGV--- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 186 rvNTTKLD-----EVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG--ALVLVDNSIMSPVLSRPLELGADIVM 258
Cdd:PRK08114 128 --TTTWFDpligaDIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISI 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 259 HSATKFIAGHSDVMAGVlAVKG----EKLAKEVYFLqnseGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSH 334
Cdd:PRK08114 206 QAGTKYLVGHSDAMIGT-AVANarcwEQLRENSYLM----GQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEH 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 335 PRVKKVYYAGLPDHPGHHLHFSQAKGAGSVFSFItgsvaLSKHLVETT--------KYFSIAVSFGSVKSLISmpcfmsh 406
Cdd:PRK08114 281 PEVARVNHPALPGCKGHEFWKRDFTGSSGLFSFV-----LKKKLTDEQlanyldnfSLFSMAYSWGGFESLIL------- 348
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 30694565 407 ASIPAEVREAR-----GLTEDLVRISAGIEDVDDLISDLDIAFK 445
Cdd:PRK08114 349 ANQPEEIAAIRpagevDFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
120-279 |
4.68e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 61.24 E-value: 4.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 120 RDALESLLAKL--DKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSdrlLSQVVPRSGVVVKRVNTTKLDEVA 196
Cdd:cd01494 2 LEELEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSR---YWVAAELAGAKPVPVPVDDAGYGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 197 A--------AIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNS----IMSPVLSRPLELGADIVMHSATKF 264
Cdd:cd01494 79 LdvaileelKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsaggASPAPGVLIPEGGADVVTFSLHKN 158
|
170
....*....|....*
gi 30694565 265 IAGhsdVMAGVLAVK 279
Cdd:cd01494 159 LGG---EGGGVVIVK 170
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
121-238 |
4.15e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 51.54 E-value: 4.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 121 DALESLLAKL--------DKADRAFCFTSGM-AALSAVTHLIKNGEEIVAGDDVYGGSdrlLSQVVPRSGVVVKRVNTTK 191
Cdd:pfam00155 42 PELREALAKFlgrspvlkLDREAAVVFGSGAgANIEALIFLLANPGDAILVPAPTYAS---YIRIARLAGGEVVRYPLYD 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 30694565 192 -------LDEVAAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD 238
Cdd:pfam00155 119 sndfhldFDALEAALKEKPKVVLHTSPHNPTGTVatlEELEKLLDLAKEHNILLLVD 175
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
139-238 |
4.43e-07 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 51.68 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 139 FTSGM-AALSAVTH---LIKNGEEIVAGDDVYGGSD---RLLSQvvpRSGVVVKRVNTTK-----LDEVAAAIGPQTKLV 206
Cdd:COG0520 82 FTRGTtEAINLVAYglgRLKPGDEILITEMEHHSNIvpwQELAE---RTGAEVRVIPLDEdgeldLEALEALLTPRTKLV 158
|
90 100 110
....*....|....*....|....*....|..
gi 30694565 207 WLESPTNPRQQISDIRKISEMAHAQGALVLVD 238
Cdd:COG0520 159 AVTHVSNVTGTVNPVKEIAALAHAHGALVLVD 190
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
189-257 |
7.11e-07 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 51.29 E-value: 7.11e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 189 TTKLDEVAAAIGPQTKLVWLESPtNPRQQISDIRKISEMAHAQGAL-VLVDNSIMSPVLSRPLELGADIV 257
Cdd:PRK00451 191 VTDLEALEAAVDDDTAAVVVQYP-NFFGVIEDLEEIAEIAHAGGALfIVGVDPVSLGLLKPPGEYGADIV 259
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
139-266 |
1.11e-06 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 50.32 E-value: 1.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 139 FTSG------MAALSAVTHLiKNGEEIVAGDDVYGgsdrllSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGP 201
Cdd:pfam00266 66 FTSGtteainLVALSLGRSL-KPGDEIVITEMEHH------ANLVPwqelakRTGARVRVLPLDEdglldLDELEKLITP 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694565 202 QTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSimSPVLSRPL---ELGADIVMHSATKFIA 266
Cdd:pfam00266 139 KTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA--QAIGHRPIdvqKLGVDFLAFSGHKLYG 204
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
179-255 |
3.48e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 49.00 E-value: 3.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 179 RSGVVVKRVNTTK-----LDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLsrPL--- 250
Cdd:cd06453 111 RTGAKLKVVPVDDdgqldLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVdvq 188
|
....*
gi 30694565 251 ELGAD 255
Cdd:cd06453 189 DLGCD 193
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
189-257 |
5.98e-06 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 48.49 E-value: 5.98e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 189 TTKLDEVAAAIGPQTKLVWLESPtNPRQQISDIRKISEMAHAQGALVLVDNSIMS-PVLSRPLELGADIV 257
Cdd:COG0403 192 VTDLEALKALLDDDVAGVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIVAADPLSlGLLKPPGELGADIV 260
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
104-280 |
6.01e-06 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 48.20 E-value: 6.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 104 AIENGPYDYTRS-GNP-TRDALESLLAK-----LDkADRAFCFTSGMAALS-AVTHLIKNGEEIVAGD---DVYGGSDRL 172
Cdd:COG0436 55 ALDDGVTGYTPSaGIPeLREAIAAYYKRrygvdLD-PDEILVTNGAKEALAlALLALLNPGDEVLVPDpgyPSYRAAVRL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 173 LsqvvprsGVVVKRVNTTK-------LDEVAAAIGPQTKLVWLESPTNP------RqqiSDIRKISEMAHAQGALVLVDN 239
Cdd:COG0436 134 A-------GGKPVPVPLDEengflpdPEALEAAITPRTKAIVLNSPNNPtgavysR---EELEALAELAREHDLLVISDE 203
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30694565 240 -------------SIMSpvlsrpLELGAD--IVMHSATK----------FIAGHSDVMAGVLAVKG 280
Cdd:COG0436 204 iyeelvydgaehvSILS------LPGLKDrtIVINSFSKsyamtgwrigYAVGPPELIAALLKLQS 263
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
110-417 |
2.50e-05 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 46.18 E-value: 2.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 110 YDYTRSGNPTRDALESLLAK----LDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVvprsGVVV 184
Cdd:cd00609 32 YYPDPGLPELREAIAEWLGRrggvDVPPEEIVVTNGAQEALSLLLRaLLNPGDEVLVPDPTYPGYEAAARLA----GAEV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 185 KRVNTTK-------LDEVAAAIGPQTKLVWLESPTNP------RQQisdIRKISEMAHAQGALVLVDNS----IMSPVLS 247
Cdd:cd00609 108 VPVPLDEeggflldLELLEAAKTPKTKLLYLNNPNNPtgavlsEEE---LEELAELAKKHGILIISDEAyaelVYDGEPP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 248 RPLELGAD----IVMHSATKFIAghsdvMA----GVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEK 319
Cdd:cd00609 185 PALALLDAyervIVLRSFSKTFG-----LPglriGYLIAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEE 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 320 QQENARKIAMYLsshprvkkvyYAGLPDHPGHHLHFSQakgaGSVFSFI----TGSVALSKHLVETTKyfsIAVSFGSVK 395
Cdd:cd00609 260 LRERYRRRRDAL----------LEALKELGPLVVVKPS----GGFFLWLdlpeGDDEEFLERLLLEAG---VVVRPGSAF 322
|
330 340
....*....|....*....|...
gi 30694565 396 SLISMPCF-MSHASIPAEVREAR 417
Cdd:cd00609 323 GEGGEGFVrLSFATPEEELEEAL 345
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
76-272 |
3.37e-05 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 45.89 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 76 LVNLDNkfdpfdamstplyqTATFKQPSAIENGPYDYTRSGNPT------------RDALESLLAKLD-----KADRAFC 138
Cdd:PLN02855 33 LVYLDN--------------AATSQKPAAVLDALQDYYEEYNSNvhrgihalsakaTDAYELARKKVAafinaSTSREIV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 139 FTSGMAA---LSAVTHLIKNgeeIVAGDDVYGGSDRLLSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGPQTK 204
Cdd:PLN02855 99 FTRNATEainLVAYTWGLAN---LKPGDEVILSVAEHHSNIVPwqlvaqKTGAVLKFVGLTPdevldVEQLKELLSEKTK 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30694565 205 LVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLE-LGADIVMHSATK--------FIAGHSDVM 272
Cdd:PLN02855 176 LVATHHVSNVLGSILPVEDIVHWAHAVGAKVLVDACQSVPHMPVDVQtLGADFLVASSHKmcgptgigFLWGKSDLL 252
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
117-286 |
3.48e-05 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 45.32 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 117 NPTRDALES--LLAKLDKADRAFCFTSG-----MAALSAVthlIKNGEEIVAGDD----VYGGSDrlLSQVVPrsgVVVK 185
Cdd:cd00615 56 DPTGPIKEAqeLAARAFGAKHTFFLVNGtsssnKAVILAV---CGPGDKILIDRNchksVINGLV--LSGAVP---VYLK 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 186 -RVNttKLDEVAAAIGPQT-----------KLVWLESPTnPRQQISDIRKISEMAHAQGALVLVDNS-----IMSPVL-S 247
Cdd:cd00615 128 pERN--PYYGIAGGIPPETfkkaliehpdaKAAVITNPT-YYGICYNLRKIVEEAHHRGLPVLVDEAhgahfRFHPILpS 204
|
170 180 190
....*....|....*....|....*....|....*....
gi 30694565 248 RPLELGADIVMHSATKFIAGHSdvMAGVLAVKGEKLAKE 286
Cdd:cd00615 205 SAAMAGADIVVQSTHKTLPALT--QGSMIHVKGDLVNPD 241
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
181-280 |
4.16e-05 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 45.51 E-value: 4.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 181 GVVVKRVNTTK-----LDEVAAAIGPQTKLVWLESPTNP------RQQISDIRKisemAHAQGALVLVD----------N 239
Cdd:COG0079 110 GAEVVEVPLDEdfsldLDALLAAITERTDLVFLCNPNNPtgtllpREELEALLE----ALPADGLVVVDeayaefvpeeD 185
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 30694565 240 SIMSPVLSRP-LelgadIVMHSATKF--IAG--------HSDVMAGVLAVKG 280
Cdd:COG0079 186 SALPLLARYPnL-----VVLRTFSKAygLAGlrlgyaiaSPELIAALRRVRG 232
|
|
| f2_encap_cargo1 |
NF041166 |
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like ... |
192-238 |
8.09e-05 |
|
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like encapsulin nanocompartments are commonly found in bacteria and archaea. Encapsulin nanocompartments, which are assembled from shell proteins, encapsulate various cargo proteins, typically peroxidases or ferritin-like proteins, to protect cells from oxidative stress caused by peroxide. Proteins of this family are cysteine desulfurases with an additional N-terminal encapsulation targeting sequence (~200 aa) that is necessary and sufficient for compartmentalization.
Pssm-ID: 469077 [Multi-domain] Cd Length: 623 Bit Score: 44.84 E-value: 8.09e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 30694565 192 LDEVAAAIGPQTKLVwleSPTnprqQISD-------IRKISEMAHAQGALVLVD 238
Cdd:NF041166 376 LDEYAKLLNPRTKLV---SVT----QVSNalgtvtpVKEIIALAHRAGAKVLVD 422
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
118-238 |
3.00e-04 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 118 PTRDALESLLAKLD----KADRAFCFTSG--MAALSAVTHLIKNGEEIVAGDDVYggsDRLLSQVVPRSGVVVK------ 185
Cdd:PRK09082 71 ALREAIAAKTARLYgrqyDADSEITVTAGatEALFAAILALVRPGDEVIVFDPSY---DSYAPAIELAGGRAVRvalqpp 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 30694565 186 --RVNttkLDEVAAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD 238
Cdd:PRK09082 148 dfRVD---WQRFAAAISPRTRLIILNTPHNPSGTVwsaADMRALWQLIAGTDIYVLSD 202
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
220-281 |
5.19e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 42.22 E-value: 5.19e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30694565 220 DIRKISEMAHAQGALVLVDNSIMS-PVLSRPLELGADIVMHSATKFIAGHS--DVMAGVLAVKGE 281
Cdd:cd00613 177 LIKEIADIAHSAGALVYVDGDNLNlTGLKPPGEYGADIVVGNLQKTGVPHGggGPGAGFFAVKKE 241
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
192-259 |
5.97e-04 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 42.02 E-value: 5.97e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694565 192 LDEVAAAIGPQTKLVWLespTNP-------RqqisDIRKISEMAHAQGALVLVD----NSIMSPVlsRPLELGADiVMH 259
Cdd:PRK04366 198 LEALKAAVGEDTAALML---TNPntlglfeR----NILEIAEIVHEAGGLLYYDganlNAILGKA--RPGDMGFD-VVH 266
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
140-238 |
8.47e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 41.56 E-value: 8.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 140 TSGMAAlsAVTHLIKNGEEIVAGDDVY----------GGSDRLLSQVVPRSGVVVKrvnttkLDEVAAAIGPQTKLVWLE 209
Cdd:PRK07777 95 TEAIAA--AVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRVPVPLVPDGRGFALD------LDALRAAVTPRTRALIVN 166
|
90 100 110
....*....|....*....|....*....|..
gi 30694565 210 SPTNPRQQI---SDIRKISEMAHAQGALVLVD 238
Cdd:PRK07777 167 SPHNPTGTVltaAELAAIAELAVEHDLLVITD 198
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
189-281 |
2.62e-03 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 40.05 E-value: 2.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 189 TTKLDEVAAAIgpqtklvwLESPtNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSR-PLELGADIVMHSATKF--I 265
Cdd:pfam02347 192 VTDLKDVFGVL--------VQYP-NTDGRIEDYKELIELAHQRKSLVVVAADLLALTLLKpPGEFGADIAVGSAQRFgvP 262
|
90
....*....|....*.
gi 30694565 266 AGHSDVMAGVLAVKGE 281
Cdd:pfam02347 263 LGYGGPHAGFFAVKKE 278
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
177-281 |
3.62e-03 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 39.30 E-value: 3.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694565 177 VPRSGVVVKRVN----TTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNS----IMsPVLSR 248
Cdd:cd06452 110 VPNTGHPEYHITpegyAEVIEEVKDEFGKPPALALLTHVDGNYGNLHDAKKIAKVCHEYGVPLLLNGAytvgRM-PVSGK 188
|
90 100 110
....*....|....*....|....*....|...
gi 30694565 249 plELGADIVMHSATKFIAGHSDVmaGVLAVKGE 281
Cdd:cd06452 189 --ELGADFIVGSGHKSMAASAPI--GVLATTEE 217
|
|
| |
