|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
1-372 |
0e+00 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 805.02 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 1 MTSSLSLHSSFVPSFADLSDRGLISKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVDGQTHSTVNNTTDSLNTMN 80
Cdd:PLN02509 1 MTSSLSLHSSFVPSFADLSDRGLVSKNSPTSVSISKVPTWEKKQISNRNSFKLNCVMEKSVDVSTSAVVDGVADCLNEMN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 81 IKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
Cdd:PLN02509 81 IKEEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 161 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIS 240
Cdd:PLN02509 161 LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 320
Cdd:PLN02509 241 EMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 30694567 321 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PLN02509 321 CLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
87-372 |
0e+00 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 535.95 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 87 VSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH 166
Cdd:TIGR01329 1 LSTLLVNTDNKNDPYDASSMPIYQTATFKQPLAIENGPYDYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALDVITR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 167 LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQ 246
Cdd:TIGR01329 81 LLNNGDEIIAGDDLYGGTDRLLTQVVPRSGVVVVHVDTTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 247 GALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIK 326
Cdd:TIGR01329 161 NALVVVDNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLAVKGEEIAKKVYFLQNSTGSGLAPFDCWLLLRGIK 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 30694567 327 TMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:TIGR01329 241 TLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQ 286
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
88-372 |
6.22e-158 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 448.61 E-value: 6.22e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 88 STLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVT 165
Cdd:pfam01053 1 DTLAVHAGQRPDPqTGAVSVPIYLTSTYVFDFAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGMAAItAAIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 166 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA 245
Cdd:pfam01053 81 ALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVDTSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDIEAIAKLAKK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 246 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGI 325
Cdd:pfam01053 161 HGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNGEELGKELYFLQNATGAVLSPFDAWLLLRGL 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 30694567 326 KTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:pfam01053 241 KTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPGHELAKRQ 287
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
88-372 |
9.19e-142 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 407.90 E-value: 9.19e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 88 STLLVNLDNKFDP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGM 158
Cdd:COG0626 4 ATRAVHAGRDPDPqTGAVSPPIYLTSTFVFPSAealaarfaGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 159 AALSAV-THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIR 237
Cdd:COG0626 84 AAISAVlLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVDPTDLAAVEAAIRPNTKLVFLETPSNPTLEVVDIA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 238 KISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFD 317
Cdd:COG0626 164 AIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVVGRDEELAERLRFLQNALGAVLSPFD 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 30694567 318 CWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:COG0626 244 AWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSHPGHELAKRQ 298
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
102-372 |
6.04e-140 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 402.74 E-value: 6.04e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 102 DAMSTPLYQTATFKQPSAIE--------NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGE 172
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEaadlfalrEGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVlLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 173 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLV 252
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFVDPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLVV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 253 DNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRI 332
Cdd:cd00614 161 DNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGEALIQRLRFLRLALGTILSPFDAWLLLRGLKTLPLRM 240
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 30694567 333 EKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:cd00614 241 ERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQ 280
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
88-372 |
2.99e-115 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 340.47 E-value: 2.99e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 88 STLLVNLDNKFDPFD-AMSTPLYQTATFKQ--PSAIENGpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SA 163
Cdd:PRK07811 14 ATRAIHAGYEPDPATgAVNPPIYASSTFAQdgVGGLRGG-YEYARTGNPTRTALEEQLAALEGGAYGRAFSSGMAATdCL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 164 VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMA 243
Cdd:PRK07811 93 LRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVDLSDLDAVRAAITPRTKLIWVETPTNPLLSITDIAALAELA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 244 HAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLR 323
Cdd:PRK07811 173 HDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALVTNDEELDEAFAFLQNGAGAVPGPFDAYLTLR 252
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 30694567 324 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK07811 253 GLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLYPGLPSHPGHEVAARQ 301
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
83-372 |
5.68e-114 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 337.51 E-value: 5.68e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 83 EEASVSTLLVNLDNKFDP-FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL 161
Cdd:PRK08064 3 MSYSIDTLLLHNQYKHDKqTGAVNVPIYHASTFHQFDFDTFGKYDYSRSGNPTREALEDIIAELEGGTKGFAFASGMAAI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 162 SAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISE 241
Cdd:PRK08064 83 STAFLLLSKGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVDMTNLEEVAQNIKPNTKLFYVETPSNPLLKVTDIRGVVK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 242 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLC 321
Cdd:PRK08064 163 LAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAVVKDEELAQKLYFLQNSFGAVLGVQDCWLV 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 30694567 322 LRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK08064 243 LRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGLQTHLGFDIQQSQ 293
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
103-372 |
2.07e-110 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 327.84 E-value: 2.07e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
Cdd:PRK07671 20 AVSVPIYQVSTYKQEAVGKHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGMAAITAVMMLFSSGDHVILTDDVYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 183 GSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 262
Cdd:PRK07671 100 GTYRVMTKVLNRFGIEHTFVDTSNLEEVEEAIRPNTKAIYVETPTNPLLKITDIKKISTIAKEKGLLTIVDNTFMTPYWQ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
Cdd:PRK07671 180 SPISLGADIVLHSATKYLGGHSDVVAGLVVVNSPELAEDLHFVQNSTGGILGPQDSWLLLRGLKTLGIRMEEHETNSRAI 259
|
250 260 270
....*....|....*....|....*....|
gi 30694567 343 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK07671 260 AEFLNNHPAVNKVYYPGLPSHPNHELAKEQ 289
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
86-359 |
1.42e-99 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 299.70 E-value: 1.42e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 86 SVSTLLVNLDNKFDPFD-AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV 164
Cdd:PRK08247 4 TIETKLAQIGNRSDERTgTVNPPVYFSTAYRHEGIGESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSGMAAIQLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 165 THLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAH 244
Cdd:PRK08247 84 MSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVNTASLKAIEQAITPNTKAIFIETPTNPLMQETDIAAIAKIAK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 245 AQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRG 324
Cdd:PRK08247 164 KHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKGQELCERLAYYQNAAGAVLSPFDSWLLIRG 243
|
250 260 270
....*....|....*....|....*....|....*
gi 30694567 325 IKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAG 359
Cdd:PRK08247 244 MKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYPG 278
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
103-373 |
6.48e-98 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 296.04 E-value: 6.48e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
Cdd:PRK06176 20 AVSVPIYQTSTYRQDAIGRPKGYEYSRSGNPTRFALEELIADLEGGVKGFAFASGLAGIHAVFSLFQSGDHVLLGDDVYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 183 GSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 262
Cdd:PRK06176 100 GTFRLFDKVLVKNGLSCTIIDTSDLSQIKKAIKPNTKALYLETPSNPLLKITDLAQCASVAKDHGLLTIVDNTFATPYYQ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
Cdd:PRK06176 180 NPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNEALAQEIAFFQNAIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCV 259
|
250 260 270
....*....|....*....|....*....|.
gi 30694567 343 AMYLSSHPRVKKVYYAGLPDHPGHHLHFSQV 373
Cdd:PRK06176 260 AEFLEKHPKVEKVYYPGLPTHPNHELAKKQM 290
|
|
| O_succ_thio_ly |
TIGR02080 |
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, ... |
101-366 |
6.67e-88 |
|
O-succinylhomoserine (thiol)-lyase; This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulfur is added by transsulfuration from Cys to yield cystathionine rather than by a sulfhydrylation step that uses H2S directly and bypasses cystathionine. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 131135 Cd Length: 382 Bit Score: 270.52 E-value: 6.67e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 101 FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDD 179
Cdd:TIGR02080 19 YGCVVPPIYLSTTYNFTGFNEPRAYDYSRSGNPTRDLLQQALAELEGGAGAVVTNTGMSAIHLVtTALLGPDDLLVAPHD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 180 VYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSP 259
Cdd:TIGR02080 99 CYGGTYRLLNALAKKGCFRVLFVDQGDEQALRAALAQKPKLVLIETPSNPLLRVVDIAKICHLAKAVGAVVVVDNTFLSP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 260 VLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 339
Cdd:TIGR02080 179 ALQNPLALGADLVLHSCTKYLNGHSDVIAGAVIAKDPQVAEELAWWANNLGVTGGAFDSYLTLRGLRTLVARMRLQQRNA 258
|
250 260
....*....|....*....|....*..
gi 30694567 340 RKIAMYLSSHPRVKKVYYAGLPDHPGH 366
Cdd:TIGR02080 259 QAIVEYLQTQPLVKKIYYPGLPDHPGH 285
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
109-372 |
2.76e-85 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 264.30 E-value: 2.76e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 109 YQTATFKQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRL 187
Cdd:PRK08249 46 YDVALGKKPGHI------YSRNTNPTVQAFEEKVRILEGAEAATAFSTGMAAISNTLYtFLKPGDRVVSIKDTYGGTNKI 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 188 LSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLEL 267
Cdd:PRK08249 120 FTEFLPRMGVDVTLCETGDHEQIEAEIAKGCDLLYLETPTNPTLKIVDIERLAAAAKKVGALVVVDNTFATPINQNPLAL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 268 GADIVMHSATKFIAGHSDVMAGVlAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLS 347
Cdd:PRK08249 200 GADLVIHSATKFLSGHADALGGV-VCGSKELMEQVYHYREINGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQ 278
|
250 260
....*....|....*....|....*
gi 30694567 348 SHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK08249 279 THPKVEAVYYPGLETHPNHEIAKAQ 303
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
101-373 |
9.03e-85 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 262.84 E-value: 9.03e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 101 FDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLIKNG 171
Cdd:PRK06234 24 FGSLATPIYQTSTFIFDSAEQGGRrfageesgYIYSRLGNPTSTEVENKLALLEGGEAAVVAASGMGAIsSSLWSALKAG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA--QGAL 249
Cdd:PRK06234 104 DHVVASDTLYGCTFALLNHGLTRYGVEVTFVDTSNLEEVRNALKANTKVVYLETPANPTLKVTDIKAISNIAHEnnKECL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 250 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEVYF--LQNSEGSGLAPFDCWLCLRGIKT 327
Cdd:PRK06234 184 VFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAG-FVVGKEEFINQVKLfgIKDMTGSVIGPFEAFLIIRGMKT 262
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 30694567 328 MALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQV 373
Cdd:PRK06234 263 LQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLESFEYYELAKKQM 308
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
99-375 |
4.78e-84 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 260.98 E-value: 4.78e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 99 DPFDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIK 169
Cdd:TIGR01328 17 DQFGALTPPIYQTSTFVFDSCEQGGNrfagqesgYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSGMGAIAAtLLTILK 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 170 NGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGAL 249
Cdd:TIGR01328 97 AGDHLISDECLYGCTFALLEHALTKFGIQVDFINMAIPEEVKAHIKDNTKIVYFETPANPTMKLIDMERVCRDAHSQGVK 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 250 VLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK-EVYFLQNSEGSGLAPFDCWLCLRGIKTM 328
Cdd:TIGR01328 177 VIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLICGKAELLQQiRMVGIKDMTGSVISPFDAWLILRGLKTL 256
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 30694567 329 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQVLK 375
Cdd:TIGR01328 257 NIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHPGHDIAAKQMRM 303
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
83-372 |
5.76e-83 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 258.01 E-value: 5.76e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 83 EEASVSTLLVNLDNKFDPFDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCF 154
Cdd:PRK08133 3 DSLGFDTLAVRAGQLRSPFGEHSEALFLTSSFVFESAAEAAArfageepgNIYSRFTNPTVTMFQERLAALEGAEACVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 155 TSGMAA-LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQI 233
Cdd:PRK08133 83 ASGMAAiLAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVDLTDLDAWRAAVRPNTKLFFLETPSNPLTEL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 234 SDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEkLAKEVYFLQNSEGSGL 313
Cdd:PRK08133 163 ADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVVGSKE-LMEEVFGFLRTAGPTL 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 30694567 314 APFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK08133 242 SPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPSHPQHELAKRQ 300
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
89-368 |
7.56e-82 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 254.77 E-value: 7.56e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 89 TLLVNLDNKFDPFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAA 160
Cdd:TIGR01325 2 TLAVRGGMLRSGFEETAEALYLTSGYVYDSAAvaakrfagELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASGMAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 161 -LSAVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKI 239
Cdd:TIGR01325 82 iFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVDGTDLSAWEAALKPNTKAVFVETPSNPLQELVDIAAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 240 SEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCW 319
Cdd:TIGR01325 162 AELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAILGSEEYMDEPVQKLLRHTGPAMSPFNAW 241
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 30694567 320 LCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:TIGR01325 242 VLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQHEL 290
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
99-368 |
9.53e-82 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 256.11 E-value: 9.53e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 99 DP-FDAMSTPLYQTATFKQPSA---------IENGpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 167
Cdd:COG2873 20 DPtTGARAVPIYQTTSYVFDDAehaadlfalKEPG-NIYTRIMNPTTDVLEKRIAALEGGVAALATASGQAAITlAILNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG 247
Cdd:COG2873 99 AEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVDPDDPEAFEAAIDPNTKAIFGETIGNPALDVLDIEAIAEIAHEHG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL--------------------------AVKGEKLAKE 301
Cdd:COG2873 179 VPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIvdggnfdwaangkfpeltepdpsyhgLVYTEAFGNA 258
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30694567 302 VY------FLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:COG2873 259 AFitkarvQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLPSHPYHEL 331
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
99-368 |
9.80e-81 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 252.29 E-value: 9.80e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 99 DPFDAMSTPLYQTATFKQPsaIENGPYD------YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNG 171
Cdd:PRK08574 15 DPYGSLQPPIYLTALFRQE--GEAYPSDrgfdlkYSREENPTLRPLEEALAKLEGGVDALAFNSGMAAISTLfFSLLKAG 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 172 EEIVAGDDVYGGSDRLLSQVVpRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK08574 93 DRVVLPMEAYGTTLRLLKSLE-KFGVKVVLAYPSTEDIIEAIKEGRTKLVFIETMTNPTLKVIDVPEVAKAAKELGAILV 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 331
Cdd:PRK08574 172 VDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWSGEFLEELWEWRRRLGTIMQPFEAYLVLRGLKTLEVR 251
|
250 260 270
....*....|....*....|....*....|....*..
gi 30694567 332 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK08574 252 FERQCRNAMAIAEFLSEHPKVAEVYYPGLPSDPYHGV 288
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
98-373 |
1.65e-78 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 247.02 E-value: 1.65e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 98 FDPFD---AMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT- 165
Cdd:PRK07503 19 YDPLDhggALVPPVYLTATFAFPTAEygaecfagEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASGMGAITATLw 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 166 HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHA 245
Cdd:PRK07503 99 TLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHVDLTDPAALKAAISDKTRMVYFETPANPNMRLVDIAAVAEIAHG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 246 QGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvLAVKGEKLAKEV--YFLQNSEGSGLAPFDCWLCLR 323
Cdd:PRK07503 179 AGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAG-LVVGGKALADRIrlEGLKDMTGAVMSPFDAFLLMR 257
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 30694567 324 GIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQV 373
Cdd:PRK07503 258 GLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFAQHALAQRQM 307
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
103-360 |
2.94e-76 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 240.11 E-value: 2.94e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTHLIKNGEEIVAGDDVYG 182
Cdd:PRK07269 24 ALVTPLHFSTTYQHPEFGQSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVLAFSVFPVGSKVVAVRDLYG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 183 GSDRLLSQVVPRSGVVVKRVNTTKldEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLS 262
Cdd:PRK07269 104 GSFRWFNQQEKEGRFHFTYANTEE--ELIAAIEEDTDIVYIETPTNPLMVEFDIEKVAKLAHAKGAKVIVDNTFYSPIYQ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 263 RPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKI 342
Cdd:PRK07269 182 RPIELGADIVLHSATKYLSGHNDVLAGVVVTNDLELYEKLFYNLNTTGAVLSPFDSYLLMRGLKTLSLRMERSTANAQEV 261
|
250
....*....|....*...
gi 30694567 343 AMYLSSHPRVKKVYYAGL 360
Cdd:PRK07269 262 VAFLKKSPAVKEVLYTGK 279
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
103-372 |
8.27e-74 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 234.88 E-value: 8.27e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVY 181
Cdd:PRK08776 30 AVTPPIVLSSNFSFDGFGNKRQYDYTRSGNPTRDLLGEALAELEGGAGGVITATGMGAINLVLNaLLQPGDTLVVPHDAY 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 182 GGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVL 261
Cdd:PRK08776 110 GGSWRLFNALAKKGHFALITADLTDPRSLADALAQSPKLVLIETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPAL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
Cdd:PRK08776 190 QKPLEFGADLVLHSTTKYINGHSDVVGGAVVARDAELHQQLVWWANALGLTGSPFDAFLTLRGLRTLDARLRVHQENADA 269
|
250 260 270
....*....|....*....|....*....|.
gi 30694567 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK08776 270 IAALLDGHAAVNQVYYPGLASHPGHALAARQ 300
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
107-372 |
2.72e-73 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 232.86 E-value: 2.72e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 107 PLYQTAT-----FKQPSAiengpYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDV 180
Cdd:PRK08045 26 PIHLSSTynftgFNEPRA-----HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVtTVFLKPGDLLVAPHDC 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 181 YGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPV 260
Cdd:PRK08045 101 YGGSYRLFDSLAKRGCYRVLFVDQGDEQALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNTFLSPA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 261 LSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENAR 340
Cdd:PRK08045 181 LQNPLALGADLVLHSCTKYLNGHSDVVAGVVIAKDPDVVTELAWWANNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQ 260
|
250 260 270
....*....|....*....|....*....|..
gi 30694567 341 KIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK08045 261 AIVKYLQTQPLVKKLYHPSLPENQGHEIAARQ 292
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
98-368 |
1.46e-72 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 230.27 E-value: 1.46e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 98 FDPFDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDkADRAFCFTSGMAALSAVTH-LIKNGEEIVA 176
Cdd:PRK07582 16 AVPGEPVLPGPVFAAPYHLSPGEPTGPDTYGRASNPTWRALEAALGELE-GAEALVFPSGMAAITAVLRaLLRPGDTVVV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 177 GDDVYGGSDRLLSQVVPRSGVVVKRVNTtklDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 256
Cdd:PRK07582 95 PADGYYQVRALAREYLAPLGVTVREAPT---AGMAEAALAGADLVLAETPSNPGLDVCDLAALAAAAHAAGALLVVDNTT 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQ 336
Cdd:PRK07582 172 ATPLGQRPLELGADLVVASDTKALTGHSDLLLGYVAGRDPELMAAVERWRLLAGAIPGPFEAWLAHRSLGTLGLRFARQC 251
|
250 260 270
....*....|....*....|....*....|..
gi 30694567 337 ENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK07582 252 ANALAVAELLAGHPAVRGVRYPGLPGDPAHEV 283
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
103-368 |
2.69e-71 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 228.78 E-value: 2.69e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEE 173
Cdd:TIGR01326 19 SRAVPIYQTTSYVFDSTehaaalfgLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVASGQAAITyAILNLAGAGDN 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 174 IVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVD 253
Cdd:TIGR01326 99 IVSSSYLYGGTYNLFSHTLKRLGIEVRFVDPDDPESLEKAIDENTKAVFAETIGNPQINVLDIEAIAEVAHRHGIPLIVD 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 254 NSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLaVKGEKL--AKEVY--FLQNSE-------------------- 309
Cdd:TIGR01326 179 NTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVI-VDGGKFdwNNGRFplFTTPDPsyhglvftetlgnpafilka 257
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30694567 310 --------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:TIGR01326 258 rvqllrdlGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASHPHHAL 324
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
101-363 |
1.35e-70 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 225.88 E-value: 1.35e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 101 FDAMSTPLYQTATFKQPSAIENGP--------YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNG 171
Cdd:PRK06767 21 KGSLTPPLFQTSTFTFETAQQGEAsfagvdpsYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSGMAAISATlIGFLKAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK06767 101 DHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADIENKIRPNTKLIFVETPINPTMKLIDLKQVIRVAKRNGLLVI 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 331
Cdd:PRK06767 181 VDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTICKTRALAEKIRPMRKDIGGIMAPFDAWLLLRGLKTLAVR 260
|
250 260 270
....*....|....*....|....*....|..
gi 30694567 332 IEKQQENARKIAMYLSSHPRVKKVYYaglPDH 363
Cdd:PRK06767 261 MDRHCDNAEKIVSFLKNHDAVEGVWY---PEG 289
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
101-368 |
1.03e-69 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 224.00 E-value: 1.03e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 101 FDAMSTPLYQTATFKQPSAIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSA-VTHLIKNGEEIVAGDD 179
Cdd:PRK08861 21 YHAVVPPIYLSTNYGFPAFGEVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTSALNLwVSALLGPDDLIVAPHD 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 180 VYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSP 259
Cdd:PRK08861 101 CYGGTYRLFNTRANKGDFKVQFVDQSDAAALDAALAKKPKLILLETPSNPLVRVVDIAELCQKAKAVGALVAVDNTFLTP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 260 VLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENA 339
Cdd:PRK08861 181 VLQKPLELGADFVIHSTTKYINGHSDVIGGVLITKTKEHAEELAWWGNCIGATGTPFDSYMTLRGIRTLGARMRVHEESA 260
|
250 260
....*....|....*....|....*....
gi 30694567 340 RKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK08861 261 QQILAYLQTQSLVGTIYHPSLPEHPGHEI 289
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
91-364 |
2.76e-66 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 214.95 E-value: 2.76e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 91 LVNLDNKFDPFDAMSTPLYQTATFKQPS--------AIENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS 162
Cdd:PRK05968 13 LITAHDEGNAFDAVVPPIFQTSLFTFDSydemedvyAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAIS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 163 A-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIgPQTKLVWLESPTNPRQQISDIRKISE 241
Cdd:PRK05968 93 StVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDGRDEEAVAKAL-PGAKLLYLESPTSWVFELQDVAALAA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 242 MAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAK---EVY-FLqnseGSGLAPFD 317
Cdd:PRK05968 172 LAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVAGSKEHIARinaEAYpYL----GAKLSPFE 247
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 30694567 318 CWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHP 364
Cdd:PRK05968 248 AWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP 294
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
100-372 |
4.65e-64 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 209.59 E-value: 4.65e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 100 PFDAMSTPLYQTATFKQPSAIE-----NGPYD---YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLIKN 170
Cdd:PRK07810 29 GFEETAEALYLTSGYVYESAAAaeaafTGELDrfvYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVfTALGALLGA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 171 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 250
Cdd:PRK07810 109 GDRLVAARSLFGSCFVVCNEILPRWGVETVFVDGEDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKV 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 251 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMAL 330
Cdd:PRK07810 189 VLDNVFATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAILGDREYIDGPVQKLMRHTGPALSAFNAWVLLKGLETLAL 268
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 30694567 331 RIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQ 372
Cdd:PRK07810 269 RVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKRQ 310
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
100-364 |
2.55e-62 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 204.99 E-value: 2.55e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 100 PFDAMSTPLYQTATFKQPSAI--------ENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKN 170
Cdd:PRK07504 24 QFGETSEALFLTQGFVYDTAEaaearfkgEDPGFIYSRYSNPTVDMFEKRMCALEGAEDARATASGMAAVTaAILCQVKA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 171 GEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 250
Cdd:PRK07504 104 GDHVVAARALFGSCRYVVETLLPRYGIESTLVDGLDLDNWEKAVRPNTKVFFLESPTNPTLEVIDIAAVAKIANQAGAKL 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 251 LVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEV--YFLQNseGSGLAPFDCWLCLRGIKTM 328
Cdd:PRK07504 184 VVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVVLSDKAWIEEHLqdYFRHT--GPSLSPFNAWTLLKGLETL 261
|
250 260 270
....*....|....*....|....*....|....*.
gi 30694567 329 ALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHP 364
Cdd:PRK07504 262 PVRVRQQTESAAAIADFLAGHPKVARVIYPGRADHP 297
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
99-368 |
2.98e-62 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 205.74 E-value: 2.98e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 99 DP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLI 168
Cdd:PRK08134 21 DPaTGARAVPIHLTTSFVFRDSdhaaalfnLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASGQAALHlAIATLM 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 169 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGA 248
Cdd:PRK08134 101 GAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVKPGDIDGWRAAIRPNTRLLFGETLGNPGLEVLDIPTVAAIAHEAGV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 249 LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG----EKLAK-----EVY---------------- 303
Cdd:PRK08134 181 PLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGrfdwEASGKfpeltEPYagfhgmvfaeestvaa 260
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30694567 304 FLQNSE-------GSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK08134 261 FLLRARreglrdfGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESHPDHAL 332
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
103-375 |
3.67e-62 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 203.91 E-value: 3.67e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATFKQPsaiENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVT-HLIKNGEEIVAGDDVY 181
Cdd:PRK06460 18 AITTPIYQTTAYHYP---EGEKYRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTAlALLKPGNSVLVHRDMF 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 182 GGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVL 261
Cdd:PRK06460 95 GRSYRFFTDYLKNWGVNVDASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCKENGSILIVDATFSTPIN 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 262 SRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEkLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARK 341
Cdd:PRK06460 175 QKPLELGADIVVHSASKFLAGHNDVIAGLAAGYGK-LLNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQ 253
|
250 260 270
....*....|....*....|....*....|....
gi 30694567 342 IAMYLSSHPRVKKVYYAGLPDHPGHHLHfSQVLK 375
Cdd:PRK06460 254 IAEFLEGHPKVVKVYYPGLKSHVDYEIA-RRVLK 286
|
|
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
103-366 |
2.46e-61 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 203.44 E-value: 2.46e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 167
Cdd:PRK07812 31 ARALPIYQTTSYtfddtdhaaalfglAEPGNI------YTRIMNPTQDVVEQRIAALEGGVAALLLASGQAAETfAILNL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQ 246
Cdd:PRK07812 105 AGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVeDPDDLDAWRAAVRPNTKAFFAETISNPQIDVLDIPGVAEVAHEA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 247 GALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVL------------------------AVKGEKLAKEV 302
Cdd:PRK07812 185 GVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIvdggtfdwtqgrfpgfttpdpsyhGVVFAELGPPA 264
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 303 YFLQ------NSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGH 366
Cdd:PRK07812 265 YALKarvqllRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEVASVNYAGLPSSPWY 334
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
99-360 |
4.08e-60 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 198.97 E-value: 4.08e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 99 DP-FDAMSTPLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAAL-SAVTHLI 168
Cdd:PRK06434 21 DPrFGNVTTPIFETSTFVYPNSekeaymdsTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSGMGAItSAILSLI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 169 KNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAaaIGPQT-KLVWLESPTNPRQQISDIRKISEMAHaqG 247
Cdd:PRK06434 101 KKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDTDRLNSLD--FDPSNyDLIYAESITNPTLKVPDIKNVSSFCH--E 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKT 327
Cdd:PRK06434 177 NDVIVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGVAGTNNKSIFNNLVERRKTLGSNPDPIQAYLALRGLKT 256
|
250 260 270
....*....|....*....|....*....|...
gi 30694567 328 MALRIEKQQENARKIAMYLSSHPRVKKVYYAGL 360
Cdd:PRK06434 257 LGLRMEKHNKNGMELARFLRDSKKISNVYYPDT 289
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
88-369 |
2.62e-59 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 198.01 E-value: 2.62e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 88 STLLVNLDNKFDPFD-AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAF 152
Cdd:PRK05994 9 ATLAVHAGAQPDPTTgARATPIYQTTSFvfndadhaaslfglQAFGNI------YTRITNPTNAVLEERVAALEGGTAAL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 153 CFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQ 231
Cdd:PRK05994 83 AVASGHAAQFLVFHtLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWADADDPASFERAITPRTKAIFIESIANPGG 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 232 QISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE--------------- 296
Cdd:PRK05994 163 TVTDIAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTfdwsksgkypmlsep 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 297 ------------------KLAKEVYFLQNSeGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYA 358
Cdd:PRK05994 243 rpeyhglvlhetfgnfafAIAARVLGLRDL-GPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYA 321
|
330
....*....|.
gi 30694567 359 GLPDHPGHHLH 369
Cdd:PRK05994 322 GLPDDPYHALA 332
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
103-368 |
8.46e-58 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 193.96 E-value: 8.46e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATF--------------KQPSAIengpydYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHL 167
Cdd:PRK06084 20 AVAVPIYQTTSYafddtqhgadlfdlKVPGNI------YTRIMNPTNDVLEQRVAALEGGVGALAVASGMAAITyAIQTI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 168 IKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG 247
Cdd:PRK06084 94 AEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAHDDIAALEALIDERTKAVFCESIGNPAGNIIDIQALADAAHRHG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 248 ALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGE---KLAKEVYFLQN----------------- 307
Cdd:PRK06084 174 VPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKfpwAEHKERFALLNtpdpsyhgvtyteafgp 253
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30694567 308 -------------SEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK06084 254 aafigrcrvvplrNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDHPEHEL 327
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
79-368 |
9.52e-58 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 193.91 E-value: 9.52e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 79 MNIKEEASVSTLLVNLDNKFDPFD-AMSTPLYQTAT--FKQPS------AIENGPYDYTRSGNPTRDALESLLAKLDKAD 149
Cdd:PRK08248 1 MSEERTFRLETLAIHAGQEIDPTTgSRAVPIYQTTSygFRDSEhaanlfSLKEFGNIYTRIMNPTTDVFEKRIAALEGGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 150 RAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTN 228
Cdd:PRK08248 81 GALAVSSGQAAITySILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVDPSDPENFEAAITDKTKALFAETIGN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 229 PRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG------------- 295
Cdd:PRK08248 161 PKGDVLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGkfdwkgsgkfpgl 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 296 -------------EKLAKEVYFLQ------NSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVY 356
Cdd:PRK08248 241 tepdpsyhglvytDAVGEAAYITKarvqllRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVS 320
|
330
....*....|..
gi 30694567 357 YAGLPDHPGHHL 368
Cdd:PRK08248 321 YPGLPSHPSYEL 332
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
123-368 |
2.90e-57 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 191.83 E-value: 2.90e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 123 GPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGEEIVAGDDVYGGSDRLLsQVVPRSGVVVKR 201
Cdd:PRK05939 37 PGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVfLTLLRAGDHLVSSQFLFGNTNSLF-GTLRGLGVEVTM 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 202 VNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIA 281
Cdd:PRK05939 116 VDATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTMTSPWLFRPKDVGASLVINSLSKYIA 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 282 GHSDVMAGVLAVKGE------KLAKEVYFLQNSEGSGLAPF------DCWLCLR---------GIKTMALRIEKQQENAR 340
Cdd:PRK05939 196 GHGNALGGAVTDTGLfdwsayPNIFPAYRKGDPQQWGLTQIrkkglrDMGATLSseaahriaiGAETLALRVDRSCSNAL 275
|
250 260
....*....|....*....|....*...
gi 30694567 341 KIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK05939 276 ALAQFLEAHPKVARVYYPGLASHPQHAR 303
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
103-364 |
1.36e-51 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 177.76 E-value: 1.36e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 103 AMSTPLYQTATF--------KQPSAIEN-GPYdYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGE 172
Cdd:PRK05613 31 ARNLPIYQTTSYvfdsaehaKQRFALEDlGPI-YSRLTNPTVEALENRIASLEGGVHAVAFASGQAAETaAILNLAGAGD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 173 EIVAGDDVYGGSDRLLSQVVPRSGVVVKRV-NTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK05613 110 HIVTSPRLYGGTETLFLVTLNRLGIEVTFVeNPDDPESWQAAVQPNTKAFFGETFANPQADVLDIPAVAEVAHRNQVPLI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKG------EKLAKEV--YF------------------- 304
Cdd:PRK05613 190 VDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGkfdwtvERDGKPVfpYFvtpdpayhglkyadlgapa 269
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694567 305 --------LQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHP 364
Cdd:PRK05613 270 fglkaragLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEKVAKVNFAGLKDSP 337
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
77-368 |
4.42e-50 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 172.69 E-value: 4.42e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 77 NTMNIKEEASVSTLLVNLDNkfDPFDA---MSTPLYQTATFKQPSA----IENGPYDYTRSGNPTRDALESLLAKLDKAD 149
Cdd:PRK05967 3 KKQLKTEKAGINTRLAHDGN--DPGDYhgfVNPPVVHASTVLFPDAetmaTRGQKYTYGTRGTPTTDALCKAIDALEGSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 150 RAFCFTSGMAALSA-VTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTN 228
Cdd:PRK05967 81 GTILVPSGLAAVTVpFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYDPEIGAGIAKLMRPNTKVVHTEAPGS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 229 PRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKgEKLAKEVYFLQNS 308
Cdd:PRK05967 161 NTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSDILLGTVSAN-EKCWPQLLEAHGT 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 309 EGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK05967 240 LGLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLEGRPDVARVLHPALPSFPGHEI 299
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
88-362 |
2.86e-48 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 168.70 E-value: 2.86e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 88 STLLVNLDnkFDPF---DAMSTPLYQTATFKQPSAiENGP--YD-----------------YTRSGNPTRDALESLLAKL 145
Cdd:PRK07049 19 ETQMLNYG--YDPElseGAVKPPVFLTSTFVFRSA-EDGRdfFDyvsgrkeppagegaglvYSRFNHPNSEIVEDRLAVY 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 146 DKADRAFCFTSGMAALSAVT-HLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVV-------VKRVNTTKLDEVAAAIGPq 217
Cdd:PRK07049 96 EGAESAALFSSGMSAIATTLlAFVRPGDVILHSQPLYGGTETLLAKTFRNFGVGavgfadgLSEAAIGAAAEAAAAKGR- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 218 TKLVWLESPTNPRQQISDIRKISEMAHAQGA------LVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvl 291
Cdd:PRK07049 175 VSLILIETPANPTNSLVDVAAVRRVADAIEArqghrpIIACDNTLLGPVFQKPLEHGADLSVYSLTKYVGGHSDLVAG-- 252
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30694567 292 AVKGEK-LAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPD 362
Cdd:PRK07049 253 AVLGRKaLIRQVRALRSAIGTQLDPHSCWMLGRSLETLVLRMERANRNARAVAEFLRDHPKVEKLHYLPFLD 324
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
104-368 |
8.53e-47 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 164.55 E-value: 8.53e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 104 MSTPLYQTATFKQPSAI------ENGP----YDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAV-THLIKNGE 172
Cdd:PLN02242 37 MSIEASATFTVMEPDTMrrmfsgELGPdrdfYIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVlLQLCSSGG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 173 EIVAGDDVYGGSDRLLSQVVPR-SGVVVKRVNTTKLDEVAAAIGP-QTKLVWLESPTNPRQQISDIRKISEMAHAQGALV 250
Cdd:PLN02242 117 HVVASNTLYGGTHALLAHFLPRkCNITTTFVDITDLEAVKKAVVPgKTKVLYFESISNPTLTVADIPELARIAHEKGVTV 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 251 LVDNSiMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGvlAVKG-EKLAKEVYFLQNSEGSGLAP-------FDcwLCL 322
Cdd:PLN02242 197 VVDNT-FAPMVLSPARLGADVVVHSISKFISGGADIIAG--AVCGpAELVNSMMDLHHGALMLLGPtmnpkvaFE--LSE 271
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 30694567 323 RgIKTMALRIekqQENARKIAMYLSshpRVK----KVYYAGLPDHPGHHL 368
Cdd:PLN02242 272 R-LPHLSLRM---KEHCRRAMEYAK---RMKelglKVIYPGLEDHPQHAL 314
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
101-366 |
1.32e-46 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 163.74 E-value: 1.32e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 101 FDAMSTPLYQTATFKQPSAIE--------NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALSAVTH-LIKNG 171
Cdd:PRK07050 25 FRSFVTPVARASTVVFPDLATmraldwrqDVQWRYGLHATPTSLALAQRLAEIEGGRHALLQPSGLAAISLVYFgLVKAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 172 EEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNTTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVL 251
Cdd:PRK07050 105 DDVLIPDNAYGPNRDHGEWLARDFGITVRFYDPLIGAGIADLIQPNTRLIWLEAPGSVTMEVPDVPAITAAARARGVVTA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 252 VDNSIMSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALR 331
Cdd:PRK07050 185 IDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGATITADAELHAKLKLARMRLGIGVSADDCSLVLRGLPSLQVR 264
|
250 260 270
....*....|....*....|....*....|....*
gi 30694567 332 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGH 366
Cdd:PRK07050 265 LAAHDRSALEVAEWLKARPEIATVLHPALPDCPGH 299
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
105-378 |
1.79e-40 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 147.19 E-value: 1.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 105 STPLYQTATFKQPSAIE--NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVY 181
Cdd:PRK09028 31 STVVFDTVAEMRHAAKNraNGEMFYGRRGTPTHFAFQAAIVELEGGAGTALYPSGAAAISnALLSFLKAGDHLLMVDSCY 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 182 GGSDRLLSQVVPRSGVvvkrvNTTKLDE-----VAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 256
Cdd:PRK09028 111 EPTRDLCDKILKGFGI-----ETTYYDPmigegIRELIRPNTKVLFLESPGSITMEVQDVPTLSRIAHEHDIVVMLDNTW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVlAVKGEKlakevYFLQNSEGSGL-----APFDCWLCLRGIKTMALR 331
Cdd:PRK09028 186 ASPINSRPFEMGVDISIQAATKYIVGHSDVMLGT-ATANEK-----HWDQLREHSYLmgqctSPDDVYLAMRGLRTLGVR 259
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 30694567 332 IEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLH----------FSQVLKSIN 378
Cdd:PRK09028 260 LAQHEKNALKVANWLATRPEVDHVRHPAFETCPGHEFFkrdfsgsnglFSFVLKQGD 316
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
107-368 |
1.48e-33 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 129.40 E-value: 1.48e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 107 PLYQTATFKQPSA--------IENGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAG 177
Cdd:PRK06702 27 PLYQSTTYKYDTSddlaalfnLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATASGQAAIMlAVLNICSSGDHLLCS 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 178 DDVYGGSDRLLSQVVPRSGVVVKRVNTT-KLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSI 256
Cdd:PRK06702 107 STVYGGTFNLFGVSLRKLGIDVTFFNPNlTADEIVALANDKTKLVYAESLGNPAMNVLNFKEFSDAAKELEVPFIVDNTL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 257 MSPVLSRPLELGADIVMHSATKFIAGHSDVMAGVLA---------------VKGEKLAKEVYFLQN-------------- 307
Cdd:PRK06702 187 ATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIdggnfdwtngkypelVEPDPSYHGVSYVQNfgaaayivkarvql 266
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 30694567 308 --SEGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHL 368
Cdd:PRK06702 267 lrDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDSNENYSL 329
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
122-366 |
1.65e-30 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 120.19 E-value: 1.65e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 122 NGPYDYTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVvvk 200
Cdd:PRK08114 51 NGELFYGRRGTLTHFSLQEAMCELEGGAGCALYPCGAAAVAnAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGV--- 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 201 rvNTTKLD-----EVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQG--ALVLVDNSIMSPVLSRPLELGADIVM 273
Cdd:PRK08114 128 --TTTWFDpligaDIAKLIQPNTKVVFLESPGSITMEVHDVPAIVAAVRSVNpdAVIMIDNTWAAGVLFKALDFGIDISI 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 274 HSATKFIAGHSDVMAGVlAVKG----EKLAKEVYFLqnseGSGLAPFDCWLCLRGIKTMALRIEKQQENARKIAMYLSSH 349
Cdd:PRK08114 206 QAGTKYLVGHSDAMIGT-AVANarcwEQLRENSYLM----GQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEH 280
|
250
....*....|....*..
gi 30694567 350 PRVKKVYYAGLPDHPGH 366
Cdd:PRK08114 281 PEVARVNHPALPGCKGH 297
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
135-294 |
3.09e-11 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 61.24 E-value: 3.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 135 RDALESLLAKL--DKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSdrlLSQVVPRSGVVVKRVNTTK----- 206
Cdd:cd01494 2 LEELEEKLARLlqPGNDKAVFVPSGTGANEAALLaLLGPGDEVIVDANGHGSR---YWVAAELAGAKPVPVPVDDagygg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 207 ---LDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNS----IMSPVLSRPLELGADIVMHSATKF 279
Cdd:cd01494 79 ldvAILEELKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAAsaggASPAPGVLIPEGGADVVTFSLHKN 158
|
170
....*....|....*
gi 30694567 280 IAGhsdVMAGVLAVK 294
Cdd:cd01494 159 LGG---EGGGVVIVK 170
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
136-253 |
2.14e-07 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 52.31 E-value: 2.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 136 DALESLLAKL--------DKADRAFCFTSGM-AALSAVTHLIKNGEEIVAGDDVYGGSdrlLSQVVPRSGVVVKRVNTTK 206
Cdd:pfam00155 42 PELREALAKFlgrspvlkLDREAAVVFGSGAgANIEALIFLLANPGDAILVPAPTYAS---YIRIARLAGGEVVRYPLYD 118
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 30694567 207 -------LDEVAAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD 253
Cdd:pfam00155 119 sndfhldFDALEAALKEKPKVVLHTSPHNPTGTVatlEELEKLLDLAKEHNILLLVD 175
|
|
| CsdA |
COG0520 |
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism]; |
154-253 |
3.23e-07 |
|
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
Pssm-ID: 440286 [Multi-domain] Cd Length: 396 Bit Score: 51.68 E-value: 3.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 154 FTSGM-AALSAVTH---LIKNGEEIVAGDDVYGGSD---RLLSQvvpRSGVVVKRVNTTK-----LDEVAAAIGPQTKLV 221
Cdd:COG0520 82 FTRGTtEAINLVAYglgRLKPGDEILITEMEHHSNIvpwQELAE---RTGAEVRVIPLDEdgeldLEALEALLTPRTKLV 158
|
90 100 110
....*....|....*....|....*....|..
gi 30694567 222 WLESPTNPRQQISDIRKISEMAHAQGALVLVD 253
Cdd:COG0520 159 AVTHVSNVTGTVNPVKEIAALAHAHGALVLVD 190
|
|
| PRK00451 |
PRK00451 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPA; |
204-272 |
5.16e-07 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPA;
Pssm-ID: 234769 [Multi-domain] Cd Length: 447 Bit Score: 51.29 E-value: 5.16e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 204 TTKLDEVAAAIGPQTKLVWLESPtNPRQQISDIRKISEMAHAQGAL-VLVDNSIMSPVLSRPLELGADIV 272
Cdd:PRK00451 191 VTDLEALEAAVDDDTAAVVVQYP-NFFGVIEDLEEIAEIAHAGGALfIVGVDPVSLGLLKPPGEYGADIV 259
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
154-281 |
7.81e-07 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 50.71 E-value: 7.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 154 FTSG------MAALSAVTHLiKNGEEIVAGDDVYGgsdrllSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGP 216
Cdd:pfam00266 66 FTSGtteainLVALSLGRSL-KPGDEIVITEMEHH------ANLVPwqelakRTGARVRVLPLDEdglldLDELEKLITP 138
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30694567 217 QTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSimSPVLSRPL---ELGADIVMHSATKFIA 281
Cdd:pfam00266 139 KTKLVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA--QAIGHRPIdvqKLGVDFLAFSGHKLYG 204
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
194-300 |
2.00e-06 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 49.39 E-value: 2.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 194 RSGVVVKRVNTTK-----LDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLsrPL--- 265
Cdd:cd06453 111 RTGAKLKVVPVDDdgqldLEALEKLLTERTKLVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVdvq 188
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 30694567 266 ELGADivmhsatkFIA--GHSDVMA---GVLAVKGEKLAK 300
Cdd:cd06453 189 DLGCD--------FLAfsGHKMLGPtgiGVLYGKEELLEE 220
|
|
| GcvP1 |
COG0403 |
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport ... |
204-272 |
4.37e-06 |
|
Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain is part of the Pathway/BioSystem: Glycine cleavage
Pssm-ID: 440172 [Multi-domain] Cd Length: 442 Bit Score: 48.49 E-value: 4.37e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 204 TTKLDEVAAAIGPQTKLVWLESPtNPRQQISDIRKISEMAHAQGALVLVDNSIMS-PVLSRPLELGADIV 272
Cdd:COG0403 192 VTDLEALKALLDDDVAGVLVQYP-NFFGVIEDLRAIAEAAHAAGALVIVAADPLSlGLLKPPGELGADIV 260
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
119-295 |
4.47e-06 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 48.20 E-value: 4.47e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 119 AIENGPYDYTRS-GNP-TRDALESLLAK-----LDkADRAFCFTSGMAALS-AVTHLIKNGEEIVAGD---DVYGGSDRL 187
Cdd:COG0436 55 ALDDGVTGYTPSaGIPeLREAIAAYYKRrygvdLD-PDEILVTNGAKEALAlALLALLNPGDEVLVPDpgyPSYRAAVRL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 188 LsqvvprsGVVVKRVNTTK-------LDEVAAAIGPQTKLVWLESPTNP------RqqiSDIRKISEMAHAQGALVLVDN 254
Cdd:COG0436 134 A-------GGKPVPVPLDEengflpdPEALEAAITPRTKAIVLNSPNNPtgavysR---EELEALAELAREHDLLVISDE 203
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 30694567 255 -------------SIMSpvlsrpLELGAD--IVMHSATK----------FIAGHSDVMAGVLAVKG 295
Cdd:COG0436 204 iyeelvydgaehvSILS------LPGLKDrtIVINSFSKsyamtgwrigYAVGPPELIAALLKLQS 263
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
132-301 |
1.82e-05 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 46.09 E-value: 1.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 132 NPTRDALES--LLAKLDKADRAFCFTSG-----MAALSAVthlIKNGEEIVAGDD----VYGGSDrlLSQVVPrsgVVVK 200
Cdd:cd00615 56 DPTGPIKEAqeLAARAFGAKHTFFLVNGtsssnKAVILAV---CGPGDKILIDRNchksVINGLV--LSGAVP---VYLK 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 201 -RVNttKLDEVAAAIGPQT-----------KLVWLESPTnPRQQISDIRKISEMAHAQGALVLVDNS-----IMSPVL-S 262
Cdd:cd00615 128 pERN--PYYGIAGGIPPETfkkaliehpdaKAAVITNPT-YYGICYNLRKIVEEAHHRGLPVLVDEAhgahfRFHPILpS 204
|
170 180 190
....*....|....*....|....*....|....*....
gi 30694567 263 RPLELGADIVMHSATKFIAGHSdvMAGVLAVKGEKLAKE 301
Cdd:cd00615 205 SAAMAGADIVVQSTHKTLPALT--QGSMIHVKGDLVNPD 241
|
|
| PLN02855 |
PLN02855 |
Bifunctional selenocysteine lyase/cysteine desulfurase |
91-287 |
2.53e-05 |
|
Bifunctional selenocysteine lyase/cysteine desulfurase
Pssm-ID: 215460 [Multi-domain] Cd Length: 424 Bit Score: 45.89 E-value: 2.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 91 LVNLDNkfdpfdamstplyqTATFKQPSAIENGPYDYTRSGNPT------------RDALESLLAKLD-----KADRAFC 153
Cdd:PLN02855 33 LVYLDN--------------AATSQKPAAVLDALQDYYEEYNSNvhrgihalsakaTDAYELARKKVAafinaSTSREIV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 154 FTSGMAA---LSAVTHLIKNgeeIVAGDDVYGGSDRLLSQVVP------RSGVVVKRVNTTK-----LDEVAAAIGPQTK 219
Cdd:PLN02855 99 FTRNATEainLVAYTWGLAN---LKPGDEVILSVAEHHSNIVPwqlvaqKTGAVLKFVGLTPdevldVEQLKELLSEKTK 175
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30694567 220 LVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSRPLE-LGADIVMHSATK--------FIAGHSDVM 287
Cdd:PLN02855 176 LVATHHVSNVLGSILPVEDIVHWAHAVGAKVLVDACQSVPHMPVDVQtLGADFLVASSHKmcgptgigFLWGKSDLL 252
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
196-295 |
3.15e-05 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 45.51 E-value: 3.15e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 196 GVVVKRVNTTK-----LDEVAAAIGPQTKLVWLESPTNP------RQQISDIRKisemAHAQGALVLVD----------N 254
Cdd:COG0079 110 GAEVVEVPLDEdfsldLDALLAAITERTDLVFLCNPNNPtgtllpREELEALLE----ALPADGLVVVDeayaefvpeeD 185
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 30694567 255 SIMSPVLSRP-LelgadIVMHSATKF--IAG--------HSDVMAGVLAVKG 295
Cdd:COG0079 186 SALPLLARYPnL-----VVLRTFSKAygLAGlrlgyaiaSPELIAALRRVRG 232
|
|
| f2_encap_cargo1 |
NF041166 |
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like ... |
207-253 |
6.04e-05 |
|
family 2A encapsulin nanocompartment cargo protein cysteine desulfurase; Capsid-like encapsulin nanocompartments are commonly found in bacteria and archaea. Encapsulin nanocompartments, which are assembled from shell proteins, encapsulate various cargo proteins, typically peroxidases or ferritin-like proteins, to protect cells from oxidative stress caused by peroxide. Proteins of this family are cysteine desulfurases with an additional N-terminal encapsulation targeting sequence (~200 aa) that is necessary and sufficient for compartmentalization.
Pssm-ID: 469077 [Multi-domain] Cd Length: 623 Bit Score: 44.84 E-value: 6.04e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 30694567 207 LDEVAAAIGPQTKLVwleSPTnprqQISD-------IRKISEMAHAQGALVLVD 253
Cdd:NF041166 376 LDEYAKLLNPRTKLV---SVT----QVSNalgtvtpVKEIIALAHRAGAKVLVD 422
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
125-346 |
7.74e-05 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 44.25 E-value: 7.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 125 YDYTRSGNPTRDALESLLAK----LDKADRAFCFTSGMAALSAVTH-LIKNGEEIVAGDDVYGGSDRLLSQVvprsGVVV 199
Cdd:cd00609 32 YYPDPGLPELREAIAEWLGRrggvDVPPEEIVVTNGAQEALSLLLRaLLNPGDEVLVPDPTYPGYEAAARLA----GAEV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 200 KRVNTTK-------LDEVAAAIGPQTKLVWLESPTNP------RQQisdIRKISEMAHAQGALVLVDNS----IMSPVLS 262
Cdd:cd00609 108 VPVPLDEeggflldLELLEAAKTPKTKLLYLNNPNNPtgavlsEEE---LEELAELAKKHGILIISDEAyaelVYDGEPP 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 263 RPLELGAD----IVMHSATKFIAghsdvMA----GVLAVKGEKLAKEVYFLQNSEGSGLAPFDCWLCLRGIKTMALRIEK 334
Cdd:cd00609 185 PALALLDAyervIVLRSFSKTFG-----LPglriGYLIAPPEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGEEHLEE 259
|
250
....*....|..
gi 30694567 335 QQENARKIAMYL 346
Cdd:cd00609 260 LRERYRRRRDAL 271
|
|
| PRK09082 |
PRK09082 |
methionine aminotransferase; Validated |
133-253 |
1.93e-04 |
|
methionine aminotransferase; Validated
Pssm-ID: 181642 [Multi-domain] Cd Length: 386 Bit Score: 42.98 E-value: 1.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 133 PTRDALESLLAKLD----KADRAFCFTSG--MAALSAVTHLIKNGEEIVAGDDVYggsDRLLSQVVPRSGVVVK------ 200
Cdd:PRK09082 71 ALREAIAAKTARLYgrqyDADSEITVTAGatEALFAAILALVRPGDEVIVFDPSY---DSYAPAIELAGGRAVRvalqpp 147
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 30694567 201 --RVNttkLDEVAAAIGPQTKLVWLESPTNPRQQI---SDIRKISEMAHAQGALVLVD 253
Cdd:PRK09082 148 dfRVD---WQRFAAAISPRTRLIILNTPHNPSGTVwsaADMRALWQLIAGTDIYVLSD 202
|
|
| GDC-P |
cd00613 |
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine ... |
235-296 |
3.96e-04 |
|
Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalysed by this protein is: Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2. Alpha-beta-type dimers associate to form an alpha(2)beta(2) tetramer, where the alpha- and beta-subunits are structurally similar and appear to have arisen by gene duplication and subsequent divergence with a loss of one active site. The members of this CD are widely dispersed among all three forms of cellular life.
Pssm-ID: 99737 [Multi-domain] Cd Length: 398 Bit Score: 42.22 E-value: 3.96e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 30694567 235 DIRKISEMAHAQGALVLVDNSIMS-PVLSRPLELGADIVMHSATKFIAGHS--DVMAGVLAVKGE 296
Cdd:cd00613 177 LIKEIADIAHSAGALVYVDGDNLNlTGLKPPGEYGADIVVGNLQKTGVPHGggGPGAGFFAVKKE 241
|
|
| PRK04366 |
PRK04366 |
aminomethyl-transferring glycine dehydrogenase subunit GcvPB; |
207-274 |
4.54e-04 |
|
aminomethyl-transferring glycine dehydrogenase subunit GcvPB;
Pssm-ID: 235292 Cd Length: 481 Bit Score: 42.02 E-value: 4.54e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 30694567 207 LDEVAAAIGPQTKLVWLespTNP-------RqqisDIRKISEMAHAQGALVLVD----NSIMSPVlsRPLELGADiVMH 274
Cdd:PRK04366 198 LEALKAAVGEDTAALML---TNPntlglfeR----NILEIAEIVHEAGGLLYYDganlNAILGKA--RPGDMGFD-VVH 266
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
155-253 |
6.50e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 41.56 E-value: 6.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 155 TSGMAAlsAVTHLIKNGEEIVAGDDVY----------GGSDRLLSQVVPRSGVVVKrvnttkLDEVAAAIGPQTKLVWLE 224
Cdd:PRK07777 95 TEAIAA--AVLGLVEPGDEVLLIEPYYdsyaaviamaGAHRVPVPLVPDGRGFALD------LDALRAAVTPRTRALIVN 166
|
90 100 110
....*....|....*....|....*....|..
gi 30694567 225 SPTNPRQQI---SDIRKISEMAHAQGALVLVD 253
Cdd:PRK07777 167 SPHNPTGTVltaAELAAIAELAVEHDLLVITD 198
|
|
| GDC-P |
pfam02347 |
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins ... |
204-296 |
2.02e-03 |
|
Glycine cleavage system P-protein; This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1.2.10 (GDC) also annotated as glycine cleavage system or glycine synthase. GDC consists of four proteins P, H, L and T. The reaction catalyzed by this protein is:- Glycine + lipoylprotein <=> S-aminomethyldihydrolipoylprotein + CO2
Pssm-ID: 396772 [Multi-domain] Cd Length: 428 Bit Score: 40.05 E-value: 2.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 204 TTKLDEVAAAIgpqtklvwLESPtNPRQQISDIRKISEMAHAQGALVLVDNSIMSPVLSR-PLELGADIVMHSATKF--I 280
Cdd:pfam02347 192 VTDLKDVFGVL--------VQYP-NTDGRIEDYKELIELAHQRKSLVVVAADLLALTLLKpPGEFGADIAVGSAQRFgvP 262
|
90
....*....|....*.
gi 30694567 281 AGHSDVMAGVLAVKGE 296
Cdd:pfam02347 263 LGYGGPHAGFFAVKKE 278
|
|
| SepCysS |
cd06452 |
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent ... |
192-296 |
2.80e-03 |
|
Sep-tRNA:Cys-tRNA synthase. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Cys-tRNA(Cys) is produced by O-phosphoseryl-tRNA synthetase which ligates O-phosphoserine (Sep) to tRNA(Cys), and Sep-tRNA:Cys-tRNA synthase (SepCysS) converts Sep-tRNA(Cys) to Cys-tRNA(Cys), in methanogenic archaea. SepCysS forms a dimer, each monomer is composed of a large and small domain; the larger, a typical pyridoxal 5'-phosphate (PLP)-dependent-like enzyme fold. In the active site of each monomer, PLP is covalently bound to a conserved Lys residue near the dimer interface.
Pssm-ID: 99745 Cd Length: 361 Bit Score: 39.30 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30694567 192 VPRSGVVVKRVN----TTKLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKISEMAHAQGALVLVDNS----IMsPVLSR 263
Cdd:cd06452 110 VPNTGHPEYHITpegyAEVIEEVKDEFGKPPALALLTHVDGNYGNLHDAKKIAKVCHEYGVPLLLNGAytvgRM-PVSGK 188
|
90 100 110
....*....|....*....|....*....|...
gi 30694567 264 plELGADIVMHSATKFIAGHSDVmaGVLAVKGE 296
Cdd:cd06452 189 --ELGADFIVGSGHKSMAASAPI--GVLATTEE 217
|
|
| |
