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Conserved domains on  [gi|31563514|ref|NP_852669|]
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N-alpha-acetyltransferase 20 isoform c [Homo sapiens]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10456837)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  15581578|10940244|9175471|27367672|26818562
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-102 1.64e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


:

Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563514    12 LFRFNNINLDPLTETYGIPFY---LQYLAHWPEYFIVAEApGGELMGYIMGKAEGsvaREEWHGHVTALSVAPEFRRLGL 88
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLdllEDWDEDASEGFFVAEE-DGELVGFASLSIID---DEPPVGEIEGLAVAPEYRGKGI 76

                          90
                  ....*....|....
gi 31563514    89 AAKLMELLEEISER 102
Cdd:pfam00583  77 GTALLQALLEWARE 90
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-102 1.64e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563514    12 LFRFNNINLDPLTETYGIPFY---LQYLAHWPEYFIVAEApGGELMGYIMGKAEGsvaREEWHGHVTALSVAPEFRRLGL 88
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLdllEDWDEDASEGFFVAEE-DGELVGFASLSIID---DEPPVGEIEGLAVAPEYRGKGI 76

                          90
                  ....*....|....
gi 31563514    89 AAKLMELLEEISER 102
Cdd:pfam00583  77 GTALLQALLEWARE 90
PRK03624 PRK03624
putative acetyltransferase; Provisional
 36-97 1.30e-07

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 46.46  E-value: 1.30e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31563514   36 LAHWPEYFIVAEApGGELMGYIMGKAEGsvareewH-GHVTALSVAPEFRRLGLAAKLMELLE 97
Cdd:PRK03624  40 LNHDPSLFLVAEV-GGEVVGTVMGGYDG-------HrGWAYYLAVHPDFRGRGIGRALVARLE 94
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-99 1.04e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.65  E-value: 1.04e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31563514  43 FIVAEApGGELMGYIMGKAEGSVAReewHGHVTALSVAPEFRRLGLAAKLMELLEEI 99
Cdd:cd04301   1 FLVAED-DGEIVGFASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEE 53
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
40-98 7.67e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 41.99  E-value: 7.67e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31563514  40 PEYFIVAEApGGELMGYIMGkAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEE 98
Cdd:COG3153  38 AGLSLVAED-DGEIVGHVAL-SPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALE 94
 
Name Accession Description Interval E-value
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 12-102 1.64e-08

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 48.67  E-value: 1.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563514    12 LFRFNNINLDPLTETYGIPFY---LQYLAHWPEYFIVAEApGGELMGYIMGKAEGsvaREEWHGHVTALSVAPEFRRLGL 88
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLdllEDWDEDASEGFFVAEE-DGELVGFASLSIID---DEPPVGEIEGLAVAPEYRGKGI 76

                          90
                  ....*....|....
gi 31563514    89 AAKLMELLEEISER 102
Cdd:pfam00583  77 GTALLQALLEWARE 90
PRK03624 PRK03624
putative acetyltransferase; Provisional
 36-97 1.30e-07

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 46.46  E-value: 1.30e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31563514   36 LAHWPEYFIVAEApGGELMGYIMGKAEGsvareewH-GHVTALSVAPEFRRLGLAAKLMELLE 97
Cdd:PRK03624  40 LNHDPSLFLVAEV-GGEVVGTVMGGYDG-------HrGWAYYLAVHPDFRGRGIGRALVARLE 94
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-99 1.04e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 42.65  E-value: 1.04e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31563514  43 FIVAEApGGELMGYIMGKAEGSVAReewHGHVTALSVAPEFRRLGLAAKLMELLEEI 99
Cdd:cd04301   1 FLVAED-DGEIVGFASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEE 53
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
40-98 7.67e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 41.99  E-value: 7.67e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 31563514  40 PEYFIVAEApGGELMGYIMGkAEGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEE 98
Cdd:COG3153  38 AGLSLVAED-DGEIVGHVAL-SPVDIDGEGPALLLGPLAVDPEYRGQGIGRALMRAALE 94
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 41-99 4.70e-05

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 38.97  E-value: 4.70e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31563514    41 EYFIVAEApGGELMGYIMGKAEGSVAREEWHGhvtaLSVAPEFRRLGLAAKLMELLEEI 99
Cdd:pfam13508   3 GRFFVAED-DGKIVGFAALLPLDDEGALAELR----LAVHPEYRGQGIGRALLEAAEAA 56
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 55-99 1.19e-04

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 37.71  E-value: 1.19e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 31563514  55 GYIMGkaegSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEEI 99
Cdd:COG0456   1 GFALL----GLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALER 41
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 42-98 2.07e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 38.02  E-value: 2.07e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 31563514    42 YFIVAEApGGELMGYImgkaegSVAReewHGHVTALSVAPEFRRLGLAAKLMELLEE 98
Cdd:pfam13673  32 FFFVAFE-GGQIVGVI------ALRD---RGHISLLFVDPDYQGQGIGKALLEAVED 78
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 43-98 5.11e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 36.89  E-value: 5.11e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31563514  43 FIVAEApGGELMGYImgkaeGSVAREEWHGHVTALSVAPEFRRLGLAAKLMELLEE 98
Cdd:COG1246  30 FWVAEE-DGEIVGCA-----ALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLA 79
Eis COG4552
Predicted acetyltransferase [General function prediction only];
72-102 9.02e-04

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 37.19  E-value: 9.02e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 31563514  72 GHVTALSVAPEFRRLGLAAKLM-ELLEEISER 102
Cdd:COG4552  73 AGITGVAVAPEHRRRGVARALLrEALAELRER 104
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 43-98 1.67e-03

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 35.41  E-value: 1.67e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 31563514  43 FIVAEApGGELMGYIMGKAEGsvareEWHGHVTALSVAPEFRRLGLAAKLMELLEE 98
Cdd:COG0454  36 FIAVDD-KGEPIGFAGLRRLD-----DKVLELKRLYVLPEYRGKGIGKALLEALLE 85
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
42-102 6.00e-03

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 34.20  E-value: 6.00e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31563514  42 YFIVAEApGGELMGYimgkAEGSVAREEWHGHVTA---LSVAPEFRRLGLAAKLMELLEEISER 102
Cdd:COG1247  53 PVLVAEE-DGEVVGF----ASLGPFRPRPAYRGTAeesIYVDPDARGRGIGRALLEALIERARA 111
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 3-96 8.07e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 33.82  E-value: 8.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563514   3 TLRAFTCDDLFRFNNINLDPLTETYGIP----------FYLQYLAHWPE----YFIVAEAPGGELMGYImgkaegSVARE 68
Cdd:COG1670   9 RLRPLRPEDAEALAELLNDPEVARYLPGppysleearaWLERLLADWADggalPFAIEDKEDGELIGVV------GLYDI 82

                        90       100       110
                ....*....|....*....|....*....|
gi 31563514  69 EWHGHVT--ALSVAPEFRRLGLAAKLMELL 96
Cdd:COG1670  83 DRANRSAeiGYWLAPAYWGKGYATEALRAL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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