NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|32564897|ref|NP_872011|]
View 

WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-176 2.10e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564897  80 SGSTNGLTFTKDREYIYSISEDGrSVRVWNKNNGVLAHQLpiSEQKSEIQAIHVTNQRLHVASG---RTLVVFRLGDEKP 156
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDG-TIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGssdKTIRLWDLETGEC 85

                        90       100
                ....*....|....*....|
gi 32564897 157 VETVISKTELTFSAFFQQDD 176
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDG 105
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-176 2.10e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564897  80 SGSTNGLTFTKDREYIYSISEDGrSVRVWNKNNGVLAHQLpiSEQKSEIQAIHVTNQRLHVASG---RTLVVFRLGDEKP 156
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDG-TIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGssdKTIRLWDLETGEC 85

                        90       100
                ....*....|....*....|
gi 32564897 157 VETVISKTELTFSAFFQQDD 176
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDG 105
WD40 COG2319
WD40 repeat [General function prediction only];
65-159 4.05e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564897  65 LNTGNIgwRQIMENPSGSTNGLTFTKDREYIYSISEDGrSVRVWNKNNGVLAHQLpiSEQKSEIQAIHVTNQRLHVASG- 143
Cdd:COG2319 275 LATGEL--LRTLTGHSGGVNSVAFSPDGKLLASGSDDG-TVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGs 349

                        90
                ....*....|....*...
gi 32564897 144 --RTLVVFRLGDEKPVET 159
Cdd:COG2319 350 ddGTVRLWDLATGELLRT 367
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-176 2.10e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 2.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564897  80 SGSTNGLTFTKDREYIYSISEDGrSVRVWNKNNGVLAHQLpiSEQKSEIQAIHVTNQRLHVASG---RTLVVFRLGDEKP 156
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDG-TIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGssdKTIRLWDLETGEC 85

                        90       100
                ....*....|....*....|
gi 32564897 157 VETVISKTELTFSAFFQQDD 176
Cdd:cd00200  86 VRTLTGHTSYVSSVAFSPDG 105
WD40 COG2319
WD40 repeat [General function prediction only];
65-159 4.05e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564897  65 LNTGNIgwRQIMENPSGSTNGLTFTKDREYIYSISEDGrSVRVWNKNNGVLAHQLpiSEQKSEIQAIHVTNQRLHVASG- 143
Cdd:COG2319 275 LATGEL--LRTLTGHSGGVNSVAFSPDGKLLASGSDDG-TVRLWDLATGKLLRTL--TGHTGAVRSVAFSPDGKTLASGs 349

                        90
                ....*....|....*...
gi 32564897 144 --RTLVVFRLGDEKPVET 159
Cdd:COG2319 350 ddGTVRLWDLATGELLRT 367
WD40 COG2319
WD40 repeat [General function prediction only];
65-171 9.14e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.97  E-value: 9.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32564897  65 LNTGNIgwRQIMENPSGSTNGLTFTKDREYIYSISEDGrSVRVWNKNNGVLAHQLPisEQKSEIQAIHVTNQRLHVASG- 143
Cdd:COG2319 233 LATGKL--LRTLTGHSGSVRSVAFSPDGRLLASGSADG-TVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLLASGs 307

                        90       100       110
                ....*....|....*....|....*....|.
gi 32564897 144 --RTLVVFRLGDEKPVETVISKTELTFS-AF 171
Cdd:COG2319 308 ddGTVRLWDLATGKLLRTLTGHTGAVRSvAF 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH