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Conserved domains on  [gi|37674289|ref|NP_932765|]
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vacuolar fusion protein CCZ1 homolog B [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 24-150 5.34e-38

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 436911  Cd Length: 112  Bit Score: 134.29  E-value: 5.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289    24 LLSFFIYNPRFGPREGQEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSK--PAKSLHTQKNRQFFNEPEENFW 101
Cdd:pfam19031   1 LPFFFVYNPTEGKKEGEEEKKILYYHPEETSLNEKLSLRGIFEALVSFTETFSPTQssPCLLIELQKYHVAYREVEDDLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 37674289   102 MVMVVRNPIiekqskdgkpvieyqeeELLDKVYSSVLRQCYSMYKLFNG 150
Cdd:pfam19031  81 LIGSVSNPD-----------------NIPDPYYSSVLEQLYRFFKLFYG 112
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 372-470 1.39e-33

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


:

Pssm-ID: 436913  Cd Length: 98  Bit Score: 122.05  E-value: 1.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289   372 KEPQFKFIYFNHMNLAEKSTVHMRKTPSVSltSVHPDLMKILGDINSDFTR-VDEDEEIIVKAMSDYWVVGKKSDRRELY 450
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQEKRQVNG--PLDPDFLRLVLDIHSDFSQsLPELKEHIVKTLNDYWVVGRKSNPRELY 78

                          90       100
                  ....*....|....*....|
gi 37674289   451 VILNQKNANLIEVNEEVKKL 470
Cdd:pfam19033  79 VILNNKNASLQDINEEAKKL 98
Intu_longin_2 pfam19032
Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and ...
 220-347 2.99e-31

Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and related proteins.


:

Pssm-ID: 465951  Cd Length: 120  Bit Score: 116.62  E-value: 2.99e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289   220 VKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPElagrdspiraempgnLQHYGRFLTGPLNLNDPDAKCRFP 299
Cdd:pfam19032   1 ILGSALLYKDYLLWSHLPKEDLQDVYLYLRQHLLLELISKE---------------SQRVGRFVTWREVFPTDASDSGED 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 37674289   300 KIFVNTDDT--YEELHLIVYKAMSAAVCFMIDAS-----VHPTLDFCRRLDSIVG 347
Cdd:pfam19032  66 KLPLNNDDTepLGRYFLLVYGALHATLCVLLEAGgctskPGPDPFYVEELDATLG 120
 
Name Accession Description Interval E-value
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 24-150 5.34e-38

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 436911  Cd Length: 112  Bit Score: 134.29  E-value: 5.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289    24 LLSFFIYNPRFGPREGQEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSK--PAKSLHTQKNRQFFNEPEENFW 101
Cdd:pfam19031   1 LPFFFVYNPTEGKKEGEEEKKILYYHPEETSLNEKLSLRGIFEALVSFTETFSPTQssPCLLIELQKYHVAYREVEDDLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 37674289   102 MVMVVRNPIiekqskdgkpvieyqeeELLDKVYSSVLRQCYSMYKLFNG 150
Cdd:pfam19031  81 LIGSVSNPD-----------------NIPDPYYSSVLEQLYRFFKLFYG 112
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 372-470 1.39e-33

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 436913  Cd Length: 98  Bit Score: 122.05  E-value: 1.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289   372 KEPQFKFIYFNHMNLAEKSTVHMRKTPSVSltSVHPDLMKILGDINSDFTR-VDEDEEIIVKAMSDYWVVGKKSDRRELY 450
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQEKRQVNG--PLDPDFLRLVLDIHSDFSQsLPELKEHIVKTLNDYWVVGRKSNPRELY 78

                          90       100
                  ....*....|....*....|
gi 37674289   451 VILNQKNANLIEVNEEVKKL 470
Cdd:pfam19033  79 VILNNKNASLQDINEEAKKL 98
Intu_longin_2 pfam19032
Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and ...
 220-347 2.99e-31

Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 465951  Cd Length: 120  Bit Score: 116.62  E-value: 2.99e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289   220 VKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPElagrdspiraempgnLQHYGRFLTGPLNLNDPDAKCRFP 299
Cdd:pfam19032   1 ILGSALLYKDYLLWSHLPKEDLQDVYLYLRQHLLLELISKE---------------SQRVGRFVTWREVFPTDASDSGED 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 37674289   300 KIFVNTDDT--YEELHLIVYKAMSAAVCFMIDAS-----VHPTLDFCRRLDSIVG 347
Cdd:pfam19032  66 KLPLNNDDTepLGRYFLLVYGALHATLCVLLEAGgctskPGPDPFYVEELDATLG 120
 
Name Accession Description Interval E-value
Intu_longin_1 pfam19031
First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain ...
 24-150 5.34e-38

First Longin domain of INTU, CCZ1 and HPS4; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1/CCZ1) family, including protein sequences of INTU, CCZ1 and HPS4 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 436911  Cd Length: 112  Bit Score: 134.29  E-value: 5.34e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289    24 LLSFFIYNPRFGPREGQEENKILFYHPNEVEKNEKIRNVGLCEAIVQFTRTFSPSK--PAKSLHTQKNRQFFNEPEENFW 101
Cdd:pfam19031   1 LPFFFVYNPTEGKKEGEEEKKILYYHPEETSLNEKLSLRGIFEALVSFTETFSPTQssPCLLIELQKYHVAYREVEDDLW 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 37674289   102 MVMVVRNPIiekqskdgkpvieyqeeELLDKVYSSVLRQCYSMYKLFNG 150
Cdd:pfam19031  81 LIGSVSNPD-----------------NIPDPYYSSVLEQLYRFFKLFYG 112
Intu_longin_3 pfam19033
Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and ...
 372-470 1.39e-33

Intu longin-like domain 3; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 436913  Cd Length: 98  Bit Score: 122.05  E-value: 1.39e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289   372 KEPQFKFIYFNHMNLAEKSTVHMRKTPSVSltSVHPDLMKILGDINSDFTR-VDEDEEIIVKAMSDYWVVGKKSDRRELY 450
Cdd:pfam19033   1 ENSLYSYVYFDPMNLALKSPLHQEKRQVNG--PLDPDFLRLVLDIHSDFSQsLPELKEHIVKTLNDYWVVGRKSNPRELY 78

                          90       100
                  ....*....|....*....|
gi 37674289   451 VILNQKNANLIEVNEEVKKL 470
Cdd:pfam19033  79 VILNNKNASLQDINEEAKKL 98
Intu_longin_2 pfam19032
Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and ...
 220-347 2.99e-31

Intu longin-like domain 2; This entry represents a longin-like domain found in Intu and related proteins.


Pssm-ID: 465951  Cd Length: 120  Bit Score: 116.62  E-value: 2.99e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37674289   220 VKYTAFLYNDQLIWSGLEQDDMRILYKYLTTSLFPRHIEPElagrdspiraempgnLQHYGRFLTGPLNLNDPDAKCRFP 299
Cdd:pfam19032   1 ILGSALLYKDYLLWSHLPKEDLQDVYLYLRQHLLLELISKE---------------SQRVGRFVTWREVFPTDASDSGED 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 37674289   300 KIFVNTDDT--YEELHLIVYKAMSAAVCFMIDAS-----VHPTLDFCRRLDSIVG 347
Cdd:pfam19032  66 KLPLNNDDTepLGRYFLLVYGALHATLCVLLEAGgctskPGPDPFYVEELDATLG 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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