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Conserved domains on  [gi|46250735|ref|NP_941966|]
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keratin-associated protein 10-2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 35-202 4.44e-12

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 62.50  E-value: 4.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    35 SCCAPAPCLTLVCTPVSCVSSPCCQAACEPSACqsgctssCTPSCCQQSSCQPACCTSSPCQ---QACCVPVCCKPVCCV 111
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSC-------CRPSCCQTSCCQPTTFQSSCCRptcQPCCQTSCCQPTCCQ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735   112 PVCCGASSCCQQSSCQPACCASSS----CQQSCRVPVCCKAVCCVPTcsessssccqqsSCQPACCTSSPCQQSCCVSVC 187
Cdd:pfam01500  75 TSSCQTGCGGIGYGQEGSSGAVSSrtrwCRPDCRVEGTCLPPCCVVS------------CTPPTCCQLHHAQASCCRPSY 142

                         170
                  ....*....|....*
gi 46250735   188 CKPVCCKSICCVPVC 202
Cdd:pfam01500 143 CGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
187-238 4.30e-06

Keratin, high sulfur B2 protein;


:

Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.75  E-value: 4.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 46250735   187 CCKPVCCKSICCVPVCsgasspcCQQSSCQPACCTSSCCRPSSSVSLLCRPV 238
Cdd:pfam13885   1 CCQPSCCQPSCCQPSC-------CQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 35-202 4.44e-12

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 62.50  E-value: 4.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    35 SCCAPAPCLTLVCTPVSCVSSPCCQAACEPSACqsgctssCTPSCCQQSSCQPACCTSSPCQ---QACCVPVCCKPVCCV 111
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSC-------CRPSCCQTSCCQPTTFQSSCCRptcQPCCQTSCCQPTCCQ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735   112 PVCCGASSCCQQSSCQPACCASSS----CQQSCRVPVCCKAVCCVPTcsessssccqqsSCQPACCTSSPCQQSCCVSVC 187
Cdd:pfam01500  75 TSSCQTGCGGIGYGQEGSSGAVSSrtrwCRPDCRVEGTCLPPCCVVS------------CTPPTCCQLHHAQASCCRPSY 142

                         170
                  ....*....|....*
gi 46250735   188 CKPVCCKSICCVPVC 202
Cdd:pfam01500 143 CGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
187-238 4.30e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.75  E-value: 4.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 46250735   187 CCKPVCCKSICCVPVCsgasspcCQQSSCQPACCTSSCCRPSSSVSLLCRPV 238
Cdd:pfam13885   1 CCQPSCCQPSCCQPSC-------CQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 35-202 4.44e-12

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 62.50  E-value: 4.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    35 SCCAPAPCLTLVCTPVSCVSSPCCQAACEPSACqsgctssCTPSCCQQSSCQPACCTSSPCQ---QACCVPVCCKPVCCV 111
Cdd:pfam01500   2 ACCGTSFCGFPTCSTGGTCGSGCCQPCCCQSSC-------CRPSCCQTSCCQPTTFQSSCCRptcQPCCQTSCCQPTCCQ 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735   112 PVCCGASSCCQQSSCQPACCASSS----CQQSCRVPVCCKAVCCVPTcsessssccqqsSCQPACCTSSPCQQSCCVSVC 187
Cdd:pfam01500  75 TSSCQTGCGGIGYGQEGSSGAVSSrtrwCRPDCRVEGTCLPPCCVVS------------CTPPTCCQLHHAQASCCRPSY 142

                         170
                  ....*....|....*
gi 46250735   188 CKPVCCKSICCVPVC 202
Cdd:pfam01500 143 CGQSCCRPACCCQCS 157
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 70-229 1.02e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 55.95  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    70 GCTSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCgassccqqSSCQPACCASSSCQQSCRVPVCCKAV 149
Cdd:pfam01500  10 GFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCC--------RPTCQPCCQTSCCQPTCCQTSSCQTG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735   150 CCvptcsesSSSCCQQSSCQPACCTSSPCQQSCCVSVCCKPVCCKSICCVPVC---SGASSPCCQQSSCQPACCTSSCCR 226
Cdd:pfam01500  82 CG-------GIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCcqlHHAQASCCRPSYCGQSCCRPACCC 154


                  ...
gi 46250735   227 PSS 229
Cdd:pfam01500 155 QCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
74-115 8.00e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.46  E-value: 8.00e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46250735    74 SCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCC 115
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 4-150 2.83e-08

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 51.72  E-value: 2.83e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735     4 STMSICSSACTNSWQVDDCPESCCELPCGTPSCCAPAPCLTLVCTPV---SCVSSPCCQAACEPSACQSGCtssCTPSCC 80
Cdd:pfam01500  12 PTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTcqpCCQTSCCQPTCCQTSSCQTGC---GGIGYG 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    81 QQSSCQPACCTSSPCQQACCVPVCCKPVCCVPVCCGASSCCQQSSCQPaCCASSSCQQSCRVPVCCKAVC 150
Cdd:pfam01500  89 QEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLHHAQAS-CCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
72-113 3.79e-08

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 48.53  E-value: 3.79e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 46250735    72 TSSCTPSCCQQSSCQPACCTSSPCQQACCVPVCCKPVCCVPV 113
Cdd:pfam13885   4 PSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 78-245 9.90e-08

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 50.17  E-value: 9.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    78 SCCQQSSCQ-PACCTSSPCQQACCVPVCCKPVCCVPVCCgassccQQSSCQPACCASSSCQQSCRVpvCCKAVCCVPTCS 156
Cdd:pfam01500   2 ACCGTSFCGfPTCSTGGTCGSGCCQPCCCQSSCCRPSCC------QTSCCQPTTFQSSCCRPTCQP--CCQTSCCQPTCC 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735   157 ESSSSCCqqsscqpACCTSSPCQQSCCVSVCCKPVCCKSICCVPVCsgasspcCQQSSCQPACCTSSCCRPSSSVSLLCR 236
Cdd:pfam01500  74 QTSSCQT-------GCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGT-------CLPPCCVVSCTPPTCCQLHHAQASCCR 139


                  ....*....
gi 46250735   237 PVCSRPASC 245
Cdd:pfam01500 140 PSYCGQSCC 148
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
187-238 4.30e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 42.75  E-value: 4.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 46250735   187 CCKPVCCKSICCVPVCsgasspcCQQSSCQPACCTSSCCRPSSSVSLLCRPV 238
Cdd:pfam13885   1 CCQPSCCQPSCCQPSC-------CQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
99-154 8.61e-06

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 41.98  E-value: 8.61e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 46250735    99 CCVPVCCKPVCCVPVCCgassccqqsscQPACCASSSCQQSCRVPVCCKAVCCVPT 154
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCC-----------QPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
84-137 2.91e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 40.44  E-value: 2.91e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 46250735    84 SCQPACCTSSPCQQACCVPVCCKPVCCVPVCCgassccqqsscQPACCASSSCQ 137
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCC-----------RPSCCRSSCCQ 43
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
170-202 6.54e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 39.29  E-value: 6.54e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 46250735   170 PACCTSSPCQQSCCVSVCCKPVCCKSICCVPVC 202
Cdd:pfam13885   9 PSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSC 41
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
145-201 8.89e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.90  E-value: 8.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 46250735   145 CCKAVCCVPTCSEssssccqqsscqPACCTSSPCQQSCCVSVCCKPVCCKSICCVPV 201
Cdd:pfam13885   1 CCQPSCCQPSCCQ------------PSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
209-245 1.85e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 1.85e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 46250735   209 CCQQSSCQPACCTSSCCRPSSSVSLLCRPVCSRPASC 245
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCC 37
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
206-245 3.87e-04

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 37.36  E-value: 3.87e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 46250735   206 SSPCCQQSSCQPACCTSSCCRPSSSVSLLCRPVCSRPASC 245
Cdd:pfam13885   3 QPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 10-145 1.69e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 38.26  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735    10 SSACTNSWQVDDCPESCCELPCGTPSCCAPAPCLTLVCTPVSCVSSpcCQAACEPSACQSGCTSSCTPSCCQQSSCQPAC 89
Cdd:pfam05287  44 SSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRS--CYSPRTSCVCSPCQTTSAGSLGFGSSSCQSLG 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 46250735    90 CTSSPCQQACCVPVCCKPVCCVPVCCgASSCCQQSSCQPACCASSSCQQSCRVPVC 145
Cdd:pfam05287 122 YGSNSCQPLGCGSSGFRPLGCLSKGF-QSLGYGSSFCRPSYVSSRSYQPSCFRPSC 176
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 173-255 2.94e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 37.46  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46250735   173 CTSSPCQQSCCVSVCCKPVCCKSICCVPVCSGAS-SPCCQQSSCQPACCTSSCCRPSSSVSLLCRPVCSRPASCSFSSGQ 251
Cdd:pfam01500  20 CGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSScCRPTCQPCCQTSCCQPTCCQTSSCQTGCGGIGYGQEGSSGAVSSR 99


                  ....
gi 46250735   252 KSSC 255
Cdd:pfam01500 100 TRWC 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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