|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
100-505 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 753.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNIKD 259
Cdd:cd17456 81 LGAWIKTGSARPDLFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNIDD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 260 QEKLAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAG 339
Cdd:cd17456 161 LDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 340 AFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLW 419
Cdd:cd17456 241 CFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 420 IVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGSA 499
Cdd:cd17456 321 VVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTI 400
|
....*.
gi 1937909538 500 LTAFIK 505
Cdd:cd17456 401 LTALIK 406
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
100-505 |
0e+00 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 645.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNIKD 259
Cdd:cd17398 81 LGAWLKLFSSSPDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 260 QEKLAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAG 339
Cdd:cd17398 161 KDEIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINTG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 340 AFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLW 419
Cdd:cd17398 241 VYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSIW 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 420 IVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGSA 499
Cdd:cd17398 321 VVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGTI 400
|
....*.
gi 1937909538 500 LTAFIK 505
Cdd:cd17398 401 LTAFIK 406
|
|
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
100-505 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 568.31 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNIKD 259
Cdd:cd17455 81 LGAWVKCASVRPDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 260 QEKL-AYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNA 338
Cdd:cd17455 161 DIDLmGHNISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 339 GAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHL 418
Cdd:cd17455 241 GTFYSVSTLLNQMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 419 WIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGS 498
Cdd:cd17455 321 IVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGI 400
|
....*..
gi 1937909538 499 ALTAFIK 505
Cdd:cd17455 401 ILTALIK 407
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
100-505 |
2.66e-119 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 357.87 E-value: 2.66e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGAWVKLGSL-EPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNIK 258
Cdd:cd17334 81 LGSVLKCIPLgQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 259 DQEKlayHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNA 338
Cdd:cd17334 161 GTKK---EFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMM 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 339 GAFYALSTLLNRMvIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSktyKETTLVVYIMTLVGMVVYTFTLNLNHL 418
Cdd:cd17334 238 GVFAGFSSVLAQI-LLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT---RMFKLIGLIILALGTVVCTFFMLLVDR 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 419 -------WIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLC 491
Cdd:cd17334 314 yglpyvtLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLLWF 393
|
410
....*....|....
gi 1937909538 492 VFLALGSALTAFIK 505
Cdd:cd17334 394 ILCTVGSCLGALFF 407
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
100-474 |
1.23e-73 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 240.25 E-value: 1.23e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGAWVKLGSLEPHL-----FPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLV 254
Cdd:cd17399 81 IGAVIRVISSLPFVdpsfrFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 255 PNIKDqeklAYHISIMFYIIGGVATLLfiLVIIVFKEKPKYPPSRAQslsyalATTDASYLSSIVRLFKNLNFVLLVITY 334
Cdd:cd17399 161 KSSED----IFLLLSIYTIPALIAVVL--ATFGVRSSVPPTPPSASA------AHESEPFFVGLKQLFKNKQYLILMLCF 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 335 GLNAGAFYALSTLLNRmvIMHFPGQEVN-AGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTL 413
Cdd:cd17399 229 GGGIGLFNALSTLLEQ--ILCPSGYSNNfAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937909538 414 NL-NHLWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQ 474
Cdd:cd17399 307 RFpNQSVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
100-494 |
5.37e-51 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 179.03 E-value: 5.37e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGAWVKLGSLEPHLFPVTM-VGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVpnik 258
Cdd:cd17397 81 AGTGLRCIPVPNHLATWLIhIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 259 dqeklayhisimFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSlsyalaTTDASYLSSIVRLFKNLNFVLLVITYGLNA 338
Cdd:cd17397 157 ------------MYLEFGWSALIFLAMLIYFPSKPPTPPSVSAS------TQRLSYKSGILSLLKNKRFWLIALAYGIPT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 339 GAFYALSTLLNrmVIMHFPG-QEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTY-KETTLVVYIMTLVGMVVYTFTLNL- 415
Cdd:cd17397 219 GVYAGWSGVLD--VNLTPFGvSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRmKLILLLLFSGATGSFLWFTLICLKl 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 416 --NHLWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTIsqGQIIDNYGS------VPGN 487
Cdd:cd17397 297 lpFSTVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL--ILIIPNIGTswmnwcLLGS 374
|
....*..
gi 1937909538 488 IFLCVFL 494
Cdd:cd17397 375 CLLSVPL 381
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
108-503 |
1.35e-31 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 125.62 E-value: 1.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 108 FSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVKLG 187
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 188 SlepHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVpnikdqEKLAYHI 267
Cdd:cd06174 81 A---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA------SSLGFGW 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 268 SIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYAlattdaSYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTL 347
Cdd:cd06174 152 RAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 348 LNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTykeTTLVVYIMTLVGMVVYTFTLNLNHLWIVFITAGS 427
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG---RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937909538 428 LGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGSALTAF 503
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
99-514 |
3.77e-29 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 119.22 E-value: 3.77e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 99 KRRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALN 178
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 179 CLGAwvkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVpnik 258
Cdd:COG2223 81 GIGL---LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 259 dqekLAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLsyalattdasyLSSIVRLFKNLNFVLLVITYGLNA 338
Cdd:COG2223 154 ----AAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 339 GAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnLNHL 418
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALA--LGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 419 WIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGS-VPGNIFLCVFLALG 497
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVA 375
|
410
....*....|....*..
gi 1937909538 498 SALTAFIKSDLRRQRAN 514
Cdd:COG2223 376 LVLTLLLYRRPRRAAAA 392
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
96-510 |
1.36e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.56 E-value: 1.36e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 96 KVSKRRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITG- 174
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGl 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 175 ---SALNCLGAWVklgslepHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPP 251
Cdd:COG2271 83 llwGLATLLFGFA-------TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 252 VLVPnikdqeklAYHISIMFYIIGGVATLLFIlviivfkekpkyppsraqslsyalattdasylssivrlfknLNFVLLV 331
Cdd:COG2271 156 WLLA--------AFGWRAAFLILGLPGLLLAL-----------------------------------------LRFWLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 332 ITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDK-SKTYKETTLVVYIMTLVGMVVYT 410
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlGRRRKLVLAIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 411 FtlnLNHLWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFL 490
Cdd:COG2271 267 L---LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLL 343
|
410 420
....*....|....*....|
gi 1937909538 491 CVFLALGSALTAFIKSDLRR 510
Cdd:COG2271 344 AALALLAALLALLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
98-467 |
1.19e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 93.50 E-value: 1.19e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 98 SKRRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAL 177
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 178 NCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPni 257
Cdd:COG2814 85 FALGSL--LCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 258 kdqeklAYHISIMFYIIGGVATLLFILVIIVFKEkpkyppsraqslsyALATTDASYLSSIVRLFKNLNFVLLVITYGLN 337
Cdd:COG2814 160 ------LFGWRWVFLVNAVLALLALLLLLRLLPE--------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 338 AGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnlNH 417
Cdd:COG2814 220 GFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALA---GS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1937909538 418 LWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFG 467
Cdd:COG2814 296 LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
107-471 |
2.00e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 92.48 E-value: 2.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 107 VFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWVkl 186
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 187 gSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVpnikdqekLAYH 266
Cdd:pfam07690 79 -LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA--------SLFG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 267 ISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALAttdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALST 346
Cdd:pfam07690 150 WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI--------VAWKALLRDPVLWLLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 347 LLNRMV-IMHFPgqEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWIVFITA 425
Cdd:pfam07690 222 YLPLYQeVLGLS--ALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1937909538 426 gSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFT 471
Cdd:pfam07690 300 -LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
133-502 |
8.21e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 72.97 E-value: 8.21e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 133 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFIL 212
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL--LAALAPS-FALLLLARALAGLAHGGFW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 213 GMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGflvppVLVPNIkdqekLAYHIS--IMFYIIGGVATLLFILVIIVFk 290
Cdd:cd17324 106 AIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLG-----RPLGGL-----LGQLLGwrAAFLAIAVLALLAALLLWRLL- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 291 ekPKYPPSRAQSLsyalattdaSYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNrmVIMHFPGQEVNAGRIGLTI 370
Cdd:cd17324 175 --PSLPPKKPGSL---------GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA--PFLTDVPGFSSSAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 371 V--IAGMFGAMISGIWLDKSKTYKettlVVYIMTLVGMVVYTFTLNLNHLWIVFITAGSLGFFMTGYLPLGFEFAVELTy 448
Cdd:cd17324 242 LfgVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA- 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1937909538 449 PESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGSALTA 502
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
233-521 |
1.66e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 72.63 E-value: 1.66e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 233 SMAVFGNQLGIAIGFLVPPVLVPNIKDQEKLAYHisIMFYIIGGVATLLFILVIIVFKEKPKYPPSRaqslsyalattdA 312
Cdd:COG2211 150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAALGYR--LTALIFAVLGLLAFLLTFFGTKERPVPEEEK------------V 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 313 SYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDK-SKty 391
Cdd:COG2211 216 SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfGK-- 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 392 KETTLVVYIMTLVGMVVYTFtLNLNHLWIVFITAGSLGFFMTGYLPLGF-------EFAVELTYPESEGVSSGLLNVSAQ 464
Cdd:COG2211 294 KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVLPWamladvvDYDEWKTGRRREGLYFGIFTFAIK 372
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1937909538 465 VFGIIFTISQGQIIDNYGSVPGN---------------IFLCVFLALGSALTAFIKSDLRRQRANKDAPETK 521
Cdd:COG2211 373 LGQALAGALAGLLLALFGYVAGAaqspsaltgirllffLLPAVLLLLAALLLLFYPLTRERHAEIRAELAAR 444
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
99-511 |
3.08e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 68.34 E-value: 3.08e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 99 KRRWAVVLVFSCYSLcNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALN 178
Cdd:COG0738 5 NYRRALIAIYLLFFL-WGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 179 CLGAwvkLGSLEPHLFPVTMVGQVICSVAQVFIL-GMPSRIASVwfGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNi 257
Cdd:COG0738 84 ALGL---LLFALAPSYPLLLLALFLLGLGLGLLDvAANPYVAAL--GPETAASRLNLLHAFFSLGALLGPLLGGLLILL- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 258 kdqeKLAYHISIMFYIIGGVATLLFILVIIVfkekpKYPPSRAQslsyalATTDASYLSSIVRLFKNLNFVLLVITYGLN 337
Cdd:COG0738 158 ----GLSLSWHLPYLILAVLLLLLALLFLRS-----KLPEIEEE------EEEAAGSAASLKSLLKNPRLLLGGLAIFLY 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 338 AGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKettlVVYIMTLVGMVVYTFTLNLNH 417
Cdd:COG0738 223 VGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR----LLRLSALLAAVGLLLALLAPG 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 418 LWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLnVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALG 497
Cdd:COG0738 299 PWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
|
410
....*....|....
gi 1937909538 498 SALTAFIKSDLRRQ 511
Cdd:COG0738 378 LLLALALKRKRRKK 391
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
98-504 |
1.08e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 66.82 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 98 SKRRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAL 177
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 178 NCLGAWvkLGSLEPHlFPVTMVGQVICSVAQVFILGMPSRIASVWFgANEVSTACSMAVFGNQLGIAIGFLVPPVLVPni 257
Cdd:COG2807 93 LAAGLL--LRSLAPS-VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAA-- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 258 kdqeklAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSlsyalattdasylSSIVRLFKNLNFVLLVITYGLN 337
Cdd:COG2807 167 ------ALGWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAA-------------ASLRSLWRSPLAWLLTLFFGLQ 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 338 AGAFYALSTLLNRMVI-MHFPGQEvnAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFT-LNL 415
Cdd:COG2807 228 SLLYYAVVAWLPPILRdAGLSAAT--AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 416 NHLWIVFITAGSLGFFmtgylPLGFEFAVELTY-PESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFL 494
Cdd:COG2807 306 PWLWAVLLGLGQGGLF-----PLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAAL 380
|
410
....*....|
gi 1937909538 495 ALGSALTAFI 504
Cdd:COG2807 381 AVLMLVAGLL 390
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
133-502 |
9.42e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 63.80 E-value: 9.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 133 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAlnCLGAWVKLGSLE---PHLFPVTMVGQVICSVAQv 209
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLL--LMGAAALLMALVgsyPVLLVLLFLVGAGYGSVQ- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 210 filGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLvpnikdqeklAYHISI-MFYIIGGVATLLFILVIIV 288
Cdd:cd17475 103 ---PGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPL----------ALHYGWrAAFVVAGLVSILAAVLFWL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 289 FKEKPKYPPSRAQSLSYALAttdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGL 368
Cdd:cd17475 170 FYREPPAASAATESASTLLR--------SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 369 TIVIAGMFGAMISGIWLDK--SKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWIVFITAGSLGFFMTGYLPLGFEFAVEL 446
Cdd:cd17475 242 VAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAES 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1937909538 447 TYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGS-VPGNIFLCVFLALGSALTA 502
Cdd:cd17475 322 AGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSyAPAWLALALLLVLAALLLL 378
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
134-504 |
2.09e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 62.59 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 134 GVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRT----IAITGSALNCLGAWVklgslephlfpVTMVGQVICSvaqv 209
Cdd:cd17319 34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKvlavSMLLWSLFTALTGFA-----------TSLTSLYVLR---- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 210 FILGM------P--SRIASVWFGANEVSTACSMAVFGNQLGIAIGflvPPVLVPnikdqekLAYHIS--IMFYIIGGVAT 279
Cdd:cd17319 99 FLLGVaeagffPgaIKALAEWFPARERGRATGLFNSGAPLGAAIG---PPLSGW-------LLLLFGwrWAFIIEGLLGL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 280 LLFILVIIVFKekpkyppsraqslsyalattdasylssivrlfknlNFVLLVITYGLNAGAFYALSTLLNRMVI--MHFP 357
Cdd:cd17319 169 LLAVLWWFYLR-----------------------------------QVWGLALGYFGINYALYGLLTWLPTYLKqaRGFS 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 358 GQEVnaGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVyIMTLVGMVVYTFTLNLNHLWIVFITAGSLGFFMTGYLP 437
Cdd:cd17319 214 LKQV--GLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASP 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1937909538 438 LGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGS-VPGNIFLCVFLALGSALTAFI 504
Cdd:cd17319 291 VFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSyTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
229-504 |
4.38e-09 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 58.79 E-value: 4.38e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 229 STACSMAVFGNQLGIAIGFLVPPVLVPNIKdqekLAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALA 308
Cdd:cd17313 144 GIINFMGGLGGVLGYLLGAILWDHNWFGFA----LGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLG 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 309 TTDASYLSSIVRLFKNLNFVLLVITYGLNA-GAFYALSTLLNRMVIMHFP-------GQEVNAGRIGLTIV-IAGMFGAM 379
Cdd:cd17313 220 EVLKSLLKLLKIMPRSLLRLLLVIFFWWIAfFPFELFFTDYMGEEVYHGTsaasshyGAGVRMGAWGLLIFsLAFLIFSL 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 380 ISGIWLDKSKTyKETTLVVYIMTLVGMVVYTFTLNLNHLWIVFITAGsLGFFMTGYLPlgFEFAVELT--YPESEGVSSG 457
Cdd:cd17313 300 PIGKLGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGG-IGWATININP--YPLVSDYHseSGRGQGTDTG 375
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 1937909538 458 LLNVSAQVFGIIFTISQGQIIDnygsVPGNIFLCVFLALGSALTAFI 504
Cdd:cd17313 376 LLNLAISLAQILVSLLAGPIID----VKGYGTVFPVAAVASFLSLVG 418
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
128-505 |
5.56e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.97 E-value: 5.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 128 IFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSAlncLGAWVKLGSLEPHLFPVTMVGQVICSVA 207
Cdd:cd17325 21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLL---LLAVSTLLFAFATSYWQLLLARFLQGLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 208 QVFIlgMPSRIASV--WFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPnikdqeklAYHISIMFYIIGGVATLLFILV 285
Cdd:cd17325 98 SAAV--WPAAMALIadIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAD--------ALGYRAPFLVCAALALLALVLA 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 286 IIVFKEKPKYPPSRAQSlsyalattDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFpgqEVNAGR 365
Cdd:cd17325 168 LLLLPEPRPPPNKRAVS--------AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELG---GLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 366 IGLTI---VIAGMFGAMISGIWLDKsKTYKETTLVVYIMTLVGMVVYTFTLNlnhLWIVFITAGSLGFFMTGYLPLGFEF 442
Cdd:cd17325 237 IGLLFgaqGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATS---FWLLLLLLALLGLGLGLVFPATLAL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1937909538 443 AVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGSALTAFIK 505
Cdd:cd17325 313 LADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
158-503 |
5.83e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 58.05 E-value: 5.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 158 VAWMLEKFGLRTIAITGSALNCLGAWVKLGSLEPHLFPVTMVGQVICSVAqVFILGMPSRIASVWFGANEvSTACSMAVF 237
Cdd:cd17355 58 VGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAG-TLAAVAFATVAAWWFERRR-GLALGILTA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 238 GNQLGiaiGFLVPPVLVPnikdqekLAYHIS--IMFYIIGGVATLLFILVIIVFKEKPKYPPSRAqslsyALATTDASYL 315
Cdd:cd17355 136 GGGLG---SLVFLPLGAA-------LIEAFGwrTALLVLALLALLVLVPVLLLLRRRPADLALRA-----YDDASPASPG 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 316 SSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGLtIVIAGMFGAMISGIWLDK-SKTYkeT 394
Cdd:cd17355 201 STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL-IGLFNIVGRLLSGWLGDRySPRR--L 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 395 TLVVYIMTLVGMVVYTFTLNLNHLWIVFitAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQ 474
Cdd:cd17355 278 LAASYALRALGLALLLLLPFPPLALLLF--AALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLG 355
|
330 340
....*....|....*....|....*....
gi 1937909538 475 GQIIDNYGSVPGNIFLCVFLALGSALTAF 503
Cdd:cd17355 356 GLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
102-504 |
8.48e-09 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 57.56 E-value: 8.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 102 WAVVLV-----FSCYSLCNAFqwiqyGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSA 176
Cdd:cd17352 2 WVVVFAsflvnFFTDGILNSF-----GVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 177 LNCLGAWvkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFgANEVSTACSMAVFGNQLGiaiGFLVPPVLvpn 256
Cdd:cd17352 77 LAALGLL--LSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVG---TFVFPPLL--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 257 ikdqeklayhiSIMFYIIGGVATLLFILVIIVFkekpkyppsraqslsyalattdASYLSSIVRLFKNLNFVLLVITYGL 336
Cdd:cd17352 148 -----------RYLLDNYGWRGALLILGGLCLN----------------------LCVCGLLLRLLKDPTFVLLALGVSF 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 337 NAGAFYALSTLLNRMVIMHfpGQEVNAGRIGLTIV-IAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTLnL 415
Cdd:cd17352 195 AMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGR-LYLYIFTLLILGLSLLAFPL-A 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 416 NHLWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLA 495
Cdd:cd17352 271 TTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACL 350
|
....*....
gi 1937909538 496 LGSALTAFI 504
Cdd:cd17352 351 LLSGVLLFL 359
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
133-502 |
4.69e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 55.27 E-value: 4.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 133 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAwvkLGSLEPHLFPVTMVGQVIcsvaQVFIL 212
Cdd:cd17320 29 LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS---LLCALASSIEQLLIARFL----QGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 213 GMPSRIASV----WFGANEVSTACSMavfgnqlgIAIGFLVPPVLVPNIKDQEKLAYHISIMFYIIGGVATLLFILVIIV 288
Cdd:cd17320 102 AAGSVVARAivrdLYSGAELAKIFSL--------LMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLF 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 289 FKEKPKYPPSRAQSlsyalattdASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGL 368
Cdd:cd17320 174 LPETLPEEKRKPLL---------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 369 TIVIAGMFGAMISGIWLDKSKTYK--ETTLVVYIMTLVGMVVYTFTLNLNHLWIV---FITAGSLGFFMtgylPLGFEFA 443
Cdd:cd17320 245 LNAIALILGSLLNGRLVRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVaplFLIFFGFGLIF----PNATSLA 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1937909538 444 VELtYPESEGVSSGLLNvSAQVFGIIFTISQGQIIDNYGSVP--GNIFLCVFLALGSALTA 502
Cdd:cd17320 321 LEP-FPHVAGTASALLG-FLQFLIGALAGALVGLLPNGTALPmgLLILVLGLLALLLLILL 379
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
133-503 |
2.18e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 49.94 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 133 YGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALN---CLGAWVKLGSLEPHLfpvtMVGQVICSVAQV 209
Cdd:cd17341 29 LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLlipLLALALAVSSYWGLL----VLGFLLGFAGAN 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 210 FILGMPSriASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNIKDQEK-LAYHISIMFYIIggVATLLFILVIIV 288
Cdd:cd17341 105 FASGQPW--ASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGfVGWRNAFFVPGI--LLAIAAVLVLLF 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 289 FKEKPKYPPSRAQSLSYALATtdasylssivrlFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGL 368
Cdd:cd17341 181 GDDLPTGKASALEFLKVQLAV------------LKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 369 TIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGM--VVYTFTLNLNHLWIvFITAGSLGFFMTGyLPLGFEFA-VE 445
Cdd:cd17341 249 LFPLAGALARPAGGWLSDRFGGRR-RLWWLFIVMTIGAalLSLSLPTSGTNLVL-FLALFVALGLGAG-AGNGSVFRmVP 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1937909538 446 LTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLALGSALTAF 503
Cdd:cd17341 326 FIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVW 383
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
94-289 |
1.01e-05 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.99 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 94 VIKVSKRRwaVVLVFSCysLCNAFQWIQYG---SINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLE-KFGLRT 169
Cdd:cd17490 187 LLSVLKDK--KLLFFSL--LAILQQMITFSttfGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYkKLGERN 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 170 IAITGSALncLGAWVKLGSLEPHLFpVTMVGQVICSVAQ--VFILGMPSRIASVwfGANEVSTAcsMAVFgnQLGIAIGF 247
Cdd:cd17490 263 TIIIGFLL--LGAYCFLIPFAPNLT-LLYLLQALNGFGTgiLFPLLMSLSIEGV--PAEQRSTA--MGFF--QAIYALGM 333
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1937909538 248 LVPPVLVPNIKDqeklAYHISIMFYIIGGVATLLFILVIIVF 289
Cdd:cd17490 334 FLGPVLVGIISE----AFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
128-503 |
1.38e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.55 E-value: 1.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 128 IFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALncLGAWVKLGSLEPHLFPVTMVgqvicsva 207
Cdd:cd17478 21 LLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLL--TGLGLSLLGFAPNYWLLLLL-------- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 208 qVFILGMPS--------RIASVWFGANEvstACSMAVF--GNQLGIAIGFLVPPVLVpnikdqEKLAYHISIMFYIIGGV 277
Cdd:cd17478 91 -VALAGIGSaafhpegaRLASQAAGGRR---GLAMSIFsvGGNLGFALGPLIAAALV------ALFGGLGLLILLIIPGL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 278 ATLLFILVIivfkeKPKYPPSRAQSLSYALATtdasylssIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFp 357
Cdd:cd17478 161 AVALLLLRL-----RPLKKPEAKKAAAKSSAR--------STLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRG- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 358 GQEVNAGRIGLTIVIAGMFGAMISGIWLDKsktYKETTlvVYIMTLVGMVVYTFTLNLNHLWIVFITAGSLGFFMTGYLP 437
Cdd:cd17478 227 YSLVFAGLLLSLFLFAGAIGTLIGGPLSDR---FGRRR--VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1937909538 438 LGFEFAVELTyPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGnIFLCVFLALGSALTAF 503
Cdd:cd17478 302 VTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
102-294 |
2.42e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.82 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 102 WAVVLVFSCYSLCNAFQWiqygSINNIFMNFY-GVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCL 180
Cdd:COG2211 231 LLLLLAYLLFFLALALVA----ALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAAL 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 181 GAWVkLGSLEPHLFPVTMVGQVICSVAQVFILGMP-SRIASV------WFGANEVSTACSMAVFGNQLGIAIG-FLVPPV 252
Cdd:COG2211 307 GLLL-LFFLGPGNLWLLLVLAALAGIGLGAILVLPwAMLADVvdydewKTGRRREGLYFGIFTFAIKLGQALAgALAGLL 385
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1937909538 253 L-----VPNIKDQEKLAYHISIMFYIIGGVATLLFILVIIVFKEKPK 294
Cdd:COG2211 386 LalfgyVAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRE 432
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
100-504 |
7.50e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 45.29 E-value: 7.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 100 RRWAVVLVFSCYSLCNAFQWIqYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC 179
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYA-WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 180 LGaWVkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFgANEVSTACSMAVFGNQLGiAIGFLVPPVLVPNikd 259
Cdd:cd17353 80 LG-FI-LSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLG-SLIFSPLIAYLIN--- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 260 qeklAYHISIMFYIIGGVATLLFILVIIVFKEKPK-YPPSRAQSLSYALATTDASYlsSIVRLFKNLNFVLLVITYGLNa 338
Cdd:cd17353 153 ----TVGVPTTFLILGIIFLIIIVIGAFLIRDPPKgWVPPGVDPLANNAENSPRDY--TPREMLRTPTFWLLWLMFFLN- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 339 gAFYALSTL-LNRMVIMHFPGQEVNAGRIGLTIV-IAGMFGAMISGIWLDKSKtYKETTLVVYIMTLVGMVvyTFTLNLN 416
Cdd:cd17353 226 -ATAGLMLIgQAKPIGQEFAGLDAGIAALAVSILsIFNGGGRPFWGWLSDKIG-RKNTLSIAFLIQGVAMF--LLPFIGS 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 417 HLWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVPGNIFLCVFLAL 496
Cdd:cd17353 302 VAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLV 381
|
....*...
gi 1937909538 497 GSALTAFI 504
Cdd:cd17353 382 ALALALLL 389
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
273-471 |
1.30e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 44.54 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 273 IIGGVATLLFILVIIVFKEKPKYPPsraqslsyalattdasylssiVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMV 352
Cdd:cd06179 231 VIGGVLLIAFGLYEWKGTKDGLLPP---------------------RLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQI 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 353 IMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVY-TFTLNLNHLWIVFITAGSLGFF 431
Cdd:cd06179 290 SLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLaLITPDNKALAIAFSVLAGIGIG 369
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1937909538 432 MTGYLPLgfeFAVELTYPESE-GVSSGLLNVSAQVFGIIFT 471
Cdd:cd06179 370 GPLVLAI---VIVQLSVPPEDiGTASGLLGSARALGGAVGT 407
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
326-503 |
1.42e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 326 NFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWLDKsKTYKETTLVVYIMTLVG 405
Cdd:cd17316 178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGIL 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 406 MVVYTFTLNLNhLWIVFITAGSLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGSVP 485
Cdd:cd17316 257 ALPLFYLLSGS-PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335
|
170
....*....|....*...
gi 1937909538 486 GNIFLCVFLALGSALTAF 503
Cdd:cd17316 336 VPALILALLAIVALIVAL 353
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
237-440 |
8.85e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.82 E-value: 8.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 237 FGNQLGIAIGFLVPPVLVPNIKDQEKlAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSraqslsyalATTDASYLS 316
Cdd:cd17332 143 FFATIGGLLVTVLPPPLVAYFGGGNA-SRGYFLTALIIGIIGIILLLICFFGTRERVVPPEE---------EKSKLPLLK 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 317 SIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMIS--GIWLDKSKTYKeT 394
Cdd:cd17332 213 SLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPplKKRFGKKKAFF-I 291
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1937909538 395 TLVVYIMTLVGMvvytFTLNLNHLWIVFITAGSLGFFMTGYLPLGF 440
Cdd:cd17332 292 GLLLAILGLLLL----FFLPPGNLVLILVLAVLAGIGYGGANLLPW 333
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
136-505 |
1.83e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 136 SAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNC-----LGAWVKLGSLEPhlfPVTMVGQVICSVAQVF 210
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAllaavLALLALLGSLSL---WLLLVLAFLLGIASAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 211 ilGMPSRIASV--WFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVpnikdqekLAYHISIMFYIiggVATLLFILVIIV 288
Cdd:cd06173 109 --FGPARQALLpeLVPKEQLVRANALNSLATQLARIIGPALGGLLV--------ALLGPGGAFAI---NALSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 289 FKEKPKYPPSRAQSLSYALAttdaSYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGrigl 368
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLR----DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYG---- 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 369 TIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWIVFITAGSLGFFMTGYLPLGFEFAVELTY 448
Cdd:cd06173 248 LLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVP 327
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1937909538 449 PESEGVSSGLLNVSAQVFGIIFTISQGQIIDNYGsVPGNIFLCVFLALGSALTAFIK 505
Cdd:cd06173 328 DELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSAVFLLAGALLLLAALLLLLL 383
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
151-478 |
2.60e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.50 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 151 YIPLLLPVAWMLEKFGLRTIaitgsalncLGAWVKLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASV--------W 222
Cdd:TIGR00894 89 QIIIQIPVGYLAGKYVFKWS---------IGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPathkiivkW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 223 FGANEVSTACSMAVFGNQLGIAIGFLVPPVLVpnikdQEKLAYHIsiMFYIIGGVATLLFILVIIVFKEKPKYPPS---- 298
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLC-----ESWGGWPM--IFYVFGIVGCAWSLLWFVFPADDPSIHPCiskf 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 299 RAQSLSYALATTDASYLSSIV--RLFKNLNFVLLVityglnaGAFYALSTLLNRMV---------IMHFPGQEvNAGRIG 367
Cdd:TIGR00894 233 EKKYINSSLQGQKGSTRQSLPikAIPKSLPVWAIW-------FAIFGHFWLYTILPtylptfiswVLRVSGKE-NGLLSS 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 368 LTIVIAGMFGaMISGIWLD--KSKTYKETTLVVYIMTLVG------MVVYTFTLNLNHLWIVFIT---AGSLGFFMTGYL 436
Cdd:TIGR00894 305 LPYLFAWLCS-IFAGYLADflKSSKTLSLTAARKIFNGIGglgpgiFAYALPYLSAAFYLTIIILtlaNAVSSGPLAGVL 383
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1937909538 437 PLGFEFAveltyPESEGVSSGLLNVSAQVFGIIFTISQGQII 478
Cdd:TIGR00894 384 INSLDLA-----PRFLGFIKGITGLPGFIGGLIASTLAGNIL 420
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
130-433 |
3.27e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.87 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 130 MNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAWvkLGSLEPHlFPVTMVGQVICSVAQV 209
Cdd:cd17503 23 MGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSL--LCGLAPN-LASLIIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 210 FILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLVPNikdqeklaYHISIMFYIIGGVATLLFILVIIVf 289
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDN--------LSWRWIFYINLPIGILALLLAPLL- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 290 kekpkyppsraqslsyalattdasylssIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMhfpGQEVNAGRIGLT 369
Cdd:cd17503 171 ----------------------------DLRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQN---VLGYSAFESGLV 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 370 IV---IAGMFGAMISGIWLDK--SKTYKETTLVVYIMTLVGMVVYTFTLNLNHL-WIVFITAGSLGFFMT 433
Cdd:cd17503 220 LApggLASAILSPLVGRLLDKfgPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIiLPLFIRGLGMGLVFM 289
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
98-385 |
4.06e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 98 SKRRWAVVLVFScysLCNAFQWIQYGSINNIF---MNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITG 174
Cdd:COG0477 9 TRRRRRALLALA---LGTFLEGLDFTIVNVALpsiAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 175 SALNCLGAwvkLGSLEPHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLGIAIGFLVPPVLV 254
Cdd:COG0477 86 LLLFGLAS---LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 255 PnikdqeklAYHISIMFYIIGGVATLLFILVIIVFKEKPKYPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITY 334
Cdd:COG0477 163 A--------ALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLL 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1937909538 335 GLNAGAFYALSTLLNRMVIMHFPGQEVNAGRIGLTIVIAGMFGAMISGIWL 385
Cdd:COG0477 235 AGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLL 285
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
131-455 |
7.11e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 7.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 131 NFYGVSAFAIDWLSMCYMLTYIPLLLPVAWMLEKFGLRTIAITGSALNCLGAwvkLGSLEPHLFPVTMVGQVICSVAQVF 210
Cdd:cd17333 24 EAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLAL---ALIFATPSIYLFVVLMFLAGLGAGI 100
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 211 ILGMpsriASVWFGANEVSTACSMAVFGNQLgIAIGFLVPPVLVPNIKDQEklaYHISIMFYIIGGVATLLFILVIIVFK 290
Cdd:cd17333 101 LDTG----ANTFVGALFEESSATRLNVLHGF-FGLGALIGPLIATSLLTSE---LSWSWAYLIIGLIYLLLAILILLTLF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 291 ekpkypPSRAQSLSYALATTDASYlsSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVIMHFPGQEVNAGrIGLTI 370
Cdd:cd17333 173 ------PELPSARNPQQSVGAFSA--SASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAG-YLLSG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 371 VIAGMFGAMISGIWLdkSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWIVFITAGsLGFFMTGYLPLGFEFAVE-LTYP 449
Cdd:cd17333 244 FWVGITIGRLLGGPI--SRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATAL-LGLFMAALFPTILSLGISnLPYA 320
|
....*.
gi 1937909538 450 ESEGVS 455
Cdd:cd17333 321 KGKGTS 326
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| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
83-245 |
8.96e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 38.42 E-value: 8.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 83 THPNELVKEDSVIKVSKRRWAVVLVFSCYSLCNAFQWIQYGSINNIFMNFYGVSAFAIDWLSMCYMLTYIPLLLPVAWML 162
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1937909538 163 EKFGLRTIAITGSALNCLGAWVKLGSlepHLFPVTMVGQVICSVAQVFILGMPSRIASVWFGANEVSTACSMAVFGNQLG 242
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLALA---GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
...
gi 1937909538 243 IAI 245
Cdd:COG2814 345 GPL 347
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